cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
Arjuna Subject : -
Articles 485 Documents
 45   46   47   48   49 
Diversity and Composition of Insect Species Associated with Natural Rattan Habitats in Namo Village, Kulawi, Central Sulawesi Nurdin, Musdalifah; Suleman, Samsurizal M; Zainal, Syech; Sabran, Moh; Agni, Raya; Trianto, Manap
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1289-1295

Abstract

Tropical forest ecosystems are home to diverse insect communities that play essential ecological roles, including pollination, decomposition, and nutrient cycling. Among the key forest plants, rattan (Arecaceae) provides both ecological and economic benefits and serves as an important microhabitat for various insect species. This study aimed to identify and analyze the diversity of insect species associated with natural rattan habitats in Namo Village, Kulawi District, Central Sulawesi, Indonesia. Insect sampling was carried out using sweep nets, pitfall traps, and yellow pan traps along rattan-dominated forest transects. A total of 125 individual insects were collected, representing 7 orders, 28 families, and 37 species. The order Hymenoptera showed the highest abundance (41.6%), dominated by Formicidae and Apidae families, followed by Coleoptera (25.6%) and Diptera (17.6%). The Shannon–Wiener Diversity Index (H’ = 2.84) indicated moderate species diversity with high evenness (E = 0.83). Functionally, the insect community consisted of pollinators (38.2%), herbivores (25.4%), decomposers (19.6%), and predators (16.8%). These findings demonstrate that natural rattan ecosystems support diverse and functionally balanced insect assemblages, reflecting stable ecological conditions and minimal anthropogenic disturbance. Conserving natural rattan stands is therefore crucial for maintaining biodiversity and sustaining ecological functions such as pollination and decomposition within tropical forest ecosystems.
Effect of Moringa Leaves and Jackfruit Seeds as Rice Substitute to Reduce Blood Glucose Levels in Mice Primantara, I Gusti Ngurah Agung Adi; Mahadewi, Komang Astri; Arimbawa, I Gede Aditya; Muljosaputro, Marvel Alden; Suryawan, Komang Dinda Bagus Putra; Santoso, Putu Nia Calista; Kartika Sari, Ni Luh Putu Eka
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1419-1426

Abstract

Most Indonesians consume white rice, which has a high Glycemic Index (GI). Eating foods with high GI can lead to the occurrence of Diabetes Mellitus (DM). DM is a metabolic disorder characterized by chronic hyperglycemia. Alternative solutions are needed to overcome diabetes mellitus, one of which is by using rice substitute which has a low Glycemic Index (GI). Moringa leaves (Moringa oleifera) and jackfruit seeds (Artocarpus heterophyllus lam.) contain flavonoids that have the potential to be used as ingredients for making rice substitute. Flavonoids function to increase antioxidant enzymes, neutralize free radicals, lower blood sugar, overcome fatigue, and protect insulin-producing pancreatic ß cells. This study aims to analyze the content, physical and chemical characteristics, and antidiabetic activity of innovative rice substitute. In this study, an rice substitute formulation was made from Moringa flour: jackfruit flour in the ratio of 3:1 (P1), 1:1 (P2), and 1:3 (P3). Analog rice was tested on mice which were divided into five groups, namely positive control, negative control, and a combination of extracts P1, P2, and P3. Data analysis was carried out using SPSS 25 software. The results obtained showed that the rice substitute formulations P1, P2, and P3 were able to reduce blood sugar in mice, but P2 best reduced blood sugar, which was 11 mg/dL and 22 mg/dL.
Formulation and Standardization of Face Wash Using Watermelon Rind Extract (Citrullus lanatus) Wijaya, Dika Putra; Rahmawati, Khofifatul; Bachtiar, Achmad Yusuf; Ridhwan, Alverdha Elvarheta Rasseta; Rahmah, Ayu Alfianita; Taufikurohmah, Titik; Danar, Danar
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1569-1578

