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All Journal Pythagoras: Jurnal Matematika dan Pendidikan Matematika Mutiara Medika: Jurnal Kedokteran dan Kesehatan Medical Laboratory Technology Journal Saintifik : Jurnal Matematika, Sains, dan Pembelajarannya Griya Journal of Mathematics Education and Application Journal of Experimental and Clinical Pharmacy (JECP) Pengabdian Kampus: Jurnal Informasi Kegiatan Pengabdian Pada Masyarakat Pharmaceutical Sciences and Research (PSR) Barigas: Jurnal Riset Mahasiswa Journal of Mathematics, Computation and Statistics (JMATHCOS) Diophantine Journal of Mathematics and Its Applications
Widayati, Ratna
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Potential of Ciplukan Leaf Extract (Physalis angulata L.) Against Streptococcus pneumoniae Growth in Vitro Rakhman, Farizky; Widayati, Ratna; Turnip, Oktaviani Naulita; Fatmaria, Fatmaria; Hanasia, Hanasia
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 1 (2025): February 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i1.1314

Abstract

Pneumonia is a disease that infects the lungs, and antibiotics such as tetracycline show a high degree of resistance. Therefore, the use of alternative natural materials, such as ciplukan leaves (Physalis angulata L.), which the Dayak people commonly use to treat lung diseases, is necessary. This study aimed to prove that the extract of ciplukan leaves can inhibit Streptococcus pneumoniae by measuring the diameter of the clear zone and determining the Minimum Inhibitory Concentration (MIC). The extract was obtained by maceration using 96% ethanol, and then concentrations of 5%, 10%, 15%, 20%, and 25% were prepared. The positive control was levofloxacin 5 µg, and the negative control was DMSO 1%. The average inhibition zone diameters of the ciplukan leaf extract were 5% (0 mm), 10% (0.17 mm), 15% (0.45 mm), 20% (1.95 mm), 25% (2.67 mm). Antibacterial test using the disk diffusion method. From the Kruskal-Wallis and Mann-Whitney Post Hoc statistical test, a significance value of <0.05 was obtained. Therefore, There is an effect of ciplukan leaf extract on Streptococcus pneumoniae at concentrations of 15%, 20%, and 25%, with the MIC 15%.
Analisa Kestabilan Bebas Penyakit Model SITRS pada Penyebaran Diare Widayati, Ratna; Hamim Muntoha, Renal; Ma'rifah, Umi; Yulianti, Nita
Diophantine Journal of Mathematics and Its Applications Vol. 3 No. 1 (2024)
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/diophantine.v3i1.33908

Abstract

This study discusses the spread of diarrhea accompanied by complications resulting in death among sufferers. It is assumed that people with diarrhea can transmit the disease to susceptible individuals. Additionally, deaths occurred due to diarrhea when treatment was not administered. Individuals who have contracted diarrhea may acquire temporary immunity and then become susceptible again. The model used is SITRS. Based on the model, disease-free equilibrium points and endemic equilibrium points are obtained. The analysis was conducted around the disease-free equilibrium point, and it was concluded that the disease-free equilibrium point is locally asymptotically stable if R0<1. Furthermore, based on the simulation results, it is shown that the model's solution tends towards a disease-free equilibrium point if R0<1. . This implies that diarrhea will disappear from the population at some point if the infection level R0<1. is met.
Analisis Kestabilan Global dan Analisis Sensitivitas pada Model Matematika Penyebaran Penyakit Gondongan Widayati, Ratna; Rachmawati, Ramya; Afandi, Nur
Griya Journal of Mathematics Education and Application Vol. 5 No. 2 (2025): Juni 2025
Publisher : Pendidikan Matematika FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/griya.v5i2.578

Abstract

Mumps is a contagious viral disease transmitted through respiratory droplets and close contact. It can cause symptoms like fever and salivary gland swelling. Despite the MMR vaccine, which offers partial protection, outbreaks persist, especially in college-aged individuals. Epidemiological models can aid in identifying effective prevention strategies for controlling mumps transmission. This paper proposes a mathematical model for mumps spread, considering quarantined individuals and complications. A global stability analysis of the mumps transmission model was performed, considering mortality and quarantine subpopulation. The Disease Free Equilibrium and Endemic Equilibrium Point are globally stable, confirmed by Lyapunov functions. Sensitivity analysis of the basic reproduction number shows that reducing birth rates and contact between infected and susceptible individuals effectively minimizes the infected population. However, increasing the natural death rate can reduce the total population, which may lower infections, but poses potential social and economic challenges for decision-makers.
Modifikasi Operator Weighted Backward Shift untuk Membentuk Operator Hypercyclic pada Ruang Barisan Nur Afandi; Damayanti, Septri; Widayati, Ratna
Griya Journal of Mathematics Education and Application Vol. 5 No. 2 (2025): Juni 2025
Publisher : Pendidikan Matematika FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/griya.v5i2.648

