Risnandya Primanagara
Fakultas Kedokteran Universitas Swadaya Gunung Jati

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Hubungan Pencahayaan, Jarak dan Lamanya Paparan Cahaya Komputer Terhadap Visus Konsumen di Penyedia Jasa Warung Internet (Warnet) di Wilayah Kabupaten Kuningan Asep Anang Surya; Risnandya Primanagara; Thysa Thysmelia Affandi
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 4, No 1 (2018): Tunas Medika Jurnal Kedokteran & kesehatan
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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ABSTRAKLatar Belakang: Istilah “penglihatan kurang” mencakup suatu kisaran yang luas. Seseorang dengan tahap dini penyakit mata mungkin memiliki penglihatan mendekati normal, selebihnya mungkin mengalami penurunan penglihatan yang sedang hingga berat. Kehidupan manusia saat ini nampaknya sudah tidak dapat lagi dilepaskan dari teknologi, khususnya Komputer. Bahkan, banyak peralatan berbasis komputer saat ini yang umum digunakan dan dimiliki oleh masyarakat, misalnya personal data assistant (PDA), Global Position System (GPS), mobile computer (desktop, laptop), mobile phone (HP), translator, dan sebagainya.Tujuan: Untuk mengetahui apakah terdapat hubungan antara pencahayaan, jarak dan lamanya paparan cahaya terhadap visus.Metode Penelitian: Jenis penelitian yang digunakan adalah observasional analitik dengan menggunakan pendekatan cross-sectional. Metode yang digunakan untuk pengambilan sampel adalah purposive sampling. Analisis data menggunakan uji statistik Gamma.Hasil: Dari hasil penelitian didapatkan bahwa terdapat hubungan antara lamanya paparan dengan visus (P Value = 0,018). Sedangkan untuk pencahaan tidak terdapat hubungan dengan visus (P Value = 0,614) dan jarak juga tidak menunjukkan adanya hubungan dengan visus secara signifikan. (P Value = 0,181). Simpulan: Terdapat hubungan yang signifikan antara lamanya paparan dengan visus. (P Value < 0,05)Kata Kunci: Pencahayaan, Jarak, Lamanya paparan, VisusABSTRACTBackground: The term "poor vision" covers a wide range. A person with an early stage of eye disease may have near normal vision, the rest may experience moderate to severe visual impairment. With human life today seems to have been unable to be released from technology, especially computers. In fact, many computer-based equipment today is commonly used and owned by the public, such as personal data assistant (PDA), Global Position System (GPS), mobile computer (desktop, laptop), mobile phone, translator.Aim: This study aim to determine the correlation between lighting, distance, and duration of computer light exposure with consumer visus.Method: The study was an analytic observational with cross sectional design. The method for sample determination was using purposive sampling. Data analysis was using Gamma.Result: The research result showed there is a correlation between duration of computer light exposure with consumer visus (P Value = 0,018), while lighting (P Value = 0,614) and distance (P Value = 0,181) has no correlation.Conclusion: There is a correlation between duration of computer light exposure with consumer visus (P Value< 0,05), while lighting and distance has no correlation.Keywords: Lighting, Distance, Exposure duration, Visus
Hubungan antara Prevalensi Glaukoma dan Riwayat Diabetes Melitus di RSUD Waled Kabupaten Cirebon Risnandya Primanagara; Permata Ayuning Tyas
