Article Per Year (5 Year)
p-Index From 2021 - 2026
2.787
P-Index
This Author published in this journals
All Journal CHEMISTRY PROGRESS JURNAL KIMIA SAINS DAN APLIKASI Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Journal of Mathematical and Fundamental Sciences INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Fitofarmaka Indonesia Jurnal Penelitian Kesehatan Suara Forikes Jurnal Wiyata : Penelitian Sains dan Kesehatan Majalah Farmaseutik Indonesian Journal of Chemistry PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Jurnal Ilmu Kefarmasian Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Farmasi dan Sains Indonesia (JFSI) Journal Pharmasci (Journal of Pharmacy and Science) Open Access Indonesian Journal of Medical Reviews Archives of The Medicine and Case Reports Medical Sains : Jurnal Ilmiah Kefarmasian J-ABDIPAMAS (Jurnal Pengabdian Kepada Masyarakat) Jurnal Etnofarmasi Journal of Health Management and Pharmacy Exploration (JOHMPE) International Journal of Global Sustainable Research Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pharma Bhakta International Journal of Contemporary Sciences (IJCS)
Rina Herowati
The Faculty Of Pharmacy, Setia Budi University, Surakarta
Religion Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 42 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search
Journal : indonesian journal of pharmacy

 1 
Antidiabetic Activity of Okra Fruit (Abelmoschus esculentus (L) Moench) Extract and Fractions in Two Conditions of Diabetic Rats Herowati, Rina
Indonesian Journal of Pharmacy Vol 31 No 1, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss1pp27

Abstract

Okra (Abelmoschus esculentus (L) Moench) fruit is empirically used in type 2 diabetes mellitus treatment. This research aims to know the antihyperglycemic activity of okra fruit extract and fractions in streptozotocin-nicotinamide (STZ-NA) induced as well as in insulin resistance diabetic rats, the effect on pancreatic cells regeneration, and the effect on immunohistochemical expression of glucose transporter-4. This study used a group of 35 male Wistar rats for STZ-NA induced diabetic model and another group of 35 rats for insulin resistance diabetic model. Gliclazide (0.72mg/kg BW) and metformin (45mg/kg BW) were used as drug control in STZ-NA induced and insulin resistance diabetes, respectively. Okra fruit ethanol extract, n-hexane, ethyl acetate, and water fraction were orally administered with dose of 200; 107; 6 and 86mg/kg BW, respectively, for 28 days after diabetic condition was obtained. Blood glucose level was measured every week. Hematoxylin-eosin staining was used to evaluate the pancreatic cells regeneration, while immunohistochemistry was used to evaluate the expression of glucose transporter-4 in muscle membrane cells, at the end of the treatment. The results revealed that ethyl acetate fraction was the most effective in lowering blood glucose level in both condition of diabetes. Ethyl acetate fraction decreased the necrosis of pancreatic cells in STZ-NA induced diabetic rats and increased the expression of glucose transporter-4 in muscle cell of insulin resistance diabetic rats.
Synthesis and gastric ulcer protective activity of chlorinated quercetin Gusdinar, Tutus; Herowati, Rina; Kartasasmita, R. E.; Adnyana, I Ketut
Indonesian Journal of Pharmacy Vol 20 No 4, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.755 KB) | DOI: 10.14499/indonesianjpharm0iss0pp163-169

Abstract

Gastrointestinal toxicity due to non-steroid anti-inflammatory drugs can be inhibited by the compounds that have antioxidant activity. Quercetin is a flavonoid that has antioxidant activity and protection effect against gastric ulcer. Chlorination of quercetin enhanced the antioxidant activity. This study aims to obtain the chlorinated derivative of quercetin and examine the protection effect against acetosal-induced gastric ulcer. Chlorination was done by the addition of chlorine at room temperature. Ulcer induction was carried out on rats by oral administration of acetosal. Incidences of gastric ulcer were determined by macroscopic and microscopic observation. Chlorination of quercetin with chlorine gas produced 6-chloroqueretin as major product. The protection effect against acetosal-induced gastric ulcer of this compound was higher than quercetin.Key words : quercetin, chlorination, gastric ulcer, NSAIDs
ANTIHYPERGLYCEMIC, ANTIOXIDANT, AND PANCREAS PROTECTIVE EFFECTS OF CORIANDRUM SATIVUM SEED IN ALLOXAN-INDUCED DIABETIC RATS Widodo, Gunawan Pamudji; Handayani, Sri Rejeki; Hierowat, Rina
Indonesian Journal of Pharmacy Vol 26 No 3, 2015
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (15.106 KB) | DOI: 10.14499/indonesianjpharm25iss3pp129

