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All Journal Jurnal Keperawatan dan Kesehatan Masyarakat CENDEKIA UTAMA Mutiara Medika: Jurnal Kedokteran dan Kesehatan The Indonesian Biomedical Journal JMM (Jurnal Masyarakat Mandiri) JCES (Journal of Character Education Society) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Bioscientia Medicina : Journal of Biomedicine and Translational Research Dinamika Journal : Pengabdian Masyarakat Jurnal Aisyah : Jurnal Ilmu Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal EMPATI (Edukasi Masyarakat, Pengabdian dan Bakti) Prosiding Seminar Nasional Program Pengabdian Masyarakat Prosiding University Research Colloquium Journal of Public Health Concerns Jurnal Pengabdian Pada Masyarakat JOURNAL OF Mother and Child Health Concerns JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit)
Brahmana, Ivanna Beru
Bagian Obstetri & Ginekologi, Program Studi Kedokteran, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta
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Mahkota Dewa (Phaleria macrocarpa) Fruit Extract Decrease Malondialdehyde, Tumor Necrosis Factor-α, and Caspase 3 Levels May Improve Infertility in Endometriosis Mice Brahmana, Ivanna Beru; Soetrisno, Soetrisno; Purwanto, Bambang; Pamungkasari, Eti Poncorini; Wasita, Brian; Budihastuti, Uki Retno; Pangestu, Mulyoto; Cempaka, Rita; Lestariningsih, Sri; Wulandari, Eka Tri; Maesaroh, Siti
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.2736

Abstract

BACKGROUND: Endometriosis, which often causes infertility, is characterized by a complex interplay between oxidative stress, inflammatory response, and apoptosis. Currently, the most effective therapy used for endometriosis is hormonal treatments, however it has many common side effects. Therefore, it is necessary to explore alternative treatments for endometriosis, including herbal ingredients. Phaleria macrocarpa fruit contains flavonoids with strong antioxidant and anti-inflammatory properties which have potency to improve fertility in endometriosis cases. However, assessments of whether P. macrocarpa might have any effect on oxidative stress, inflammatory response, and apoptosis in relation to endometriosis are still limited. This study was conducted to identify the effect of P. macrocarpa fruit ethanol extract (PMFEE) in improving infertility by assessing oxidative stress, inflammatory response, and apoptosis parameters in endometriosis mice model.METHODS: Female Balb/C mice were endometriosis-induced, and treated either with 6.5 µg/day Letrozole, 7.5 mg/kgBW/day PMFEE, or 15 mg/kgBW/day PMFEE for 14 days. Heatlhy mice were also included as control. Mice were necropsied, then the uterus and fat tissue around the uterus was collected. Malondialdehyde (MDA) as oxidative stress marker, tumor necrosis factor (TNF)-α as inflammatory marker, and Caspase-3 as apoptosis marker were assessed using enzyme-linked immunosorbent assay (ELISA).RESULTS: In uterus, MDA and TNF-α levels were significantly different among all groups (p<0.05). PMFEE both at 7.5 and 15 mg/kgBW/day lowered MDA and TNF-α compared to the healthy mice and mice receiving Letrozol. Meanwhile, Caspase-3 levels were quite indifferent among groups, showing that PMFEE was able to maintain the Caspase-3 levels in the endometriosis-induced mice.CONCLUSION: PMFEE reduces the MDA and TNF-α, also maintains Caspase-3 levels in the uterus of endometriosis-induced mice, suggesting it might have potential to improve fertility in endometriosis mice.KEYWORDS: Phaleria macrocarpa, endometriosis, infertility, MDA, TNF-α, Caspase-3
The effect of intervention using audio-visual media and demonstration on changes in feeding behavior and nutritional status of children under five Eny Retna Ambarwati; Reni Tri Lestari; Ivanna Beru Brahmana; Widyastuti Andriyani; Murgi Handari; Istichomah Istichomah; Agnes Erida Wijayanti; Riadinata Riadinata; Fika Pratiwi
THE JOURNAL OF Mother and Child Health  Concerns Vol. 5 No. 1 (2026): April Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Persatuan Perawat Nasional Indonesia (PPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/mchc.v5i1.2700

Abstract

Background: Childhood malnutrition remains a significant public health concern in Indonesia, with maternal knowledge and feeding practices playing a crucial role in determining children's nutritional outcomes.Purpose: to evaluate the effectiveness of a health promotion intervention combining audio-visual media and practical demonstrations in improving maternal feeding practices and the nutritional status of children under five. Method: A quasi-experimental one-group pretest–posttest design was conducted among 42 mothers and their under-five children at Tapak Dara Integrated Health Post, Bantul, Yogyakarta. Maternal knowledge and feeding practices were assessed using structured questionnaires, while children's nutritional status was measured through weight-for-age Z-scores. The intervention included educational video sessions followed by hands-on demonstrations. Data were analyzed using paired t-tests or Wilcoxon signed-rank tests and chi-square tests.Results: Most participants were of reproductive age (54.8%), had secondary education (59.5%), and were employed (76.2%). Post-intervention findings showed significant increases in knowledge scores (17.2 to 18.9; p<0.001) and practice scores (18.3 to 19.4; p<0.001). The proportion of children with good nutritional status improved from 61.9% to 73.8%. Significant associations were found between knowledge and feeding practices (p=0.012) and between feeding practices and nutritional status (p=0.008). Conclusion: Audio-visual and demonstration-based interventions effectively enhance maternal feeding practices and child nutritional status.
Co-Authors Ana Majdawati Ana Majdawati Ana Majdawati Ana Majdwati Andriyani, Widyastuti Ayu Laksmi Salsabila Ayu Laksmi Salsabila Bambang Purwanto Brian Wasita Desma Ayu Lestari Desma Ayu Lestari Devi Permata Sari devi permata sari Eka Tri Wulandari, Eka Tri Elsye Maria Rosa Eny Retna Ambarwati Erna Rochmawati Eti Poncorini Pamungkasari Farindira Vesti Rahmasari Farindira Vesti Rahmasari Fika Pratiwi Fitri Khoirunnisa Fitri Khoirunnisa Galuh Suryandari ika setyawati Iman Permana Inayati Inayati Inayati Inayati Intan Hanifah Mutmainnah Istichomah Istichomah Iswanto Iswanto Kiswarjanu, Dienda Sesioria Assyakur Larasati, Raden Rara Pandhan Budi Lilis Suryani Makiyyah, Nurul MULYOTO PANGESTU Murgi Handari Naufal Hanif Amrulloh Naufal Hanif Amrulloh Ravikha Aprilia Ganarsih Ravikha Aprilia Ganarsih Reni Tri Lestari Riadinata Riadinata Rita Cempaka Rizky Aprilia Kusumawardhani Rizky Aprilia Kusumawardhani Shanti Wardaningsih Siti Maesaroh SN Nurul Makiyah Soetrisno Soetrisno Sri Lestariningsih Sulistiari Retnowati Suryandari, Galuh Uki Retno Budihastuti Widyastuti Andriyani Wijayanti, Agnes Erida Yuliantini, Lisa Sophia