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All Journal Jurnal Teknologi Laboratorium Jurnal Penelitian Kesehatan Suara Forikes Health Notions THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Window of Health : Jurnal Kesehatan Jurnal Ilmu dan Teknologi Kesehatan Jurnal Analis Medika Biosains (JAMBS) INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Poltekita : Jurnal Ilmu Kesehatan JPP Jurnal Kesehatan Poltekkes Palembang Jaringan Laboratorium Medis Medica Arteriana (Med-Art) Medicra (Journal of Medical Laboratory Science/Technology) CENDEKIA : Jurnal Ilmu Pengetahuan Devotion: Journal of Research and Community Service International Journal of Advanced Health Science and Technology HEALTHY: Jurnal Inovasi Riset Ilmu Kesehatan Analis Kesehatan Sains (e-Journal) Jurnal Rakat Sehat : Pengabdian Kepada Masyarakat Jurnal Pengabdian Kesehatan Beguai Jejama Strada Jurnal Ilmiah Kesehatan (SJIK) Folia Medica Indonesiana
Evy Diah Woelansari
Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Surabaya Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Hubungan Kadar C-Reactive Protein dengan Ekspresi Sel Polimorfonuclear pada Penderita Diabetes Melitus Tipe 2 Disertai Ulkus Diabetikum Syafira, Nurah; Woelansari, Evy Diah; Arifin, Syamsul Diah
JPP JURNAL KESEHATAN POLTEKKES PALEMBANG Vol 19 No 2 (2024): JPP (Jurnal Kesehatan Poltekkes Palembang)
Publisher : Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jpp.v19i2.2458

Abstract

Latar Belakang: Diabetes melitus tipe 2 disebut juga dengan diabetes melitus noninsulin dependent (NIDDM) merupakan penyakit yang terjadi karena resistensi insulin dan kecacatan dalam produksi insulin. Kondisi DM tidak terkontrol menyebabkan bertambahnya risiko terjadinya komplikasi seperti ulkus diabetikum. Ulkus diabetikum merupakan salah satu komplikasi dari DM berupa luka kronik, umumnya terjadi pada daerah dibawah pergelangan kaki dan berhubungan dengan peningkatan morbiditas, mortalitas, dan penurunan kualitas hidup. C-Reaktif Protein dan sel Polimorfonuklear (PMN) merupakan biomarker inflamasi. Metode: studi ini dilakukan untuk mengetahui hubungan antara kadar C-Reactive Protein dengan jumlah sel Polimorfonuclear pada penderita diabetes melitus tipe 2 disertai ulkus diabetikum. Jenis peneliian ini adalah observasional analitik dengan rancangan post-test design. Sampel ditentukan dengan teknik pengambilan sampel saturated sampling pada pasien di RSUD Syarifah Ambami Rato Ebu Bangkalan yang sesuai dengan kriteria inklusi. Sampel dianalisa dengan alat Architect plus c4000 untuk mengetahui kadar C-Reactive Protein dan dianalisa dengan alat Cell Dyn Ruby untuk mengetahui jumlah sel Polimorfonuclear. Hasil: penelitian diadapatkan 27 sampel dan di uji korelasi dengan uji Spearman menunjukkan adanya hubungan positif antara kadar C-Reactive Protein dengan sel neutrofil (p =0,001 ; r =0,608) dan hubungan negatif antara kadar C-Ractive Protein dengan sel eosinofil dan basofil (p =0,001 ; r =-0,581 : p =0,007 ; r =-0,507) Kesimpulan: kadar C-Reactive Protein dan ekspresi sel Polimorfonuclear yang terdiri dari sel neutrofil, sel eosinofil dan sel basofil pada penderita diabetes melitus tipe 2 disertai ulkus menunjukkan hasil terdapat korelasi searah dengan kekuatan erat antara kadar CRP dan jumlah sel neutrofil. Sedangkan kadar CRP dengan sel eosinofil dan basofil terdapat korelasi tidak searah dengan kekuatan sedang.
Kolesterol dan Tekanan Darah Lansia di Posyandu Abiyoso Polkesbaya Christyaningsih, Juliana; Rusyadi, Luthfi; Minarti, Minarti; Mamik, Mamik; Pestariati, Pestariati; Mutiarawati, Diah Titik; Suliati, Suliati; Sasongkowati, Retno; Woelansari, Evy Diah; Suhariyadi, Suhariyadi; Istanto, Wisnu; Endarini, Lully Hanni; Museyaroh, Museyaroh
JURNAL RAKAT SEHAT (JRS) : Pengabdian Kepada Masyarakat Vol 2 No 2 (2023): Jurnal Rakat Sehat: Pengabdian Kepada Masyarakat
Publisher : UPPM Poltekkes Kemenkes Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/jrs.v2i2.35