Abstract

The purpose of this study was to determine the utilization of watermelon rind waste as an active ingredient in the manufacture of liquid soap preparations and to obtain the best formulation of watermelon rind extract liquid soap that is physically stable. Watermelon rind waste contains many nutritious substances, such as antioxidants, that are beneficial for skin health but have not been widely utilized. This study utilizes citrulline compounds in watermelon rind, which act as antioxidants and potential vasodilators, to be used as active ingredients in the manufacture of bath soap preparations with the aim of removing dirt and stimulating blood circulation. Research method includes the preparation of thick watermelon rind extract, the preparation of salt solution, and the preparation of liquid soap preparation formulas with varying concentrations of watermelon rind extract. Evaluation includes an organoleptic test, pH, viscosity, foam height, foam stability, homogeneity, and spreadability to obtain a liquid soap formula with stable physical properties. Result showed that watermelon rind extract has the potential to be an active ingredient in liquid soap preparations in order to utilize waste and provide benefits for skin health.
Molecular Dynamic Study of Java Cardamom (Wurfbania compacta) Leaf Compounds Targeting Xanthine Oxidase for Antihyperuricemia Nofriyaldi, Ali; Fadilah, Nitya Nurul; Isnaeni, Selvy
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.%p

Abstract

Hyperuricemia is a disorder marked by elevated concentrations of uric acid in the bloodstream, which can trigger gout and other metabolic complications. Conventional therapies such as allopurinol are effective but often cause side effects. This study aims to explore the potential of bioactive compounds from cardamom leaves (Wurfbania compacta) as antihyperuricemic agents through an in silico approach. The methods used include mining phytochemical data from the literature, predicting pharmacokinetic properties and toxicity (ADMET), molecular docking as well as molecular dynamic. The screening results show that the compound with the most stable interaction from cardamom (Wurfbania compacta) with receptors that play a role in inhibiting xanthine oxidase enzyme in silico is the compound kaempferol with a Binding energy value of -8.1 kcal/mol and Ki 1.15 uM (micromolar). ADMET analysis indicates that the main candidate has a good pharmacokinetic profile and low toxicity potential. Based on the results of the RMSD and RMSF molecular dynamic analysis, the kaempferol compound shows a stable level of interaction and has 3 amino acid similarities with the comparison drug allopurinol, namely THR1010, VAL1011 and ALA1078, so it has the potential to be used as a candidate antihyperuricemia drug. These findings suggest that cardamom leaves have prospects as a source of natural antihyperuricemia compounds. Further in vitro and in vivo studies are needed to verify the biological activity and safety of its use.
Endophytic Bacteria from Mimosa pudica L.: Morphological and Biochemical Traits and Biocontrol Activity against Alternaria porri Madjid, Mazlina
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1385-1389

Abstract

Shallot (Allium cepa L.) is an important horticultural commodity whose productivity is frequently constrained by purple blotch disease caused by Alternaria porri. Excessive reliance on synthetic fungicides for disease control has raised concerns related to environmental sustainability and pathogen resistance. Endophytic bacteria, which inhabit internal plant tissues without causing harm, represent a promising source of biological control agents. This study aimed to characterize the morphological and biochemical traits and to evaluate the biocontrol activity of endophytic bacteria isolated from Mimosa pudica L. against A. porri. A total of twelve endophytic bacterial isolates were obtained from healthy roots, stems, and leaves of M. pudica using a surface sterilization technique. The isolates exhibited diverse colony morphology and growth characteristics. Biochemical characterization revealed that most isolates were gram-positive, catalase-positive, motile, and capable of starch hydrolysis. Antagonistic activity was evaluated using a dual culture assay on potato dextrose agar. The results demonstrated that several isolates effectively inhibited the mycelial growth of A. porri. Among them, isolates MP5 and MP11 showed the highest inhibitory effects, with growth inhibition percentages of 58.2% and 48.7%, respectively, and were classified as having high antagonistic activity. The strong inhibitory performance of selected isolates suggests their ability to produce antifungal metabolites or to suppress pathogen growth through competitive interactions. Overall, endophytic bacteria isolated from M. pudica, particularly isolates MP5 and MP11, exhibit significant potential as environmentally friendly biological control agents for managing purple blotch disease in shallot cultivation.
Hepatoprotective Activities of Seed Extract and Fractions of Telfairia occidentalis on Doxorubicin-Induced Hepatotoxicity in Rats Nwosu, Ugochi Queenette; Osigwe, Chinyelu C.; Uwaeme, Ugonma Florence; Fabian, Unyime A.; Okokon, Jude Efiom
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1529-1536

