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All Journal Humaniora Lensa: Kajian Kebahasaan, Kesusastraan, dan Budaya MEDIA MEDIKA INDONESIANA Jurnal Anestesi Perioperatif Folia Medica Indonesiana Journal of Agromedicine and Medical Sciences Biomedika Briliant: Jurnal Riset dan Konseptual Journal of Medicine and Health Care : Jurnal Ilmiah Ilmu Kesehatan Oto Rhino Laryngologica Indonesiana Lembaran Sejarah Majalah Biomorfologi (Biomorphology Journal) Jurnal Riset Akuntansi dan Manajemen Malahayati (JRAMM) Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Indian Journal of Forensic Medicine & Toxicology Masyarakat Indonesia PROFESSIONAL HEALTH JOURNAL Journal Philosophy of Law Journal of Medicine and Health

Bambang Purwanto

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Author-ID : 1567294

Religion Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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PENGARUH EKSTRAK ETHANOL PROPOLIS TERHADAP EKSPRESI PROTEIN Bcl2, CYCLIN D1 DAN INDUKSI APOPTOSIS PADA KULTUR SEL KANKER KOLON Haryono Yuniarto; Sumardi Maryono; Bambang Purwanto
Biomedika Vol 9, No 1 (2017): Biomedika Februari 2017
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v9i1.4343

Kanker kolorektal menempati urutan kejadian kanker ketiga di seluruh dunia, dengan lebih dari 1 juta angka kejadian tiap tahunnya. Berbagai strategi terapi pengobatan kanker kolorektal tetapi relatif belum optimal. Oleh karena itu, terdapat kebutuhan mengembangkan terapi alternatif sebagai pendamping. Propolis menunjukkan aktivitas proapoptosis pada berbagai jenis sel kanker. Mengetahui pengaruh pemberian propolis yang berasal dari Kerjo, Karanganyar, Indonesia terhadap induksi proses apoptosis dan aktivitas antiproliferasi, terutama terkait dengan penekanan ekspresi protein Bcl 2 dan cyclin D1 pada kultur sel WiDr (cell line kanker kolon). Penelitian eksperimental laboratorik menggunakan post test with control group design. Penelitian dilakukan pada kultur sel WiDr (sel kanker kolon) dengan pemberian propolis. Pengamatan ekspresi protein Cyclin D1 dan Bcl2 dilakukan dengan metode imunositokimia, sedangkan pengamatan induksi apoptosis dilakukan dengan flowcytometry. Analisis statistik dengan uji Kruskal-Wallis, signifikan bila p 0,05. Rata-rata ekspresi Bcl2 pada kelima kelompok yaitu kontrol 83.40 ± 0.69 μg/ml, EEP 1/2 IC50 60.63 ± 0.40, EEP IC50 33.77 ± 1.08 μg/ml, EEP 2 IC50 24.28 ± 1.91 μg/ml, 5fluorouracil 12.74 ± 2.19 μg/ml. Terdapat perbedaan bermakna ekspresi Bcl2 antara kelompok uji dibandingkan kelompok kontrol (p 0,001). Rata-rata ekspresi cyclin D1 pada kelima kelompok yaitu kontrol 83.77 ± 0.39 μg/ml, EEP 1/2 IC50 61.44 ± 0.41, EEP IC50 36.67 ± 1.18 μg/ml, EEP 2 IC50 24.50 ± 0.38 μg/ml, 5fluorouracil 13.42 ± 1.04μg/ml. Terdapat perbedaan bermakna ekspresi cyclin D1 antara kelompok uji dibandingkan kelompok kontrol (p 0,001). Pemberian ekstrak etanol propolis mempunyai pengaruh menekan ekspresi Bcl2, cyclin D1, dan menginduksi apoptosis pada kultur sel kanker kolon (WiDr Cell Line). Kata Kunci: Ekstrak Ethanol Propolis, Bcl2, cyclin D1, Sel WiDr

PENGARUH PEMBERIAN 1,25 DIHYDROXYVITAMIN D (CALCITRIOL) TERHADAP KADAR FIBROBLAST GROWTH FACTOR-23 DAN ALBUMINURIA PADA PASIEN PENYAKIT GINJAL KRONIK STADIUM V YANG MENJALANI HEMODIALISIS Intan Herlina; Bambang Purwanto; Sugiarto Sugiarto
Biomedika Vol 9, No 1 (2017): Biomedika Februari 2017
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v9i1.4344