Abstract

As people age, the physical state of the human body will gradually deteriorate due to a decrease in the quantity of cells present, leading to a gradual reduction in functionality referred to as the aging process. In elderly humans (aged more than 60 years) excessive cholesterol levels and high blood pressure are one of the causes of diseases such as heart disease which has been recognized by WHO as the number one cause of death in the world. The buildup of fatty deposits on the linings of blood vessels has the potential to lead to obstructions within the blood vessels. The objective of this initiative is to enhance understanding regarding the hazards associated with cholesterol. This outreach effort took place in July 2023, conducted at Posyandu Abiyoso, Surabaya Health Polytechnic. The activity consists of several processes 1). conducting a survey of the location of the Abiyoso posyandu of the Surabaya Health Polytechnic, 2). Opening registration and taking participants' personal data, 3) conducting participant health interviews, 4). Checking cholesterol levels and blood pressure of participants. From the community service activities carried out, it was found that 42 of the 65 (64.6%) participants who took part in the examination at the integrated service post had high cholesterol levels, and 60 of the 65 (92.3%) participants had high blood pressure or hypertension. By conducting health checks on cholesterol levels and blood pressure, there is an expectation that the society will come to realize and comprehend. the dangers of hypertension and hypercholesterolemia so that the community can prevent the occurrence of sustainable diseases.
Kadar HbA1c, Kadar TSH dan Jumlah Sel Neutrofil pada Penderita Diabetes Mellitus Tipe 2 Cheppy Juwita Ayuningrum; Evy Diah Woelansari; Suhariyadi Suhariyadi
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 14, No 2 (2023): April 2023
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf14227

Abstract

Type 2 diabetes mellitus accounts for between 90% and 95% of diabetes, with the highest proportion in low- and middle-income countries. To monitor the metabolic status of people with type 2 diabetes mellitus, a hemoglobin-glycosylated (HbA1c) examination is usually performed. This study aimed to determine the correlation between HbA1c levels and TSH levels and the number of neutrophil cells in people with type 2 diabetes mellitus. This research was conducted from January to February 2022 at Bangil Hospital, Pasuruan Regency. This type of research was analytic observational with a cross-sectional approach. The population of this study were patients with type 2 diabetes mellitus at Bangil Hospital, Pasuruan Regency, and the sample size was 30 patients selected using a purposive sampling technique. Data collection in this study was carried out by blood tests using an immunoassay analyzer to obtain HbA1c and TSH levels. Data collection was also carried out by blood tests using a hematology analyzer to obtain data on the number of neutrophil cells. Data were analyzed by correlation test. The results showed that the p-value for the correlation test between HbA1c and TSH levels was 0.094; while the p value for the correlation test between HbA1c levels and the number of neutrophil cells was 0.021. It was concluded that there was no correlation between HbA1c levels and TSH and there was no correlation between Hba1c levels and the number of neutrophil cells in type 2 diabetics.Keywords: HbA1c; TSH; neutrophils; type 2 diabetes mellitus ABSTRAK Diabetes mellitus tipe 2 menyumbang antara 90% dan 95% diabetes, dengan proporsi tertinggi di negara berpenghasilan rendah dan menengah. Untuk pemantauan status metabolik penderita diabetes mellitus tipe 2 ini, biasanya dilakukan pemeriksaan hemoglobin-glikosilat (HbA1c). Penelitian ini bertujuan untuk mengetahui korelasi antara kadar HbA1c dengan kadar TSH dan jumlah sel netrofil pada penderita diabetes mellitus tipe 2. Penelitian ini dilakukan pada bulan Januari sampai Februari 2022 di RSUD Bangil Kabupaten Pasuruan. Jenis penelitian ini adalah obsevasional analitik dengan pendekatan cross-sectional. Populasi penelitian ini adalah pasien penderita diabetes mellitus tipe 2 di RSUD Bangil Kabupaten Pasuruan, dan ukuran sampel adalah 30 pasien yang dipilih menggunakan teknik purposive sampling. Pengumpulan data dalam penelitian ini dilakukan dengan pemeriksaan darah menggunakan immunoassay analyzer untuk mendapatkan hasil kadar HbA1c dan kadar TSH. Pengumpulan data juga dilakukan dengan pemeriksaan darah menggunakan hematologi analyzer untuk mendapatkan data jumlah sel netrofil. Data dianalisis dengan uji korelasi. Hasil penelitian menunjukkan bahwa nilai p untuk uji korelasi antara kadar HbA1c dengan TSH adalah 0,094; sedangkan nilai p untuk uji korelasi antara kadar HbA1c dengan jumlah sel netrofil adalah 0,021. Disimpulkan bahwa tak ada korelasi antara kadar HbA1c dengan TSH dan ada ada korelasi antara kadar Hba1c dengan jumlah sel netrofil pada penderita diabetes tipe 2.Kata kunci: HbA1c; TSH; netrofil; diabetes mellitus tipe 2
Korelasi antara Trombositopenia Imunoglobulin M dan Imunoglobulin G pada Anak yang Menderita Dengue Haemorrhagic Fever Hariyanto Hariyanto; Evy Diah Woelansari; Suliati Suliati
STRADA : Jurnal Ilmiah Kesehatan Vol. 7 No. 1 (2018): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v7i1.142

