cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Pudyastuti Kusumaningrum
Contact Email
mot.farmasi@ugm.ac.idm
Phone
-
Journal Mail Official
mot.farmasi@ugm.ac.id
Editorial Address
-
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
Arjuna Subject : -
Articles 552 Documents
 51   52   53   54   55 
Diversity and Ethnobotanical Significance of Wild Solanum Species in Odisha, India Panda, Taranisen; Mishra, Nirlipta; Rahimuddin, Shaik; Pradhan, Bikram Kumar; Apollo, Master; Mohanty, Raj Ballav
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.89633

Abstract

Across the globe, individuals continue to rely on plants to meet fundamental human requirements, including sustenance, attire, housing, and healthcare. Among the diverse plant families, Solanaceae houses thousands of species worldwide, with many of them being wild and plays a pivotal role in preserving biodiversity and holds substantial ethnobotanical significance. Within this family, the Solanum genus holds particular significance in traditional medicine and human nutrition, boasting three major food crops: S. melongena (eggplant), S. lycopersicum (tomato), and S. tuberosum (potato), staples in daily diets worldwide. This study delves into the diversity of the Solanum genus in Bhadrak district, Odisha, India, with a primary focus on assessing its distribution and ethnobotanical importance. A field survey involving 97 respondents (76 male; 21 female) was conducted, involving interviews with local communities, traditional healers, and agricultural practitioners. The study documents six Solanum species with both food and medicinal applications. These species have been used to address a wide array of health issues, including asthma, coughs, bronchitis, liver problems, oral ulcers, rheumatism, skin diseases, tuberculosis, and toothaches. Various plant parts, such as leaves, roots, fruits, and seeds, are commonly employed in these remedies. Moreover, the Solanum species' remarkable adaptability to diverse environments highlights their resilience and ecological significance. The present findings serve as a platform for future research on Solanum's contributions to traditional medicine and ecological systems. Interdisciplinary collaboration among researchers, indigenous communities, and policymakers, are essential for sustainable utilization of Solanum genus, paving the way for a more healthful and harmonious coexistence with our natural world.
Formulation and Antioxidant Activity of Gotu Kola Jelly Candy with Plant-based Polymers as a Gelling Agent Devi, Dwitya Devi Nurlistyo; Darsih, Cici; Yuniarti, Nunung; Ardiningtyas, Bondan; Laksitorini, Marlyn Dian
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.89699

Abstract

Centella asiatica or gotu kola has a long history as a brain supplement. Gotu kola supplements are sold as liquid and dried extract which is less attractive for a younger generation. Jelly candy is an alternative dosage form with better acceptability across ages. However, the use of animal-derived polymers such as pork gelatine in the candy restricts those who practice vegetarian and halal lifestyles from consuming the products. This study aims to explore plant-based polymers glucomannan and kappa-carrageenan as gelling agents in the preparation of gotu kola jelly candy. Preparation of the jelly candy formula was designed based on Simplex Lattice Design. Evaluation of physical characteristics of jelly candy includes organoleptic, weight uniformity, moisture content, pH, and elasticity. The antioxidant activity of gotu kola before and after the manufacturing process was evaluated. The results showed that a combination of kappa-carrageenan 1.33% and glucomannan 0.67% is the optimum formula. Adding more proportion of kappa-carrageenan reduced jelly elasticity and moisture content. While adding glucomannan improved its elasticity responses but increased moisture content. Evaluation of the antioxidant activity of gotu kola in jelly candy suggested that gotu kola experienced a significant reduction in antioxidant activity following the production process. The IC50 of the crude extract initially was129.23 ppm while post jelly candy manufacturing, the IC50 increased to 197.49 ppm. This study suggested that improvement in extraction and production processes is necessary to maintain gotu kola antioxidant activity.
Mauli Banana Stem Gel: A Potential Material for Dentin Remineralization Analyzed Using Fourier Transform Infrared Spectroscopy Carabelly, Amy Nindia; Rahman, Yajma Kamiila; Puspitasati, Dewi; Erlita, Isyana; Wydiamala, Erida
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.90537

