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Suandy, Suandy
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Antibacterial activity of ashitaba leaf extract against Streptococcus pneumoniae Hutabarat, Tommy Daniel Patar P.; Suandy, Suandy; Natali, Oliviti; Djuang, Michelle Hendriani; Akbar, Khainir; Oentari, Widyaningsih; Putri, Riri Rizan; Dalimunthe, Siti Aisyah
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7824

Abstract

Infection by Streptococcus pneumoniae represents a significant global health concern, necessitating the exploration of novel antimicrobial agents, particularly in light of escalating antibiotic resistance. This study aimed to identify the phytochemical constituents and to evaluate the antibacterial activity of an ethanol extract of Ashitaba leaves (Angelica keiskei) against S. pneumoniae. This experimental study employed a post-only control group design. Extraction was performed using ethanol via maceration, followed by qualitative phytochemical screening. Antibacterial activity was assessed using the disc diffusion method at concentrations of 50, 100, and 150 mg/mL, with ciprofloxacin as a positive control. Inhibition zone data were analysed using non-parametric statistical tests. Phytochemical screening indicated the presence of flavonoids, alkaloids, saponins, tannins, glycosides, and steroids/triterpenoids. The extract demonstrated antibacterial activity with mean inhibition zones of 16.57 mm at 50 mg/mL, 26.23 mm at 100 mg/mL, and 29.87 mm at 150 mg/mL. Statistical analysis revealed no significant difference in inhibition zones among the three extract concentrations, whereas all concentrations differed significantly from the positive control, ciprofloxacin (53.67 mm). It is concluded that the ethanol extract of Ashitaba leaves contains diverse bioactive compounds and exhibits significant in vitro antibacterial activity against S. pneumoniae, although its efficacy remains inferior to the synthetic antibiotic ciprofloxacin.
Co-Authors Ananda, Rayhan Khozin Aulia Andri Hidayat, Andri Aulia, Nathasyia Aurellia, Fransisca Budi, Andre Caroline S, Cecilia Chairul, Muhammad Chiuman, Linda Cristoffel, Abraham Dalimunthe, Siti Aisyah Dewani, Yunita Djuang, Michelle Hendriani Epafroditus, Nikos Febriyanti Gulo, Putri Gusbakti Rusip Halim, Angel Jonathane Handoko, Erwin Hanna, Jessica Lise Henny Henny, Henny Hura, Risna Pebriani Hutabarat, Tommy Daniel Patar P. kasdir, Kasdir Khainir Akbar, Khainir Lubis, Ilham Akbar Lumban Tobing, Andrico Napolin Lumbantobing, Andrico Napolin Luwis, Kevin Mahulae, Aris Josua Manurung, Rachel Gita Berlian Mutia, Maya Sari Nadapdap, Marshall Jeremia Nasution, Ali Napiah Nasution, M. Andriady Saidy Natali, Oliviti Neswita, Elfia Oentari, Widyaningsih Putri, Indah Juwita Dwi Putri, Riri Rizan Rambe, Natasya Septiana Rohen, Rohen Salsabila Purba, Putri Yasmin Sanoesi, Vindelin Sitompul, Fernandes Susianto Susianto Tarigan, Aditya Aginta Tarigan, Setia Budi Tobing, Andrico Napolin Lumban Tua Rajagukguk, Samuel Joshua Hamonangan Widhiasi, Lia Kristiani Widya Yanti Sihotang Wienaldi, Wienaldi Yolanda Eliza Putri Lubis Yumardika, Deza Zai, Arni Marlinda Zendrato, Ronauli Muliani Zuhdi, Muhammad Fikri Zuhra, Layla