Abstract

Telfairia occidentalis Hook (cucurbitaceae) seeds, which is used in the preparation of soups and as medicine traditionally to treat various diseases by the Ibibios was investigated for effect against doxorubicin-induced hepatotoxicity. The seed extract (138 -553 mg/kg) and fractions; dichloromethane (DCM) and aqueous, 276 mg/kg) were evaluated for hepatoprotective activity against doxorubicin-induced liver injury in rats. Liver function parameters, liver oxidative stress markers and liver histology were used to assess the liver protective potential of the extract and fractions. The seed extract and fractions significantly (p<0.05-0.01) reduced the serum levels of AST, ALT, ALP, total and direct bilirubin that were elevated by doxorubincin. Also, the reduced levels of total protein and albumin by doxorubicin were increased by the extract coadministration. The levels of GSH, GST, SOD, GPx, and CAT that were decreased by doxorubicin were significantly (p<0.01) elevated and raised MDA level was reduced by the seed extract and fractions. Histology of the liver sections of extract -treated animals showed reductions in the pathological features compared to the organotoxic-treated animals. The chemical pathological changes were consistent with histopathological observations suggesting marked hepatoprotective potential. The anti-toxic effect of this plant may in part be mediated through the chemical constituents of the plant. The seeds of Telfairia occidentalis possess anti-toxicant properties which can be exploited in the treatment of doxorubicin related toxicities.
Identification of Lactic Acid Bacteria (LAB) Consortium from Tempeh Jember Based on 16S rRNA Gene Sequences as Potential Probiotic Candidates Azizah, Siti Nur; Rosida, Rosida; Febiaocti, Rizka Yolanda; Nurmalasari, Dewi Riskha; Sipriyadi, Sipriyadi
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1339-1346

Abstract

The development of pharmaceutical raw materials as local Indonesian probiotic concentrates requires attention to strain identity accuracy, safety, and health potential. This is due to the high potential of probiotics in preventing and addressing various health disorders from infancy to old age. Previous research successfully obtained lactic acid bacteria (LAB) isolates as probiotic candidates from tempeh produced in Jember, and preclinical testing showed that administering a consortium of five LAB isolates at a dose of 10^8 CFU/ml to BALB/c mice was an effective treatment for further application. This study aimed to perform molecular identification of the consortium of five LAB isolates from tempeh in Jember, East Java, based on 16S rRNA gene sequences. The consortium includes TA1, TB1, TK1, TK2, and TK4 isolates. This study used both qualitative descriptive and quantitative methods. Identification based on the 16S rRNA gene to determine LAB species strains involved bacterial genomic DNA isolation, amplification of the bacterial 16S rRNA gene, PCR product analysis, and phylogenetic identification and analysis. DNA amplification results showed that the consortium of five LAB isolates produced DNA fragments with bands of approximately 1300 bp. BLAST-N and phylogenetic analysis of the 16S rRNA gene showed that TB1 had 99.05% similarity with Kosakonia cowanii JCM 10956, TA1 had 99.46% similarity with Lactiplantibacillus plantarum JCM 1149, TK1 had 99.38% similarity with Lactiplantibacillus pentosus 124-2, TK2 had 96.86% similarity with Pseudomonas fluvialis ASS-1, and TK4 had 99.38% similarity with Lactiplantibacillus plantarum NBRC 15891. TA1, TB1, and TK4 were identified as non-pathogenic LAB strains, while TK1 and TK2 were not classified as LAB. 
Association Between Visceral Fat and Monocyte Count in Type 2 Diabetes Mellitus: Evidence from a Referral Hospital Study Heryaman, Henhen; Aji, Alfi Alfisa; Kusumawati, Maya
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1477-1482

Abstract

The majority of patients with type 2 diabetes mellitus (T2DM) exhibit central obesity. Central obesity is characterized by an abnormally high accumulation of visceral adipose tissue. Individuals with both obesity and T2DM often present with additional immune dysfunction, including significantly elevated monocyte counts compared to metabolically healthy obese individuals. A recent study has demonstrated a correlation between visceral fat and monocyte count in young adults with obesity; however, this association remains unclear in patients with T2DM. A cross-sectional observational study was conducted using a total sampling design from August to September 2022 at AMC Hospital, Indonesia. History taking, physical examination, and laboratory examination were conducted. Visceral fat, monocyte count, and confounders (age, gender, diagnosis duration of T2DM, glycemic control (using FBG), BMI, WC, number of comorbidities, and number of drug use) were observed. In the complete sample (n = 57), after adjusting for confounding variables, there was no statistically significant association between visceral fat and monocyte count (adjusted ? = 86.635, 95% CI [–19.050, 192.321], P = 0.106). However, after excluding one influential subject and controlling for confounders, a significant association was observed (adjusted ? = 110.023, 95% CI [11.111, 208.935], P = 0.030). There was a significant association between visceral fat and monocyte count in T2DM.
Comparative Antidepressant, Anxiolytic, and Acute Toxicity Evaluation of Lemon Peel and Peppermint Leaves Extracts in Mice Ni'ma, Neli Syahida; Savitri, Annisa Aulia; Sukendra, Dyah Mahendrasari; Hardiansyah, Ronny Meilano; Puspaningtias, Ika Ayu; Fathurahman, Gavriel Fauzan; Linasari, Septia
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1297-1304