Abstract

Dental caries requires remineralizing agents to restore the dentin. Mauli banana stem gel is predicted to be an alternative material for mineral deposition during the remineralization process. Fourier transform infrared spectroscopy (FTIR) can analyze substances that indicate dentin remineralization. This study aimed to conduct an FTIR analysis of Mauli banana stem gel as a potential substitute material for dentin remineralization. The study utilized dentin slices obtained from the first premolars of the maxilla, which were demineralized using EDTA. Subsequently, the dentin slices were treated with CPP-ACP, 50% MBSG, 62,5% MBSG, and artificial saliva. A test tube containing 15 ml of artificial saliva was placed inside the smeared material, which was applied twice a day. It was left for three minutes and then rinsed with deionized water before being incubated at 37 °C. Basting was carried out for 21 days, and FTIR observations were performed. The major absorbance peaks detected were O-H and N-H stretch; C-H stretch; SCN stretch; Amide I; CO32-(v3) and collagen; Amide II; CH2 scissoring; C-H deformation; C-H stretching; Amide III; and PO43-(V3). MBSG demonstrated superior retention of dentin collagen compared to the control group, but it could not maintain the mineral content level on day 21. MBSG demonstrated a decrease in crystallinity due to a rise in carbonate content in the hydroxyapatite lattice. The study's findings indicate that MBSG remains unsuitable for dentin remineralization. Additional additives are necessary to enhance the levels of collagen and minerals in remineralized dentin.
Formulation and Physical Evaluation of Orthosiphon aristatus Leaf Extract Granule Preparation as Herbal Beverage Candidate Al-Hakim, Nur Achsan; Nur Fauziyyah, Salma Alifia; Purnamasari, Nira; Faramayuda, Fahrauk
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.91009

Abstract

Developing Orthosiphon aristatus (Blume) Miq. leaf extract of purple varieties into granule dosage forms is expected to facilitate consumption, storage, and can extend the shelf life of the product. This study aims to develop the formulation and evaluation of granule preparations of O. aristatus leaf extract of purple varieties, with a comparison of lactose and maltodextrin fillers to produce the best formula. The granule dosage forms were prepared using wet granulation method. Furthermore, the variation of granule preparation formula consists of F1 (extract with lactose), F2 (extract with maltodextrin), F3 (extract with a combination of lactose and maltodextrin 1:1), F4 (freeze dried extract with lactose), F5 (freeze dried extract with maltodextrin), and F6 (freeze dried extract with a combination of lactose and maltodextrin 1:1). The physical evaluation of granules comprised moisture content testing, flowability, compressibility index, particle size distribution, and granule dissolving time. Results from the physical evaluation of granules over 28 days of storage indicated that all six formulas met the criteria for good granules, with F3 emerging as the optimal formula due to its superior physical stability and visually appealing appearance upon dissolution. To conclude, this study demonstrates that O. aristatus leaf extract can be effectively formulated into instant granule preparations suitable for herbal beverage or alternative medicine. Moreover, by modifying the filler material, the physical stability of the granule preparation can be maintained.
Antioxidant and Anti-Breast Cancer from Uncaria gambir Roxb Leaves: In Silico & In Vitro Study Iskandar, Dodi; Rollando, Rollando; Susana, Susana; Amperawati, Suharyani; Indrastuti, Y Erning; Afthoni, Muhammad Hilmi
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.92604

