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INDONESIA
Indonesian Journal of Tropical and Infectious Disease
Published by Universitas Airlangga
ISSN : 20851103     EISSN : 23560991     DOI : -
Core Subject : Health, Science,
Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health
This journal is a peer-reviewed journal established to promote the recognition of emerging and reemerging diseases specifically in Indonesia, South East Asia, other tropical countries and around the world, and to improve the understanding of factors involved in disease emergence, prevention, and elimination. The journal is intended for scientists, clinicians, and professionals in infectious diseases and related sciences. We welcome contributions from infectious disease specialists in academia, industry, clinical practice, public health, and pharmacy, as well as from specialists in economics, social sciences and other disciplines.
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Articles 8 Documents
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Search results for , issue "Vol. 13 No. 3 (2025)" : 8 Documents clear
Antibacterial Effects of Cranberry and Lime Extracts Against Uropathogenic Escherichia coli (UPEC). Nasution, Afrida Aryani; Mayasari, Evita; Simatupang, Maria Magdalena; Amelia, Sri; Alona, Ivana
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.64056

Abstract

Urinary tract infections (UTIs) continue to increase in the number of cases and death rates every year. This increase in the number of deaths is due to an increasing trend in UTI cases in elderly patients. In Indonesia, UTI is generally caused by the uropathogenic Escherichia coli (UPEC) strain. The existence of resistant bacterial infections also triggers increased mortality in UTI patients. Several types of herbs, such as cranberries, are often used traditionally to treat UTI symptoms. Another herb that is also known to have antibacterial effects is lime. This experimental study examined the in vitro antimicrobial effects of ethanol extract of cranberry (Vaccinium macrocarpon) and ethanol extract of lime (Citrus aurantifolia L.) against UPEC by the Kirby-Bauer disc diffusion method. This study used a clinical sample obtained from an outpatient diagnosed with UTI in the Prof. dr. Chairuddin P. Lubis Universitas Sumatera Utara Hospital in March 2023. The UPEC strain was isolated and identified using the Vitek 2 Compact automated system at a local university hospital. The antimicrobial susceptibility test results indicated that the ethanol extract of cranberry did not produce an inhibition zone at concentrations of 12.5%, 25%, 50%, 60%, 70%, and 96%. The ethanol extract of lime demonstrated inhibitory zones against UPEC, with a mean diameter of 12.01 mm at a concentration of 12.5% and a mean diameter of 15.62 mm at 96%. The cranberry extract did not demonstrate an inhibitory zone against UPEC in vitro, whereas the lime extract did.
Incidence and Risk Factors for Renal Dysfunction in HIV Patients Anti-Retroviral Therapy-Naïve that accepts TLD at Prof. Dr. dr. IGNG Ngoerah Hospital: A Prospective Cohort Study Duarsa, Made Dyah Vismita Indramila; Somia, I Ketut Agus
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.65513

Abstract

The administration of TLD in ART-naive HIV patients can reduce kidney function, with certain risk factors potentially exacerbating side effects. This study investigates the incidence of kidney dysfunction and associated risk factors among ART-naive HIV patients initiating treatment with TLD. A prospective cohort study was conducted at Prof. Dr. dr. IGNG Ngoerah Hospital. The study population comprised HIV-1-infected, ART-naive adults selected through simple random sampling. Data were collected between July and August 2024, with a two-week follow-up after the initial ART dose. SPSS version 25 was used for data analysis, including chi-square, paired-sample t-tests, and logistic regression tests. A p-value of ≤0.05 was considered significant. Among 52 patients (18 women, 34 men; mean age 40.29±11.23 years), 13 (25%) experienced kidney dysfunction before ART, increasing to 24 (46.2%) two weeks after treatment. GFR changes were insignificant (100.48±22.999 vs. 96.303 ± 23.059, p-value=0.1). However, age at diagnosis and anemia are found to be significant as risk factors for kidney dysfunction in bivariate analysis (RR = 6.071, 95%CI 1.823-20.217, p-value=0.002; RR = 3.091, 95%CI 0.990-9.647, respectively). Based on multivariate analysis, the age of diagnosis is an independent risk factor of kidney dysfunction (adjusted RR = 6.071, 95%CI 1.823-20.217, p-value=0.003). Other factors, including gender, BMI, hypertension, diabetes, and hepatitis, were insignificant (p-value>0.05). Age at diagnosis emerged as an independent risk factor for renal dysfunction in ART-naive individuals starting TLD.
Genetic Mutations and Polymorphisms Related to Severity, Mortality, and Antibody-Dependent Enhancement of Dengue Virus (DENV) Infection: A Literature Review Purnamasidhi, Cokorda Agung Wahyu; Junior, Darren; Satya Diksha, I Gusti Ngurah Ariestha; Hiranandini Prawista, I Gusti Ayu Maha; Guptha, I Dewa Gede Agung Siwa; Pratyaksa, I Gusti Ngurah Dinda; Indratmo, Novea; Suteja, Richard Christian; Harkitasari, Saktivi
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.70457

