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Journal : Paediatrica Indonesiana

Soil-transmitted helminth infection, intestinal permeability, and intestinal inflammation in preschool-age children Aulia, Gina; Djuardi, Yenny; Supali, Taniawati
Paediatrica Indonesiana Vol. 65 No. 3 (2025): May 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.3.2025.232-8

Abstract

Background Soil-transmitted helminth (STH) infection is a major health problem in low-and middle-income countries (LMIC). The presence and activity of STH can cause changes in the intestinal mucosa, including cell damage that can affect intestinal permeability and stimulate immune responses such as inflammation. Objective To assess the inflammatory and permeability status of the intestinal mucosa in various STH infections in preschool-age children residing in Nangapanda District, Ende Regency, East Nusa Tenggara. Methods In this cross-sectional study, stool samples were obtained from children aged 12-59 months and examined for worm eggs using the Kato Katz method. Concentrations of biomarkers for intestinal permeability and inflammation were measured by enzyme-linked immunosorbent assay (ELISA). We measured fecal alpha-1-antitrypsin (AAT) as an intestinal permeability biomarker and fecal calprotectin (FC) as an intestinal inflammation biomarker and evaluated the association between these biomarkers with STH infection. Results The prevalence of STH infection in 111 evaluated preschool-age children was 17.1%. Ascaris lumbricoides was the predominant species, followed by Trichuris trichiura. Most subjects (64.7%) had AAT levels >0.27 mg/g, while only 35.1% had FC >50 mg/kg. STH infection status was not significantly associated with AAT concentration status, even when analyzed by STH species. A significant association was found only between T. trichiura infection and FC concentration. In this study, which included infected and uninfected groups, children infected with T. trichiura had higher concentrations of FC than those uninfected. Conclusion STH infection was not significantly correlated with fecal biomarkers except between T. trichiura infection status and increased gut inflammatory biomarker. AAT levels were generally elevated in the evaluated preschool-aged population regardless of STH infection, indicating that other factors may have contributed to increased gut permeability.
Co-Authors Aafanisa, Farena Agung Dewantoro Ahmad Sopian, Ahmad Al-Hafiz, Mohammad Alexandre, Nahla Dany Alita, Dini Arum Andriyani Rahmah Fahriati Arief, Ilham Asep Hidayat Asmara, Ratna Dewi Lintang Ayu Werawati Azzahra, Aristi Beny Maulana Satria Bheta Sari Dewi Dede Komarudin Desy Darmayanti DEWI FITRIANI Esadini, Aya Rana Fauzan, Suhaimi Fenita Purnama Sari Indah Fitriani, Reka Fu’adah, Intan Tsamrotul Gama Bagus Kuntoadi Gita Ayuningtyas Hairunnisa Hairunnisa Herdaningsih, Sulastri Herdaningsih, Sulatri Holidah Holidah, Holidah Humaira Fadhilah Inderiyani, Inderiyani Kristiyowati, Anis Dwi Kurniawati, Dewi Indah Listiana, Ida Luciana Luciana Lukman Handoyo Manuruyah, Phuja Arinda Mutiasih , Pipit Mutohharoh, Hopipah Nasar, Nur Afni Syariah Nasar, Nur Syariah Afni Neneng Sri Purwaningsih Ni Bodro Ardi Novena Simanjutak, Shania Nur Hasanah Nurhaetami, Cut Intan Nurihardiyanti Nurihardiyanti, Nurihardiyanti Nurwulan Adi Ismaya Pamungkas, Abi Rafdi Putra PUJI LESTARI Puji Rahayu Putra, Rifqi Sonia Putrajaya, Fadly Putri, Annisa Septyana Rahmawati, Rahmawati Ramdan, Raka Fahri Ratna Sitorus Rini, Wahyu Sulistyo RIRIS ANDRIATI Rita Dwi Pratiwi Robertus, Sumardi ROYANI ROYANI Ruslihagi, Farid Rustini, Ira Safitri, Putri Purnama Saputri, Laras Tri Sasmito, Priyo Sayyidah, Sayyidah Septiyana, Annisa Setiawan, Usep Sheli, Sheli Shinta Dewi, Yasmin Siti Novy Romlah Siva Fauziah, Siva SORAYA RATNAWULAN MITA, SORAYA RATNAWULAN Sucipto Sucipto Sulistyo Rini, Wahyu Sumarwati Susanti, Debi Tania Rizki Amalia Taniawati Supali TITA HARDIANTI Uswatun Hasanah Veri, Veri Vina Fauziah Yenny Djuardi Yulis Adriana Zahra, Annisa Fairuz Zihan, Nindya Rahmi