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Effectiveness Probiotics as Anti-Aging for Facial Skin: A Systematic Review Putu Adinda Novyta Arsha Putri; Ida Ayu Manik Partha Sutema; I Putu Gede Adi Purwa Hita; I Gusti Ayu Rai Widowati
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22558

Abstract

Premature skin aging is increasingly prevalent among individuals in their mid-20s to 30s, influenced by genetic, lifestyle, and environmental factors. Probiotics have emerged as a promising natural intervention to address this issue. This systematic review aimed to evaluate the effectiveness of oral and topical probiotics in preventing and managing signs of premature skin aging. A systematic search of PubMed and Scopus was conducted for Randomized Controlled Trials (RCTs) published between 2020 and 2025, using PICO-based inclusion and exclusion criteria. Methodological quality was assessed with the JBI checklist. Of 202 articles screened, eight RCTs were included. Results showed that oral probiotics improved skin quality by enhancing collagen production (24%), hydration (18%), and antioxidant activity, while topical probiotics reduced wrinkles (22%) and increased skin density (15%). In conclusion, oral and topical probiotics represent effective dual strategies for combating premature skin aging, though further studies are needed to optimize strain-specific formulations.
PROFIL HEMATOLOGI PADA PENDERITA TUBERKULOSIS SEBELUM DAN SESUDAH PENGOBATAN OAT DI PUSKESMAS KOTA DENPASAR I Gusti Agung Ayu Satwikha Dewi; Ida Ayu Manik Partha Sutema; Ni Putu Widiantari; Ni Putu Diah Monica Yanti; Ni Ketut Sari Merta Dewi
Klinikal Sains : Jurnal Analis Kesehatan Vol. 13 No. 1 (2025): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikalsains.v13i1.5447

Abstract

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that attacks the lungs as well as several systems such as gastrointestinal, central nervous, and liver. TB cases have become a global issue, in 2022 Bali has 3,040 cases and Denpasar City has the highest number reaching 1,063 cases. TB treatment is crucial to be handled effectively and efficiently. Examination of hematologic profiles provides important information about the impact of TB and response to treatment. Currently, there is little information on the relationship between hematology profile and OAT treatment of TB patients at the primary health care level such as puskesmas. The purpose of this study was to examine the hematological profile of TB patients before and after OAT treatment at the Denpasar City Health Center. The sampling technique in this study was accidental sampling conducted at the Denpasar City Health Center in January-September 2024. This study was a prospective cohort study supported by literature review. Hematology profile examination of 32 EDTA blood samples was examined using a hematology analyzer including hemoglobin, erythrocyte, leukocyte, platelet, and ESR profiles. Paired T-test results showed that the four hematological profiles had a sig. value smaller than 0.05 (p<0.05), indicating that there was a significant difference between the hematological profiles of TB patients before and after OAT treatment at the Denpasar City Health Center.
Hubungan tingkat pengetahuan terhadap perilaku swamedikasi penggunaan obat analgesik di Banjar Baluk II Kecamatan Negara: The relationship between knowledge level and self-medication behavior in the use of analgesic drugs in Banjar Baluk II, Negara District Putu Negia Suci Cahyani Buana; Ni Putu Wintariani; Gde Palguna Reganata; Ida Ayu Manik Partha Sutema
Widya Kesehatan Vol. 7 No. 2 (2025): Widya Kesehatan
Publisher : Universitas Hindu Indonesia (UNHI) Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32795/v6kdej02

