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Pharmascience
Published by Universitas Lambung Mangkurat
ISSN : 23555386     EISSN : 24609560     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Pharmascience memuat naskah hasil penelitian dan artikel review bidang kefarmasian. Naskah dapat berasal dari mahasiswa, dosen, peneliti, dan lembaga riset. Setiap naskah yang diterima redaksi Jurnal Pharmascience akan ditelaah oleh Mitra Bebestari dan Anggota Redaksi. Jurnal Pharmascience terbit 2 (dua) kali dalam setahun yaitu Februari dan Oktober. Redaksi menerima pemesanan Jurnal Pharmascience untuk berlangganan atau pembelian setiap terbitan.
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Articles 360 Documents
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Pharmacokinetic Interaction Between Bay Leaves (Syzygium polyanthum) Infusion and Captopril in Rats Nur, Amran; Rahmat, Septian Dwi; Fiskia, Ermalyanti; Marhamah, Marhamah
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.23772

Abstract

Captopril, an ACE inhibitor, is commonly prescribed as first-line therapy for hypertension. In practice, patients often combine synthetic drugs with herbal remedies such as bay leaves (Syzygium polyanthum), raising concerns about potential interactions. This study investigated the effect of bay leaves infusion on the pharmacokinetic profile of captopril in white rats (Rattus norvegicus). Ten rats were divided into two groups: group 1 received 25 mg of captopril, while group 2 received the same dose in combination with bay leaves infusion. Blood samples were collected via the tail vein at 0; 0.5; 1; 2; 4; 6; 12 and 24 hours, and analyzed using a UV-VIS spectrophotometer (205 nm). Pharmacokinetic parameters assessed included absorption rate constant (Ka), elimination rate constant (Ke), half-life (t½), peak time (tmax), maximum concentration (Cpmax), and area under the curve (AUC). Results showed that bay leaves infusion increased Cpmax (2.646 → 3.105 µg/ml), prolonged t½ (3.347 → 16.116 h), and elevated AUC (23.382 → 56.479 µg.h/ml). These findings indicate that bay leaves infusion significantly alters the pharmacokinetic profile of captopril.
Molecular Docking Studies and ADME-Tox Prediction of Phytocompounds from Lycopersicon esculentum mill. as a Drug Candidate for Alopecia Treatment Oktoba, Zulpakor; Patala, Recky; Sayoeti, Muhammad Fitra Wardhana; Sangging, Putu Ristyaning Ayu; Soleha, Tri Umiana
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24836

Abstract

Alopecia is a disorder of the hair follicles that causes hair loss, either in limited areas or throughout the entire body. This study aims to evaluate the potential and molecular interactions of compounds found in the Rampai plant (Lycopersicon esculentum Mill.). The Rampai plant is known to contain various secondary metabolites such as alkaloids, flavonoids, arbutin, amygdalin, and pectin, which have the potential to be developed as antialopecia drug candidates through an in-silico approach to androgen receptors (PDB ID: 4K7A) and ADME-Tox profile predictions. The in-silico approach was conducted using the molecular docking method to predict the interaction between the active compounds from the Rampai plant and the androgen receptor using Autodock Tools 1.5.7 and Vina software, while the ADME-Tox analysis was conducted through the pkCSM platform. The molecular docking results showed that the reference ligand (Minoxidil) had an affinity energy of −7.353 kcal/mol, while the test compound with the best affinity was isorhamnetin with a value of −8.398 kcal/mol, which was lower (more stable) than Minoxidil. In addition, the ADME-Tox prediction results for isorhamnetin show favorable pharmacokinetic characteristics, especially in terms of skin permeability, absorption and distribution. Thus, isorhamnetin has the potential as an androgen receptor antagonist and a role in the development of therapies for alopecia.
Molecular Basis for the Enhanced CDK2 Inhibition by Artesunate: Superior Binding Affinity to the ATP-Catalytic Site Pratama, Mohammad Rizki Fadhil; Mulyani, Evi; Suratno, Suratno; Kumar, Punet; Tjahjono, Daryono Hadi; Kartawinata, Tutus Gusdinar
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24555

