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Global Medical and Health Communication
Published by Universitas Islam Bandung
ISSN : 23019123     EISSN : 24605441     DOI : https://doi.org/10.29313/gmhc
Core Subject : Health, Science,
Dentistry Health Professions Immunology & microbiology Nursing Public Health
Global Medical and Health Communication is a journal that publishes research articles on medical and health published every 4 (four) months (April, August, and December). Articles are original research that needs to be disseminated and written in English. Subjects suitable for publication include but are not limited to the following fields of anesthesiology and intensive care, biochemistry, biomolecular, cardiovascular, child health, dentistry, dermatology and venerology, endocrinology, environmental health, epidemiology, geriatric, hematology, histology, histopathology, immunology, internal medicine, nursing sciences, midwifery, nutrition, nutrition and metabolism, obstetrics and gynecology, occupational health, oncology, ophthalmology, oral biology, orthopedics and traumatology, otorhinolaryngology, pharmacology, pharmacy, preventive medicine, public health, pulmonology, radiology, and reproductive health.
Arjuna Subject : Kedokteran - Epidemilogi
Articles 422 Documents
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The Effect of Curcuma and Garcinia Peel on Rat PPARα Gene Expression Induced by High-Fat Diet Jasaputra, Diana Krisanti; Yumilia, Hoo; Gunadi, Julia Windi; Lesmana, Ronny; Permadi, Andieni Faqhira
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.10993

Abstract

High levels of fat in the blood are a risk factor for nonalcoholic steatohepatitis liver disease. Indonesian medicinal plants that can decrease blood fat levels are turmeric and mangosteen peel. One of the mechanisms of blood fat-lowering drugs is to increase the expression of the PPARα gene. The purpose of this study was to assess the effect of turmeric and mangosteen peel on the expression of the PPARα gene in the rat liver induced by a high-fat diet. This research was conducted at Maranatha Biomedical Research Laboratory in February–October 2021, using male Wistar rats that were divided into 5 groups (n=5): negative control groups (no treatment), positive control groups (high-fat diet), turmeric, mangosteen, and fenofibrate groups, that was given high-fat diet continued by ethanol extract of turmeric, ethanol extract of mangosteen peel, and fenofibrate. At the end of the study, the animals were terminated, and the liver was extracted for RNA extraction and semi-quantitative PCR. The results showed that there was an increase in PPARα gene expression in the turmeric group and fenofibrate group, which were significantly different from the positive control group that received a high-fat diet (p<0.05) and between the fenofibrate group compared to negative controls that received standard chow diet (p<0.05). In conclusion, turmeric and fenofibrate are suggested to increase the expression of the PPARα gene in the liver induced by a high-fat diet.
Impact of the COVID-19 Pandemic on Laboratory Services Triyani, Yani; Herawati, Rita; Rahmawati, Rahmawati; Permatasari, Ranti
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.12223

Abstract

The positive impact of the coronavirus disease 2019 (COVID-19) pandemic is that hospital laboratory services are excellent when other services are declining. Aside from molecular biology laboratory (polymerase chain reaction, PCR) services for COVID-19 diagnostics, public demand has dramatically increased. It is a retrospective descriptive study that uses data on the total number and types of results of laboratory examination orders that have been verified from the laboratory information system of a hospital from 2018 to 2022. Data analysis is presented in the frequency of the number and type of results of laboratory examination orders and differences in requests for laboratory services before and during the pandemic since the government established it on March 8, 2020. The total number of laboratory requests between January 2018 and December 2022 was 1,943,539 services. The highest increase in laboratory examination services was in molecular biology (98.4%). As the need for community services increases for the PCR severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) examination, which is used in addition to diagnosing confirmed COVID-19 patients, it is also necessary for the community to conduct tracing if a family member has a COVID infection or travel requirements and follow-up for hospital employee exit tests who contracted COVID-19. In conclusion, the COVID-19 pandemic has positively impacted laboratory performance. There have been changes and an increase in the number and types of laboratory examination services and personal performance and management in laboratories.
Arbovirus Detection of Adult Female Aedes aegypti for Dengue Surveillance: a Cohort Study in Bandung City, Indonesia Faridah, Lia; Ekawardhani, Savira; Fauziah, Nisa; Djati, Imam Damar; Putra, Ramadhani Eka; Watanabe, Kozo
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.12749