Abstract

DHF merupakan demam berdarah dengue yang disebabkan oleh virus dengue yang ditularkan oleh nyamuk Aedes aegypti. Demam Berdarah Dengue dengan gejala umum demam, nyeri sendi, lekopenia dengan salah satunya trombositopeni. Demam akibat infeksi virus menyebabkan respon imun yaitu IgM dan IgG yang berasal dari limfosit B. Penelitian ini bertujuan untuk membuktikan adanya hubungan antara trombositopeni dengan imunoglobulin M dan imunoglobulin G pada anak yang menderita DHF. Penelitian ini bersifat deskriptif analitik yang dilakukan antara bulan Januari sampai Juni 2013 di laboratorim RSU Dr. Iskak Tulungagung. Dari pemeriksaan terhadap 60 kasus yang mengalami penurunan trombosit < 100.000/mm3 atau trombositopeni terdapat hasil IgG yang reaktif 23 (38,3%) IgG yang nonreaktif 14 (23,3%) IgM yang reaktif 26 (43,3%) IgM yang non reaktif 11 (18,3%) yang negatif IgG dan IgMnya walaupun trombositopeni sebanyak 23 (28,3%) dari hasil penelitian lanjutan dengan statistik dilakukan uji non parametrik corelation didapatkan p = 0,000 pada IgG dan p = 0,000 pada IgM artinya p < α. Artinya ada hubungan antara trombositopenia dengan imunoglobulin M dan imunoglobulin G pada anak yang menderita dengue haemorhagic fever. Korelasi yang terjadi antara yang terjadi adalah korelasi yang kuat dan searah artinya apabila trombosit naik maka IgM dan IgG naik atau sebaliknya. Untuk hubungan IgG dan IgM didapat nilai r = 0,590 pada α = 0,01. Artinya hubungan IgG dan IgM mempunyai kuat hubungan sedang dan searah.
Correlation Of Neutrophil Lymphocyte Ratio (NLR) Value With Incidence Of Tuberculosis Disease In Patients With Diabetes Mellitus Istiqomah, Istiqomah; Suhariyadi, Suhariyadi; Woelansari, Evy Diah
Jurnal Analis Medika Biosains (JAMBS) Vol 11, No 1 (2024): JURNAL ANALIS MEDIKA BIOSAINS (JAMBS)
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jambs.v11i1.332

