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All Journal Jurnal Pembelajaran dan Biologi Nukleus Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Farmanesia FARMASAINKES FASKES : Jurnal Farmasi, Kesehatan, dan Sains Jurnal ABDIMAS MUTIARA Jurnal Bakti Nusantara JURNAL TEKNOLOGI, KESEHATAN DAN ILMU SOSIAL
Fitri, Raissa
Program Studi S1 Farmasi, Universitas Sari Mutiara Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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PENETAPAN KADAR KALSIUM SECARA KOLORIMETRI PADATULANG IKAN PATIN (Pangasius hypophthalmus) DALAM FORMULA PASTA GIGI Fitri, Raissa; Purba, Sondang; Wilson Sembiring, Antonius
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 2 No. 2 (2020): JURNAL TEKNOLOGI, KESEHATAN, DAN ILMU SOSIAL (TEKESNOS)
Publisher : Universitas Sari Mutiara Indonesia

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Abstract

Ikan patin merupakan salah satu jenis ikan air tawar yang mempunyai nilai ekonomis penting. Ikan ini banyak digemari terutama di luar pulau Jawa seperti pulau Sumatera dan Kalimantan.Tulang Ikan Patin(Pangasius hypophthalmus) mengandung beberapa mineral termasuk kalsium yang sangat dibutuhkan oleh tubuh manusia.Tulang Ikan Patin memiliki kandungan kalsium yang cukup tinggi. Penelitian ini bertujuan untuk mengetahui kadar kalsium pada Tulang Ikan Patin dan pada sediaan Pasta Gigi. Jenis penelitian bersifat eksperimental dengan metode kolorimetri. Dilakukan analisis kuantitatif pada panjang gelombang maksimum 503,00 nm, dan diperoleh persamaan garis regresi linier yaitu y= 0,0625X+0,0014 dengan nilai koefisien korelasi (r) sebesar 0,9985. Hasil penelitian diperoleh kandungan kalsium pada tulang ikan patin  sebesar 22,6117 mg/100g, kadar kalsium dalam sediaan pasta gigi formula I sebesar 5,8468 mg/100g dan kadar .kalsium dalam sediaan pasta gigi formula II sebesar 6,2348 mg/100g.
Phytopharmaceutical Approach in the Development of Red Ginger (Zingiber officinale var. rubrum) Ointment for Inflammation and Pain Management Fitri, Raissa; Br Ginting, Grace Anastasia; Asdian, Fanny; Siahaan, Destina Karinia; Nurfadilla, Sulistia; Adiansyah, Adiansyah
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 3: Jurnal Pembelajaran Dan Biologi Nukleus September 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i3.8135

Abstract

Background: Red ginger (Zingiber officinale var. rubrum) is a variant of Z. officinale distinguished by its elevated levels of phenolic compounds—particularly gingerols, shogaols, and zingerone—that exhibit potent anti-inflammatory and analgesic effects. Topical formulations enable localized drug delivery, reducing systemic exposure and minimizing adverse effects commonly associated with oral nonsteroidal anti-inflammatory drugs (NSAIDs). Methodology: Dried red ginger rhizomes were powdered and extracted with 70% ethanol via maceration. The concentrated extract was incorporated into a white soft paraffin–lanolin base to produce ointments containing 5%, 10%, and 15% w/w extract. The formulations were assessed for physicochemical stability, including organoleptic characteristics, pH, spreadability, adhesion, and homogeneity. Anti-inflammatory activity was evaluated using the carrageenan-induced paw edema model in Wistar rats (n = 6 per group), with blank base and diclofenac sodium ointment (1% w/w) serving as negative and positive controls, respectively. Findings: All ointments exhibited stable physicochemical properties within pharmacopeial acceptance limits (pH 5.2–5.9; spreadability 5.6–6.4 cm; adhesion >1 s). In vivo, red ginger ointments significantly reduced paw edema in a dose-dependent manner (p < 0.05). The 15% formulation achieved 60.8% inhibition (0.47 ± 0.05 mL at 5 h), comparable to diclofenac ointment (0.48 ± 0.06 mL; p = 0.71). Contribution: The study establishes that red ginger retains pharmacological activity when formulated into a topical base, confirming its potential as a stable, safe, and effective phytopharmaceutical for localized inflammation management. These findings support further preclinical and clinical studies toward its development as a natural alternative to synthetic topical NSAIDs
Co-Authors Adiansyah Adiansyah, Adiansyah Anastasia, Grace Aprili Yanti Simatupang Asdian, Fanny Aulia Fitri, Aulia br Ginting, Grace Anastasia Chandra, Devina Cut Masyithah Thaib Dharmawan, Hariyadi Dikki Miswanda Dinda Sari Utami Eva Diansari Marbun Fitrianty, Novi Anisyah Furqan, Mainal Gabena Indrayani Dalimunthe Gaho, Grace Ekariani Ginting, Grace Anastasi Ginting, Grace Anastasia br Ginting, Ovalina Sylvia Br. Halawa, Tristan Haris Munandar Nasution Hutauruk, Dumartina Julia Reveny Lubis, Minda Sari Mainal Furqan Modesta Harmoni Tarigan Monica Suryani Nanda, Farahlina Nasri Nurfadilla, Sulistia Prayoga, Andre Priltius, Natanael Purba, Sondang Sembiring, Antonius Wilson Siahaan, Destina Karinia Sianipar, Artha Yuliana Silitonga, Maringan Simatupang, Aprili Yanti Siti Maimunah Siti Nurbaya Siti Nurbaya Situmorang, Manahan Sulwiyatul K Sani Supartiningsih SURBAKTI, CHRISTICA ILSANNA Syukur Berkat Waruwu Tarigan, Modesta Harmoni Tarigan, Yenni Gustian Thaib, Cut Masyithah Urip Harahap Utama, Rezza Fikrih Wilson Sembiring, Antonius Yuniarti, Rafita Zebua, Besti Eynzel Zulmai Rani