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All Journal Jurnal Biometrika dan Kependudukan (Journal of Biometrics and Population) Jurnal Penelitian Kesehatan Suara Forikes Health Notions Manuju : Malahayati Nursing Journal 2-TRIK: TUNAS-TUNAS RISET KESEHATAN Jurnal Analis Medika Biosains (JAMBS) Poltekita : Jurnal Ilmu Kesehatan JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan Jurnal Teknokes International Journal of Advanced Health Science and Technology HEALTHY: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Pengabdian Kepada Masyarakat Mulawarman JHeS (Journal of Health Studies) SEHAT : JURNAL KESEHATAN TERPADU Analis Kesehatan Sains (e-Journal) Jurnal Rakat Sehat : Pengabdian Kepada Masyarakat Jurnal Sains Student Research Jurnal Pengabdian Kesehatan Beguai Jejama Health Dynamics Media Penelitian dan Pengembangan Kesehatan Jurnal Teknokes
Endarini, Lully Hanni
Jurusan Teknologi Laboratorium Medis Poltekkes Kemenkes Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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EFEKTIVITAS PEMBERIAN TABLET TAMBAH DARAH TERHADAP KADAR HEMOGLOBIN PADA SISWI Susanti, Reni; Krihariyani, Dwi; Endarini, Lully Hanni; Suliati, Suliati
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 4 No. 2 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v4i2.6391

Abstract

ABSTRACT Iron deficiency anemia is a common nutritional problem among adolescent girls in developing countries such as Indonesia, affecting both health and academic performance. The government has implemented a school-based iron supplementation program to address this issue. This study aims to evaluate the effectiveness of iron tablet supplementation in increasing hemoglobin levels among 10th-grade female students at MAN 3 Magetan. The study used a quasi-experimental design with a one-group pre-test and post-test approach. A total of 122 students aged 15–18 years participated based on inclusion criteria and parental consent. The intervention involved weekly iron tablet supplementation for three months. Hemoglobin levels were measured before and after the intervention using a HemoCue device, and data were analyzed using the Wilcoxon Signed-Rank test. The results showed a significant increase in hemoglobin levels after the intervention (p < 0.05). Prior to supplementation, 39% of the students were anemic, which decreased to 8% after the intervention, with 92% having normal hemoglobin levels. These findings indicate that regular iron supplementation effectively improves hemoglobin levels and reduces anemia prevalence. The program should be continued with sustained nutrition education and monitoring of compliance to ensure long-term effectiveness. ABSTRAK Anemia defisiensi zat besi merupakan masalah gizi yang umum pada remaja putri di negara berkembang seperti Indonesia, berdampak pada kesehatan dan prestasi belajar. Pemerintah telah menjalankan program pemberian tablet tambah darah (TTD) di sekolah sebagai upaya pencegahan. Penelitian ini bertujuan mengevaluasi efektivitas pemberian TTD terhadap peningkatan kadar hemoglobin pada siswi kelas X di MAN 3 Magetan. Desain penelitian menggunakan kuasi eksperimen dengan pendekatan one group pre-test dan post-test. Sebanyak 122 siswi usia 15–18 tahun menjadi responden berdasarkan kriteria inklusi dan persetujuan orang tua. Intervensi berupa pemberian TTD dilakukan seminggu sekali selama tiga bulan. Kadar hemoglobin diukur sebelum dan sesudah intervensi menggunakan alat HemoCue, dan data dianalisis dengan uji Wilcoxon Signed-Rank. Hasil menunjukkan peningkatan signifikan kadar hemoglobin setelah intervensi (p < 0,05). Sebelum intervensi, 39% siswi mengalami anemia, sementara setelahnya hanya 8%, dengan 92% memiliki kadar hemoglobin normal. Temuan ini menunjukkan bahwa pemberian TTD secara rutin efektif meningkatkan kadar hemoglobin dan menurunkan prevalensi anemia. Program ini perlu dilanjutkan secara berkelanjutan dengan edukasi gizi dan pemantauan kepatuhan konsumsi untuk hasil jangka panjang.
Detection of mecA Gene in Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated from Diabetic Ulcer Swab Samples Aliyya Noor Izzati; Suliati; Lully Hanni Endarini; Syamsul Arifin
International Journal of Advanced Health Science and Technology Vol. 6 No. 1 (2026): February
Publisher : Forum Ilmiah Teknologi dan Ilmu Kesehatan (FORITIKES)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ijahst.v6i1.500