Abstract

Uncaria gambir Roxb (URG) is one of the plants from West Kalimantan predicted to contain antioxidant and anti-breast cancer. This study aims to test the antioxidant and anti-breast cancer potential. UGR leaves were extracted by infusion method using water for 15 minutes with 4 repetitions at a temperature 70oC. A thick extract of 96.2351 grams (29.979%) was obtained from a sample weight of 321 grams of dried UGR leaves. In vitro antioxidant assay of the extract was investigated using 2,2-diphenylpicrylhydrazyl (DPPH) with positive control using quercetin and ascorbic acid, and the Ferric Reducing Antioxidant Power (FRAP) method. In silico screening showed that the biological agents in UGR had the potential as TP53 expression enhancer, antioxidant, anticarcinogenic, chemopreventive, and free radical scavenger. The antioxidant bioassay results showed IC50 values of 81.21 μg/mL, 73.39 μg/mL, and 9.17 μg/mL in DPPH for extract samples with positive control quercetin, sample extracts with positive control Vitamin C and Vitamin C with positive control quercetin, respectively. Meanwhile, the antioxidant activity of extract samples with the FRAP method showed value of 66,05 μg/mL. Anticancer bioassay result showed that UGR leaves extract with water solvent had the stron potentgial to inhibit 4T1 cells with IC50  87.72 μg/mL.
Scoping Review: Study of Herbs Consumption for Self-Medication in Indonesia 2019-2022 Azzahra, Fatimah; Astuti, Ayun Dwi; Arifin, Bustanul; Alam, Gemini
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.94091

Abstract

Indonesia is a country that has high biodiversity and is rich in traditional medicine from natural ingredients or herbs. One use of these natural ingredients is as a treatment for self-medication. Many previous studies have been carried out but none has reviewed it systematically, especially during the Covid-19 pandemic. This research was carried out systematically using the PRISMA statement approach using the Google Scholar data bank. Out of 2,214 papers in the 2019-2022 period,  45 articles/scientific papers papers met the criteria, including inclusion and exclusion criteria, for a description/profile of the use of natural ingredients or herbs as self-medication for traditional medicine. The central region of Java (D.I.Y Yogyakarta and Central Java) is the region with the largest number of articles. The distinctiveness of Indonesia's approach to self-medication lies in its utilization of various natural elements to address similar ailments, which can be attributed to geographical factors, cultural beliefs, and diverse knowledge across different regions. Meanwhile, Covid-related studies were very limited due to the availability or the preference for chemical self-medication.
Characterization and Antioxidant Potential of Acacia nilotica Synthesized Callus and Seed Nanoparticles Ibe, Ifeanyi Jude; Zailani, Hauwa Ahmed; Dahiru, Mubarak Muhammad; Gali, Ishaku Adamu
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.94215

Abstract

This research aimed to explore the callogenesis, characterization, and antioxidant potential of Acacia nilotica callus and seed silver nanoparticles. The callus induction was accomplished using plant growth hormones. The silver nanoparticles (AgNPs) were synthesized from the seed and callus extracts and characterized using Gas chromatography-mass spectroscopy (GC-MS), X-ray diffraction (XRD), and Scanning electron microscopy (SEM). The antioxidant activities were evaluated by 1, 1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) assays, molecular docking, and molecular dynamics simulations. The callus formation ranged from 77% to 100%. The AgNPs exhibited a face-centered cubic structure with the size predicted to be 25 nm while the SEM images showed the AgNPs had clustered topography and variable surface morphology. Exactly 33 and 26 compounds were respectively identified in the callus and seed with 8-Hexadecenal 14-methyl- (Z)- (7.71%) and linoleic acid (15.77%) being the most abundant, respectively. A significantly (p < 0.05) higher DPPH and FRAP activities were demonstrated by the callus at the highest dose (1 mg/ml). Moreover, 22-Stigmasten-3-one and 3-(azepan-1-yl)-1,2-benzothiazole 1,1-dioxide, respectively from the callus and seed exhibited the most favorable docking interactions with xanthine oxidase, cytochrome P450 21A2, and myeloperoxidase with a possible activity disruption. Conclusively, the callogenesis technique might be regarded as a reliable alternative to produce pharmacologically active secondary metabolites and nanoparticles against oxidative stress-linked ailments. Moreover, 22-Stigmasten-3-one and 3-(azepan-1-yl)-1,2-benzothiazole 1,1-dioxide might be good starting materials for novel therapeutics synthesis against oxidative stress.
In vivo Wound Healing Activity of Tamanu Oil (Calophyllum inophyllum l.) Extracted by Cold-Pressed and Hot-Pressed Methods and Their Fatty Acids Composition Rakhmawati, Rita; Wahyuni, Dinar Sari Cahyaningrum; Ainurofiq, Ahmad; Hadi, Saptono; Choiri, Syaiful; Retnaningtyas, Estu; Pratama, Tiara Dewi Salindri
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.97146