Abstract

Latar belakang: Pengobatan sendiri adalah praktik lokal untuk menyelesaikan perawatan kesehatan untuk diri sendiri tanpa berkonsultasi dengan ahli kesehatan. Tujuan: Tujuan dari penelitian ini adalah untuk memahami hubungan antara tingkat informasi dan perilaku pengobatan sendiri obat penghilang rasa sakit di Banjar Baluk II, Wilayah Negara, dan hubungan sosiodemografi antara tingkat informasi dan pengobatan sendiri. Penelitian menggabungkan pendekatan cross-sectional untuk penyelidikan kuantitatif. Metode: Penelitian ini termasuk kuantitatif jenis penelitian observasional analitik dengan pendekatan cross sectional. 95 responden dijadikan sebagai contoh penelitian. Lokasi penelitian ini dilakukan di Banjar Baluk II Kecamatan Negara dilakukan pada bulan Maret sampai bulan Mei tahun 2023. Analisis statistik menggunakan pengujian analisis korelasi pada uji Spearmen’s Rank. Hasil: Terdapat 42 (44,2%) responden yang memiliki informasi kurang, 46 (48,4%) yang memiliki informasi cukup, dan 7 (7,4%) yang memiliki informasi sangat baik. Ada 57 responden (60,0%) yang berperilaku baik saat menggunakan obat penghilang rasa sakit untuk pengobatan sendiri, dan 38 responden (40,0%) berperilaku baik. Tingkat pengetahuan terhadap perilaku terdapat nilai Spearmen’s Rank yang positif sebesar 0,514 termasuk dalam kategori sedang dengan signifikansi sebesar 0,000 (0,000<0,05). Terdapat hubungan antara usia (r=0, 0,334), pendidikan (r= 0,443) dan pekerjaan (r= 0,303) (p-value= 0,000). Kesimpulan: Terdapat hubungan signifikan antara tingkat pengetahuan terhadap perilaku swamedikasi obat analgesik di Banjar Baluk II Kecamatan Negara adalah cukup baik serta terdapat hubungan yang signifikan antara usia, pendidikan dan pekerjaan.
Online Pharmacy Education: Challenges and Perceptions from an Academic Perspective I Gusti Ayu Rai Widowati; Ida Ayu Manik Partha Sutema; Ni Putu Aryati Suryaningsih
International Journal of Pedagogy and Teacher Education Vol 9, No 1 (2025): International Journal of Pedagogy and Teacher Education - April
Publisher : The Faculty of Teacher Training and Education (FKIP), Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ijpte.v9i1.98016

Abstract

The digitalization of education is reshaping pharmacy instruction through the integration of online learning systems. While the adoption of digital learning continues to grow, research on the perceptions, readiness, and challenges faced by students and faculty in Indonesia remains limited. Understanding these factors is essential for formulating effective strategies in online education. This study investigates the perceptions, readiness, and obstacles encountered by pharmacy students and faculty at Bali International University in relation to online education. It further explores barriers to digital learning and their impact on development needs. Employing a sequential explanatory mixed-methods design, the study first gathered quantitative data, followed by qualitative insights through in-depth interviews. A total of 329 respondents participated in the research. The quantitative results revealed no significant association between readiness (OR = 0.957, 95% CI = 0.869–1.055, p = 0.399) or attitude (OR = 1.059, 95% CI = 0.929–1.207, p = 0.364) and development needs. However, barriers showed a statistically significant correlation with development (OR = 1.777, 95% CI = 1.066–2.964, p = 0.027). Qualitative data, analyzed using a thematic framework, identified five central themes: accessibility, collaboration, ICT utilization, professional development, and the broader implications of digitalization in pharmacy education. This study underscores the transformative potential of digital technology and the importance of addressing existing challenges to enhance the quality and accessibility of pharmacy education. These improvements are vital to equipping future pharmacists with the competencies required to thrive in global healthcare systems and effectively contribute to integrated pharmacy services worldwide.
THE EFFECT OF LAVENDER AROMATHERAPY ON DYSMENORRHOEA STUDENTS IN INSTITUTE OF HEALTH SCIENCE MEDICA PERSADA BALI AA Sg Dewi Pradnya Pramita; IA Manik Partha Sutema; Dhiancinantyan Windydaca Brata Putri
Journal Pharmaceutical Science and Application Vol. 2 No. 1 (2020): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i01.p02

