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Suandy, Suandy
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Pengaruh Ekstrak Kulit Durian Sidikalang Terhadap Kadar Glukosa dan Histopatologi Pankreas Tikus Wistar Budi, Andre; Tarigan, Aditya Aginta; Suandy, Suandy
JUKEJ : Jurnal Kesehatan Jompa Vol 4 No 3 (2025): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol4.Iss3.1994

Abstract

Diabetes melitus merupakan masalah kesehatan global. Ekstrak kulit durian (Durio zibethinus) kaya senyawa fenolik, berpotensi antidiabetik. Tujuan penelitian ini adalah untuk menilai efek antihiperglikemik serta proteksi histologis pankreas ekstrak kulit durian pada tikus Wistar yang diinduksi aloksan. Penelitian ini menggunakan desain eksperimental dengan kelompok kontrol dan beberapa dosis ekstrak. Kadar glukosa darah diukur pada baseline, setelah induksi, dan pada hari ke-5,10,15. Pankreas diperiksa secara histopatologi dan jumlah pulau Langerhans dihitung. Hasil penelitian menunjukan bahwa ekstrak kulit durian sidikalang menurunkan glukosa darah secara bermakna pada hari ke‑15 dibanding kontrol, dengan kecenderungan respons dosis. Kerusakan histologis acinar/insula tidak berbeda bermakna, namun jumlah pulau Langerhans kelompok ekstrak lebih tinggi signifikan dibanding kontrol (p=0,006). Kesimpulan ekstrak kulit durian menunjukkan efek antihiperglikemik dan menjaga pulau Langerhans pada model aloksan, sehingga berpotensi sebagai adjuvan fitoterapi untuk pengendalian glukosa. Penelitian lanjutan perlu menguji biomarker stres oksidatif dan uji toleransi glukosa untuk memperkuat mekanisme.
Efek Ekstrak Kulit Durian (Durio zibethinus) Terhadap Kadar Glukosa Darah dan Histopatologi Hepar Tikus Wistar yang Diinduksi Aloksan Hura, Risna Pebriani; Budi, Andre; Suandy, Suandy
JUKEJ : Jurnal Kesehatan Jompa Vol 4 No 3 (2025): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol4.Iss3.2005

Abstract

Kulit durian (Durio zibethinus) kaya flavonoid yang berpotensi menurunkan glukosa darah dan melindungi hepar, namun bukti in vivo terstandar masih terbatas. Tujuan: Mengevaluasi efek ekstrak kulit durian terhadap kadar glukosa darah dan gambaran histopatologi hepar pada tikus Wistar yang diinduksi aloksan. Metode: Dua puluh lima tikus jantan diacak ke lima kelompok: kontrol negatif, kontrol positif (metformin 45 mg/kgBB), serta ekstrak 125, 250, dan 500 mg/kgBB (per oral). Glukosa darah diukur pra-induksi, pasca-induksi, hari ke-5, 10, dan 15; jaringan hepar dinilai semikuantitatif (nekrosis, kongesti, inflamasi) oleh penilai tersamar. Analisis menggunakan model berulang lintas waktu dan uji lanjutan yang sesuai. Hasil: Setelah induksi, terjadi hiperglikemia pada semua kelompok. Penurunan glukosa bermakna terlihat pada hari ke-10 dan 15 (p<0,05), dengan efek terbesar pada metformin, diikuti dosis ekstrak 250–500 mg/kgBB. Skor histopatologi hepar tidak berbeda bermakna antar kelompok. Kesimpulan: Ekstrak kulit durian menunjukkan aktivitas antihiperglikemik yang bergantung dosis, sementara bukti hepatoprotektif belum konklusif pada ukuran sampel ini. Diperlukan standarisasi ekstrak dan uji dengan daya (power) memadai untuk konfirmasi.
Strain Bakteri Asam Laktat SBM10 dari Matriks Berbasis Nabati Berupa Fermentasi Sirup Beras Merah: Evaluasi Keamanan In Vitro dan Karakterisasi Colin, Vito; Suandy, Suandy; Chiuman, Linda
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1099