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 3, No 4 (2016): Tunas Medika Jurnal Kedokteran & Kesehatan
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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ABSTRAKGlaukoma adalah penyakit pada mata yang ditandai adanya peningkatan tekanan intraokular, atrofi papil saraf optik, dan berkurangnya luas lapang pandang. Glaukoma dikaitkan dengan berbagai gangguan vaskular dan endokrin seperti Diabetes Melitus. Hal ini dihubungkan dengan suplai darah terhadap saraf optik yang mengakibatkan lebih rentan terhadap kerusakan glaukomatus. Penelitian ini bertujuan untuk mengetahui hubungan antara prevalensi Glaukoma dan riwayat   Diabetes Melitus di Poliklinik Mata Rumah Sakit Umum Daerah Waled, Kabupaten Cirebon. Metode penelitian yang digunakan adalah observasional analitik dengan desain case-control yang menggunakan pendekatan retrospektif. Sampel pada penelitian ini dibagi menjadi dua kelompok yaitu kelompok kasus (pasien glaukoma) dan kelompok kontrol (pasien non-glaukoma) Sampel diperoleh dengan teknik purposive sampling dengan besar sampel sebanyak 60 pasien glaukoma dan 120 pasien non-glaukoma. Sebanyak 24 orang (40,00%) mempunyai riwayat Diabetes Melitus dan sebanyak 36 orang (60,00%) tidak mempunyai riwayat Diabetes Melitus dari 60 orang yang termasuk glaukoma positif (+). Hasil Uji Chi-Square antara prevalensi Glaukoma dan riwayat  Diabetes Melitus menunjukkan hasil p value = 0.000 (p≤0,05) dan hasil uji Chi-Square antara masing-masing jenis Glaukoma dan riwayat Diabetes Melitus hanya Glaukoma Primer Sudut   Terbuka saja yang menunjukkan ada hubungan dengan nilai p value = 0,004 (p < 0,05). Hasil penelitian ini dapat disimpulkan bahwa terdapat hubungan yang bermakna antara prevalensi  Glaukoma dan riwayat Diabetes Melitus.Kata Kunci :  Diabetes Melitus, Glaukoma, Mata, Tekanan Intraokular, RSUD Waled. ABSTRACTGlaucoma is a disease of the eye which is marked by the increase of intraokular pressure, atrophy of optical papilla nerve and the decrease of total eye vision. Glaucoma is interconnected with various vaskular and endocrine disturbances such as Diabetes Melitus. Thus this thing is linked with blood supply towards optical nerve which is causing it to become more prone to glaucomatous damage. To know of the coherency between the prevalence of Glaucoma with the history of diabetes Melitus in ophthalmology department of Waled Regional Public Hospital, Cirebon. Analytical observational  with case control design which is using retrospective sample approach. Sample in this research is divided into two groups; the first one is glaucoma patient group, the second one is control group (non-glaucoma patient). Sample received using purposive sampling with the size of sample is determined with the total number  60 Glaukoma and 120 Non-Glaukoma. A total of 24 patients ( 40.00 % ) had a history of Diabetes Mellitus and 36 patients ( 60.00 % ) had no history of Diabetes Mellitus of 60 people including Glaucoma positive ( + ) . Chi - Square Test Results between the Glaucoma Prevalence and Diabetes Mellitus shows p value = 0.000 ( p≤0,05 ) and Chi - Square test results between each type of glaucoma and Diabetes Mellitus only primary open angle glaucoma showed that there contact with the p value = 0.004 ( p < 0.05 ). There was a significant correlation between Glaucoma prevalence and Diabetes Mellitus .Keywords : Diabetes mellitus , Glaucoma , Eye , Intraocular Pressure , Waled Regional Public Hospital .