Penyebab utama morbiditas dan mortalitas pada pasien Penyakit Ginjal Kronik adalah insiden kardiovaskuler yang didasari oleh proses aterosklerosis yang menyebabkan meningkatnya morbiditas dan mortalitas. Ginjal merupakan tempat utama sintesa 1,25 Dihydroxyvitamin D (Calcitriol), sehingga dengan adanya kerusakan ginjal menyebabkan defisiensi 1,25 Dihydroxyvitamin D (Calcitriol). Pada pasien Penyakit Ginjal Kronik terjadi peningkatan Fibroblast Growth Factor-23 dan Albuminuria akibat dari aktifitas Renin Angiotensin Aldosteron Sistem. Aktifitas RAAS mempengaruhi 1,25 Dihydroxy vitamin D (Calcitriol), Fibroblast Growth Factor-23 melalui Angiotensin 2 dengan cara menghambat reseptor Angiotensin I (AT1) melalui Nicotinmide Adenine Dinucleotide Phosphate Oxidase (NADPH Oksidase) dan Stress Oxidativ. Beberapa penelitian menyimpulkan pemberian 1,25 Dihydroxyvitamin D (Calcitriol) mempunyai efek renoprotektif, anti inflamasi dan antiproteinuric dengan cara menghambat reseptor Angoitensin I (AT1) sehingga mengakibatkan menurunnya albuminuria. Tujuan Penelitian ini adalah untuk membuktikan pemberian 1,25 Dihydroxyvitamin D (Calcitriol) dapat menurunkan kadar Fibroblas Growth Factor-23 dan albuminuria pada pasien Penyakit Ginjal Kronik stadium V yang menjalani hemodialisis. Penelitian ini merupakan penelitian eksperimen dengan randomisasi, subyek penelitian 30 orang, dibagi dalam dua kelompok sampel, kelompok plasebo 15 orang dan kelompok perlakuan 15 orang. Dalam perjalanan, kelompok placebo drop out 4 pasien karena keluarga pasien tidak menyetujui untuk melanjutkan penelitian dan satu lagi mengalami perburukan, sehingga jumlah sampel menjadi 26 orang, terbagi menjadi kelompok placebo sebanyak 11 orang yang diberi placebo dan kelompok perlakuan 15 orang diberi calcitriol 1x0,5 μg peroral selama 4 minggu. Karakteristik penelitian yang berupa variabel kualitatif, uji homogenitas dilakukan menggunakan uji Chi Square. Uji beda dua Rerata menggunakan uji t pada p0.005. Pada kelompok plasebo (n=11) ; Kadar Fibroblast Growth Factor-23 sebelum dan sesudah perlakuan (876,24±795,93 RU/mL vs 1235,69±791,71 RU/mL; p=0,059) dan Albuminuria (72,30±195,06 μg/ mg vs 320,14±208,90 μg/mg; p=0,001). Pada kelompok perlakuan (n=15); Kadar Fibroblast Growth Factor-23 sebelum dan sesudah perlakuan (1210,96±845,97 RU/mL vs 612,33±487,32 RU/mL; p=0,002) dan Albuminuria (206,63±327,25 μg/mg vs 192,89±316,00 μg/mg; p=0,001). Terdapat perbedaan yang bermakna pada selisih ratarata kadar Fibroblast Growth Factor-23 (Delta-FGF-23) sebelum dan sesudah perlakuan pada kelompok placebo vs kelompok perlakuan (-359,45±560,23 RU/mL vs 598,63±608,27 RU/mL; p=0,001) dan selisih rata-rata Albuminuria (Delta-albuminuria) sebelum dan sesudah perlakuan pada kelompok placebo vs kelompok perlakuan (-247,84±189,48 μg/mg vs 13,73±23,15μg/mg;p=0,001. Pemberian suplementasi 1,25 Dihydroxyvitamin D (calcitriol) menurunkan kadar FGF-23 albuminuria secara bermakna pada pasien penyakit ginjal kronik stadium V yang menjalani hemodialisisKata Kunci: Penyakit Ginjal Kronis Stadium V, 1,25 Dihydroxyvitamin D (Calcitriol), Fibroblast Growth Factor-23, Albuminuria

SHOE INSOLE FOR ECCENTRIC ACTIVITIES ON DAILY APPLICATION PREVENTS MUSCULAR DAMAGE AND IMPROVES FASTING BLOOD GLUCOSE Ahmad Abdullah; Herdianty Kusuma; Elyana Asnar; Bambang Purwanto
Folia Medica Indonesiana Vol. 53 No. 4 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Airlangga