Abstract

This study aimed to identify the most potent CDK2 inhibitor among seven artemisinin derivatives and, critically, to elucidate its binding mechanism and compare its affinity with that of the natural ligand, ATP. Molecular docking was performed using AutoDock 4.2.6 toward inactive and active forms of CDK2. Ligands were optimized using the Hartree-Fock method basis set 6-311G. Blind docking on the active form was used to determine the inhibition mechanism, employing the free energy of binding (ΔG) and dissociation constant (Ki) as affinity markers. Artesunate was the most potent derivative, exhibiting the highest affinity towards the active CDK2 form, with a ΔG of -11.7 kcal/mol and a Ki of 2.66 nM. Blind docking confirmed an ATP-competitive inhibition mechanism. Remarkably, Artesunate's Ki was significantly lower than that of ATP (8.73 nM). This enhanced affinity is attributed to specific interactions between the hemisuccinate side chain and the critical amino acid region, from 13-Gly to 16-Gly. Artesunate is suggested as a potent, ATP-competitive CDK2 inhibitor with an affinity exceeding that of ATP. These hypothesis-generating results suggest anticancer potential, yet require validation via MD or assays; limitations like scoring bias and protein flexibility necessitate cautious interpretation regarding the 13-Gly to 16-Gly target.
Metabolite Profiling of The Antioxidant Properties of The Aquatic Plant Cyperus involucratus Employing UHPLC-HRMS Windyaswari, Ari Sri; Faramayuda, Fahrauk; Billa, Salsa Rizqyana; Miarsih, Maria Tri; Ayu, Inna Puspa; Pratiwi, Niken Tunjung Murti; Krisanti, Majariana; Dwiyanti, Fifi Gus
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24618

Abstract

The genus Cyperus is widely recognized as decorative flora. Empirically, Cyperus plants have been utilized to treat wounds, inflammation, and digestive disorders. While the genus is reported to exhibit antioxidant properties, scientific data regarding Cyperus involucratus remains limited. This research aimed to identify antioxidant compounds in C. involucratus using Ultra-High-Performance Liquid Chromatography-High Resolution Mass Spectrometry (UHPLC-HRMS). The C. involucratus methanolic extract was obtained through maceration using a 70% methanol solvent. Separation was performed using a UHPLC gradient system with a flow rate of 0.3 mL/min , while compound identification was conducted using a Quadrupole-Orbitrap MS detector in positive mode. The radical scavenging activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The analysis identified 175 metabolites within the methanolic extract. Based on mzCloud library matching with confidence scores of 97.4–100%, 12 primary bioactive compounds were identified: oleamide, α -linolenic acid, kaempferol, scutellarin, hexadecanamide, 1-linoleoyl glycerol, 1-stearoy-rac-lglycerol, adenine, adenosine, L-tyrosine, stearamide and nootkatone. The extract possessed a moderate radical scavenger with an IC50 value of 57.94 μg/mL. These findings provide a scientific foundation for further investigation of C. involucratus as a potential natural antioxidant, although further in vivo studies are required to validate its broader pharmacological outcomes.
Formulation and Characterization of Gelatin Nanoparticles from Manis Rejo Leaf Extract (Vaccinium variangiaefolium (Bl.) Miq.) with Glutaraldehyde Concentrations Variations as Crosslinker Christian, Yulius Evan
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.23706

Abstract

Manis Rejo (Vaccinium variangiaefolium (Bl.) Miq.) is a plant that dominates at the Tangkuban Parahu area and grows in mountainous regions. Its leaves contain flavonoids with various benefits. The ethyl acetate extract of these leaves has demonstrated cytotoxic activity, making it a potential active compound in nanoparticle-based drug delivery systems. This study aimed to investigate the effect of variations in the glutaraldehyde concentration on the characteristics of the gelatination nanoparticles encapsulating the Manis Rejo leaf extract. The organoleptic properties, moisture content, and solubility of the extract were evaluated and then developed into nanoparticles (NPs) using the desolvation method with glutaraldehyde concentrations of 100 µl, 200 µl, and 300 µl. The characterization included the nanoparticle stability, particle size, polydispersity index (PDI), zeta potential, and morphology. The results showed that the extract was green, had a distinctive odor, a dry texture, a moisture content of 4.31%, and was soluble in ethyl acetate (1:10). The nanoparticles remained physically stable for 20 days at room temperature (25 oC), with particle sizes of 343.4±4.4 nm, 226.3±23.1 nm, and 199.7±1.6 nm, and PDIs of 0.381±0.0234, 0.446±0.0895, and 0.177±0.0195, respectively. The zeta potential values ranged from 15.8±1.1 to 17.8±1.1 mV. Transmission Electron Microscopy (TEM) analysis of formula III revealed a spherical morphology supporting the nanoparticle stability. Glutaraldehyde variation significantly influenced the particle size and PDI.
Lumbricus Rubellus Earthworm Extract Hydrogel for Treatment of Diabetic Ulcer Wounds Lestari, Diana Tri; Jauhar, Muhamad; Retnowati, Eko
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22880