ANTIDIABETIC EFFECT OF COMBINED Muntingia calabura L. LEAF EXTRACT AND METFORMIN ON RATS Adhy Nugroho; Risnandya Primanagara; Pahmi Budiman Sahputra Basyir
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Diabetes mellitus is a disease that causes blood glucose levels to increase. There are several therapies that can be done to reduce blood glucose levels in diabetes such as metformin, biguanides medicine and kersen (Muntingia calabura L.) leaves as an alternative. Treatment with combination of both is expected to further reduce blood glucose levels. This study aims to measure the effectiveness of the combination of metformin and Muntingia calabura L. leaf extract on blood glucose levels. Methods: This was an experimental research with pretest-posttest control group. The samples were 24 Sprague-Dawley rats divided into 4 groups, first group (K1) negative control was given only aquadest, second group (K2) positive control (+) was given 45 mg/kgBW metformin, third group (K3) was treated with 300 mg/kgBW Muntingia calabura leaf extract, and the fourth group (K4) was given the combination of 300 mg/kgBW Muntingia calabura leaf extract and  45 mg/kgBW metformin. Blood glucose levels were measured and analyzed using paired t-test and one-way ANOVA. Results: The combination of 300 mg/kgBW of Muntingia calabura extract and 45 mg/kgBB of metformin reduces 131.77 ± 3.57 mg/dl of blood glucose levels (p<0.05). This result is better than only metformin (92.68 ± 3.10 mg/dl) or only Muntingia calabura leaf extract (91.70 ± 4.40 mg/dl). There is a possibility that the synergistic effect of Muntingia calabura leaf extract and metformin caused the increased effectivity in reducing blood sugar level.Conclusion: The combination of Muntingia calabura and metformin is more effective in reducing blood glucose levels compared to a single dose of metformin or Muntingia calabura L. extract alone.
CALCULATING COLONY OF Candida spp. AMONG CHILDREN WITH INTELLECTUAL DISABILITY IN CIREBON Dhini Oktaviani; Amanah Amanah; Eni Suhaeni; Risnandya Primanagara
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Children and adults with Intellectual Disability and Autism Spectrum Disorders (ASD) have decreased intestinal permeability and enzyme activity, causing gastrointestinal (GI) problems that are more frequent and more severe than in children from the general population. The immune system which is part of the intestinal barrier in children with Intellectual Disability (ID) experiences various disorders and becomes more susceptible to fungal invasion, such as Candida spp. This present study aims to calculate the colony of Candida spp. in the digestive tract of Children with Intellectual Disability (ID) in the city of Cirebon.Method: This is an observational study with cross-sectional design using purposive sampling. The study was conducted in November 2018-February 2019. The sample (ID) group consists of 31 individuals from Special Needs School and 60 individuals from National elementary school (non-ID) in the city of Cirebon. The inclusion criteria were children ages 6-12 years and the exclusion criteria were children under antifungal treatment and children under cytotoxic or immunosuppressive drugs.  The fecal samples from the ID group and non-ID were examined at the Laboratory of the Faculty of Medicine, Universitas Swadaya Gunung Jati Cirebon, Indonesia using Digital Colony counter. Collected data were stored and analyzed using computer aided Statistical program. Mann-Whitney analysis of variance techniques were used to test the hypotheses. Results: The results showed that there are significant differences in the colonies of Candida spp. between the ID group and non-ID group. Median colony of Candida spp. in the ID group is 39.00 with mean colony of 126.90 while the median colony of non-ID group is 3.00 with mean colony of 40.93 (p<0.001).Conclusion: There are significant differences between the Candida spp. colonies in the ID group with the non-ID.
ANTIDIABETIC EFFECT OF COMBINED CINNAMOMUM CASSIA EXTRACT AND METFORMIN IN RATS Jibril Ali Syariati Assajad; Muhammad Edial Sanif; Risnandya Primanagara
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Diabetes mellitus is a group of metabolic diseases characterized with hyperglycemia. This metabolic dysregulation can lead to complications in many organs and even lead to death. Diabetes mellitus can be treated by giving metformin or Cinnamomum cassia. Treatment with a combination of both is expected to better reduce blood glucose levels. This study measured the effectiveness of the combination of metformin and Cinnamomum cassia extract to blood glucose.Methods: This study used Pre-Post-Test control group design using 24 random male white rats divided into 4 groups using Simple random sampling. All groups were induced by alloxan of 150 mg/kg BW, Group 1 was given aquades, group 2 was given metformin of 45 mg/kg BW, group 3 was given Cinnamomum cassia extract 200 of mg/kg BW, and group 4 was given a combination of metformin of 45 mg/kg BW extract Cinnamomum cassia of 200 mg/kg BW. Afterwards, the collected data was analyzed using paired T test and one way ANOVA along with the corresponding post-hoc.Results: The results of this study indicate the effect of administering a combination of cinnamon extract of 200 mg/kg BW and metformin of 45 mg/kg BW to blood glucose levels (p <0.05) with a glucose decrease value of 122.80 ± 2.77 mg/dl better than a single dose of metformin with a glucose reduction value of 92.68 ± 3.10 mg/dl and Cinnamomum cassia extract with a glucose decrease value of 107.16 ± 4.80 mg/dl. This is because there is a different mechanism between cinnamon extract and metformin.Conclusion: In this study, three treatments showed a different decrease in blood sugar levels. Administration of a combination of Cinnamomum cassia extract of 200 mg/kg BW and metformin of 45 mg/kg BW caused the highest decrease. These results provide an opportunity for better treatment of diabetes.
