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Journal : Jurnal Farmasi

Uji Aktivitas Antioksidan Kombinasi Ekstrak Sarang Semut ( Myrmecodia Pendans) dan Daun Sirsak (Annona muricata) dengan Metode DPPH (2,2-diphenyl-1-picrilhidrazyl) Wimpy; Suharyanto
Jurnal Farmasi (Journal of Pharmacy) Vol. 3 No. 1 (2014): Jurnal Farmasi (Journal of Pharmacy), October 2014
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Free radicals are highly reactive molecules containing one or more unpaired electrons in its outer orbital Free radicals attackelectron binding molecules in the surrounding areas. Malfunctioning cells, damage cell structures, and even mutations are the effects of free radical. Antioxidants can inhibit reactive oxygen and free radicals in the human body. The compound flavonoid, which is contained in thesoursop’s leaf and sarang semut act as anti-oxidants. This researchaimsto test the antioxidant activity of the combination of extracted sarang semut (Myrmecodia pendans) and Soursop’s leaf (Annona muricata) with DPPH (2,2-diphenyl-1-picrilhidrazyl) method. This researchwas conducted by plant extraction Sarang semut and soursop’s leaf with maceration The results showed that ultrasonic extraction techniqueall fractions are detected such as alkaloids, flavonoids, saponins and tannins, water fraction of sarang semut has76.64 ppm IC50 and the butanol fractions has 76.82 ppm IC50, the combination of extracted sarang semut and extracted soursop’s leaf (1: 1) have 71.09 ppm IC50, the water fraction soursop leafhas 73.48 ppm IC50, and butanol fraction has 99.70 ppm so we can conclude that the water fraction of sarang semut is better than butanol fraction of sarang semut extract. The combination between extracted soursop’sleaf and extracted sarang semut with a ratio of 1: 1 has a better antioxidant activity than the singular.
Metode Ekstraksi Sarang Semut (Myrmecodia Pendans) dengan Teknik Maserasi untuk Menghasilkan Obat Alternatif Kanker Paru Suharyanto; Purwono, Bambang
Jurnal Farmasi (Journal of Pharmacy) Vol. 4 No. 1 (2015): Jurnal Farmasi (Journal of Pharmacy), October 2015
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Cancer is a growing cells of any type of cell and tissue in the body anywhere, a large number of diseases are characterized by tissue and cell type of origin. Each year found nearly 6 million new patients known to have cancer, and more than 4 million of them died. Until now cancer treatment is done by 3 ways: surgery, radiation, and drug delivery of anti -neoplastic or anti- cancer. However, all three treatments over a lot of side effects to the patient. This study aims to conduct a series of pre-clinical trials to determine the optimal dose of Sarangsemut plant ( Myrmecodia pendens ) can be used as a drug to cure lung cancer. The specific objective of this research is to extract Sarangsemut plant ( Myrmecodia pendens ) and soursop leaves to produce drugs alterlatif cancer disease. Benefits of this research can be used.
Uji Praklinis Anti-Kanker Myrmecodia Pendans Pada Tikus Putih yang Diinduksi 7,12 –dymethylbenz[α]anthracene (DMBA) Suharyanto; Haryadi, Winarto
Jurnal Farmasi (Journal of Pharmacy) Vol. 7 No. 1 (2018): Jurnal Farmasi (Journal of Pharmacy), October 2018
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Cancer is a growing cells of any type of cell and tissue in the body anywhere, a large number of diseases are characterized by tissue and cell type of origin . Each year found nearly 6 million new patients known to have cancer, and more than 4 million of them died. Until now cancer treatment is done by 3 ways: surgery, radiation, and drug delivery of anti -neoplastic or anti- cancer. The treatments is good however over a lot of side effects to the patient. This study aims to conduct a series of pre-clinical trials to determine the optimal dose of Myrmecodia pendens can be used as a drug to cure lung cancer .The specific objective of this research is to extract Myrmecodia pendens Plant to produce drugs alternative cancer disease. Benefits of this research can be used directly by the public to be used as an herbal medicine, to treat cancer Testing is done by creating a model of lung cancer cells from rats induced with 7,12-dimethylbenz[a]anthracene (DMBA) as much as 10 times along 5 weeks. Therapy is done by adding 250mg/kgW, 500 mg/kgW and 750 kg/KgW extracts Based on the Histopathology test showed that Myrmecodia Pendans extract dose of 750 mg / kg body weight can improve lung tissue damaged by exposure to DMBA.
Co-Authors Adi Darmawan Aditya, Nurdicky Febrian Ahmad Sulaiman, Ahmad Akbar, Raden Mohamad Adha Alimah, Nadhira Inas Andri Yano, Aan Anggraini, Anastasia Puspa Anggraini, Rika Zulvamita Asep Sofyan Azizah Shalihah A Bambang Haryanto Bambang Purwono Barokah, Sinatria Bayu Adi Bieng Brata Charlos Malino Dendi Haris Dwijayanti, Ririn Dyah Ari Wulandari Edi Sulistyawan Fachrudy Asj'ari Fachrudy Asj’ari Faradilla Rosita Firdausia, Yuli Kurnia Firmansyah, Angga Maulana Ghozin Hari Nugroho Hartika, Citra Haura Zahra , Winsa Hayati, Rini Nur Hermawan, Angga I Made Bagus Dwiarta Ismiarti Istrianto, Kadi Kadori Krisna Murti Anugraha Kurman, Mathilda Laksamana, Patria Larasati, Rakhma Fitria Latif, Nashrudin Mahardhika, Bogie Prastowo Mantani, Sayuri Mildawani , M.M.T.S Mohammad Afrizal Miradji Muhammad Hakim A Maulana Ishaq Mulyono S. Baskoro Muslimin, Muhammad Syahrizal Mustaruddin Nashrudin Latif Nurdina Nurdina Nuri Sabilah, Liha Nurlela, Eli Perangin angin, Robet Pranata, Maulana Septian Dwi Pratiwi, Nugraheni Nur Prayitno, Muhamad Riyono Edi Purbo Wartoyo, Bayu Puspito, Sigit Rahayu, Risma Dewi Nur Robi’ati Fauziyah Rufi’i Sabariah Sari, Ratih Purnama Saripudin Saripudin Suhardiyah, Martha Sulistyowati, Beta Indi Sumaryo Supriyanto Suripin Susilowati Sutrisno, Bagus Oktori TAUDLIKHUL AFKAR Tony Susilo Wibowo Ulfa Puspa Wanti Widodo Ully Wulandari, Ully untung lasiyono Urip Santoso Wahju Krisna Hidajat Wardi Warnoto Widiar Onny Kurniawan Wimpy Winarto Haryadi Woki Bilyaro Yurike