Abstract

Plant-based fermentation offers a route to develop nondairy probiotic candidates, yet syrup-like matrices remain underexplored compared with solid or beverage systems. This study investigated fermented red rice syrup (prepared from red rice and barley malt powder) as a source of lactic acid bacteria (LAB) and advanced one isolate, SBM10. Cultivation on MRS supplemented with CaCO₃ yielded acidogenic colonies. A stable morphotype (SBM10) was purified and exhibited a LAB consistent profile, Gram-positive rods, catalase negative, TSIA K/A without H₂S, Simmons citrate negative, gelatinase negative, CO₂ positive in Durham and γ-hemolytic on 5% sheep blood agar. Under gastrointestinal stress models (4 h, 37 °C), tolerance relative to controls was 27.14% at pH 3.0 and 35.58% in 0.3% oxgall. In disk diffusion assays, the cell-free supernatant (CFS) showed no inhibition of Escherichia coli or Staphylococcus aureus. Thus, no antibacterial activity was detected by disk diffusion under the conditions tested, whereas amoxicillin produced zones of 13.95 mm and 12.43 mm, respectively. SBM10 presents a safety-supportive, LAB-typical profile with partial tolerance to gastric-like acidity and bile. Although no disk diffusion antagonism was detected for the CFS, the results motivate taxonomic confirmation and process/formulation optimization, such as improving acid/bile robustness and re-evaluating antimicrobial potential with complementary assays, to clarify the suitability of SBM10 for plant-based functional applications.
Escherichia Coli Contamination Test on Thai Tea Drinks in the Ayahanda Street Area Using the MPN Method Dhea F. Mendrofa, Dorkas; Joshua Hamonangan Tua Rajagukguk, Samuel; Suandy, Suandy
Journal of Social Research Vol. 4 No. 11 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i10.2854

Abstract

Thai tea is one of the drinks that are popular with urban people. However, the less hygienic processing and presentation can be a source of microbiological contamination. This study aims to detect the presence of Escherichia coli in Thai tea drinks sold on Jalan Ayahanda, Medan, using the Most Probable Number (MPN) method. The research design was quantitative descriptive with a laboratory experimental approach, using ten samples from Thai tea sellers. The results showed that all samples were positive for coliform with an MPN value of 15–460 MPN/100 mL, eight samples were positive for the BGLB confirmatory test, and one sample (10%) was positive for Escherichia coli in EMB media. Based on the SNI standard (0/100 mL), the positive sample was declared unfit for consumption. These findings confirm the importance of implementing good hygiene and sanitation in the processing and sale of beverages to ensure food safety. They also contribute to the limited body of knowledge on street-level food safety risks in densely populated urban corridors and highlight the urgent need for strengthened street-food hygiene monitoring and consumer awareness to prevent microbial foodborne illness.
Efektivitas Ekstrak Bawang Putih Tunggal Terhadap Gambaran Histopatologi Ginjal Dan Kadar Ureum Kreatinin Rattus Novergicus Yang Mengalami Dislipidemia Rambe, Natasya Septiana; Suandy, Suandy; Chiuman, Linda
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62239

Abstract

Heart disease and kidney failure are both increased by dyslipidemia. There are a lot of antioxidant and nephroprotective chemicals in just one clove of garlic (Allium sativum L.), including allicin, flavonoids, and organosulfur compounds. This study set out to examine the effects of a single garlic extract on the urea, creatinine, and uric acid levels in rats with dyslipidemia (Rattus norvegicus). There was an examination of the renal histopathology picture as well. This research used an experimental tack by using a control group design with pre- and post-tests. Each of the four groups consisted of 24 male Wistar rats' tails: the control group (aquades), the experimental group (simvastatin 2.1 mg/kgBB), the garlic extract alone group (200 mg/kgBB), and the highest dose (400 mg/kgBB). Each group followed a high-fat diet for a full month. Both the 200 mg/kgBB and 400 mg/kgBB doses of garlic extract significantly decreased the levels of ureum, creatinine, and uric acid (p<0.05) as compared to the negative control group. Kidney histopathology also revealed improvement, with less congestion, necrosis, and cell death. The positive control and the 400 mg/kgBB group showed similar effects after delivery. Rats with dyslipidemia showed improvements in renal histology and decreased levels of ureum, creatinine, and uric acid after administration of a single garlic extract.
Hubungan Konsumsi Kopi Dengan Kadar Asam Urat, Kolestrol, dan Body Mass Index (BMI) di Warkop Asli Medan Ananda, Rayhan Khozin Aulia; Lubis, Yolanda Eliza Putri; Suandy, Suandy
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62247

Abstract

Coffee consumption has become part of people's lifestyle, especially among the productive age group. Coffee contains active compounds known to affect purine metabolism, lipid profile, and nutritional status. This study aims to analyze the relationship between coffee consumption and uric acid levels, cholesterol, and Body Mass Index (BMI) among consumers at Warkop Asli Medan. This study employed a descriptive observational design with a cross-sectional approach conducted from May to August 2025. A total of 96 respondents were selected using purposive sampling technique. Data were collected through questionnaires and direct examinations including uric acid levels, cholesterol, and BMI measurements. Data analysis used chi-square test with significance level of α = 0.05. The majority of respondents were male (65.6%) with moderate coffee consumption (59.4%). Examination results showed 81.3% of respondents had normal uric acid levels, 76.0% had normal cholesterol levels, and 60.4% had normal BMI. Bivariate analysis showed no significant relationship between coffee consumption and uric acid levels (p=0.426), BMI (p=0.160), and cholesterol (p=0.905). There is no significant relationship between coffee consumption and uric acid levels, cholesterol, and BMI among consumers at Warkop Asli Medan.
Uji Daya Hambat Kombinasi Ekstrak Daun Nanas (Ananas Comosus (L.) Merr.) dan Daun Sirih Hijau (Piper Betle L.) Terhadap Bakteri Propionibacterium Acnes dan Staphylococcus Aureus Zuhra, Layla; Lubis, Yolanda Eliza Putri; Suandy, Suandy
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62296