EFFECTIVENESS OF ORALLY USE CATFISH (Clarias gariepinus) SKIN AND MEAT ON WOUND LENGTH AND FIBROBLAST DENSITY IN INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Sri Utami Fauziah; Risnandya Primanagara; Tiar M Pratamawati; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Treatment for wounds that are currently often given is use povidone-iodine. But, this antiseptics also kills fibroblast tissue which is useful for forming new tissue. One of the other ways to treatment for wounds is use catfish. The contents found in catfish (Clarias gariepinus) is albumin which is a globular protein that is useful in the formation of body tissues, such as postoperative wounds and burns. This study aims to determine the effect of skin and meat of catfish (Clarias gariepinus) on wound length and fibroblast density in incision wounds of Wistar rat (Rattus norvegicus).Methodology: This study is an experimental study with Post Test Only Control Group Design using Wistar rats which are divided into five groups. The control group (aquadest) and treatment groups 1, 2, 3 and 4 are given the skin and meat of catfish (Clarias gariepinus) orally at a dose of 12.5 mg / 200 g BW, 25 mg / 200 g BW, 37.5 mg / 200 g BW, and 50 mg / 200 g BW. After 10 days, the rats are killed to take the wound tissue for histological preparations to observe fibroblast density. Then, it is analyzed by ANOVA test or the alternative.Results: There is an effect of giving catfish skin and meat (Clarias gariepinus) orally at different dose. The administration of catfish skin and meat (Clarias gariepinus) at a dose of 37.5 mg / 200 g BW and 50 mg / 200 g BW is better than other doses assessed from wound length and fibroblast density in Wistar rat incision wounds (Rattus norvegicus).Conclusion: The use of catfish for wound healing can be applied. This method can reduce wound length and increase fibroblast density at certain doses.
ANTIDIABETIC EFFECT OF COMBINED Muntingia calabura L. LEAF EXTRACT AND METFORMIN ON RATS Adhy Nugroho; Risnandya Primanagara; Pahmi Budiman Sahputra Basyir
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Diabetes mellitus is a disease that causes blood glucose levels to increase. There are several therapies that can be done to reduce blood glucose levels in diabetes such as metformin, biguanides medicine and kersen (Muntingia calabura L.) leaves as an alternative. Treatment with combination of both is expected to further reduce blood glucose levels. This study aims to measure the effectiveness of the combination of metformin and Muntingia calabura L. leaf extract on blood glucose levels. Methods: This was an experimental research with pretest-posttest control group. The samples were 24 Sprague-Dawley rats divided into 4 groups, first group (K1) negative control was given only aquadest, second group (K2) positive control (+) was given 45 mg/kgBW metformin, third group (K3) was treated with 300 mg/kgBW Muntingia calabura leaf extract, and the fourth group (K4) was given the combination of 300 mg/kgBW Muntingia calabura leaf extract and 45 mg/kgBW metformin. Blood glucose levels were measured and analyzed using paired t-test and one-way ANOVA. Results: The combination of 300 mg/kgBW of Muntingia calabura extract and 45 mg/kgBB of metformin reduces 131.77 ± 3.57 mg/dl of blood glucose levels (p<0.05). This result is better than only metformin (92.68 ± 3.10 mg/dl) or only Muntingia calabura leaf extract (91.70 ± 4.40 mg/dl). There is a possibility that the synergistic effect of Muntingia calabura leaf extract and metformin caused the increased effectivity in reducing blood sugar level. Conclusion: The combination of Muntingia calabura and metformin is more effective in reducing blood glucose levels compared to a single dose of metformin or Muntingia calabura L. extract alone. Keywords: Diabetes mellitus, M. calabura leaf extract, blood sugar levels.