The eccentric contraction has been proven to improve Glut-1 expression in muscle and fasting glucose levels in mice. The same eccentric contraction occurs in human being when walking or running while wearing high heels. Innovation on the eccentric contraction with high heels can be done by using a specific shoe insole. The design of the rear insole is made thicker than the front. The purpose of this study was to determine the effects of insole use specified for eccentric activities on daily work shoes on the skeletal muscle damage after wearing the specified insole. Skeletal muscle damage was measured based on sTnI level. This was experimental study with pretest-posttest design. The subjects involved were non-diabetic woman workers in Faculty of Medicine of Universitas Airlangga, and were divided into two groups. Each group represented group members who wore 5-degree and 10-degree insoles respectively. The angle used for the shoe insoles were 5° and 10° respectively. These insoles were worn on weekdays for one week. Blood was taken one day after the subjects stop wearing the insoles. Data results showed that the levels of fasting blood glucose (FBG) of subjects who wore the 10-degree insole had a value of p<0.05. The use of insole lead to decreased levels of fasting blood glucose (FBG). This study found that the sTnI levels in the 5-degree and 10-degree insole groups had no significant effect on troponin I skeletal muscle levels before and after treatment.

The Effect of Eccentric Activity on Glucose Transporter Type 4 in Gastrocnemius Muscle of Streptozotocin-induced Diabetes Mellitus Mice Adelia Handoko; Bambang Purwanto; Arifa Mustika
Journal of Agromedicine and Medical Sciences Vol 3 No 3 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i3.6144

Diabetes mellitus (DM) is a metabolic disorder with increasing mortality rate. Decrease in GLUT-4 levels was found in diabetics resulting in an increase in postprandial blood glucose levels. Various innovative treatment have been developed, one of them is exercise. Exercise is growing fast today, especially eccentric contraction based exercise that potentially increase GLUT-4 muscle’s level. The aim of the present study was to investigate the effect of eccentric activity on glucose transporter type 4 in gastrocnemius muscle of streptozotocin-induced diabetes mellitus mice. Diabetic mice were grouped randomly into 2 groups. One group was given single bout of eccentric excercise by downhill running on 10o degree decline treadmill and the other group was given eccentric activity by downhill running on 0o degree. The GLUT-4 muscle’s level were measured after treadmill. Data obtained from each group were then analyzed using independent t-test, significant results were found (p<0.05). The conclusion of this study is single bout eccentric downhill running activity with 10o angel increases the levels of GLUT-4 muscles. Key words: Glucose Transporter Type 4, eccentric, Diabetes Mellitus, Muscle

Pengaruh Faktor-Faktor Motivasi Terhadap Produktivitas Kerja Karyawan Pada Rumah Sakit Pertamina Bintang Amin Bandar Lampung Sri Murtini; Agus Sutardjo; Bambang Purwanto
Jurnal Riset Akuntansi dan Manajemen Malahayati Vol 2, No 1 (2013): Volume 2 Nomor 1
Publisher : Universitas Malahayati

Human resources is still very important and be the center of attention in an organization orcompany to survive in the era of globalization coupled with increasing competition levels.Productivity is closely linked to the progress and success of a company. The company will not besuccessful if not supported by the productivity of its employees. Employee productivity increaseswhen employees are motivated to work. Motivation can be defined as an individual's personalcircumstances that encourage the desire of individuals to perform certain activities in order to achievea goal. In this research the Influence Factors of Motivation Of Employee Productivity At Rumah SakitPertamina Bintang Amin were discussed.Data collection methods used in this research was by usingquestionnaires or questionnaire with a sample of all employees remains at Rumah Sakit PertaminaBintang Amin totaling 47 respondents comprising of the employees at the Medical Inpatient,Outpatient and Midwives whereas analytical models used was a multiple linear regression wereprocessed using SPSS 16 software. The results of this study stated that motivational factors with RSquare of 0.473 or 47.3% and the remaining 52.7% (100% -47.3%) affected by other factors. F testresults stating that the motivating factors simultaneously influence the productivity of employees withF observed (7.350) > F table (2.44) and the probability value (0.000) < alpha (0.05). T test results states thatphysiological needs t observed (2.667) > t table (2.01410)and the probability of 0.011 < alpha (0.05) so thatthe partial effect on employee productivity..Keywords: Motivation Factors and Employee Productivity

Pengaruh Pengumuman Stpck Split Terhadap Abnormal Return Dan Abnormal Trading Volume Activity (Pada Perusahaan-Perusahaan Yang Terdaftar Di BEI Periode 2010-2014) Irena May Rani; Erna Listyaningsih; Bambang Purwanto
Jurnal Riset Akuntansi dan Manajemen Malahayati Vol 6, No 1 (2017): Volume 6 Nomor 1
Publisher : Universitas Malahayati