Abstract

Jerawat vulgaris merupakan kondisi inflamasi kronis pada kelenjar pilosebasea yang ditandai dengan berbagai jenis lesi. Bakteri utama yang berperan dalam patogenesis jerawat adalah Propionibacterium acnes dan Staphylococcus aureus. Terapi antibiotik konvensional dapat menimbulkan efek samping dan resistensi, sehingga diperlukan alternatif antimikroba dari bahan alam. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri kombinasi ekstrak etanol daun nanas (Ananas comosus (L.) Merr.) dan daun sirih hijau (Piper betle L.) terhadap bakteri P. acnes dan S. aureus. Ekstrak dibuat dengan metode maserasi menggunakan etanol 96% pada konsentrasi 20%, 40%, dan 60%. Uji antibakteri dilakukan menggunakan metode difusi cakram (Kirby-Bauer) pada media Nutrient Agar, dengan klindamisin sebagai kontrol positif dan aquadest sebagai kontrol negatif. Hasil penelitian menunjukkan bahwa kombinasi ekstrak pada semua konsentrasi mampu membentuk zona hambat terhadap P. acnes (diameter rata-rata: 20,23 mm; 22,69 mm; 24,85 mm) dan S. aureus (diameter rata-rata: 20,51 mm; 20,23 mm; 24,74 mm), dengan zona hambat terbesar pada konsentrasi 60%. Analisis statistik menunjukkan perbedaan signifikan pada P. acnes (p = 0,016), namun tidak pada S. aureus (p = 0,284). Temuan ini mendukung potensi kombinasi ekstrak daun nanas dan sirih hijau sebagai alternatif agen antibakteri topikal untuk pengobatan jerawat, khususnya terhadap P. acnes. Penelitian lebih lanjut diperlukan untuk mengkaji mekanisme kerja dan keamanan penggunaannya.
DAMPAK PEMBERIAN SIRUP BERAS MERAH FERMENTASI BUBUK BARLEY TERHADAP BERAT BADAN TIKUS WISTAR DIABETES YANG DIINDUKSI ALOKSAN Suandy, Suandy; Aurellia, Fransisca; Nasution, M. Andriady Saidy
Jambura Journal of Health Sciences and Research Vol 6, No 4 (2024): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v6i4.27569

Abstract

Pengobatan farmakologis diabetes menghadapi tantangan berupa biaya tinggi dan resiko hipoglikemia, sehingga diperlukan alternatif pemanis pengganti gula. Kebaruan penelitian ini karena menggunakan beras merah yang difermentasi terhadap perubahan berat badan tikus diabetes. Tujuan penelitian untuk mengevaluasi dampak sirup beras merah yang difermentasi dengan bubuk malt barley terhadap berat badan tikus yang diinduksi aloksan. Penelitian ini menggunakan metode ekperimen murni dengan desain pre test dan post test yang menggunakan tikus wistar (Rattus norvegicus) pada empat kelompok yang dibagi acak yaitu K-, K+, P1, dan P2. Berat badan diukur pada hari ke-0, 7, 14, 21, dan 28. Hasil Tukey HSD menunjukkan bahwa terdapat perbedaan bermakna antara kelompok kontrol negatif dengan kelompok dosis 15 mg/kgBB dengan nilai p=0,023 (p 0,05). Kesimpulan penelitian ini bahwa pemberian sirup beras merah dengan dosis 15 mg/kg BB efektif dalam meningkatkan berat badan tikus diabetes. Hal ini mengindikasikan bahwa sirup beras merah bisa menjadi alternatif terapi untuk diabetes karena kandungan aktif dalam sirup beras merah berperan dalam perbaikan sel beta pankreas dan produksi insulin.
Antimicrobial Activity Test of The Combination of Pineapple Leaf Extract (Ananas Comosus) and Green Betel Leaf Extract (Piper Betle L) Against Candida Albicans Buaya, Adjani; Lubis, Yolanda Eliza Putri; Suandy, Suandy
Journal of Social Research Vol. 4 No. 11 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i10.2841