Abstract

The dengue virus (DENV) is a blood-borne Flavivirus transmitted through vectors and ranks as the fastest-spreading tropical disease globally. Dengue infection could exhibit mild to severe symptoms depending on various factors. Antibody-dependent enhancement (ADE) is a cross-reactive phenomenon between different DENV strains that clinicians should be aware of, as it leads to a higher incidence of dengue with warning signs and severe dengue. On the molecular level, many genes contribute to the severity and pathophysiology of ADE. Mutations and polymorphisms in these genes could alter the course of dengue infection. This article aims to comprehensively review studies that measure the impact of dengue-related genetic mutations and polymorphisms on the severity, mortality, and ADE of DENV infection. We performed a literature review to identify relevant articles on PubMed, Science Direct, Europe PMC, and Google Scholar. The review examines polymorphisms across multiple gene families: Fcγ receptors, cytokines (TNF-α, TGF-β1, IL-10), immune regulatory genes (MICB, PLCE1, RIPK2), antigen-presenting machinery (DC-SIGN, TAP), and host defense mechanisms (VDR, CTLA-4, MBL, HPA). These genetic variations have population-specific effects and may confer both protection in some populations and increased susceptibility to severe outcomes of dengue in others. The effects of these polymorphisms are context-dependent and differ according to the phase of infection, ethnicity, and gene-gene interactions. Overall, it could be concluded that aside from external factors, polymorphisms on human genes regulating mechanisms and components related to dengue infection have been extensively discussed to play a role in the overall clinical outcome.
Evaluation of Mangrove, Acanthus ilicifolius Aqueous Extract on Inhibition of Dengue Virus Replication: In Vitro and Molecular Docking Approach Wiradana, Putu Angga; Wiartini, Ni Wayan Ayu Wiartini; Sucipto, Teguh Hari; Herdiansyah, Mochammad Aqilah; Permatasari, Anak Agung Ayu Putri; Widhiantara, I Gede; Sari, Ni Kadek Yunita Sari; Darmanto, Win; Panjaitan, Novaria Sari Dewi Panjaitan; Kusala, Muhammad Khaliim Jati Kusala
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.71217

Abstract

Dengue virus (DENV) infection is a worldwide health risk, presenting severe symptoms with possibly lethal consequences. The search for effective antiviral drugs against DENV has largely focused on natural products. Mangrove, Acanthus ilicifolius, has been empirically shown to exhibit various biological activities and good safety profiles.  The purpose of this investigation was to examine the antiviral activity of A. ilicifolius aqueous extract against DENV, and the way it functions of action of its bioactive components function was explored utilizing an in vitro and molecular docking method. Aqueous extract of A. ilicifolius leaves was made, and its therapeutic potential was examined using half cytotoxic concentration (CC50) and effective concentration (EC50) on Vero cells using the MTT method. The selectivity index (SI) value was determined from the ratio of CC50 and EC50. A total of 12 ligand compounds reported to be contained in the extract were prepared for molecular docking using AutoDock Vina, followed by in silico drug-like potential.  A. ilicifolius water extract achieved the greatest Vero cell viability rate of 159.80% at a concentration of 31.25 μg/mL. A. ilicifolius extract at 100 μg/mL demonstrated the greatest DENV-3 inhibitory rate of 79.69%. The CC50 value was 78.55 μg/ml, and the EC50 value was 64.37 μg/mL.  The SI value calculated from the ratio of CC50 to EC50 was 1.22. Molecular docking identified stigmasterol, stigmasterol-3-O-β-d-glucopyranoside, and quercetin as the primary compounds with the greatest docking values (-7.9 kcal/mol, -7.6 kcal/mol, and -7.7 kcal/mol, respectively).  The findings of this study demonstrate the anti-DENV capability of the A. ilicifolius extract compound, which can limit viral multiplication via biological agents that interact with virus attachment within host cells, with an SI value of 1.22.
Correlation Between Platelet and Hematocrite Values with Duration Fever in Dengue Hemorrhagic Fever (DHF) Patients at Dr. Soedomo General Hospital, Trenggalek Alelo, Richardo Reynaldi Sakka; Sucipto, Teguh Hari; Soegijanto, Soegeng; Wardhani, Puspa
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.73388