Abstract

Diabetic ulcers represent a serious complication of diabetes mellitus, often becoming chronic wounds prone to infection due to impaired immunity, poor vascularization, and persistent hyperglycemia. Among the most frequently identified pathogens in such wounds is Staphylococcus aureus, with methicillin-resistant S. aureus (MRSA) strains posing significant therapeutic challenges due to their resistance to β-lactam antibiotics. This resistance is typically mediated by the mecA gene, which encodes penicillin-binding protein 2a (PBP2a), a protein with reduced affinity for β-lactams. This study aimed to detect the presence of the mecA gene in MRSA strains isolated from diabetic ulcer swabs and to examine the relationship between phenotypic resistance and genotypic confirmation. A total of 30 swab samples were collected from patients with diabetic ulcers at the Diabetes Wound Care Clinic in Surabaya. Bacterial identification was performed using standard microbiological techniques, and cefoxitin disk diffusion was used to screen for MRSA phenotypically. Genomic DNA from cefoxitin-resistant isolates was subjected to conventional PCR using mecA-specific primers, with electrophoresis to detect the expected 304 bp DNA fragment. Of the 30 samples, 19 (63%) were confirmed to be S. aureus, and among them, 6 isolates (31.6%) were resistant to cefoxitin. However, none of these isolates were positive for the mecA gene by PCR, although the positive control showed the expected band. This discrepancy suggests the possibility of other resistance mechanisms beyond mecA, highlighting the importance of molecular methods in confirming MRSA. These findings reinforce the need for integrated phenotypic and genotypic diagnostics to ensure accurate detection and appropriate treatment of MRSA infections
DRUG MANAGEMENT STRATEGIES IN DISASTER SITUATIONS Nuri Handayani; Imat Rochimat; Tovani Sri; Lully Hanni Endarini; Suliati Suliati
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.3152

Abstract

Bencana merupakan rangkaian peristiwa yang mengancam dan mengganggu kehidupan dan penghidupan masyarakat. Bencana dapat memberi dampak pada sector kesehatan, infrastruktur dan ekonomi. Penelitian ini bertujuan untuk mengeksplorasi pengelolaan obat pada situasi kebencanaan di Indonesia, mengidentifikasi hambatan serta memberikan rekomendasi strategis. Penelitian ini menggunakan studi deskriptif kualitatif. Populasi dari penelitian ini yaitu tenaga farmasi yang terlibat langsung melakukan pekerjaan kefarmasian selama bencana. Data dikumpulkan dari 10 informan yang terdiri atas tenaga farmasi Dinas Kesehatan Kota/Kabupaten dan anggota Apoteker Tanggap Bencana (ATB) di daerah terdampak bencana. Data dikumpulkan melalui wawancara mendalam. Data yang diperoleh dianalisis menggunakan teknik analisis tematik dengan menggunakan model Miles dan Huberman. Hasil penelitian ini menunjukkan bahwa pengelolaan obat dalam situasi bencana di Indonesia belum berjalan optimal. Untuk mengatasi hal tersebut dibutuhkan koordinasi lintas sektor dan sistem pencatatan terintegrasi untuk memastikan ketersediaan obat yang efektif dan tepat sasaran. Rekomendasi yang dihasilkan meliputi penerapan SOP khusus, sistem pengadaan obat satu pintu dan program edukasi untuk pengungsi mengenai cara cerdas menggunakan obat terutama saat situasi bencana. Hasil penelitian ini dapat menjadi panduan untuk perbaikan manajemen pengelolaan obat di situasi darurat dan mendukung pengembangan kebijakan pengelolaan perbekalan farmasi dalam penanganan bencana.
Analysis of the Leukocyte Profile for Peripheral Blood Smear Stained with Diff-Count Based on Fixation Time Variation Museyaroh Museyaroh; Musholli Himmatun Nabilah; Lully Hanni Endarini
Health Dynamics Vol 2, No 2 (2025): February 2025
Publisher : Knowledge Dynamics