Abstract

Tamanu oil is a promising natural wound healer due to its chemical compounds, particularly fatty acids. Cold-pressed or hot-pressed methods are commonly used to obtain this oil from Calophyllum seed. However, there needs to be research documenting the impact of these two extraction methods on the fatty acid profile and wound healing activity. Therefore, the study aims to characterize the fatty acid profiles of cold-pressed and hot-pressed tamanu oils using Gas Chromatography and evaluate their wound healing activity in vivo. The fatty acid profiles were analyzed using GC, and the wound healing tests were conducted on animal subjects divided into four groups: negative control, positive control (Bioplacenton®), cold-pressed tamanu oil, and hot-pressed tamanu oil. Cold-pressed tamanu oil showed superior fatty acid characteristics with an acid value of 38,71 Mg KOH/g fat and a peroxide value of 3,0095 mEq O2/kg, indicating that oil is stable against oxidation.  The length of the wound was observed daily for up to 8 days to assess its effect. The parameters observed were the percentage of wound healing and the total AUC based on the average length of the wound. Cold-pressed tamanu oil demonstrated the highest wound healing efficacy compared to both the positive control and hot-pressed tamanu oils. Both cold (11,67± 0,78) and hot-pressed tamanu oil (11,87 ± 0,61) exhibited significant differences in AUC value compared to the negative control group (13,07 ± 0,38), highlighting the potential of tamanu oil as a wound healing agent.
Red Ginger Effect on Yield Percentage and Antioxidant Activity in Red Ginger–Angkak Combination Nugraha, Fajar; Fahrurroji, Andhi; Anastasia, Desy Siska; Meilvina, Meilvina
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.89432

Abstract

Red ginger and angkak are often combined in Chinese cuisine to maintain health. Both of these ingredients are known to have potent antioxidant activity respectively, but the combination of red ginger and angkak has never been studied. The purpose of this research is to see the effect of the amount of red ginger on the percentage of yield and antioxidant activity in the combination of red ginger and angkak. Red ginger and angkak extracts are combined, each ingredient is extracted singly. The amount of red ginger was varied, namely 10, 20, 30, and 40 g. In comparison, the number of angkak remains at 55 g. Both materials were extracted by kinetic heat at a temperature of 600C and a stirring speed of 800 rpm for 120 minutes. The yield percentage of the viscous extract obtained was calculated, and its antioxidant activity was analyzed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. In addition, the chromatogram profile test of red ginger and angkak was also carried out. Increasing the amount of red ginger in the red ginger - angkak extract did not have a significant effect (p>0.05) on the yield percentage but had a significant effect (p<0.05) by increasing the antioxidant activity of the red ginger - angkak extract. The combined extracts' antioxidant activity was less than the red ginger extract. The ginger chromatogram profile shows ten different spots, while angkak has three different spots.
Anti-aging Effect of Black Garlic Through Anti-senescence, Gelatinase Inhibition Mechanism, and Formulation of NLC Serum Effendi, Fatiha Citra; Nabila, Klarissa; Maharani, Dini; Widayanti, Wasita Rachma; Jauhari, Fahmi Ihsanuddin; Meiyanto, Edy; Lukitaningsih, Endang
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.90878

