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Permatasari, Silvani
Department Of Biology, Faculty Of Medicine, Universitas Palangka Raya, Palangka Raya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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The Effect of Bajakah Kalalawit (Uncaria gambir) Stem Extract on Spermatozoa Viability In Vitro Permatasari, Silvani; Artika, Fitha Nadia; Handayani, Septi; Widayati, Ratna; Trinovita, Elsa
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.513-518

Abstract

The prevalence process impairs sperm biochemistry and function by generating high levels of Reactive Oxygen species (ROS) and damaging sperm cells. In addition, ROS imbalance leads to decreased sperm viability, mitochondrial dysfunction, and DNA damage. The administration of Bajakah Kalalawit stem extract (Uncaria gambir (W. Hunter) Roxb.) is stated to maintain sperm quality. In vitro sperm viability tests have not been widely conducted. This study aims to determine the effect of Bajakah Kalalawit stem extract (Uncaria gambir (W. Hunter) Roxb.) on sperm viability in vitro. This research is experimental research, the type of design used is posttest only with control group design. The sample was determined by consecutive sampling and the samples taken were 15. The statistical test using LSD Post-Hoc test obtained between groups there were significant differences with p <0.05. The compounds contained in the ethanol extract of Bajakah Kalalawit stem (Uncaria gambir (W. Hunter) Roxb.) are terpenoids, flavonoids, steroids, saponins and alkaloids. Viability of spermatozoa increased significantly from the concentration of 50ng/mL with a percentage of 74.13%, 100ng/mL by 83.00%, 500ng/mL by 87.60% and 1000ng/mL by 91.27%. The ethanol extract of Bajakah Kalalawit stem (Uncaria gambir (W. Hunter) Roxb.) can affect the viability of spermatozoa in vitro.
Co-Authors Agnes Frethernety Agnes Frethernety Alexandra, Francisca Diana Andreyan Cesarianto Anna Marthea Veronica Aprilliana, Riska Arini Ratnasari Arnino A Artika, Fitha Nadia Astri Widiarti ASTRID TERESA Astrid Teresa Balyas, Abi Bakring Berliani, Victoria Chandra Chandra Dea Tutut Dede Z. A Dewi Klarita Furtuna Dewi Klarita Furtuna Dhaniang, Natasya Dwi Ari Pujianto Elsa Trinovita Ervi Audina Munthe Fadhiyatulqalbi Ahmad, Farah Fauziyah Fatmaria, Fatmaria Febrianto E. P Florence Felicia Florence Felicia Fraulein Aryati Fraulein Aryati Frethernety, Agnes Furtuna, Dewi Klarita Furtuna, Dwi Klarita Galih Indra Permana Hairunnida Rahmatina Halisa, Nida Handayani, Septi Herlina Eka Shinta I Gde Eka A Idsan, Rakha Satya Indah Noniika Indria Augustina Jhon Paris Pasaribu Kahanjak, Donna Novina Krestina, Widya Lia Sasmithae Malasinta Malasinta Malinda, Okta Mallewa, Nurul Ilmi Marliah, Dinda Masaris Mery Irayanti Misbah Misbah Muhammad Aldri Muntir Guru Singa Nabila Putri Aditya Natalia Resoldes LBN Tobing Natalia Sri Martani Nawan, Nawan Ni Putu Saraswati Ni Putu W.S.W Nida Halisa Nuha, Alya Firyal Nurfianto, Sigit Oktaviannur, Zoelva Patricia, Tisha Rahmidiati Ramadhani, Ahmad Ratna Widayati Ratna Widayati Ria Eriani Rian Ka Praja Rini Fitri R Seiya, Saint Septi Handayani Sherly Marselina Sitorus, Elisabeth Prihana Rotua Syamsul Arifin Syarpin Syarpin Syarpin Tangdibali, Annisa Zaskia Alexandra Tasya, Tasya Theressia Angel Lady Saragih Tisha Patricia Toemon, Agnes Immanuela Tri Widodo Vani Vrenika Widayati, Ratna Widya Krestina Yanuardi Ikhsan Yenisa Jestin Ganindyatama Ysrafil, Ysrafil