Abstract

Dengue surveillance is an important activity to prevent dengue outbreaks. This activity becomes a significant challenge for the region with limited logistic capabilities. Developing a simple mathematical model to predict the possibility of dengue incidence provides a reliable early warning system. This study compared the correlation between vector (adult female Aedes aegypti) and arbovirus detection on a vector to dengue incidence, which generalized linear mixed models tested. The incidence of adult female Aedes aegypti and dengue fever cases were interpolated through third-power inverse distance weighting (IDW). A spatial correlation between female Aedes aegypti incidence and dengue incidence was obtained from polynomial regression. Collection sites were 16 villages in Bandung city, one of the significant dengue endemic areas in January–December 2017. A total of 8,402 mosquitoes of Aedes aegypti, Aedes albopictus, and Culex sp., with 17% belonging to Aedes aegypti as the subject of the dengue virus (DENV) infection test. Data analysis only showed a weak correlation between the numbers of adult female Aedes aegypti and dengue incidence. On the other hand, there is no correlation between positive dengue infection of vector and dengue incidence. This study highlights the importance of constant arbovirus surveillance and integrated surveillance methods on all possible dengue vectors to develop an early warning system for dengue incidence.
Personal Perceptions of Filariasis of Patients at Kodi Bolaghar Subdistrict, Southwest Sumba Regency, East Nusa Tenggara, Indonesia Ora, Anderias Parawatu; Irfan, Irfan; Landi, Soleman
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.9777

Abstract

Perception is a mental process that occurs in humans that will show how we see, hear, feel, give, and feel around us. Patients' positive and negative self-perceptions are internal factors that significantly affect the healing process. Chronic filariasis patients experience a decline in physical condition, which becomes a mental burden for the patients and their families. Patients may experience negative stigma from their family and surrounding community. Some communities still believe in myths, supernatural powers, and magic, and patients suffer illness due to their evil deeds or that they have violated cultural norms that were passed down from generation to generation. How patients perceive themselves, their environment, and their families are rarely studied, though this information is essential to elucidate their needs. Kodi Balaghar subdistrict in the Southwest Sumba regency, East Nusa Tenggara, still has many filariasis cases. This study aimed to know the self-perception of filariasis patients in the Kodi Balaghar subdistrict, Southwest Sumba regency. We have selected ten patients to collect answers regarding self-perception from March to May 2021. The results of our study showed that respondents perceive themselves more negatively to both themselves and their families. We conclude that emotional and spiritual support from family, community, religious leaders, and medical personnel are critical to building self-confidence, life expectancy, enthusiasm, and fighting power to survive and undergo treatment for the disease.
Cytotoxicity of Combination Doxorubicin and Garcinia picrorrhiza Fruit Extract on Fibroblast Cell Utami, Sri; Endrini, Susi; Batubara, Lilian; Rahmah, Nunung Ainur; Syarif, Irfan; Nafik, Said; Arrahmani, Betharie Cendera; Novianto, Agung; Kusuma, Hanna Sari Widya; Widowati, Wahyu
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.10985

Abstract

Combining chemotherapeutic agents such as doxorubicin with herbal products or other compounds that can enhance cytotoxicity without side effects is required. Thus, we aimed to observe the cytotoxicity of doxorubicin and sesoot (Garcinia picrorrhiza) fruit ethanolic extract (GpKar) on human fibroblast cells, BJ. This study used a post-test-only control randomized group design with n=3 and a number group of 5. The method used in this research is cell number, and viability was measured with (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay. Treatments consisted of a combination of doxorubicin (0.02 μg/ml) and GpKar of 66.47 µg/ml (DES1), 132.94 µg/ml (DES2) and 265.89 μg/ml (DES3). The data were analyzed using a one-way ANOVA and Duncan post hoc tests. DES3 showed the lowest viability among treatments (89.32%). DES1 and DES2 showed high viability (>90%), 97.93%, and 95.08%, respectively. Thus, the combination of doxorubicin (0.02 μg/ml) and GpKar (66.47 µg/ml) was considered safe for further use in the following assay. In summary, the combination of doxorubicin and GpKar showed high viability in normal fibroblast cells.
Clove Extract and Grape Seed Oil Nanoemulsion for Oral Diseases Therapy: Antibacterial and Antioxidant Activities Hartati, Julia; Damayanti, Meta Maulida; Nur, Ismet Muchtar; Furqaani, Annisa Rahmah; Sari, Ajeng Kartika; Rachmawati, Meike; Siddiq, Tita Barriah; Fakih, Taufik Muhammad; Radina, Faqih
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.12916