CALCULATING COLONY OF Candida spp. AMONG CHILDREN WITH INTELLECTUAL DISABILITY IN CIREBON Dhini Oktaviani; Amanah Amanah; Eni Suhaeni; Risnandya Primanagara
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Children and adults with Intellectual Disability and Autism Spectrum Disorders (ASD) have decreased intestinal permeability and enzyme activity, causing gastrointestinal (GI) problems that are more frequent and more severe than in children from the general population. The immune system which is part of the intestinal barrier in children with Intellectual Disability (ID) experiences various disorders and becomes more susceptible to fungal invasion, such as Candida spp. This present studyaims to calculate the colony of Candida spp. in the digestive tract of Children with Intellectual Disability (ID) in the city of Cirebon. Method: This is an observational study with cross-sectional design using purposive sampling. The study was conducted in November 2018-February 2019. The sample (ID) group consists of 31 individuals from Special Needs School and 60 individuals from National elementary school (non-ID) in the city of Cirebon. The inclusion criteria were children ages 6-12 years and the exclusion criteria were children under antifungal treatment and children under cytotoxic or immunosuppressive drugs. The fecalsamples from the ID group and non-ID were examined at the Laboratory of the Faculty of Medicine, Universitas Swadaya Gunung Jati Cirebon, Indonesia using Digital Colony counter. Collected data were stored and analyzed using computer aided Statistical program. Mann-Whitney analysis of variance techniques were used to test the hypotheses. Results: The results showed that there are significant differences in the colonies of Candida spp. between the ID group and non-ID group. Median colony of Candida spp. in the ID group is 39.00 with mean colony of 126.90 while the median colony of non-ID group is 3.00 with mean colony of 40.93(p<0.001). Conclusion: There are significant differences between the Candida spp. colonies in the ID group with the non-ID. Keywords: Intellectual Disability (ID), Candida spp., Gastrointestinal
EFFECTIVENESS OF ORALLY USE CATFISH (Clarias gariepinus) SKIN AND MEAT ON WOUND LENGTH AND FIBROBLAST DENSITY IN INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Sri Utami Fauziah; Risnandya Primanagara; Tiar M. Pratamawati; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Treatment for wounds that are currently often given is use povidone-iodine. But, this antiseptics also kills fibroblast tissue which is useful for forming new tissue. One of the other ways to treatment for wounds is use catfish. The contents found in catfish (Clarias gariepinus) is albumin which is a globular protein that is useful in the formation of body tissues, such as postoperative wounds and burns. This study aims to determine the effect of skin and meat of catfish (Clarias gariepinus) on wound length and fibroblast density in incision wounds of Wistar rat (Rattus norvegicus). Methodology: This study is an experimental study with Post Test Only Control Group Design using Wistar rats which are divided into five groups. The control group (aquadest) and treatment groups 1, 2, 3 and 4 are given the skin and meat of catfish (Clarias gariepinus) orally at a dose of 12.5 mg / 200 g BW, 25 mg / 200 g BW, 37.5 mg / 200 g BW, and 50 mg / 200 g BW. After 10 days, the rats are killed to take the wound tissue for histological preparations to observe fibroblast density. Then, it is analyzed by ANOVA test or the alternative. Results: There is an effect of giving catfish skin and meat (Clarias gariepinus) orally at different dose. The administration of catfish skin and meat (Clarias gariepinus) at a dose of 37.5 mg / 200 g BW and 50 mg / 200 g BW is better than other doses assessed from wound length and fibroblast density in Wistar rat incision wounds (Rattus norvegicus). Conclusion: The use of catfish for wound healing can be applied. This method can reduce wound length and increase fibroblast density at certain doses. Keywords: Fibroblasts, incision wounds, catfish, Clarias gariepinus, wound healing