Abstract

Aging associated with cellular senescence was responsible for the degradation of collagen and elastin by activation of matrix metalloproteinases (MMPs) that produced wrinkles. Black garlic is known to have an anti-aging potency on premature aging. This study aims to reveal the anti-aging potency of black garlic through anti-senescence and gelatinase inhibition mechanisms and its formulation of Nanostructured Lipid Carrier Serum. Black Garlic Extract (BGE)  was macerated with ethanol 50% then heated with low temperature at 50°C. The extract obtained was profiled with Thin Layer Chromatography and antioxidant activity was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The cytotoxic effect of BGE was examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on Vero cells. Anti-senescence effect of BGE was conducted by SA-β-Gal assay. The inhibition of gelatinase activities was predicted by molecular docking using MOE2010 software. The preparation of Nanostructured Lipid Carrier (NLC) is done by High Shear Homogenization method, then the best formula continued to make NLC-BGE Serum. The BGE contained S-allyl cysteine as a major organosulfur compound. BGE showed non-toxic to Vero cells with IC50 >500 μg/mL. Furthermore, 50 μg/mL of BGE showed inhibits doxorubicin-induced senescence in Vero cells. BGE also appeared to have good affinity on inhibitory domains of MMP-1 (∆G -7,754 kcal/mol) and MMP-2 (∆G -9,130 kcal/mol). NLC-BGE serum formula has met nanoparticles criteria and showed good stability. Based on this study, BGE revealed anti-senescence and gelatinase inhibition that is considered to have high anti-aging properties and can be applied in the NLC-BGE serum formula.

Page 53 of 56 | Total Record : 552

 51   52   53   54   55 

Filter by Year

2010 2025


Reset
Filter By Issues
All Issue Vol 30, No 2 (2025) Vol 30, No 1 (2025) Vol 29, No 3 (2024) Vol 29, No 2 (2024) Vol 29, No 1 (2024) Vol 28, No 3 (2023) Vol 28, No 2 (2023) Vol 28, No 1 (2023) Vol 27, No 3 (2022) Vol 27, No 2 (2022) Vol 27, No 1 (2022) Vol 26, No 3 (2021) Vol 26, No 2 (2021) Vol 26, No 1 (2021) Vol 25, No 3 (2020) Vol 25, No 2 (2020) Vol 25, No 1 (2020) Vol 24, No 3 (2019) Vol 24, No 2 (2019) Vol 24, No 1 (2019) Vol 23, No 3 (2018) Vol 23, No 2 (2018) Vol 23, No 1 (2018) Vol 22, No 3 (2017) Vol 22, No 2 (2017) Vol 22, No 1 (2017) Vol 21, No 3 (2016) Vol 21, No 2 (2016) Vol 21, No 1 (2016) Vol 20, No 3 (2015) Vol 20, No 3 (2015) Vol 20, No 2 (2015) Vol 20, No 2 (2015) Vol 20, No 1 (2015) Vol 20, No 1 (2015) Vol 19, No 3 (2014) Vol 19, No 3 (2014) Vol 19, No 2 (2014) Vol 19, No 2 (2014) Vol 19, No 1 (2014) Vol 19, No 1 (2014) Vol 18, No 3 (2013) Vol 18, No 3 (2013) Vol 18, No 2 (2013) Vol 18, No 2 (2013) Vol 18, No 1 (2013) Vol 18, No 1 (2013) Vol 17, No 3 (2012) Vol 17, No 3 (2012) Vol 17, No 2 (2012) Vol 17, No 2 (2012) Vol 17, No 1 (2012) Vol 17, No 1 (2012) Vol 16, No 3 (2011) Vol 16, No 3 (2011) Vol 16, No 2 (2011) Vol 16, No 2 (2011) Vol 16, No 1 (2011) Vol 16, No 1 (2011) Vol 15, No 3 (2010) Vol 15, No 3 (2010) Vol 15, No 2 (2010) Vol 15, No 2 (2010) Vol 15, No 1 (2010) Vol 15, No 1 (2010) More Issue