Abstract

Background: Menstrual pain (dysmenorrhoea) is a symptom characterized by discomfort in the abdomen during menstruation. Lavender aromatherapy is beginning to be sought as one of the non-pharmacological therapies because the use of NSAIDs is reported to cause many side effects. The main components of lavender, linalool (35%) and linalyl acetate (51%) are efficacious as analgesics and maximally absorbed through the skin. Objective: This study aims to determine the effect of lavender aromatherapy on the menstrual pain of female college students at the Persada Medika Institute of Bali. Methods: Quasy experimental with one group pre-posttest design. The study was followed by 38 female students with moderate to severe pain using the random sampling technique. Data were analyzed using the non-parametric Wilcoxon test with p <0.05. Results: The results prior to lavender aromatherapy showed moderate pain at 73.7% and severe pain 26.3%. After lavender aromatherapy was administered, they showed moderate pain at 21% and mild pain at 79%. The Wilcoxon test indicated that the value of p = 0,000, where p <0.05. Conclusion: There is an effect of lavender aromatherapy to decrease menstrual pain (dysmenorrhoea) of female college students at the Persada Bali Institute of Health Sciences. Keywords: Aromatherapy Lavender; Dysmenorrhoea; Pain Scale; Linalool; Linalyl Acetate
SIDE EFFECTS PROFILE OF ANTIPLATELET MEDICATION IN PATIENTS WITH CORONARY HEART DISEASE AT BHAYANGKARA HOSPITAL BALI-INDONESIA Anak Agung Indah Astrijayanti; Ida Ayu Manik Partha Sutema; Ni Putu Wulanda Evayanti; Ni Ketut Tria Purnamisari; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 2 No. 2 (2020): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i02.p02

Abstract

Introduction: Coronary heart disease (CHD) is a disorder of heart function due to a lack of blood in the heart muscle due to narrowing of the coronary arteries. Antiplatelet in patients with CHD is a therapy that must be obtained by patients throughout their lives to prevent recurrent attacks and deaths from CHD. In the Province of Bali, especially in Denpasar, there is a lack of information about the type of side effects that occur on antiplatelet medication, so it is necessary to do a related study. Objective: The aim of this study is to identify the type of side effects that occur on antiplatelet medication in patients with CHD. Methods: A cross-sectional study involving 97 patients was done by observed the CHD patients treated with antiplatelet medication. Side effects were evaluate using Naranjo Algorithm. Patients were divided into three groups, including a low dose aspirin user group, clopidogrel user group, and aspirinclopidogrel combination user group. Results: Antiplatelet side effects that occur in patients include headache (2.06%), diarrhea (1.03%), cyanosis (1.03%), gastrointestinal bleeding (8.25%), heartburn (11.34%), and nausea (6.19%). These side effects only occurred in 31.96% of the total subjects. The incidence of aspirin side effects was significantly greater than clopidogrel as well as aspirin-clopidogrel in combination (p <0.05). Conclusion: Patients with CHD who use antiplatelet agents in the long term to be more aware of the potential side effects that will occur, especially heartburn in chronic low-dose aspirin users. Keywords: Coronary Heart Disease; Side Effects; Antiplatelet; Aspirin; Clopidogrel
KNOWLEDGE, ATTITUDES, AND PRACTICES OF PHARMACEUTICAL PERSONNEL IN ANTIBIOTIC SERVICES AT DENPASAR CITY PHARMACY Manik Partha Sutema, Ida Ayu; Rai Widowati, I Gusti Ayu; Putri, Putu Adinda Novyta Arsha
Jurnal Farmasi Kryonaut Vol 4 No 2 (2025): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v4i2.156