Abstract

Diabetes mellitus is a non-communicable disease (PTM) that is chronic and can weaken the immune system so that sufferers are 3 times more likely to suffer from pulmonary TB. In chronic infection there is continuous inflammation which is characterized by the presence of neutrophils themselves and will be followed by low lymphocyte values due to immune system pathways that do not work perfectly. The purpose of this study was to determine the correlation between the Neutrophil Lymphocyte Ratio (NLR) and the incidence of Tuberculosis in Diabetes Mellitus patients at the Jorongan Health Center, Probolinggo Regency. This research is a correlative analytic study with a cross sectional approach. A total of 30 samples of diabetes mellitus patients at the Jorongan Health Center from January to April 2023. The NLR examination method was with a hematology analyzer and tuberculosis patients were examined using Molecular Rapid Test. The statistical test uses Spearman's nonparametric test. The results showed that there was a correlation between NLR values and the incidence of tuberculosis in diabetes mellitus patients at the Jorongan Health Center, p = 0.003 and r = 0.521. Further research needs to be carried out involving larger samples and other laboratory tests related to the immune system in patients with diabetes mellitus.
Korelasi Kadar High Sensitivity C-Reactive Protein (hs-CRP) Dan Kolesterol Low Density Lipoprotein (LDL) Pada Perokok Aktif Dengan Aktivitas Fisik Rizqiyah, Aliya Ayu; Woelansari, Evy Diah; Suhariyadi, Suhariyadi
THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Vol 6 No 1 (2023): The Journal Of Muhammadiyah Medical Laboratory Technologist
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jmlt.v6i1.14363

Abstract

Jombang Regency was the 10th most prevalent smoker in East Java in 2018 and experienced an increase in the prevalence of smokers by 0.1% from 2013. The high number of smokers raises a concern. Smoking may lead to an increase of hs-CRP and LDL cholesterol levels, where the increase in these two parameters is closely related to the formation of atherosclerotic plaques, as a cause of cardiovascular disease. Physical activity of each individual is something that needs to be known because it affects the levels of hs-CRP and LDL cholesterol. This study aims to analyze the correlation between hs-CRP and LDL cholesterol in active smokers with physical activity. This study used an observational analytic study with a cross-sectional design. This research was conducted in March-April 2022 with a total sample of 32 active smokers who work as pedicab drivers at Pondok Pesantren 'DU', Jombang Regency. The hs-CRP examination was carried out using the Latex Turbidimetric Assay method, while the LDL cholesterol examination was using the Homogeneous Enzymatic Colorimetric Assay method. Based on the statistical analysis of the Spearman correlation, the results obtained p>0.05 (p = 0.687, r = 0.074), which means that there is no correlation between levels of hs-CRP and LDL cholesterol in active smokers with physical activity.
PERBANDINGAN STATUS ANTI-HBs (Hepatitis B surface Antibody) DAN JUMLAH LIMFOSIT PADA PESERTA PROGRAM VAKSINASI HEPATITIS B DENGAN DAN TANPA KOMORBID DIABETES MELITUS TIPE 2 Widiastutik, Dyah; Suhariyadi, Suhariyadi; Rahayuningsih, Christ. Kartika; Woelansari, Evy Diah
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 4 No. 4 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v4i4.6582

