Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Jurnal Kesehatan Andalas

Pengaruh Hormon Androgen terhadap Ekspresi Gen CD52 di Epididimis Mencit (Mus musculus) Silvani Permatasari; Dwi Ari Pujianto; Astrid Teresa
Jurnal Kesehatan Andalas Vol 9, No 2 (2020): Online June 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i2.1224

Abstract

Androgen has an important role in regulation epididymal sperm maturation  Epididymal sperm maturation is occurs via interactions between sperm and proteins secreted by epididymal genes that are specifically expressed in a region-specific manner. Mice CD52 exhibited expression in all regions in epididymis. However, the regulation of its expression by androgen is needed to be known as a gene candidate that involved in sperm maturation. Objective: This study was aimed to analyze regulation of mice CD52 expression by androgen and a bioinformatics analysis was performed to predict functional domains of CD52. Methods: bioinformatics analysis using Motif Scan. For experiment, mice divided into 5 groups. The groups were control was injected ethanol 0,1 mL/day and others groups were  3, 5, 10, and 15 day used a androgen receptor antagonist, flutamide that dilute in ethanol at a dose of 50 mg/kg/day. And then quantitative real-time RT-PCR was used to analyse expression of CD52 and it’s normalized to Beta actin. Result: CD52 contained a two potential phosphorylation sites for protein kinase C and casein kinase II, N-myristoylation, and N-glycosylation that showed CD52 is secretory protein and predict it’s attached to sperm membrane. Expression of CD52 was decrease about 93% than control. Conclusion: CD52 expression depend on androgen.Keywords:  androgen; epididymis; sperm maturation; expression of CD52
Co-Authors Agnes Frethernety Agnes Frethernety Alexandra, Francisca Diana Andreyan Cesarianto Anna Marthea Veronica Aprilliana, Riska Arini Ratnasari Arnino A Astri Widiarti ASTRID TERESA Astrid Teresa Balyas, Abi Bakring Berliani, Victoria Chandra Chandra Dea Tutut Dede Z. A Dewi Klarita Furtuna Dewi Klarita Furtuna Dhaniang, Natasya Dwi Ari Pujianto Elsa Trinovita Ervi Audina Munthe Fadhiyatulqalbi Ahmad, Farah Fauziyah Fatmaria, Fatmaria Febrianto E. P Florence Felicia Florence Felicia Fraulein Aryati Fraulein Aryati Frethernety, Agnes Furtuna, Dewi Klarita Furtuna, Dwi Klarita Galih Indra Permana Hairunnida Rahmatina Halisa, Nida Handayani, Septi Herlina Eka Shinta I Gde Eka A Idsan, Rakha Satya Indah Noniika Indria Augustina Jhon Paris Pasaribu Kahanjak, Donna Novina Krestina, Widya Lia Sasmithae Malasinta Malasinta Malinda, Okta Marliah, Dinda Masaris Mery Irayanti Misbah Misbah Muhammad Aldri Muntir Guru Singa Nabila Putri Aditya Natalia Resoldes LBN Tobing Natalia Sri Martani Nawan, Nawan Ni Putu Saraswati Ni Putu W.S.W Nida Halisa Nuha, Alya Firyal Nurfianto, Sigit Oktaviannur, Zoelva Patricia, Tisha Rahmidiati Ramadhani, Ahmad Ratna Widayati Ratna Widayati Ria Eriani Rian Ka Praja Rini Fitri R Seiya, Saint Septi Handayani Sherly Marselina Sitorus, Elisabeth Prihana Rotua Syamsul Arifin Syarpin Syarpin Syarpin Tangdibali, Annisa Zaskia Alexandra Tasya, Tasya Theressia Angel Lady Saragih Tisha Patricia Toemon, Agnes Immanuela Tri Widodo Vani Vrenika Widayati, Ratna Widya Krestina Yanuardi Ikhsan Yenisa Jestin Ganindyatama Ysrafil, Ysrafil