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All Journal MOTORIK Jurnal Ilmu Kesehatan (Journal of Health Science) Biology, Medicine, & Natural Product Chemistry Biomedika Jurnal Kesehatan Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Martabe : Jurnal Pengabdian Kepada Masyarakat MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmu Kesehatan Jurnal Mandala Pengabdian Masyarakat Lontara: Journal of Health Science and Technology Proceeding Biology Education Conference Abdi Psikonomi Journal of Innovation Research and Knowledge Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Jurnal Pengabdian Masyarakat Medika International Journal of Health Science and Technology Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Lontara Journal Of Health Science And Technology Biomedika
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Fakultas Kedokteran Universitas Muhammadiyah Surakarta
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Journal : Biomedika

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INVESTIGATION OF THE ANTIBACTERIAL EFFICACY OF DERSONO WATER APPLE LEAVES (SYZYGIUM MALACCENSE) AS A SUBSTITUTE THERAPY FOR STREPTOCOCCUS PYOGENES INFECTIONS Rosyidah, Devi Usdiana; Mahmudah, Nur; Fithriyah, Sa’idatul; Sintowati, Retno
Biomedika Vol 17, No 2 (2025): Biomedika August 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i2.12007

Abstract

Streptococcus pyogenes caused different illnesses, including pharyngitis and dermatological infections. The Dersono water apple leavesSyzygium malaccense) are recognized for their bioactive ingredients, which may serve as antibacterial agents. This study purpose was to determine the antibacterial potential of ethanol extract and acetone fraction of Syzygium malaccense against Streptococcus pyogenes infection. This research was a laboratory xperiment, a post-test only with control group design. Assessing growth inhibition by measuring the diameter of halo around the well of blood agar plate. Statistical tests using the Sapiro-Wilk test, Lavene test, Kruskal Wallis est and Mann-Whitney test. The study's findings demonstrated that the ethanol extract 25% (11.80 mm) and 50% (16.51) concentrations and acetone fraction of Dersono water apple leaves, at 25% (11.25 mm) and 50% (12.08) concentrations, had strong inhibitory power. The concentrations of 6.25% (8.15 mm) and 12.50% (9.63 mm), the ethanol extract's inhibitory power was superior than the concentrations of 6.25% (4.42 mm) and 12.50% (3.38 mm) acetone fraction, had moderate range. Both the ethanol extract and the acetone fraction's phytochemical analyses identified alkaloids, tannins, and saponins. The conclusion was ethanol extract and acetate fraction of Dersono water apple leaves have antibacterial effects against Streptococcus pyogenes.
Co-Authors Adelia Triana Putri Adhimass Wicaksono Adhimass Wicaksono, Adhimass Afif Iqbal Hibatullah Almansyah, Wanda Emdia Ambarwati Angesti Atiqah Ranasatri Anika Candrasari Anindita Putri Handayani Arismar, Fiqi Rahardian Arrantissi, Syauqi Hanif Aryati, Mandarini Dwi Putri Aulia Setyaningsih Ayustine Winarta, Selly Azenta, Moch. Tabriz Azmi, Aninditha Syavela Davina, Aifa Putri Dessy Wahyuni Devi Usdiana Rosyidah Diah Rachmawati DIAH RACHMAWATI Dodik Nursanto Em Sutrisna Erna Herawati Erna Herawati, Erna Fachroni Rahman Fachroni Rahman, Fachroni Fadhila, Zahra Hayuna Farisin Hanif Luthfilhadi Fauziah, Nida Faradisa Fithriyah, Saidatul Fithriyah, Sa’idatul Fitriyah, Sa?idatul Geraldo Zikri Azmi Ramadhan Handayani, Alya Nurkinasih Putri Handayani, Anindita Putri Hartia, Nabila Putri Hasna Zahro Iftikhonsa Hibatullah, Afif Iqbal Hidayah Karuniawati Juninda, Larasati Khayla Febriannisa Kurniati, Yunu Prastyo Kusumaningrum, Tanjung Anitasari Indah Lestari, Nining Lian Adhalia Listiana Masyita Dewi Listyani Hidayati Maulana, Taqwa Ziyan Maulida Khotimah Muhammad Aji Akbar Muhammad Aji Akbar, Muhammad Aji Muhammad Nabil Miqdam Muhammad Shoim Dasuki Muwakhidah, Muwakhidah N Nurhayani N. Juni Triastuti Nafasadila, Fatma Nafila, Alfin Nining Lestari Nur Mahmudah Nur Mahmudah Nurhayani nurhayani Nurhayati Nurhayati Oktaberika Putri Indah Yasinta Paramadina, Izzati Puspitasari, Metana Ratih Pramuningtyas Riandini Aisyah Rif'aini, Fidhia Nur Rizkia Nur Ramadhani Rochmadina Suci Bestari Rosyid Prasetyo Rosyidah, Dewi Usdiana Sa’idatul Fitriyah, Sa’idatul Safari Wahyu Jatmiko Salsabila, Naura Santosa, Talitha Ulima Santoso, Talitha Ulima Sares Daselva Sa’idatul Fitriyah Selly Ayustine Winarta Siti Mulyati Siti Soekiswati Sri Darnoto Sri Wahyu B Sri Wahyuni Sujono Sujono Sulistyani Sulistyani Sulistyani Sulistyani Supraba, Intan Pratiwi Susanto, Syarafina Ayu Putru Sutopo, Tri Talitha Ulima Santoso Tanjung Anitasari Indah Kusumaningrum Tanti Azizah Tanti Azizah Sujono Tri Agustina Tri Agustina, Tri Tri Sutopo Triwijaya, Dedy Utami, Indari Wahyu B, Sri Wahyu Jatmiko, Safari Yasinta, Oktaberika Putri Indah Yuni Prastyo Kurniati Yusuf Alam Ramadhan Yusuf Alam Romadhon Zahrani, Ayu Zahro Iftikhonsa, Hasna