Abstract

Anti-HBs and lymphocyte count are used to assess the success of hepatitis B vaccination. Healthcare workers are at high risk of contracting hepatitis B, making routine vaccination essential. This study was conducted at RSUD Caruban, Madiun Regency, involving 44 participants of the hepatitis B vaccination program, both with and without type 2 diabetes mellitus comorbidity. Examinations were carried out six months post-vaccination. The study employed a comparative analytical method with a cross-sectional approach and was conducted in February 2025. The instruments used were the Eclia-Mindray CL-900i with the ELISA method and the Sysmex XN-350 with the Flow Cytometry method. In the group with type 2 diabetes mellitus, the average Anti-HBs titer was 77.53 mIU/mL, whereas in the non-diabetic group it was 882.06 mIU/mL. The average lymphocyte count was also higher in the non-diabetic group (38.91%) compared to the group with diabetes mellitus (22.52%), although both were within the normal range. There were differences in Anti-HBs status and lymphocyte counts between hepatitis B vaccination participants with and without type 2 diabetes mellitus comorbidity. ABSTRAKAnti-HBs dan jumlah limfosit digunakan untuk menilai keberhasilan vaksinasi hepatitis B. Tenaga kesehatan memiliki risiko tinggi tertular hepatitis B, sehingga vaksinasi rutin diperlukan. Penelitian ini dilakukan di RSUD Caruban Kabupaten Madiun, pada 44 peserta vaksinasi hepatitis B, baik dengan maupun tanpa komorbid diabetes melitus tipe 2. Pemeriksaan dilakukan enam bulan setelah vaksinasi. Penelitian ini menggunakan metode komparatif analitik dengan pendekatan cross-sectional, dilaksanakan pada bulan Februari tahun 2025. Instrumen yang digunakan adalah Eclia-Mindray CL-900i, dengan metode ELISA dan Sysmex XN-350, dengan metode Flow Cytometry. Pada kelompok dengan diabetes melitus tipe 2, rata-rata titer Anti-HBs adalah  77,53 mIU/mL, sementara kelompok tanpa diabetes melitus rata-ratanya adalah 882,06 mIU/mL. Untuk jumlah limfosit rata-ratanya lebih tinggi pada kelompok tanpa diabetes melitus yaitu sebesar 38,91 % dibandingkan kelompok dengan komorbid diabetes melitus tipe 2 sebesar 22,52%, meskipun keduanya dalam batas normal. Terdapat perbedaan status Anti-HBs dan jumlah limfosit pada peserta program vaksinasi hepatitis B dengan dan tanpa komorbid diabetes melitus tipe 2.
HUBUNGAN JUMLAH SEL LEUKOSIT MONONUKLEAR (MONOSIT, LIMFOSIT) DENGAN HASIL UJI TUBEX TF TERHADAP PASIEN SUSPEK DEMAM TIFOID Kumahartati, Intan; Woelansari, Evy Diah; Istanto, Wisnu; Suhariyadi, Suhariyadi
CENDEKIA: Jurnal Ilmu Pengetahuan Vol. 5 No. 4 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/cendekia.v5i4.7143

Abstract

Typhoid fever can be diagnosed in suspected patients through the Tubex TF test, which has a relatively high sensitivity and specificity of 73%. Typhoid fever can also be diagnosed by examining the number of mononuclear leukocytes, particularly monocytes and lymphocytes, which are indicators of bacterial infection. Typhoid fever is a disease caused by Salmonella typhi. Typhoid fever cases in Indonesia range from 350 to 810 per 100,000 people, with a prevalence of 1.6%. The purpose of this study was to determine the relationship between the number of mononuclear leukocytes (monocytes and lymphocytes) and Tubex TF results in patients suspected of typhoid fever. This study was an analytical observational study and the sampling technique used was consecutive sampling, with all subjects meeting the selection criteria, amounting to 63 samples. The number of mononuclear leukocytes (monocytes, lymphocytes) was determined using a Hematology Analyzer and the Tubex TF test was determined using the IMBI method. Spearman's correlation test was used for statistical analysis. The findings showed a significant correlation between the number of monocytes and the Tubex TF results in patients suspected of typhoid fever (p = 0.006 < ? = 0.05). In contrast, no significant correlation was found between the number of lymphocytes and the Tubex TF results in the same group of patients (p = 0.296 > ? = 0.05). ABSTRAKDiagnosis demam tifoid pada pasien suspek dapat dilakukan melalui uji Tubex TF yang menunjukkan sensitivitas dan spesifisitas yang relative tinggi, yaitu sebesar 73%. Demam tifoid dapat pula didiagnosis dengan pemeriksaan jumlah sel leukosit mononuklear, khususnya sel monosit dan sel limfosit yang akan menjadi indikator ketika terjadi infeksi akibat bakteri. Demam tifoid adalah penyakit yang disebabkan oleh infeksi bakteri Salmonella typhi. Kasus demam tifoid di Indonesia berkisar antara 350 hingga 810 per 100.000 penduduk, dengan prevalensi 1,6%. Tujuan penelitian ini, untuk mengetahui hubungan jumlah sel leukosit mononuklear (monosit, limfosit) dengan hasil Tubex TF pada pasien suspek demam tifoid. Penelitian ini merupakan penelitian observasional analitik dan juga teknik pengambilan sampelnya ialah dengan cara Consecutive Sampling yaitu semua subyek yang memenuhi kriteria pemilihan yaitu sebanyak 63 sampel. Jumlah sel leukosti mononuclear (monosit, limfosit) ditentukan dengan alat Hematology Analyzer dan uji Tubex TF ditentukan dengan metode IMBI. Uji korelasi Spearman digunakan untuk analisis statistik. Temuan menunjukkan adanya hubungan yang signifikan antara jumlah monosit dan hasil Tubex TF pada pasien yang diduga demam tifoid (p = 0,006 < ? = 0,05). Sebaliknya, tidak ditemukan korelasi yang signifikan antara jumlah limfosit dan hasil Tubex TF pada kelompok pasien yang sama (p = 0,296 > ? = 0,05).
Serodiagnosis Profiling of Anti SARS-CoV-2 Among Blood Donor Surabaya Indonesia Woelansari, Evy Diah; Sasongkowati, Retno; Christiyaningsih, Juliana
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3367

