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All Journal Jurnal Veteriner Indonesia Medicus Veterinus Majalah Kedokteran Bandung Jurnal Kesehatan Masyarakat Althea Medical Journal Journal of Biomedicine and Translational Research Jurnal Kesehatan Andalas Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Universa Medicina Journal of Medicine and Health JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Jurnal SPORTIF : Jurnal Penelitian Pembelajaran PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JOURNAL OF SPORT EDUCATION (JOPE) Jurnal Ilmu Faal Olahraga Indonesia Journal of Medicine and Health Folia Medica Indonesiana
Hanna Goenawan
Departemen Anatomi, Fisiologi Dan Biologi Sel Fakultas Kedokteran Universitas Padjadjaran, Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Veteriner

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Ethionamide Modulates of Thyroid Stimulating Hormone, Thyroxine, and Triiodothyronine Levels in White Ratstimulating Hormone (TSH), Thyroxine (T4), and Triiodothyronine (T3) Serum are potentially modulated Level by Ethionamide in Rats ronny lesmana; Fani Rahma Yenita; Prayudi Santoso; Hanna Goenawan; Arto Yuwono Soeroto; Yuni Susanti Pratiwi; Nova Sylviana; Iwan Setiawan; Vita Murniati Tarawan; Unang Supratman
Jurnal Veteriner Vol 21 No 3 (2020)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Multidrug-Resistant Tuberculosis (MDR-TB) infection is not solely caused serious impact for patient and cause long recovery process. Multidrug-Resistant Tuberculosis needs specific treatment approach using second-line TB drugs. Ethionamide as one of medication used in MDR-TB are known to cause greater side effects compared to the first-line drugs. One of side effect like hypothyroidism is remain unclear. There is limited study about role of ethionamide cause hypothyroidism. In this present study, 24 male, wistar rats were divided into three groups: ethionamide group; positive control positive (propylthiouracil) and negative control group (received distilled water only) and treated accordingly for 12 week. Under ketamine and xylazine anesthesia, blood sample were collected from retroorbital vein at 8 and 12 week, put in EDTA tube and stored -20Ë%C until use. After last sampling, rat were sacrificed using CO2 chamber. Our data showed that thyroid stimulating hormone (TSH) levels in ethionamide group is increased from 8 weeks to 12 weeks significantly, but there is no significant changes in control groups. Thyroxine (T4) levels is trend decreased from 8 weeks to 12 weeks compared to control groups. There is no change of Triiodothyronine (T3) levels. Effect of ethionamide on thyroid hormone (T3 and T4) levels was not prominent and there were no significant changes observed. Interestingly, we observed an increase of TSH level after ethionamide treatment. Taken together, 12 week treatment of ethionamide tablet might potentially modulate thyroid hormone (T3 and T4) levels that is reflected from an increase of TSH levels in the plasmas feed back negative mechanism.
Co-Authors . SETIAWAN Abdul Hadi Hassan Adjat Setiadjati Rasjad Ahmad Kurniawan Ahmad Kurniawan Aldo, Mochammad Ali Satia Graha Ambrosius Purba Ambrosius Purba Ambrosius Purba Andi Wijaya Arto Yuwono Soeroto Astrid Feinisa Khairani Astrid, Stephanie Averina Octaxena Aslani Aziis Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Bahjah, Firda Hanan Baniasih, Akbar I. Baniasih, Akbar I. Bela Ita Karina Bertha Pangaribuan Daba, Mariel Daniel Womsiwor Darmayanti, Meita Decky Gunawan, Decky Diana Krisanti Jasaputra Dimpuulina Erna Mariati Edward J Hadi Elvine Gunawan Euis Julaeha Fachrul Ihsan, Muhammad Fani Rahma Yenita Felix Samuel Ferdyan Efza Fifi Veronica Fitri Fadhilah Genta Syaifrin Laudza Gilang Muhamad Nur Iqbal Gita Widya Pradini Goenadi, Julia Windi Gunadi, Julia Windi Herry Herman Hidayat, Shaffana Huda, Fathul Huda, Fathul Imam Megantara Irma Ruslina Defi Isa Mahendra Iwan Setiawan Iwan Setiawan Iwan Setiawan Jatnika, Danti Dja Julia Windi Gunadi Julia Windi Gunadi Juliati Juliati Kartika Hajar Kirana, Kartika Hajar Kastella, Faysal Lisda Amalia Mariel Daba Mas Rizky A.A. Syamsunarno Melisa I. Barliana Muhtado, Azmi Raffi Mulyanaga, William Giovanni Nova Sylviana Nuroh Najmi Nurunnisa Sholeha Letto Oktorina, Lenny Prasetyo, Wibowo Budi Prayudi Santoso Qiantori, Adziqa Ammara Radhiyanti, Putri Teesa Rahdiyanti, Putri Teesa Ramadhanti, Julia Ray, Hamidie Ronald Daniel Reni Farenia Reni Farenia Ronny Lesmana Roro Wahyudianingsih Rosdianto, Aziis Mardanarian Rosdianto, Aziiz Mardanarian Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Siti Baitul Mukarromah Sofiyanti, Santi Sri A. Sumiwi sugianli, Adhi Sunarjati Sudigdoadi Supriatno Salam Susanti Husen Susianti Susianti Tarawan, Vita M. Taufik Hidayat Teddy Hidayat Teresa Lucretia, Teresa Tiodora Arimenda Br. Subekti Titing Nurhayati Trianing Tyas Kusuma Unang Supratman Upik Rahmi, Upik Vita Murniati Tarawan Vita Murniati Tarawan Lubis Wahyu Widowati Wuri, Rahmitiana Yudi Feriandi Yulia Sofiatin Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti