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All Journal Jurnal Kedokteran Brawijaya JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Syntax Literate: Jurnal Ilmiah Indonesia Preventif Journal Jambura Journal of Health Sciences and Research Jurnal Keperawatan Priority Jurnal Prima Medika Sains Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Empiricism Journal Kieraha Medical Journal Jurnal Impresi Indonesia Journal of Social Research Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Locus Penelitian dan Pengabdian Jurnal Sains dan Teknologi Buletin Kedokteran dan Kesehatan Prima Jurnal Pendidikan Indonesia (Japendi) Eduvest - Journal of Universal Studies Ranah Research : Journal of Multidisciplinary Research and Development Journal of Pharmaceutical and Sciences. JUKEJ: Jurnal Kesehatan Jompa
Suandy, Suandy
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Antibacterial activity of ashitaba leaf extract against Streptococcus pneumoniae Hutabarat, Tommy Daniel Patar P.; Suandy, Suandy; Natali, Oliviti; Djuang, Michelle Hendriani; Akbar, Khainir; Oentari, Widyaningsih; Putri, Riri Rizan; Dalimunthe, Siti Aisyah
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7824

Abstract

Infection by Streptococcus pneumoniae represents a significant global health concern, necessitating the exploration of novel antimicrobial agents, particularly in light of escalating antibiotic resistance. This study aimed to identify the phytochemical constituents and to evaluate the antibacterial activity of an ethanol extract of Ashitaba leaves (Angelica keiskei) against S. pneumoniae. This experimental study employed a post-only control group design. Extraction was performed using ethanol via maceration, followed by qualitative phytochemical screening. Antibacterial activity was assessed using the disc diffusion method at concentrations of 50, 100, and 150 mg/mL, with ciprofloxacin as a positive control. Inhibition zone data were analysed using non-parametric statistical tests. Phytochemical screening indicated the presence of flavonoids, alkaloids, saponins, tannins, glycosides, and steroids/triterpenoids. The extract demonstrated antibacterial activity with mean inhibition zones of 16.57 mm at 50 mg/mL, 26.23 mm at 100 mg/mL, and 29.87 mm at 150 mg/mL. Statistical analysis revealed no significant difference in inhibition zones among the three extract concentrations, whereas all concentrations differed significantly from the positive control, ciprofloxacin (53.67 mm). It is concluded that the ethanol extract of Ashitaba leaves contains diverse bioactive compounds and exhibits significant in vitro antibacterial activity against S. pneumoniae, although its efficacy remains inferior to the synthetic antibiotic ciprofloxacin.
Prevalence of ulcer disease among patients with diabetes mellitus at Royal Prima Hospital Medan Tua, Grace Angelina Tarigan; Amir, Widya Pasca; Suandy, Suandy; Sopacua, Erwin; Handayani, Putri; Tambunan, Adrian Nurrachman; Putra, Ananda Rahmat; Rahimi, Armon
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.7888

Abstract

Background: Diabetes mellitus is a chronic metabolic disorder with a rapidly increasing prevalence, often leading to serious complications such as diabetic ulcers, which significantly affect quality of life and increase healthcare costs. This study aimed to determine the prevalence of ulcers in patients with diabetes mellitus treated at Royal Prima Medan Hospital and to analyze the associated factors. Methods: This quantitative observational study employed a retrospective design and analyzed medical record data collected between 2021 and 2025. A total of 58 patients were selected using purposive sampling. Data analysis was conducted using the Chi-Square test and ANOVA with a 95% confidence level. Results: The majority of the respondents were male (63.8%) and within the 56–65-year age group (34.5%). The most common skin condition was diabetic ulcers (82.8%), followed by diabetic bullae (12.1%) and viral infections (5.2%). The mean blood glucose level was 246.33 mg/dL, indicating hyperglycemia. Statistical analysis revealed no significant association between gender and skin disease type (p = 0.895) and no significant difference in blood glucose levels across types of skin disease (p = 0.135). Conclusion: There was no significant correlation between skin disease type and blood glucose levels, suggesting that clinical management should also address other behavioral and metabolic factors.
The Effect of Single Garlic Extract (Allium Sativum Var. Solo Garlic) Administration on Weight Gain in Male Rattus Wistar Rats with Dyslipidemia Miranda Winda Sari Sitorus; Suandy, Suandy; Linda Chiuman
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 5 (2025): Oktober 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i5.6494