Abstract

Coriandrum sativum is a medicinal plant, used in traditional medicine for diabetes therapy. The goal of the this study was to determine the antidiabetic, antioxidant and pancreas protection effects of ethanol extracts of C. sativum seeds (CSE) in alloxan-induced diabetic rats. The male Wistar rats were induced diabetic by intraperitoneal injection of alloxan (150mg/kg BW). CSE was prepared and administrated orally to the animals at the dose of 125 and  250mg/kg for 28 days. Blood glucose level was measured, and antioxidant status was assessed by determining the activities of superoxide dismutase, glutathione peroxidase as well as malonyl aldehyde in liver. Histopathological study of pancreas was conducted at the end of experimental period. Both dose of SCE  showed the glucose lowering effect, corrected antioxidant status of diabetic animals in liver and protected the pancreas organ from damage. Key words: Coriandrum sativum seed, antihyperglycemia, antioxidant, pancreas protection
The Antihyperglicemic Activity of ethanol Extract of Fenugreek seed (Trigonella foenum graecum L) and its effect on the GLUT-2 expression of Streptozotocin Nicotinamide Induced Rats Jena Hayu Widyasti; Gunawan Pamudji Widodo; Rina Herowati
Indonesian Journal of Pharmacy Vol 29 No 1, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1465.75 KB) | DOI: 10.14499/indonesianjpharm29iss1pp10

Abstract

Insulin is an important factor in glucose transport. Glucose transporter (GLUT-2) in pancreatic β cell membranes is responsible for glucose transport that will stimulate insulin secretion. The purpose of this research was to investigate the antihyperglycemic activities of extract of Trigonella foenum-graecum L. (fenugreek) seed and the effects on GLUT-2 protein expression in pancreatic β cells on Streptozotocin-Nicotinamide-induced (STZ-NA) rats. This research utilized five groups of male Wistar rats. Group I was normal control group, while Groups II-V were induced with STZ-NA. Group II was negative control group (CMC Na 1%); group III was positive control group (Glibenclamide); group IV and V was examined group (fenugreek seed ethanol extract of 100mg/kg bw and 200 mg/kg bw)). The test compounds were orally administered for 14 days. Measurement of blood glucose levels and observation of the expression of GLUT-2 protein in pancreatic β cells in rats were conducted by immunohistochemistrical method. The research results revealed that the examined group dose of 200 mg/kg bw of fenugreek seed extract appeared to show blood glucose level decline that was proportionate to that of the positive control group. The increased density of GLUT-2 protein in pancreatic β cells significantly occurred in the group injected with 200 mg/kg bw compared to the group injected with 100 mg/kg bw. Hence, 200 mg/kg bw of fenugreek seed ethanol extract was able to decrease blood glucose levels and increase the GLUT-2 protein expression in pancreatic β cells in STZ-NA-induced rats with the effectiveness that was comparable to the positive control group
Co-Authors admaja, wika Afriliza, Dini Alfian Bagas Pratama Ana Indrayati Andri Prasetiyo Arief Nurrochmad Aris Susilo Ayuning Siwi, Mayang Aditya Bahi, Rizky Resvita R. BETA K. PRAMUDYAWARDHANI Dewi, Lucia Vita Inandha Dwi Ningsih, Dwi Dyah Susilowati Eka Fitriani Eleonora Maryeta Toyo Elly Suoth Endang Sri Rejeki Franz June Navirius Gunawan Pamudji Gunawan Pamudji Gunawan Pamudji Widodo Gunawan Pamuji Widodo Gusdinar, Tutus Handayani, Sri Rejeki Harno Dwi Pranowo Harsono, Samuel Budi Harsono, Samuel Budi Hasmar, Wahyu Nuraini I Ketut Adnyana Ika Purwidyaningrum Jausi Jannah Kartasasmita, R. E. Keswara, Yane Dila Kusniawati, Mega Ayu Listyani, Tiara Ajeng M Afrizal Firmansyah M. Wahyu Ariawan Madyo Adrianto Muhamad Ansory, Hery Nugroho Wisnu Putro Nuraini Harmastuti NURAINI HARMASTUTI Nuraini Harmastuti Okky Intan Mawarni Pamudji, Gunawan Pratamaa, Yuga Purnamasari, Nur Aini Dewi Rahmadani Rahmadani Rahmana Emran Kartasasmita Rahmana Emran Kartasasmita Rifkarosita Putri Ginaris Rosa Juwita Hesturini Samuel Budi H Septina D Haryanti Setiaji Wisnu Wardana Sofia Mubarika Sunarti Sunarti Supriyadi T.N Saifullah Sulaiman TN Saifullah Sulaiman Tri Murti Andayani Tuti Alawiyah Tutus Gusdinar Tutus Gusdinar Kartawinata Widia Wati Widiastuti Widiastuti Widyasari, Meylinda Widyasti, Jena Hayu Widyastuti, Lita Windi Astuti Wisnu, M. Ari Wiwin Herdwiani