Abstract

Dengue Hemorrhagic Fever (DHF) is an endemic disease in Indonesia with laboratory manifestations such as thrombocytopenia and hemoconcentration. The duration of fever in DHF can be an indicator of disease severity, but its relationship to laboratory parameters such as platelets and hematocrit requires further study. The purpose of this research is to determine the relationship between platelet and hematocrit values and the duration of fever in DHF patients at Dr. Soedomo Trenggalek Regional General Hospital. This study used a cross-sectional design with secondary data from the medical records of 71 dengue fever patients. Statistical analysis used the Spearman correlation test to assess the relationship between platelets and hematocrit with fever duration. 54.93 % of patients were male, with the largest age group being young adults (26–45 years, 39.44%). The maximum duration of fever was 5 days (54.93 %). There was a weakly significant relationship between decreased platelets and increased duration of fever (p = 0.025; r = 0.266). However, there was no significant relationship between hematocrit and duration of fever (p = 0.359; r = -0.111). Platelets can be used as an indicator to estimate the duration of fever in dengue fever patients, while hematocrit did not show a significant relationship. These findings support the importance of platelet monitoring for the clinical management of dengue fever, although factors such as fluid therapy and disease phase need to be considered in hematocrit interpretation.
Robusta Coffe-Derived Silver Nanoparticles as a Natural Photosensitizer for Photodynamic Inactivation of Bacterial Biofilms Amruloh, Yazid Muhammad; Astuti, Suryani Dyah; Arifianto, Deny; Nurdin, Dezy Zahrotul Istiqomah; Zaidan, Andi Hamim; Widiyanti, Prihartini; Yaqubi, Ahmad Khalil; Winarno; Abd Razak, Nasrul Anuar
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.74709

Abstract

Bacterial biofilm formation represents a major challenge in clinical settings, as it contributes to persistent infections and resistance to conventional antimicrobial treatments. This study investigates the effectiveness of blue laser therapy combined with AgNPs-CR in inhibiting biofilm formation by Escherichia coli and Staphylococcus aureus, common infection agents, in a four-group sample set. Silver nanoparticles, known for their antibacterial, antifungal, and antiviral properties, are widely used in biomedical devices. First, the control group (T0) included samples without laser irradiation. Second, the Escherichia coli and Staphylococcus aureus groups (A1 and A2) were irradiated with a 405 nm diode laser at various exposure times and silver nanoparticle concentrations. Third, the E. coli and S. aureus groups (A3 and A4) were also irradiated with the 405 nm diode laser under varying durations and concentrations of silver nanoparticles. In groups A2 and A4, the bacteria were treated with the photosensitizer AgNPs-CR, incubated for 30 minutes, and then irradiated for 90, 120, 150, and 180 seconds. The results were analyzed using a two-way factorial ANOVA and a Post-hoc Tukey test, with a significance level of p < 0.05. Photodynamic therapy (PDT) significantly inhibited bacterial biofilms in samples with irradiation, with the most significant reduction observed at a concentration of 2 mM and 180 seconds of irradiation, compared to samples without irradiation. Staphylococcus aureus was the most susceptible to AgNPs, showing a high biofilm inhibition percentage of 94.82% at 180 seconds of irradiation with a 2 mM concentration. Fluorescence microscope analysis revealed the presence of bacterial DNA corresponding to 180 colonies.
Activity of Alginate-Gelatin Hydrogels Containing Metal-Organic Frameworks Against Escherichia coli and Staphylococcus aureus for Wound Dressing Application Mulyati, Tri Ana; Ekowati, Juni; Sariwati, Atmira; Agustina, Lia; Wardani, Siska; Erawati, Erawati; Pujiono, Fery
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.77403