Abstract

Candida albicans is an opportunistic fungus that can cause infections, especially in individuals with low immune systems. Efforts to control this fungal infection can be done by utilizing natural ingredients as an alternative antifungal. Pineapple leaves (Ananas comosus) and green betel leaves (Piper betle L) are known to contain active compounds with antimicrobial properties. This study aims to determine the inhibitory power of a combination of pineapple leaf and green betel leaf extracts on the growth of Candida albicans and to compare their effectiveness at various concentrations. This research is a laboratory experimental study using the disc diffusion method. Three groups of extract concentration combinations were used: 20%, 40%, and 60%. The diameter of the inhibition zone was measured in millimeters, and data were analyzed using a one-way ANOVA test followed by a Tukey HSD test. The results showed that the 20% concentration produced the largest average inhibition zone diameter of 38.32 mm, while the 40% and 60% concentrations produced 28.46 mm and 28.31 mm, respectively. The ANOVA test showed a significant difference between groups (p < 0.05), and the Tukey HSD test showed that the 20% concentration was significantly different from the other two groups. The combination of pineapple leaf and green betel leaf extracts at a concentration of 20% was the most effective concentration in inhibiting the growth of Candida albicans compared to concentrations of 40% and 60%.
Effectiveness of Earthworm Extract on the Lipid Profile of Diabetic Wistar Rats Suandy, Suandy; Chiuman, Linda; Halim, Angel Jonathane
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.3

Abstract

Various metabolic diseases, such as diabetes mellitus, are characterized by hyperglycemia, stemming from decreased insulin action, secretion, or both. The use of chemical medicines for diabetes mellitus, especially acarbose, involves regulating the digestion and absorption of complex carbohydrates. However, acarbose may disrupt liver function, prompting exploration into alternative sources for treatment, such as earthworm extract. The purpose of this study was to identify the effectiveness of ethanol extract and coelomic fluid from earthworms (E. eugeniae) on the lipid profile of male diabetic wistar rats (R. norvegicus) in vivo. The research hypothesis is that earthworm extracts could effectively lower the lipid profile of diabetic Wistar rats. This research is experimental research with pre-test and post-test control study group design, using an in vivo method. The results of the one-way ANOVA test of HDL were p=0.441; p=0.441; p=0.000; for LDL were p=0.691; p=0.101; p=0.049; for total cholesterol were p=0.107; p=0.347; p=0.486; and for triglycerides were p=0.028; p=0.926; p=0.553 on days 0, 7, and 14, respectively. Based on the research data, both ethanol extract and a combination of ethanol extract and coelomic fluid were able to reduce lipid profile levels on the 7th and 14th days. Earthworm extract has the potential to promote repair of β cells and is anti-inflammatory which can be used to reduce lipid profile levels.
Co-Authors Adek Amansyah Ananda, Rayhan Khozin Aulia Andri Hidayat, Andri Aulia, Nathasyia Aurellia, Fransisca Buaya, Adjani Budi, Andre Caroline S, Cecilia Chairul, Muhammad Chiuman, Linda Colin, Vito Cristoffel, Abraham Dewani, Yunita Dhea F. Mendrofa, Dorkas Epafroditus, Nikos Febriyanti Gulo, Putri Gusbakti Rusip Halim, Angel Jonathane Handoko, Erwin Hanna, Jessica Lise Henny Henny, Henny Hura, Risna Pebriani Jannah, Ratu Mutiara Raudhatul Joshua Hamonangan Tua Rajagukguk, Samuel kasdir, Kasdir Lubis, Ilham Akbar Lumban Gaol, Nova Elisabeth Lumban Tobing, Andrico Napolin Lumbantobing, Andrico Napolin Luwis, Kevin Mahulae, Aris Josua Manurung, Rachel Gita Berlian Mauli, Cleorisa Adventina Mutia, Maya Sari Nadapdap, Faskanita Maristella Nasution, Ali Napiah Nasution, M. Andriady Saidy Neswita, Elfia Putri, Indah Juwita Dwi Rajagukguk, Samuel Joshua Hamonangan Tua Rambe, Martina Lailam Rambe, Natasya Septiana Rohen, Rohen Sanoesi, Vindelin Sinaga, Maretha Ezra Tabitha Sitompul, Fernandes Susianto Susianto Syahputra, Fahmi Syifa, Talitha Tarigan, Aditya Aginta Tarigan, Setia Budi Tobing, Andrico Napolin Lumban Tua Rajagukguk, Samuel Joshua Hamonangan Widhiasi, Lia Kristiani Widya Yanti Sihotang Wienaldi, Wienaldi Yolanda Eliza Putri Lubis Yumardika, Deza Zai, Arni Marlinda Zendrato, Ronauli Muliani Zuhdi, Muhammad Fikri Zuhra, Layla