Tujuan penelitian ini adalah untuk mengetahui terdapat perbedaan pada abnormalreturn dan abnormal trading volume activity sebelum dan sesudah dilakukannya stock splitpada perusahaan-perusahaan yang terdaftar di BEI yang melakukan stock split periode 2010-2014. Penelitian ini menggunakan sampel 35 perusahaan yang diambil dengan menggunakanmetode purposive sampling. Periode jendela (event windows) yang digunakan dalampenelitian ini adalah 7 hari yang terdiri dari 3 sebelum, 1 hari saat, dan 3 hari sesudah stocksplit.Alat analisis data menggunakan uji normalitas dan paired sample t-test. Hasil penelitianmenunjukkan bahwa tidak terdapat perbedaan yang signifikan pada abnormal return danabnormal trading volume activity sebelum dan sesudah stock split pada periode 2010-2014 diBEI. Hal ini mengindikasikan bahwa pasar modal di Indonesia selama periode penelitiantermasuk dalam pasar efisien bentuk setengah kuat. Dalam hal ini investor tidak bisamemperoleh abnormal return sehubungan dengan adanya stock split.

Pengaruh Likuiditas Dan Profitabilitas Terhadap Kinerja Keuangan Pt Aneka Gas Industri Natar Lampung Selatan Lusi Mirnawati; Lestari Wuryanti; Bambang Purwanto
Jurnal Riset Akuntansi dan Manajemen Malahayati Vol 4, No 2 (2015): Volume 4 Nomor 2
Publisher : Universitas Malahayati

Abstract. This research aims to analyze and determine the effect of the liquidity and profitability ofthe finacial performance of Varios Industrial Gases Natar PT Southern Lampung. Population in thestudy of financial statements the sample that is used as a 6 period financial statements. Analysis modelused in completing this study is to test the classical assumption of date normality test, autocorrelationtest, multicollineariry test and heteroscedasticity tast. Regarding there is influence between liquidityand profitability on thefinancial perfomance of Various Industrial Gases Natar PT Southem Lampungtext partially or simulteancously.

Pengaruh Struktur Keuangan Terhadap Profitabilitas Perusahaan Pada PT Darma Henwa Tbk Refli Sudrajat; Nurmala Nurmala; Bambang Purwanto
Jurnal Riset Akuntansi dan Manajemen Malahayati Vol 2, No 1 (2013): Volume 2 Nomor 1
Publisher : Universitas Malahayati

Financial structure is a combination of all sources of financing that the company obtainedshort-term debt , long-term debt and common stock and preferred stock ( equity ) , the use of sourcesof financing can be used as a measure of the increase in profits in a company , so the effect of debt andcapital can serve as a main point company to finance company in terms of maximizing the value of thecompany . This research was conducted at PT Darma Henwa Tbk period 2007-2010 by using multiplelinear regression analysis .Based on the results obtained by multiple linear regression analysis equationY = -7.998 - 0.025 0.242 X1 + X2 . Test simultaneously obtained significant F value = 0.001 < α 0.05,which means that the financial structure is represented by the variable Debt to Equity Ratio ( DER )and Debt to Assets Ratio ( DAR ) simultaneously significant effect on the profitability of the companyat PT Darma Henwa Tbk , as well as the variable DAR , which became the most dominant variablesknown to affect the profitability of seeing the value that is equal to 1.606 Standardized Coefficients .The influence of financial structure is represented by the variable DER and Debt to Assets Ratio tocompany profitability is equal to 59.5 %.Keywords: DER, DAR

Pengaruh Rasio Margin Laba, Rasio Lancar, Rasio Cepat,Rasio Utang Jangka Panjang, Rasio Hasil Pengembalian Investasi, Rasio Utang, Rasio Perputaran Piutang, Rasio Hasil Pengembalian Ekuitas Dan Rasio Perputaran Aktiva Tetap Terhadap Pertumbuhan Laba Sebelum Dan Sesudah Pemisahan Air Traffic Control, Studi Kasus Pada PTAngkasa Pura II Persero) Periode 2011 2014 Umi Khanifah; Erna Listyaningsih; Bambang Purwanto
Jurnal Riset Akuntansi dan Manajemen Malahayati Vol 5, No 2 (2016): Volumr 5 Nomor 2
Publisher : Universitas Malahayati