Abstract

The growth of micro-organisms that acquire resistance to most commercially available antibiotics is occurring rapidly. Consequently, a pressing necessity exists to identify and detect new antimicrobial substances. This study aimed to analyze the antioxidant and antibacterial activity of nanoemulsion clove extract and grape seed oil. This research was conducted in June 2023 using experimental methods at the Research Laboratory of the Universitas Islam Bandung Pharmaceutical Study Program by developing a nanoemulsion preparation containing clove extract (Syzygium aromaticum L.) and grape seed oil (Vitis vinifera L.). Antioxidant activity was tested using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Antibacterial activity was tested using the agar diffusion method by measuring the growth inhibitory diameter of Staphylococcus aureus and Streptococcus mutans bacteria and divided into four groups formulas based on the addition of clove extract with different concentrations in the nanoemulsion base (FA=0.25%, FB=0.5%, FC=0.75%, and FD=1%) to see the best results. The result shows nanoemulsion preparations have antioxidant properties in the DPPH test. The FA formula has the highest IC50, namely 1,117.56 ppm. The antibacterial activity of Staphylococcus aureus and Streptococcus mutans has an inhibition zone, although it is still in the category of inhibiting bacterial growth, but does not kill growth. The nanoemulsion formulation, comprising clove extract and grape seed oil, has exhibited exceptional antioxidant properties and substantial antimicrobial efficacy against prevalent oral bacterial strains.
Histopathological Review of Granuloma in Diagnosis of Tuberculosis Lymphadenitis (TBL) Purbaningsih, Wida; Rachmawati, Meike; Triyani, Yani; Rahmi, Fadhilat Sabila
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.12742

Abstract

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and is the second leading cause of death from an infectious disease. Indonesia has the highest TB cases in West Java, East Java, and Central Java. Tuberculosis lymphadenitis (TBL) represents about 30–40% of cases of extrapulmonary tuberculosis. The study aimed to study the clinical and histopathological characteristics of TBL patients. The research design in this study used an exploratory, descriptive method. Data was taken from Al Islam Hospital Bandung as medical records from January 2019 to December 2020. The result showed that TBL primarily affects patients aged 6–11 years (28%), male gender (57%), patients not working (25%), and those residing in the East Bandung area (34%). Histopathological appearance showed granulomas of caseous necrosis, epithelioid cells, and Langhan's cells, indicated by types 1, 2, and 3. The most common type was type 1 (47%), which was more widely distributed in the right neck (46%) with size 1–3 cm. In conclusion, the frequency of TBL is higher in boys aged 6–11 years, residents of the East Bandung area, and patients who did not work. Well-formed granuloma of enlarged lymph nodes in the right neck with size 1–3 cm is most commonly found in TBL.
Effectiveness of Machine Learning for COVID-19 Patient Mortality Prediction Using WEKA Khuluq, Husnul; Yusuf, Prasandhya Astagiri; Perwitasari, Dyah Aryani
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.12119

