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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Syntax Literate: Jurnal Ilmiah Indonesia YARSI Medical Journal JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal Cermin Dunia Kedokteran Journal of Social Research Journal of General-Procedural Dermatology & Venereology Indonesia Cermin Dunia Kedokteran
Kariosentono, Harijono
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Humanities Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Cermin Dunia Kedokteran

 1 
Eritema Nodosum Leprosum Berat pada Pasien Kusta Lepromatosa: Laporan Kasus Pramudita, Adelia Wuri; Kariosentono, Harijono; Evanti, Annisa Marsha; Asaduddin, Aiman Hilmi
Cermin Dunia Kedokteran Vol 51 No 12 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i12.1116

Abstract

A case of a 58-year-old woman with lepromatous leprosy and severe ENL reaction is reported. The patient has symptoms of pustules for 1 year and the nodules were getting worse in the last week, accompanied by fever, joint pain, nausea, and vomiting. Physical examination revealed madarosis, infiltrates of both ears, and multiple painful erythematous nodules on the extremities and trunk. Slit skin smear examination showed bacterial index +3 and morphological index of 15%. Histopathological examination revealed neutrophil infiltration and vasculitis in the upper dermis. The patient was diagnosed with lepromatous leprosy and severe ENL reaction. The patient received multidrug therapy and methylprednisolone (62.5 mg/day), which was gradually reduced. The ENL reaction is caused by the deposition of M. leprae antigens and antibodies in small blood vessels, resulting in vasculitis and the release of enzymes that damage tissues. ENL reactions are commonly found in multibacillary MH and occur before, during, and after treatment. This reaction is mediated by cytokines produced by T-helper-2 (Th2). ENL reactions can cause disability.
Mekanisme Pertahanan Mukokutan terhadap Infeksi Candida: Analisis Pramudita, Adelia Wuri; Kariosentono, Harijono; Evanti, Annisa Marsha; Widyastuti, Zilpa
Cermin Dunia Kedokteran Vol 52 No 3 (2025): Oftalmologi dan Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i3.1157

Abstract

Candida albicans is a commensal organism that can may become invasive and fatal under certain circumstances. Several genetic variations in the human genome towards susceptibility to Candida infections have been identified. There are a number of genes associated with Candida virulence factors, host environment, and immune response. C-type lectin receptors (CLRs) are characterized by leucine-rich and nucleotidebinding domains that can detect intracellular signals through various types of cytoplasmic domains. CLRs are family of PRRs that bind glycan through recognition of extracellular carbohydrate and mediate intracellular signaling through various type of cellular domains, resulting in a decrease of neutrophils and facilitating the occurrence of fungal infections. This study review the genetic determinant of defense mechanisms and immune deficiencies against Candida infection.
Co-Authors Adjie, Sugih Primas Ahmad Fiqri, Ahmad Alia, Vrenda Anggraeni, Reti Annisa Marsha Evanti Asaduddin, Aiman Hilmi Aulia Rahman Aulia Yasmin, Aulia Budiani, Dyah R Cahyono, Aris Dewi, Susanti Rosmala Dhamayanti, Marsita Endy Diana, Rina Dita Eka Novriana Ellistasari, Endra Yustin Ilona, Sri Esa Imelda Betaubun, Ance Indah Julianto, Indah Irawanto, Muh. Eko Irawanto, Muhammad Eko Kusumawardani, Arie Monica, Pristia Widya Mustifah, Etty Farida Nila Kusumasari Noviani, Laura Nurrachmat Mulianto Nurul Hidayati Pramudita, Adelia Wuri Pricilla, Erlina Rafika Paramitasari, Anggana Rahma, Alfina Rieka Sulaikha, Khalida Rinandari, Ummi Rini Hastuti Risman, Muhammad Rosmarwati, Ervina Tri Irfanti, Rakhma Triasari Oktavriana TUTIK RAHAYU Veraida, Ainun Widhiati, Suci Widyastuti, Zilpa Wirawan, Eka Putra Yuda Heru Fibrianto Yuyun Rindiastuti