Abstract

Background: The misuse of antibiotics is a major trigger for antibiotic resistance, one of the world's biggest health threats. Pharmacies hold the key in delivering accurate antibiotic information and services. This study aims to measure the understanding, views, and actions of pharmacy technical staff in Balinese pharmacies regarding antibiotics, while also investigating what influences their behavior. This cross-sectional survey was conducted from September to December 2024 in 9 regions of Bali, collecting data via questionnaires about knowledge, attitudes, and practices. Analysis shows that the majority (64.2%) of pharmaceutical technical staff have good knowledge about antibiotics, and almost all (96.9%) strongly agree with the rational use of antibiotics. However, there is a serious exception: 11.95% of them still dispense antibiotics without a doctor's prescription, a practice that risks worsening resistance. In conclusion, although pharmacy technical staff in Bali have a strong knowledge base and attitude, there are still gaps in practice that need to be urgently addressed through continuous and equitable education to prevent the increase of antibiotic resistance.
Co-Authors AA Sg Dewi Pradnya Pramita Alma Lystia Savitri Mahayasa Anak Agung Indah Astrijayanti Andani, Cokorda Istri Ratih Ardianta, I Putu Riska Ayu Dyahsavira Setyartini Desak Made Widyanthari Dewa Ayu Putu Satrya Dewi Dewa Ayu Putu Satya Dewi Dewa Ayu Putu, Satrya Dewi Dewi, D.A.P Satrya Dewi, DAP Satrya Dewi, Ni Made Ayu Candra Dhiancinantyan Windydaca Brata Putri I Gede Suasnawa I Gede Widhiantara I GUSTI AGUNG AYU SATWIKHA DEWI - I Gusti Ayu Agung Septiari I Gusti Ayu Diah Candra Dewi I Gusti Ayu Rai Widowati I Gusti Made Aman I Gusti Ngurah Agung Windra Wartana Putra I Made Bakta I Made Jawi I Putu Aris Septa Permana I Putu Gede Adi Purwa Hita I Putu Gede Adi Purwa Hita I Putu Gede Adi Purwa Hita I Putu Riska Ardinata I Putu Tangkas Suwantara Ida Bagus N Maharjana IGA Ari Septiari Intan Prima Asri Ni Komang Juliani, Ni Kadek Kadek Tiana Dewi, Ni Ketut Agus Adrianta Ketut Agus Adrianta Luh Putu Widiastini Made Krisna Adi Jaya Made Krisna Adi Jaya Maharianingsih, Ni Made Maharianingsih, NM Maharjana, I.B.N Manuaba, I.A Ratih Wulansari Manuaba, IA Ratih Wulansari Maseni, I Gusti Ayu Komang Putri Ni Kadek Arinda Ni Ketut Sari Merta Dewi Ni Ketut Sari Mertadewi Ni Ketut Tria Purnamisari Ni Ketut Tria Purnamisari Ni Made Andrinia Ratih Sri Indarswari Ni Made Maharianingsih Ni Made Sudiari Ni Made Yunitasari Ni Nyoman Sri Budayanti Ni Putu Aryati Suryaningsih Ni Putu Aryati Suryaningsih Ni Putu Diah Monica Yanti Ni Putu Widiantari Ni Putu Wulanda Evayanti Ni Putu Wulanda Evayanti Ni Putu Yuliana Assari Putra, IGNA Windra Wartana Putri, Kadek Sephia Adiana Putri, Putu Adinda Novyta Arsha Putu Adinda Novyta Arsha Putri Putu Negia Suci Cahyani Buana Putu Yudhistira Budhi Setiawan Putu Yudhistira Budisetiawan Rai Widowati, I Gusti Ayu Rajdev Dhillon Ratih, Andrinia Reganata, Gde Palguna Saputra, I Wayan Agus Gede Manik Septiari, I Gusti Ayu Agung Sukmantari, Pande Ni Nuhung Suryaningsih , Ni Putu Aryati Suryaningsih, N.P Aryati Suryaningsih, NP Aryati Wartana Putra, I Gusti Ngurah Agung Windra Widowati, I Gusti Ayu Rai - Wijayaningrum, I Dewa Ayu Indah Windidaca Brata Putri, Dhiancinantyan Wintariani, Ni Putu Wintariani, Ni Putu Aryati Yanti, Ni Komang Semara