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Siti Rahma
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Other

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REVIEW ARTICLE: VALIDATION OF GAS CHROMATOGRAPHY-MASS SPECTROMETRY (GC-MS) METHODS IN THE ANALYSIS OF VOLATILE COMPOUNDS IN NATURAL MATERIALS Ki Agus Rifki Fauzan; Maria Febriani Wea Bii; Atikah Salsabila; Siti Rahma; Destiana Wulandari; Ari Yanto
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 10, No 2 (2025)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v10i2.9195

Abstract

Natural ingredients from plants are a major source of volatile compounds with biological activities such as antimicrobial, antioxidant, anti-inflammatory, and antifungal, particularly in essential oils. Testing of these compounds relies on reliable techniques such as gas chromatography-mass spectrometry (GC-MS), which separates and identifies components through retention time and mass spectra, with validation ensuring linearity, precision, accuracy, limit of detection (LOD), and limit of quantification (LOQ). This review article assesses the use and validation of GC-MS methods for the analysis of volatile compounds from natural ingredients, based on national and international literature over the past five years. The review approach included a structured search of databases such as PubMed, ScienceDirect, Google Scholar, and SINTA journals, with a focus on validation parameters and GC-MS instrument settings. The findings show that GC-MS stably detects key compounds such as monoterpenes and sesquiterpenes with 97-99% accuracy, and validates them according to AOAC standards (R² > 0.99; RSD < 8%; recovery 80-100%), where different extraction techniques affect their biological content and effectiveness. GC-MS validation is important to encourage innovation of environmentally friendly natural products in the pharmaceutical, food, and cosmetic sectors as a substitute for synthetic preservatives.
Co-Authors ABDUL MUIS Adinda Harahap Ahmad Yudi Ahmad Zaki Alfin Renaldi Almadison Amantawidya Durratul Hikmah Annida Evilia Miranda Apriwelni, Siska Arfit Shafi Anis Ari Yanto Arief Hidayat Afendi Atikah Salsabila Dani Kurniawansyah Desi Meliani Destiana Wulandari Dewi Kusumawati Fahrur Rizal Fiansi Dwi Arista Goldie Melinda Wijayanti Gus Salza Nazwa Hafsyah Aulia Hariani Hertiana Husna Sari Ilham Ramadhan Daulay Indar Kartinanda P. Khairani Sakdiah Ki Agus Rifki Fauzan Lilik Anirowati Lukman Lukman Maria Febriani Wea Bii Mochammad Imron Awalludin Mohamad Reynaldi Muchsin Muh Taufik Muhammad Fadly Chaniago Muhammad hazil Ali Kahar Novridah Reanti Purba Nugraha Bintang Wirawan NUR KOMARIAH Parlaungan Gabriel Siahaan Prahardian Putri Putri Habibah Siregar Rahmi La Indah Ravael Marelano Harefa Rela Idola Pakpahan Relita Sanlia Sitompul Reni Septiyanti Rifqi, A. Ikram Riski Anla Pater Romadhon Salsabila Junaidi Siti Nursya'adah Siti Suaibah Nasution Siti Zahra Fatimah Sitti Fatimah M. Arsad Slamet Hidayat Sony Sulaksono Wibowo, Sony Sulaksono Syamzaimar Syamzaimar Tasya Azzahra Theresia Ok’twoka Ekgiyoga Tubuon, Yulinda Novita Wahdini, Wahdini Wiana Delviani Widyarini Weningtyas, Widyarini Zenia F Saraswati