MALNUTRISI DAN ANEMIA PADA KEHAMILAN Dini Norviatin; Putri Mela Jelita Lestari; Risnandya Primanagara
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 8, No 1 (2022): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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Latar Belakang: Kurang Energi Kronis (KEK) merupakan keadaan dimana ibu mengalami kekurangan makanan selama menahun atau kronis yang dapat mengakibatkan terjadinya gangguan kesehatan pada ibu sehingga kebutuhan ibu hamil akan zat gizi semakin tinggi untuk tidak terpenuhi. Terjadinya KEK diakibatkan oleh kurangnya asupan energi makronutrien seperti karbohidrat, protein, dan lemak maupun mikronutrien terutama vitamin A, vitamin D, asam folat, zat besi, seng, kalsium dan iodium. Kurangnya zat besi dan asam folat dapat menyebabkan kadar hemoglobin (Hb) dalam darah berkurang, sehingga terjadi anemia. Tujuan: Untuk mengetahui hubungan antara kadar Hb dengan kejadian KEK pada ibu hamil di Puskesmas Beber. Metode: Penelitian ini merupakan penelitian observasional analitik dengan rancangan cross sectional dilakukan pada bulan Maret-April 2021. Penelitian ini menggunakan data sekunder yang didapat dari buku kohort ibu bulan Januari-Desember 2019 di Puskesmas Beber Kabupaten Cirebon. Besar sampel 289 responden dan pengambilan sampel menggunakan teknik simple random sampling. Analisis data menggunakan analisis univariat dan bivariat dengan uji korelasi spearman. Hasil: Analisis kadar Hb dengan kejadian KEK pada ibu hamil didapatkan p-value <0,001 (p<0,05). Simpulan: Terdapat hubungan bermakna antara kadar Hb dengan kejadian KEK pada ibu hamil di wilayah kerja Puskesmas Beber Kabupaten Cirebon.Kata Kunci: Kadar Hemoglobin (Hb), Kurang Energi Kronis (KEK) Background: Chronic Energy Deficiency (CED) is a condition where the mother experiences chronic or chronic food shortages which can lead to health problems in the mother so that the needs of pregnant women for nutrients are higher and not fulfilled. The cause of CED is a lack of energy intake from macronutrients such as carbohydrates, protein, and fat or micronutrients, especially vitamin A, vitamin D, folic acid, iron, zinc, calcium and iodine and others. Lack of iron and folic acid can cause hemoglobin (Hb) levels in the blood to change, especially anemia. Aim: This study aims to determine the relationship between Hb levels and the incidence of CED in pregnant women at Beber Public Health Centre. Methods: This study was an analytical observational study with a cross sectional design and was carried out from March to April 2021. This study used secondary data obtained from the maternal cohort book from January to December 2019 at the Beber Public Health Centre, Cirebon Regency. The sample size in this study was 289 and the sample was taken using a simple random sampling technique. Data analysis used univariate and bivariate analysis with correlation spearman. Results: The results of the analysis of Hb levels with the incidence of CED in pregnant women obtained a p-value <0.001 (p<0.05). Conclusion: Based on the research, there was a significant relationship between Hb levels and the incidence of KEK in pregnant women in the work area of Beber Public Health Centre, Cirebon Regency.Keywords: Hemoglobin Level, Chronic Energy Deficiency (CED).