The objective of this research are found regression from net profit margin, current ratio,quick ratio, long term dept to equity ratio, return on inverstment, dept to equity ratio, turn over ratio,return on equity and fixed asset turn over ratio toward growing profit (before and after separation AirTraffic Control, case study in PT Angkasa Pura II Persero) with partial altough simultaneous. Andalso for found the different of financial performance in PT Angkasa Pura II (before and afterseparation Air Traffic Control, case study in PT Angkasa Pura II Persero) with used Paired Sample ttest.The research used approachment quantitative. Data used in this research is secondary data likeas financial quartely report PT Angkasa Pura II (Persero) period 2011 2014. Population from thisresearch is financial report PT Angkasa Pura II (Persero) from years 1984 2014. Taken sampletechnique that used Sistematic Sampling, with period from years 2011 2014. Method for analysisdata is regression linear analysis method and different test Paired Sample t-test that processed usedSPSS 20.0 program for windows. The result have indicate with partial test, only net profit margin thathave significat regression toward growing profit while current ratio, quick ratio, long term dept toequity ratio, return on inverstment, dept to equity ratio, turn over ratio, return on equity and fixedegression toward growing profit in PT Angkasa Pura II(Persero). The result from Simultaneous test have indicate if net profit margin that have significantregression toward growing profit while current ratio, quick ratio, long term dept to equity ratio,return on inverstment, dept to equity ratio, turn over ratio, return on equity and fixed asset turn overPT Angkasa Pura II (Persero). And forresult from different test Paired sample t-test have indicate if perfomance financial before and afterseparation Air Traffic Control is different. Performance Financial before separation Air TrafficControl more better than after separation Air Traffic Control

POTENCY OF VINEGAR THERAPY IN OTOMYCOSIS PATIENTS Eman Sulaiman; Bambang Purwanto; Lina Lasminingrum; Yussy Afriani Dewi; Sally Mahdiani
Journal of Medicine and Health Vol. 1 No. 2 (2015)
Publisher : Universitas Kristen Maranatha

Otomycosis is an outer ear canal infection caused by fungi. Clinicians are trying to find out the most effective antifungal drug for treating otomycosis. Traditionally Apple cider vinegar has been used for the treatment of various diseases, including antifungal.The high cost in otomycosis treatment effort, long duration of treatment, high recurrence rate, and the difficulty in the application of drugs in the otomycosis treatment have encouraged the researcher to do this study. Having evaluated Â the improvement of clinical symptoms, otoscopy view and examination of KOH 10% in patients receiving apple cider vinegar therap, this study uses descriptive study design of four otomycosis patients in the ORL HNS outpatient clinic of Hasan Sadikin Hospital Bandung from July to August 2014. Having evaluated a clinical symptoms improvement, it is found out that there is an increase of otoscopy view and examination of KOH 10% in patients receiving apple cider vinegar. In other words, there is an Improvement of clinical symptoms, otoscopy view, and examination of KOH 10% in patients receiving apple cider vinegar therapy. Topical apple cider vinegar therapy gives a good result in the improvement of clinical symptom,otoscopy view, and examination of KOH 10% in otomycosis Â patients.Â Keywords: otomikosis, sign and symptoms improvement, apple cider vinegar.

Co-Authors AA Subiyanto Adelia Handoko Agus Sutardjo Ahmad Abdullah Ahmad Nur Huda Aldika Akbar, Muhammad Ilham Arifa Mustika Aryati Bambang Wirjatmadi Budi Prasetyo Darmika Caroline Didik Prasetyo Eko Budi Koendhori, Eko Budi Elyana Asnar Eman Sulaiman Erna Listyaningsih Esti Tantri Anandani Fitriana, Farida Gadis Meinar S Haqqelni Nur Rosyidah Hari Basuki Notobroto Hari Setiono Haryono Yuniarto Herdianty Kusuma I Gusti Bagus Wiksuana Idha Kusumawati Ilman F Martanegara Imam Susilo Indri Ngesti Rahayu Intan Herlina Irena May Rani Iwin Sumarman Izzati, Dwi Jusak Nugraha Kusnanto Kusnanto Lestari Wuryanti Lina Lasminingrum Lusi Mirnawati M. Yogiarto Made Dian Kusumawati Moh. Ali Azis Natasha Tiara Bernadette Nur Hayati Nurmala Nurmala Nurmala Nurmala Paulus Kusnanto Rahma Anindita Raihan Akbar Muhammad Refli Sudrajat Riri Handayani Rochana Ruliyandari Rohmatul Ummah Sally Mahdiani Semedi, Bambang Pujo Setiawan, Philia Shinta F Boesoirie Sony Wibisono Sugiarto Sugiarto Sumardi Maryono Suradi Maryono TATI NURHAYATI Teti Madiadipoera Tri Hardi Susanto Umi Khanifah Warigit Dri Atmoko Yoes Prijatna Dachlan Yopie Wiguna Yuan Guruh Pratama Yussy Afriani Dewi

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