Abstract

Timely detection of patients with a high mortality risk in coronavirus disease 2019 (COVID-19) can substantially improve triage, bed allocation, time reduction, and potential outcomes. A potential solution is using machine learning (ML) algorithms to predict mortality in COVID-19 hospitalized patients. The study's objective was to create and verify individual risk assessments for mortality using anonymous demographic, clinical, and laboratory findings at admission, as well as to assess the possibility of death using machine learning. We used a standardized format and electronic medical records. Data from 2,313 patients were collected from two Muhammadiyah hospitals from January 2020 to July 2022. Utilizing each patient's clinical manifestation state at admission and laboratory parameters, 24 demographic, clinical, and laboratory results were studied. The algorithms analyzed were AdaBoost, logistic regression, random forest, support vector machine, naïve Bayes, and decision tree, which were applied through WEKA version 3.8.6. Random forest performed better than the other machine learning techniques, with precision, sensitivity, receiver operating characteristic (ROC), and accuracy of 78.6%, 78.7%, 85%, and 78.65%, respectively. The three top predictors were septic shock (OR=21.518, 95% CI=4.933–93.853), respiratory failure (OR=15.503, 95% CI=8.507–28.254), and D-dimer (OR=3.288, 95% CI=2.510–4.306). Machine learning–based predictive models, especially the random forest algorithm, may make it easier to identify patients at high risk of death and guide physicians' appropriate interventions.
Difference between Nutrition Status in First and Recurrent Ischemic Stroke Patients: a Retrospective Cross-Sectional Study Amalia, Lisda; Khairunnisa, Shafa Ayu
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.11051

Abstract

Malnutrition in stroke patients can be caused by neurological deficits such as decreased consciousness, dysphagia, cranial nerve paresis, and hemiparesis/hemiplegia. The condition of malnutrition seriously impacts healing and can exacerbate the underlying disease, in this case, stroke, so malnutrition in stroke patients extends the length of stay and increases morbidity and mortality. This study compares nutritional status between first and recurrent ischemic stroke patients based on body mass index (BMI) and subjective global assessment (SGA). This study is a comparative analysis of the medical records of ischemic stroke patients in Dr. Hasan Sadikin General Hospital Bandung from January 2018 until December 2020. The chi-square and Fisher's exact tests were used for statistical analysis. The significance criteria are the p-value if p≤0.05 means statistically significant. A total of 236 subjects in both groups of first and recurrent ischemic stroke patients consisting of 130 men and 106 women with an average age of 56.64 and 61.75 years, and the majority had risk factors for hypertension. The first ischemic stroke group has a good nutrition status compared with the recurrent stroke group (p<0.05). Thirteen patients (11.02%) of first ischemic stroke and 11 patients of recurrent ischemic stroke (9.32%) were underweight, 67 patients (56.78%) of first ischemic stroke and 74 patients of recurrent ischemic stroke (62.71%) had average weight, 31 patients (26.27%) first ischemic stroke and 33 patients (27.97%) recurrent ischemic stroke were overweight, five patients (4.24%) first ischemic stroke and seven patients (5.93%) recurrent ischemic stroke were obese (p<0.05). In conclusion, there was a significant difference in the nutritional status of first and repeated ischemic stroke patients. The nutritional status of recurrent ischemic stroke patients is worse than that of first ischemic stroke patients.
AI-SPOT: a Novel Artificial Intelligence enabled Sport Optimisation Tracker to Enhance Performance and Prevent Injury in Elite Footballers Angus, Aaron Chen; Sirisena, Dinesh
Global Medical & Health Communication (GMHC) Vol 12, No 1 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i1.12788

Abstract

This study introduces AI-SPOT, a novel artificial intelligence tool for optimizing performance and preventing injuries in elite footballers. Data were collected from four Singapore Premiere League clubs and the National Team, encompassing 68 male footballers over two seasons (2021–2022). The comprehensive dataset included diverse metrics, injury records, and automated live match data from established databases. AI-SPOT employs Python's scikit-learn for predictive analytics, using techniques like logistic regression and XGBoost, and was further developed with TensorFlow. Its effectiveness in injury prediction and performance assessment was validated with extensive local and international data sources. The system's potential for broader sports applications was underscored by user experience assessments, indicating a significant shift towards AI-driven strategies in sports management. Despite its reliance on high-quality, sport-specific data, AI-SPOT's adaptability highlights its role as a transformative tool in sports analytics, paving the way for advanced, data-driven approaches in sports management and strategy formulation.

Page 36 of 43 | Total Record : 422

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