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hd20202

Abstract

Background: Peripheral blood smear examination (HDT) is a test to observe the morphology of blood cells microscopically. A peripheral blood smear is a simple method, and its examination is widely available in laboratories. The advantage of peripheral blood smear examination is its ability to assess various components of peripheral blood cells, such as cell morphology (erythrocytes, leukocytes, and platelets). One of the commonly used methods for peripheral blood smear examination is Giemsa staining. The process of Giemsa staining fixation aims to preserve the cell structure and its components before the staining is performed. The precise fixation time is key to obtaining optimal staining results, which allows for accurate observation of cell morphology. The aim of this study is to analyze the morphology of leukocyte profiles in peripheral blood smears stained with Giemsa based on variations in fixation time to determine the optimal time. Methods: This research was conducted in August-September 2024. The sample in this study was whole blood taken from the academic community of the Department of Medical Laboratory Technology and examined with a peripheral blood smear using Giemsa staining, and analyzed using descriptive statistical tests with the SPSS for Windows 22 software. Results: The research results showed that at a fixation time of 3 minutes, 60% were good and 40% were less good; at 5 minutes, 100% were good; at 10 minutes, 100% were good; at 15 minutes, 40% were good and 60% were less good; and at 20 minutes, 20% were good and 80% were less good. Conclusion: The best time variation in Giemsa staining using phosphate buffer is fixation for 5 minutes and 10 minutes, where all preparations (5 preparations) are 100% in the good category.
FACTORS INFLUENCING MATERNAL MORTALITY IN EAST JAVA USING GENERALIZED POISSON REGRESSION Lully Hanni Endarini; Hardian Bimanto
Jurnal Biometrika dan Kependudukan Vol. 15 No. 1 (2026): JURNAL BIOMETRIKA DAN KEPENDUDUKAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbk.v15i1.2026.117-127

Abstract

Elevated maternal mortality rates underscore the limited effectiveness of maternal health improvement efforts to date. In East Java Province, data from 2020 revealed more maternal deaths than the previous year. This increase was partly due to the COVID-19 pandemic, which limited antenatal care visits and made it harder to monitor high-risk pregnancies. This study set out to find the factors that influence maternal mortality in East Java. Researchers used district and city-level data from the 2020 East Java Provincial Health Report and analyzed it as secondary data. They applied Poisson regression analysis, and because the data showed overdispersion, they also used the Generalized Poisson Regression (GPR) model. The main variable studied was the number of maternal deaths (Y), while the independent variables were The availability ratio of healthcare workers (X₁), The rate of complications during obstetric care (X₂), and The availability of health centers (X₃). The results showed overdispersion in the maternal mortality data. Results from the Poisson regression model indicated that every independent variable significantly influenced maternal deaths. In the GPR model, only The availability ratio of healthcare workers (p=0.001) and The rate of complications during obstetric care (p=0.018) were statistically significant. The study determines that the Generalized Poisson Regression model is better for examining maternal mortality factors in East Java, as it fits the data more accurately, as shown by a lower AIC value.
PENGARUH PEMBERIAN BORAKS TERHADAP KADAR HEMOGLOBIN MENCIT (MUS MUSCULUS) SEBAGAI INDIKATOR ANEMIA Titis Cahyaningrum; Lully Hanni Endarini; Wisnu Istanto; Christ Kartika R
SEHAT : Jurnal Kesehatan Terpadu Vol. 5 No. 3 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/s-jkt.v5i3.62478

Abstract

Boraks merupakan bahan kimia berbahaya yang masih sering disalahgunakan sebagai bahan tambahan pangan untuk meningkatkan kekenyalan dan daya simpan makanan, meskipun penggunaannya telah dilarang karena berpotensi menimbulkan gangguan kesehatan, salah satunya anemia akibat kerusakan eritrosit oleh radikal bebas yang dihasilkan boraks. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian boraks terhadap kadar hemoglobin sebagai indikator anemia pada mencit (Mus musculus). Penelitian eksperimental kuantitatif dengan desain Posttest Only Control Group ini menggunakan 32 ekor mencit jantan yang dibagi menjadi empat kelompok, yaitu kelompok kontrol (C), kelompok dosis 1 (KP1) 1,51 mg/kgBB, kelompok dosis 2 (KP2) 3,02 mg/kgBB, dan kelompok dosis 3 (KP3) 4,52 mg/kgBB. Boraks diberikan secara oral (gavage) selama 14 hari, kemudian kadar hemoglobin diperiksa menggunakan hematology analyzer dan dianalisis menggunakan uji Kruskal-Wallis dan Mann-Whitney. Rata-rata kadar hemoglobin menurun seiring peningkatan dosis boraks, yaitu 14,9 g/dL (C), 12,4 g/dL (KP1), 10,7 g/dL (KP2), dan 8,8 g/dL (KP3). Uji Kruskal-Wallis menunjukkan nilai signifikansi 0,000 (p<0,05), sedangkan uji Mann-Whitney menunjukkan nilai p-value 0,001 (p<0,05) pada seluruh perbandingan kelompok. Simpulan: Pemberian boraks berpengaruh signifikan terhadap penurunan kadar hemoglobin mencit (Mus musculus) sebagai indikator anemia; semakin tinggi dosis boraks yang diberikan, semakin rendah kadar hemoglobin yang dihasilkan.
PENGARUH WAKTU PEMISAHAN PLASMA TERHADAP KADAR GLUKOSA DARAH MENGGUNAKAN TABUNG NAF DAN TABUNG EDTA Hanun Zhalma; Anik Handayati; Sri Sulami Endah Astuti; Lully Hanni Endarini
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 4 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i4.14120