Abstract

SARS-CoV-2 antibody detection is used as a response to natural infection and vaccination. Antibody response is very important in viral seroepidemiology and the potential role of antibodies in disease. This study was to determine serodiagnosis anti SARS-CoV-2 among blood donor Surabaya detect antibodies with protein molecular weight as serodiagnosis and immune response to SARS-CoV-2 in donors in Surabaya. The research used in this study was exploratory descriptive design. Samples from blood donors as many as 150 samples at UTD PMI Surabaya. The examination was carried out by detecting IgG SARS-CoV-2 antibodies ELISA method and followed by protein molecular weight examination SDS-PAGE method (semi-log The results of the ELISA method antibody examination showed that 67 people had IgG antibody titers against SARS-CoV2 (44.7%) and 83 people were negative (55.3%) (COI: 0.1535-0.1569). Furthermore, the results of the SDS- PAGE method examination obtained the average molecular weight in band 1: 49.73 kDA, band 2: 25.26 kDA; band 3: 19.63.4 kDA; band 4: 12.35 kDA and band 5: 7.33 kDA. There were IgG antibody of SARS CoV-2 in blood donor Surabaya meanwhile from protein screening results we could not find protein of spike SARS-CoV-2 in Blood donor Surabaya.
KORELASI ANTARA NEUTROPHIL LYMPHOCYTE RATIO (NLR) DAN C-REACTIVE PROTEIN (CRP) PADA PASIEN ANAK SUSPEK SEPSIS Purnomowati, Anik; Woelansari, Evy Diah; Sasongkowati, Retno
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 4 No. 3 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v4i3.6611