Abstract

Bacterial infections, such as S. aureus and E. coli, remain a global health issue, particularly concerning bacterial resistance, which often leads to serious complications. One approach to address this problem is the development of Metal Organic Frameworks (MOFs), known for their high conductivity and antibacterial activity. Zn-based MOFs are known to possess strong antibacterial activity because Zn²⁺ ions can damage bacterial cell membranes, disrupt enzymatic processes, and induce oxidative stress. In comparison, Zr-based MOFs are well known for their excellent chemical stability and biocompatibility. In this study, hydrogels containing three types of MOFs-Zn-BDC, Zn-Fer, and Zr-BDC were developed. This research aims to synthesize and characterize alginate-gelatin hydrogels containing MOFs and evaluate their antibacterial activity. The results indicate that the modification of alginate-gelatin hydrogels with MOFs has been successfully synthesized, as evidenced by FTIR, XRD, and SEM-EDS analyses. The materials successfully produced include Hy/Zn-BDC, Hy/Zn-Fer, and Hy/Zr-BDC. Antibacterial activity testing shows that adding MOF into the hydrogel matrix significantly increases the inhibition against S. aureus and E. coli compared to the hydrogel without MOF. Among the three MOF variants, Hy/Zn-BDC showed the highest antibacterial activity, followed by Hy/Zn-Fer and Hy/Zr-BDC. Specifically, Hy/Zn-BDC inhibited S. aureus growth by 95% and E. coli by 100%, accompanied by the lowest effective inhibitory concentration values (2.0 mg/mL and 2.4 mg/mL, respectively). These results demonstrate the high effectiveness of Zn-based MOF in enhancing the antibacterial performance of the hydrogel as well as its potential development for wound dressing applications.
Comparison of Clinical Characteristics of Pulmonary Tuberculosis Patients with and without Diabetes Mellitus at Dr. Soetomo Hospital Idwar, Fadiah Dini Putri; Wahyunitisari, Manik Retno; Wironegoro, Rio; Rosyid, Alfian Nur
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.78117

Abstract

Tuberculosis (TB) is a transmissible infectious condition attributable to Mycobacterium tuberculosis. Common symptoms of tuberculosis include a persistent cough lasting more than two weeks, fever, fatigue, malaise, and unintended weight loss. These symptoms may become more severe in individuals with co-infected Diabetes Mellitus (DM) due to impaired immunity. In 2021, approximately 400,000 people were reported to have TB-DM. Active TB can disrupt glucose tolerance, contributing to TB-DM2. Studies indicate this combination affects disease progression and treatment outcomes from both patients. This study employed an observational design with descriptive and analytical approaches. The study utilized medical record data from individuals diagnosed with TB who were managed at Dr. Soetomo General Academic Hospital in 2023.  There were 245 total patients, comprising 151 TB without DM and 94 TB with DM cases. The analysis demonstrated a statistically significant difference in mean age between the two groups (p = 0.000). In both groups, the majority were male (69.5%; 63.8%). Cough was more frequent in TB with DM patients (p = 0.038). The most common systemic symptom in both groups was weight loss (70.9%; 63.8%). AFB and GeneXpert MTB/RIF assays results showed no significant differences in between. However, significant differences were found in leukocyte, ALT, AST, and BUN levels (p = 0.001; 0.004; 0.019; 0.007). Radiological examinations showed no significant differences. TB patients with and without DM differ significantly in age, symptoms, and several laboratory parameters, suggesting that comorbidity may influence TB characteristics and clinical presentation.

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