Abstract

The linear operator T: X --> X is called an hypercyclic operator if there exist such that the orbit of under the operator T is dense in X. This study aims to construct an explicit hypercyclic operator on the sequence space \(\ell^p\), by modifying the backward shift operator using a non-constant weight sequence. This approach differs from Rolewicz's classical method, which used constant weights. The method applied is constructive and formal, relying on deductive reasoning in mathematical proofs. Two operators—weighted left and right shifts—are introduced and their properties are analyzed, including their composition and iterative behavior. The main result is the construction of a specific operator \(S_\bold{a}\) weighted by \(\bold{a}=(a_n)\) that is proven to be hypercyclic. The proof involves demonstrating the existence of a vector whose orbit under \(S_\bold{a}\) is dense in \(\ell^p\).
Gastroprotective Potential of Medicinal Plant From Central Kalimantan: Sungkai Leaves (Peronema canescens Jack)-Ultrasonic Assisted Extraction in Rats Induced with Absolute Ethanol Savitri, Dilasari; Trinovita, Elsa; Widayati, Ratna; Handayani, Septi; Nugrahini, Sintha
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Peptic ulcer disease is a gastrointestinal disorder associated with significant morbidity and mortality. Enhancing the quality of life of patients with peptic ulcers often involves integrating conventional treatments with complementary alternative therapies. One such alternative therapy is herbal remedies, which local communities have long recognized. Sungkai leaves (Peronema canescens Jack) contain various bioactive components, including flavonoids, alkaloids, saponins, tannins, steroids, and phenolic compounds. This study aimed to assess the gastroprotective properties of sungkai leaf extract (Peronema canescens Jack) by analyzing the average size of gastric lesions in male Wistar rats exposed to absolute ethanol. The research used a true experimental design with a posttest-only control group approach involving six treatment groups, each consisting of four rats. Gastroprotective activity was macroscopically evaluated by measuring the average size of the gastric lesions. Statistical analyses were conducted using the Kruskal-Wallis and Mann-Whitney tests for post hoc comparisons. Results showed that the normal group had an average lesion size of 0 mm, the negative control group had 115.37±50.53 mm, and the positive control group had 7.40±2.57 mm. For the groups treated with sungkai leaf extract, the 100 mg/kgBW dose resulted in 6.86±3.83 mm lesions, the 200 mg/kgBW dose in 9.65±10.27 mm, and the 400 mg/kgBW dose in 29.50±19.68 mm. Statistical analysis using SPSS 26 revealed a significant difference between the groups,with a Kruskal-Wallis test result of p=0.002. These findings show that sungkai leaf extract exhibits gastroprotective activity compared with omeprazole, as seen by the smaller average size of gastric lesions in male Wistar rats treated with absolute ethanol.
Co-Authors Adelia, Sirli Adryannoor, Muhammad Rafli Arif Rahman Jabal Arini Ratnasari Augustina, Indria Balyas, Abi Bakring Dian Mutiasari, Dian Eka Susilowati, Eka Elsa Trinovita Fatmaria, Fatmaria Frethernety, Agnes Hamim Muntoha, Renal Hanasia, Hanasia Handayani, Septi Kristiani, Friska Merilia Dwi Lestarisa, Trilianty Ma'rifah, Umi Maulia, Desi Rahma Mizan Ahmad Natalia Sri Martani Nita Yulianti, Nita Nugrahini, Sintha Nuha, Alya Firyal Nur Afandi Patricia, Tisha Permatasari, Silvani rachmawati, Ramya Rakhman, Farizky Ranintha br Surbakti Ranti, Dalia Reviladi, Intrada Rian Ka Praja Savitri, Dilasari Septri Damayanti Sibarani, Juliet Valeria Sitorus, Elisabeth Prihana Rotua Sofiyati, noor Toemon, Agnes Immanuela Turnip, Oktaviani Naulita