Abstract

A diabetic ulcer is a complication that requires serious treatment because it is the highest cause of amputation. This condition has an impact on the morbidity, mortality, and socioeconomics of people with diabetes. Therefore, accuracy is needed in managing diabetic ulcers, one of which is natural ingredients that have potential as topical ulcer medicines, namely the Lumbricus rubellus earthworm. This study aims to find out the most effective formula for the treatment of diabetic ulcer wounds. The formula for this drug candidate is made using the hydrogel preparation formulation using an HPMC 940 base with variations in the active ingredient of lumbricus worm extract of 20%, 50%, and 80% to obtain the desired hydrogel preparation. The candidate drug will be tested, namely physical tests including organoleptic tests, homogeneity tests, pH tests, viscosity tests, spreadability tests, and adhesive tests. After that in vivo trial using Wistar rat experiments. The results of the organoleptic test showed that the three formulas were in gel form with a distinctive extract odor, but the three preparations showed different colors, namely brownish yellow, dark brown, and blackish brown. The three formulations appear homogeneous, having a pH between 4.36 and 4.44 and a viscosity between 5,376 cp and 5,894 cp. The spreading power in formulas 2 and 3 is good, and formula 2 has good adhesion. The results of this study demonstrate that the group treated with 50% Lumbricus rubellus topical extract experienced the most significant and rapid wound healing among all intervention groups. Lumbricus extract can be used as a topical gel preparation for wound care, with the best formulation at a concentration of 50%.
Antibiotic Use Patterns in Obstetric and Gynecological Surgery Patients: A Quantitative Descriptive Study Using ATC/DDD and DU90% Methods Azzahra, Maryamah; Intannia, Difa; Dwi Sandi, Dita Ayulia; Saksono, Reni Yustiati; Yosita, Revina Aditya; Lingga, Herningtyas Nautika
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24199

Abstract

Surgical site infections (SSIs) are common postoperative complications in obstetric and gynecological surgery, with incidence rates up to 20% in cesarean sections. Antibiotics are the primary strategy for SSI prevention; however, antibiotic utilization patterns in this surgical setting remain poorly characterized locally. This study describes the antibiotic use profile, AWaRe classification, DDD/100 patient-days values, and DU90% segment among obstetric and gynecological surgery patients at Ulin Regional General Hospital, Banjarmasin, in 2024. A retrospective, non-experimental quantitative descriptive design was employed. Of 313 medical records reviewed, 137 met the inclusion criteria. A total of 173 antibiotic prescriptions were identified. Ceftriaxone was the most frequently used antibiotic (61.84%), with cephalosporins predominating (91.91%) and parenteral administration in 75.72% of cases. Based on the WHO AWaRe 2022 classification, 85.55% of antibiotics were in the Watch group and 13.29% in the Access group; no Reserve antibiotics were used. Ceftriaxone had the highest DDD/100 patient-days (33.74). Ceftriaxone and cefixime comprised the DU90% segment. These findings highlight a predominance of Watch-group antibiotics and support the need for targeted stewardship interventions
Total Flavonoid Content, Antibacterial Activity and In Silico Toxicity Prediction of Ethanolic Extract from Murraya koenigii Leaves against Streptococcus mutans Nasution, Haris Munandar; Nasri, Nasri; Fauzi, Ziza Putri Aisyia; Rani, Zulmai; Pulungan, Ainil Fithri; Kaban, Vera Estefania
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22436