Abstract

ABSTRACT Sepsis neonatorum is one of the biggest triggers of neonatal deaths in Indonesia. The Diagnosis of sepsis is difficult to establish due to non-specific symptoms, so accurate, affordable, and easily accessible biomarkers are needed. Commonly used biomarkers such as C-Reactive Protein (CRP) and Procalcitonin (PCT) have limited cost and availability. Neutrophil lymphocyte Ratio (NLR) is a promising alternative because it can be obtained from a routine complete blood count. The study intends to determine the correlation between the value of NLR and CRP in children indicated sepsis in RSUD dr. Sayidiman Magetan. The study was classified as cross sectional based analytical observational in 33 pediatric patients suspected of sepsis during October 2024 to March 2025. Spearman correlation testing is used in the data analysis of this study because the distribution of data is not normal based on the Shapiro-Wilk test. The average value of NLR was 6.72% and CRP was 70.16 mg/L. Spearman correlation test results showed a moderate correlation between NLR and CRP with a correlation coefficient of 0.407 (p = 0.019). There is a significant moderate correlation between NLR and CRP in pediatric patients with suspected sepsis, so NLR can potentially be used as an alternative inflammatory marker to detect pediatric sepsis. ABSTRAK Sepsis neonatorum ialah satu di antara pemicu terbesar terhadap kematian neonatal di Indonesia. Diagnosis sepsis sulit ditegakkan karena gejala yang tidak spesifik, sehingga dibutuhkan penanda biologis (biomarker) yang akurat, terjangkau, dan mudah diakses. Biomarker yang umum digunakan seperti C-Reactive Protein (CRP) dan Procalcitonin (PCT) memiliki keterbatasan biaya dan ketersediaan. Rasio Neutrofil Limfosit (Neutrophil Lymphocyte Ratio/NLR) menjadi alternatif yang menjanjikan karena dapat diperoleh dari hitung darah lengkap rutin. Penelitian bermaksud mengetahui korelasi antara nilai NLR dan CRP pada anak terindikasi sepsis di RSUD dr. Sayidiman Magetan. Penelitian tergolong observasional analitik berbasis cross sectional pada 33 pasien anak suspek sepsis selama Oktober 2024 hingga Maret 2025. Pengujian korelasi Spearman dimanfaatkan dalam analisis data penelitian ini sebab distribusi data tidak normal berdasarkan uji Shapiro-Wilk. Nilai rata-rata NLR sebesar 6,72% dan CRP sebesar 70,16 mg/L. Hasil uji korelasi Spearman menunjukkan adanya korelasi sedang antara NLR dan CRP dengan koefisien korelasi sebesar 0,407 (p = 0,019). Terdapat korelasi sedang yang signifikan antara NLR dan CRP pada pasien anak suspek sepsis, sehingga NLR berpotensi digunakan sebagai penanda inflamasi alternatif untuk mendeteksi sepsis anak.
Co-Authors , Suhariyadi ., Pestariati A.A. Ketut Agung Cahyawan W Abror, Yogi Khoirul Adelia Gita Prasasti Alifiah, Salsabiil Rochman Aliya Ayu Rizqiyah Anggraini, Anita Dwi Anita Dwi Anggraini Aprilyadi, Nadi Arifin, Syamsul Diah Arta, Shela Yuni Aryati Aryati Ayu Puspitasari, Ayu Cheppy Juwita Ayuningrum Christ Kartika Rahayuningsih Christiyaningsih, Juliana Diah Titik Mutiarawati Edy Haryanto Eka Safitri, Devayanti Endarini, Lully Hanni Entuy Kurniawan Kurniawan Evi Yunita Nugrahini Fadia Rakhmalia Fortuna Aliza Dewi Ginarsih, Yuni Handayati, Anik Hariyanto Hariyanto Hermiyanti, Pratiwi Ira Puspita Sari Ira Rahayu Tiyar Istanto, Wisnu Istiqomah Istiqomah istiqomah istiqomah Juliana Christyaningsih Kasiati Kiaonarni O.W Krihariyani, Dwi Kumahartati, Intan Lembunai Tat Alberta Liliek Soetjiatie Lully Hani Endarini Luthfi Rusyadi Mamik Mamik Mamik Mamik Minarti Minarti Minarti Minarti Mohd Nazil Salleh Mujayanto Museyaroh, Museyaroh Mutiarawati, Diah Titik Nabilah, Musholli Himmatun Niswata, Navila Arfianti Novikasari, Caturizkyana Nur Hatijah Nurwening TW P, Teresia Retna Pertiwi, Resty Cahya Prasasti, Adelia Gita Purnomowati, Anik Purwati Purwati Puspa Wardani Rahayu Sumaningsih Rahayuningsih, Christ Kartika Rahayuningsih, Christ. Kartika Rahma Yuliana, Putri Ramadhany, Rieke Dwi Retno Sasongkowati Retno Sasongkowati Retno Sasongkowati Rieke Dwi Ramadhany Riyanto, Digdo Rizqiyah, Aliya Ayu Salsabiil Rochman Alifiah Sasongkowati, Retno Sri Sulami Endah Astuti Sri Utami Suhariyadi Suhariyadi Suhariyadi Suhariyadi Suhariyadi Suhariyadi Suhariyadi Suhariyadi Suhariyadi Suhariyadi Suliati Suliati Suliati Suliati Suliati Sumasto, Hery Syafira, Nurah Teta Puji Rahayu Widiastutik, Dyah Wisnu Istanto Yohanes Kambaru W Zerlinda, Nur