Abstract

Background: Dyslipidemia is an abnormal condition (increase or decrease) in cholesterol lipoproteins, including an increase in total cholesterol, triglycerides, and low-density lipoprotein (LDL) levels, as well as a decrease in high-density lipoprotein (HDL) levels. Metabolism plays a role in converting nutrients into compounds necessary for life processes, such as energy sources (ATP). Research Objective: To determine the effect of administering single garlic extract (Allium sativum var solo garlic) on weight gain in male Rattus winstar rats with dyslipidemia. Research Methods: This quasi-experimental study used 24 male Wistar rats, single garlic extract, butter, quail eggs, used cooking oil, and scales. The study population consisted of 24 male Wistar rats, which were divided into four groups of six rats each using Federer's formula. The treatments in this study were: the positive group was given standard feed and simvastatin; the negative group was given standard feed and aquabides; treatment group 1 was given 200 mg/kgBW of single garlic extract; and treatment group 2 was given 400 mg/kgBW of single garlic extract. Body weight assessments were conducted four times, namely on days 7, 14, 21, and 28. The research data analyzed were total cholesterol, LDL count, HDL count, triglyceride count, and body weight. Data were analyzed for normality using the Shapiro-Wilk test, and if normally distributed, continued with a one-way parametric ANOVA test and Tukey HSD post-hoc test. Data were analyzed using IBM SPSS 23 for Windows, with P values < 0.05 interpreted as statistically significant. Research Results: The mean values and standard deviations for the positive group were 234±13.20 on day 7, 223±12.29 on day 14, 231.83±11.99 on day 21, and 227.5±10.15 on day 28. Negative group on day 7 (237.33±18.52), day 14 (240±7.84), day 21 (238.5±17.28) and day 28 (239.16±9.62). Treatment 1 on day 7 (261.5±27.22), day 14 (296±21.63), day 21 (316.33±21.05) and day 28 (334.16±17.03). Treatment 2 on day 7 (290±10.62), day 14 (327.16±7.41), day 21 (344.33±45.39) and day 28 (385.83±13.43). Administration of 400 mg/kgBW single garlic extract significantly (P = 0.02 < 0.05) increased the body weight of rats compared to the positive and negative control groups. Conclusion: Based on the results of this study, single garlic extract in test animals showed an increase in body weight in dyslipidemic rats, indicating the need for further research on the mechanism of weight gain due to the administration of single garlic extract.
Co-Authors Adek Amansyah Amir, Widya Pasca Ananda, Rayhan Khozin Aulia Andri Hidayat, Andri Aulia, Nathasyia Aurellia, Fransisca Buaya, Adjani Budi, Andre Caroline S, Cecilia Chairul, Muhammad Chiuman, Linda Colin, Vito Cristoffel, Abraham Dalimunthe, Siti Aisyah Dewani, Yunita Dhea F. Mendrofa, Dorkas Djuang, Michelle Hendriani Epafroditus, Nikos Febriyanti Gulo, Putri Gusbakti Rusip Halim, Angel Jonathane Handoko, Erwin Hanna, Jessica Lise Henny Henny, Henny Hura, Risna Pebriani Hutabarat, Tommy Daniel Patar P. Joshua Hamonangan Tua Rajagukguk, Samuel kasdir, Kasdir Khainir Akbar, Khainir Lubis, Ilham Akbar Lumban Gaol, Nova Elisabeth Lumban Tobing, Andrico Napolin Lumbantobing, Andrico Napolin Luwis, Kevin Mahulae, Aris Josua Manurung, Rachel Gita Berlian Mauli, Cleorisa Adventina Miranda Winda Sari Sitorus Mutia, Maya Sari Nadapdap, Marshall Jeremia Nasution, Ali Napiah Nasution, M. Andriady Saidy Natali, Oliviti Neswita, Elfia Oentari, Widyaningsih Putra, Ananda Rahmat Putri Handayani Putri, Indah Juwita Dwi Putri, Riri Rizan Rahimi, Armon Rajagukguk, Samuel Joshua Hamonangan Tua Rambe, Martina Lailam Rambe, Natasya Septiana Rohen, Rohen Rudi Chandra Salsabila Purba, Putri Yasmin Sanoesi, Vindelin Sinaga, Maretha Ezra Tabitha Sitompul, Fernandes Sitorus, Dwi Novita Sopacua, Erwin Susianto Susianto Tambunan, Adrian Nurrachman Taniago, Davina Tarigan, Aditya Aginta Tarigan, Setia Budi Tobing, Andrico Napolin Lumban Tua Rajagukguk, Samuel Joshua Hamonangan Tua, Grace Angelina Tarigan Widhiasi, Lia Kristiani Widya Yanti Sihotang Wienaldi, Wienaldi Yolanda Eliza Putri Lubis Yumardika, Deza Zai, Arni Marlinda Zendrato, Ronauli Muliani Zuhdi, Muhammad Fikri Zuhra, Layla