Abstract

Depression and anxiety are prevalent psychiatric disorders, and current treatments are often limited by side effects, delayed onset, and resistance. Natural products are being explored as safer alternatives, and lemon peel (Citrus limon) and peppermint leaves (Mentha × piperita L.) contain diverse bioactive compounds with neuroprotective potential. This study evaluated the antidepressant and anxiolytic effects of their ethanolic extracts, individually and in combination, in male Swiss Webster mice. Phytochemical screening confirmed the presence of alkaloids, flavonoids, phenols, tannins, saponins, and steroids in both extracts. Antidepressant activity, assessed by the Forced Swimming Test (FST) and Tail Suspension Test (TST), showed that both extracts and their low-dose combination significantly reduced immobility time, with effects comparable to fluoxetine. In contrast, the high-dose combination did not enhance efficacy. Anxiolytic activity, evaluated using the Elevated Plus Maze (EPM) and Light-Dark Box (LDB), revealed that peppermint extract exerted the strongest effect, followed by the low-dose combination and lemon peel. Acute oral toxicity testing at 2000 mg/kg showed no mortality or adverse effects. These findings suggest that lemon peel and peppermint extracts possess antidepressant and anxiolytic properties with favorable safety profiles, supporting their potential as natural alternatives or adjuncts for managing mood disorders.
In Silico Study of the Antibacterial Activity of Bioactive Compounds from Portulaca oleracea L. Herb Extract against Propionibacterium Acnes Maulida, Nadhifa Dini; Aqidah, Nur; Ilmiah, Nanda Ma’rifatul; Nabillah, Maprilia Nur; Ramadhany, Niken Ayu; Usman, Mohammad Rofik
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1427-1435

Abstract

Acne vulgaris is a common dermatological condition primarily caused by the bacterium Propionibacterium acnes. The use of natural compounds as alternative therapies has gained attention due to their lower side effects compared to synthetic agents. This study aimed to evaluate the antibacterial potential of bioactive compounds present in purslane (Portulaca oleracea L.) herbs against P. acnes through an in silico approach. Out of 15 identified compounds, 12 satisfied Lipinski’s parameters, and 9 compounds were selected for further analysis. Pharmacokinetic and toxicity predictions were performed using the pkCSM platform to determine the ADMET profiles, while ligand–receptor interactions were analyzed via molecular docking against the Exo-x-sialidase protein target (PDB ID: 7LBV). The ADMET prediction results indicated that most compounds exhibited good solubility, high absorption, moderate skin permeability, and favorable distribution and metabolism profiles. Docking visualization revealed the presence of hydrogen bonds and hydrophobic interactions with key residues at the receptor’s active site. Interestingly, butylated hydroxytoluene demonstrated the lowest binding energy (–6.56 kcal/mol), which was better than that of the positive control (–6.17 kcal/mol), indicating a stronger binding affinity. Overall, Portulaca oleracea shows promise as a natural source of antibacterial compounds against P. acnes, warranting further in vivo investigation.

Page 48 of 49 | Total Record : 485

 45   46   47   48   49 

Filter by Year

2014 2025


Reset
Filter By Issues
All Issue Vol 14, No 2 (2025) Vol 14, No 1 (2025) Vol 13, No 2 (2024) Vol 13, No 1 (2024) Vol 12, No 2 (2023) Vol 12, No 1 (2023) Vol 11, No 2 (2022) Vol 11, No 1 (2022) Vol 10, No 2 (2021) Vol 10, No 1 (2021) Vol 9, No 2 (2020) Vol 9, No 1 (2020) Vol 8, No 2 (2019) Vol 8, No 1 (2019) Vol 7, No 2 (2018) Vol 7, No 1 (2018) Vol 6, No 2 (2017) Vol 6, No 1 (2017) Vol 5, No 2 (2016) Vol 5, No 1 (2016) Vol 4, No 2 (2015) Vol 4, No 1 (2015) Vol 3, No 2 (2014) Vol 3, No 1 (2014) More Issue