Abstract

Dental caries is a chronic disease exclusive to humans and remains one of the most prevalent oral health problems worldwide. The increasing emergence of antibiotic resistance and the adverse effects associated with conventional antimicrobials have encouraged the exploration of natural plant-derived compounds for caries prevention. Murraya koenigii leaves are widely used as a culinary ingredient and are known to possess various therapeutic properties, including antioxidant, antibacterial, anti-inflammatory, and hepatoprotective activities. This study aimed to evaluate the total flavonoid content, antibacterial activity, and in silico toxicity profile of the ethanolic extract of M. koenigii leaves against Streptococcus mutans, a primary cariogenic pathogen. Total flavonoid content was determined using the aluminum chloride colorimetric method, while antibacterial activity was assessed using the agar disk diffusion assay. The toxicity profile of major flavonoid constituents was further analyzed using in silico ADMET prediction tools. The results showed that the ethanolic extract of M. koenigii leaves contained a high total flavonoid content (281.83 ± 10.23 mg QE/g extract) and exhibited strong antibacterial activity against Streptococcus mutans, producing inhibition zones ranging from 14.4 to 19.4 mm in a concentration-dependent manner. In silico analysis indicated that the major flavonoid constituents possessed favorable pharmacokinetic characteristics with low predicted toxicity risks. These findings suggest that the ethanolic extract of M. koenigii leaves is rich in flavonoids and demonstrates significant antibacterial potential, supporting its promise as a natural antibacterial agent for oral health applications. Further studies focusing on compound isolation, formulation development, and in vivo validation are recommended.
Evaluation of the Rationality of the Use of Antibiotics in Paediatric Diarrheal Patients in Hospital Inpatient Facilities in the City of Bandung Suherman, Linda Purnamawati; Pratama, Intan Wulan Putri; Margayani, Eni; Rachmawati, Vidya
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24652

Abstract

Diarrhoea in children is often associated with irrational antibiotic use, even though the cause is not bacterial infection. Excessive antibiotic use can increase antibiotic resistance, a significant problem in healthcare. This study aimed to evaluate the rationality of antibiotic use in paediatric inpatients with diarrhoea at a single hospital in Bandung, including demographic characteristics, types of antibiotics used, and appropriate indication, drug selection, dosage, and administration intervals. This study was observational, using a non-experimental descriptive analysis design. Data collection was conducted retrospectively from January to December 2024. Out of a total population of 229 patient medical records, 54 patient medical records met the inclusion criteria and were used as the study sample. The rationality of drug use refers to the Indonesian Ministry of Health’s guideline. The results showed that 55.6% of patients were male, with toddlers (46.2%) being the largest age group. Ceftriaxone was the most commonly prescribed antibiotic (24%). The rationality of antibiotic use was 100% for indications and drug selection, 94.4% for dosage, and 90.7% for the interval between doses. However, the identified discrepancies in dosage (5.6%) and administration intervals (9.3%) require immediate attention to minimize the risk of therapeutic failure and antibiotic resistance. 
Impact of Drying Time and Temperature Variation on the Antioxidant Activity of Cat's Whiskers (Orthosiphon stamineus Benth) Faramayuda, Fahrauk; Syam, Akhirul Kahfi; Prasetyo, Chandra Putra; Farhan, Farhan
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.23323

Abstract

Cat's whiskers (Orthosiphon stamineus Benth.) is an herbal plant known for its significant antioxidant activity, making it a valuable resource in traditional medicine. This study aims to investigate the effects of different drying temperatures and durations on the antioxidant activity of cat's whiskers using the DPPH (2,2-diphenyl-1-picrylhydrazyl) reagent. The research was conducted through a systematic analysis of drying temperatures of 40, 50, and 60°C over 1, 2, and 3 days, to establish a correlation between drying parameters and antioxidant activity. Statistical analysis using two-way ANOVA revealed that drying conditions significantly influenced antioxidant activity, whereas water content remained stable across all treatments. Based on the results, the optimal drying condition is 60°C for 1 day, which exhibited the highest antioxidant activity, with an IC50 of 13.62 μg/mL and a water content of 3.69%. This study advances scientific knowledge, particularly regarding the most effective drying methods for cat's whiskers to preserve the stability of the plant's bioactive compounds. Ultimately, these findings provide a scientific basis for developing standardized drying protocols to maximize the therapeutic benefits of cat's whiskers in health applications.

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