Abstract

The accuracy of blood glucose results is influenced by various factors, one of the most important of which is the pre-analytical stage. Blood glucose levels can decrease if plasma separation is delayed, because blood cells continue to carry out the glycolysis process. The method used in this study was an experiment with a posttest-only control group design, employing purposive sampling that involved 5 respondents and 4 treatment conditions for each type of tube based on Federer’s formula. The sample consisted of sixth-semester students in the D3 medical laboratory technology programme who met the inclusion and exclusion criteria. Blood glucose levels were measured using the GOD-PAP method with a BIOBASE chemistry analyser. The results of the analysis showed that blood glucose levels in both types of tubes decreased as the plasma separation delay time increased. For NaF plasma, the One-Way ANOVA test yielded a p-value > 0.05, indicating that variations in the plasma separation delay time had no significant effect. In contrast, the Kruskal-Wallis test for EDTA plasma yielded a p-value < 0.05, which indicated a significant difference in each delay time variation. Based on these results, NaF plasma was better able to maintain stable blood glucose levels during the plasma separation delay compared to EDTA plasma. This is caused by the sodium fluoride content in the NaF tube, which acts as an antiglycolytic agent, so it is able to inhibit the glycolysis process and maintain stable glucose levels in the blood. ABSTRAK Keakuratan hasil glukosa darah dipengaruhi oleh berbagai faktor, salah satunya yang paling penting pada tahap pra-analitik. Kadar glukosa darah dapat mengalami penurunan apabila pemisahan plasma ditunda, karena sel-sel darah tetap melakukan proses glikolisis. Metode yang digunakan dalam penelitian ini adalah eksperimen dengan desain Posttest Only Control Group Design menggunakan teknik purposive sampling yang melibatkan 5 responden dan 4 perlakuan setiap jenis tabung berdasarkan rumus Federer. Pemilihan sampel terhadap mahasiswa Program Studi D3 Teknologi Laboratorium Medis semester 6 sesuai kriteria inklusi dan eksklusi. Pemeriksaan kadar glukosa darah dilakukan menggunakan metode GOD-PAP dengan BIOBASE Chemistry Analyzer. Hasil analisis menunjukkan bahwa kadar glukosa darah pada kedua jenis tabung mengalami penurunan seiring dengan bertambahnya waktu penundaan pemisahan plasma. Pada plasma NaF hasil uji One Way ANOVA diperoleh nilai p>0.05, sehingga variasi waktu penundaan pemisahan plasma tidak memberikan pengaruh yang signifikan. Sebaliknya, plasma EDTA uji statistik Kruskal Wallis menunjukkan nilai p<0.05, yang mengindikasikan adanya perbedaan yang signifikan pada setiap variasi waktu penundaan. Berdasarkan hasil tersebut, plasma NaF lebih mampu mempertahankan stabilitas kadar glukosa darah selama penundaan pemisahan plasma dibandingkan plasma EDTA. Hal ini disebabkan oleh kandungan natrium fluorida pada tabung NaF yang berperan sebagai agen antiglikolitik, sehingga mampu menghambat proses glikolisis dan menjaga kestabilan kadar glukosa dalam darah.
PENGGUNAAN METHYLENE BLUE SEBAGAI PENGGANTI HEMATOKSILIN PADA SEDIAAN HISTOLOGI Naysilla Wardaniya; Juliana Christyaningsih; Lully Hanni Endarini; Anita Dwi Anggraini
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 4 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i4.14653

Abstract

Histological staining plays an essential role in enhancing the visualization of cellular and tissue structures. Hematoxylin, the nuclear stain used in the Hematoxylin–Eosin (HE) method, has several limitations, including relatively high cost and limited storage stability, necessitating the development of more economical alternatives such as methylene blue. This laboratory experimental study aimed to evaluate the use of methylene blue as a substitute for hematoxylin in mouse liver histological sections. The control group was stained using the Hematoxylin–Eosin method, while the treatment groups received methylene blue at concentrations of 10%, 11%, and 13%. Slide quality was evaluated microscopically using a scoring method based on nuclear clarity, cytoplasmic appearance, and color uniformity, followed by Kruskal–Wallis and Mann–Whitney analyses. The control group produced 100% good-quality slides. The 10% methylene blue group yielded 16.7% good and 83.3% fairly good slides. The 11% concentration produced 83.3% fairly good and 16.7% poor slides, whereas the 13% concentration resulted in 66.6% fairly good and 33.3% poor slides. The Kruskal–Wallis test revealed a significant difference among the groups (p=0.000; p<0.05). These findings indicate that methylene blue, particularly at a concentration of 10%, has potential as an alternative nuclear stain to hematoxylin because it produced the best staining quality among the treatment groups. ABSTRAK Pewarnaan sediaan histologi berperan penting dalam memperjelas struktur sel dan jaringan. Hematoksilin sebagai pewarna inti pada metode Hematoksilin-Eosin (HE) memiliki keterbatasan, antara lain harga yang relatif mahal dan stabilitas penyimpanan yang kurang baik, sehingga diperlukan alternatif pewarna yang lebih ekonomis, seperti methylene blue. Penelitian ini bertujuan mengetahui penggunaan methylene blue sebagai pengganti hematoksilin pada sediaan histologi jaringan hati mencit. Penelitian menggunakan desain eksperimental laboratorium dengan kelompok kontrol pewarnaan Hematoksilin-Eosin dan kelompok perlakuan methylene blue konsentrasi 10%, 11%, dan 13%. Kualitas preparat dinilai secara mikroskopis menggunakan metode skoring berdasarkan kejelasan inti sel, sitoplasma, dan keseragaman warna, kemudian dianalisis menggunakan uji Kruskal–Wallis dan Mann–Whitney. Hasil menunjukkan kelompok kontrol menghasilkan 100% preparat berkategori baik. Pada methylene blue 10% diperoleh 16,7% preparat berkategori baik dan 83,3% cukup baik, konsentrasi 11% menghasilkan 83,3% cukup baik dan 16,7% tidak baik, sedangkan konsentrasi 13% menghasilkan 66,6% cukup baik dan 33,3% tidak baik. Uji Kruskal–Wallis menunjukkan perbedaan yang signifikan antar kelompok (p=0,000; p<0,05). Dengan demikian, methylene blue berpotensi digunakan sebagai pewarna alternatif pengganti hematoksilin, terutama pada konsentrasi 10% yang menghasilkan kualitas preparat terbaik di antara kelompok perlakuan.
Co-Authors ., Pestariati A'yunin, Zahratin Nisa' Ahmad Yudianto Alda Nugrahini Aliyya Noor Izzati Anggraini, Anita Dwi Ayu , Puspitasari Ayu Puspitasari Christ Kartika R Dewi Ika , Pratiwi Diah Titik Mutiarawati Diah Titik Mutiarawati Edy Haryanto Edy Haryanto Endah Astuti, Sri Sulami Era Fitria Yunita Evy Diah Woelansari Farah Adelia Qotrunnada Handayati, Anik Hanun Zhalma Hardian Bimanto Imat Rochimat Indah Lestari Indah, Lestari Indira Ayuni Sri Pramasti Istanto, Wisnu Juliana Christyaningsih Junaedi, Winda Rachmawati Kartika Rahayuningsih, Christ Krihariyani, Dwi Liliek Soetjiatie Luthfi Rusyadi Mamik Mamik Mamik Mamik Masdiva Putri Hidayah Maulida Azmi Wimasni Inah MINARTI Minarti Minarti Museyaroh, Museyaroh Musholli Himmatun Nabilah Mutiarawati, Diah Titik Mutiarawati, Diah Titik Nada Nabilah Wulandari Nadeak, Juan Carlos Naysilla Wardaniya Nuri Handayani Pratiwi Dewi Ika Rahma Faisa Talitha Ratno Tri Utomo Reni Susanti Rina Idawati Sari, Sintia Mustika Sasongkowati, Retno Shofan Ilham Sulaiman Sri Sulami Endah Astuti Sri Utami Suhariyadi Sulaiman, Shofan Ilham Suliati Suliati Suliati Suliati Syamsul Arifin Talitha, Rahma Faisa Titin Muslihatin, Titin Titis Cahyaningrum Tovani Sri Vemy Rahmany Kurniawan Yasmin, Aisha Amelia Yuni Eka Cahyana Yuyun Dwi Wahyuni