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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat The Indonesian Biomedical Journal IDJP (Indonesian Journal of Pharmaceutics) Indonesian Journal of Chemistry Pharmacology and Clinical Pharmacy Research Martabe : Jurnal Pengabdian Kepada Masyarakat Bioscientia Medicina : Journal of Biomedicine and Translational Research Majalah Farmasetika Jurnal Ilmiah Farmako Bahari Journal of Community Development Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmiah Kesehatan (JIKA) Gunung Djati Conference Series
Gofarana Wilar
Fakultas Farmasi Universitas Padjadjaran
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Pemantauan Terapi Obat Pada Pasien Lupus Eritematosus Sistemik Co-Morbid Infeksi Cytomegalovirus, Chronic Kidney Disease, dan Ventilator Associated Pneumonia di Ruang Intensive Care Unit RS Pemerintah Kota Bandung Salsabila, Alisha Zahra; Wilar, Gofarana
Farmaka Vol 22, No 2 (2024): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v22i2.48493

Abstract

Lupus Eritematosus Sistemik (SLE) biasa disebut penyakit seribu wajah merupakam penyakit autoimun yang bersifat kronis dengan manifestasi berubah-ubah dan menyerang hampir semua organ. SLE adalah jenis lupus dengan kejadian terbanyak dibanding lupus lainnya. Data dari Lupus Foundation of America pada tahun 2023 menunjukkan bahwa SLE menyumbang angka sekitar 70% dari tiga jenis lupus lainnya. Pemantauan Terapi Obat (PTO) ini dilakukan pada pasien Ny. RI berusia 24 tahun selama tujuh hari di ruang intensif salah satu Rumah Sakit Pemerintah di Bandung. Diagnosis utama pasien, yaitu SLE dengan infeksi cytomegalovirus (CMV), Chronic Kidney Disease (CKD), dan Ventilator Assosciated Pneumonia (VAP) dengan pemberian obat berupa ceftazidime avibactam, fosfomisin, meropenem, vankomisin, paracetamol, n–acetylcystein, lovenox, hidroksiklorokuin, dexamethasone, calos, asam folat, amlodipin, esomeprazole, KCl, dan kalsium glukonat. Perawatan dan terapi yang diterima oleh pasien berisiko menimbulkan efek samping obat yang kompleks akibat penggunaan terapi polifarmasi jangka panjang sehingga perlu dilakukan pemantauan terapi ketat untuk meminimalkan terjadinya efek obat yang tidak diinginkan dan memastikan pemberian obat yang tepat. Berdasarkan hasil pengkajian dan analisis PTO terapi yang diberikan sudah sesuai dosis dan indikasi, tetapi menyebabkan beberapa efek samping yang kompleks akibat penggunaan terapi polifarmasi jangka panjang.
Edukasi Hidup Sehat Tanpa Diabetes Dengan Pemanfaatan Tanaman Obat Bagi Masyarakat Desa Mekarjaya Banjaran Musfiroh, Ida; Megantara, Sandra; Holik, Holis Abdul; Susilawati, Yasmiwar; Wilar, Gofarana
Journal of Community Development Vol. 3 No. 3 (2023): April
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v3i3.113

Abstract

Diabetes mellitus in Indonesia now ranks 5th with the highest number of diabetes mellitus sufferers in the world. At present, the prevalence has increased from 6.2% compared to 2019. Diabetics need to get effective and safe drugs in order to avoid various complications. In addition to using pharmacological therapy, it is also necessary to carry out non-pharmacological therapy. One type of medicinal plant that is known to be effective in reducing sugar is ginger and cinnamon, but there has not been much reported on its processing other than in the form of a decoction or marinade. The purpose of carrying out this PPM activity is to increase the knowledge and understanding of the people of Mekarjaya Banjaran Village regarding the use of medicinal plants as anti-diabetics, and provide knowledge about making ginger-cinnamon instant powder drinks. The activity method is carried out in 3 stages, namely the planning, implementation, evaluation and follow-up stages. The results of this PPM activity show that the community has a better understanding of efforts to be healthy in preventing diabetes through the use of ginger-cinnamon medicinal plants, and how to process them through instant powders. The evaluation is carried out based on the results of the initial test and the final test as a method for measuring the achievements of this PPM activity.
Analysis of Potentially Inappropriate Prescriptions (PIP) Based on STOPP/START Criteria in Geriatric Patients with Cardiovascular Disorders at Hasan Sadikin Hospital, Bandung, West Java, Indonesia Fathurrahmi, Fathurrahmi; Wilar, Gofarana; Levita, Jutti; Winarni, Rina
Pharmacology and Clinical Pharmacy Research Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i3.50436

Abstract

The geriatric population in Indonesia is increasing rapidly every year. The large number of drugs consumed by geriatric patients results in potentially inappropriate prescriptions (PIP) in the form of mis-prescribing drugs (potentially inappropriate medicines or PIM) and under-prescribing drugs (potentially prescription omission or PPO). In Indonesia, especially in Bandung, there is limited research on PIP in geriatric patients with cardiovascular disorders (CVDs). This study aims to identify PIP and factors that influence PIM and PPO based on STOPP/START criteria and the relationship between the incidence of PIM and kidney function in geriatric inpatients with CVDs at Hasan Sadikin Hospital, Bandung, West Java, Indonesia. The present retrospective study was cross-sectionally conducted from January to December 2022. The Chi-square tests were carried out to determine factors that were significantly related to PIM and PPO. Of the 192 patients, 33.4% patients experienced PIM with the most being NSAIDs with eGFR <30 mL/min/1.73 m2 (36%). As many as 35% of patients experienced PPO with the most frequent PPO not being given angiotensin-converting enzyme inhibitor (ACEi) in patients with systolic heart failure (41.8%). Factors that were significantly associated with PIM were comorbid kidney dysfunctions (OR 5; 95% CI: 2.367-10.342), and no factors were found that were significantly associated with PPO. Taking everything into consideration, it was found that PIM and PPO were common in hospitalized geriatric patients with CVDs. Kidney dysfunctions are a risk factor for PIM. These findings suggest that it is important to evaluate prescribing for geriatric patients during hospitalization using STOPP/START criteria to reduce the prevalence of PIP
PEMANTAUAN TERAPI PASIEN PENDERITA TUBERKULOSIS DENGAN RIWAYAT HIPERTENSI PADA SALAH SATU RUMAH SAKIT DI BANDUNG Zahra, Hasna Shafira; Cristin, Elsa Daw; Wilar, Gofarana; Setiadi, Anggi
Farmaka Vol 20, No 3 (2022): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v20i3.39794

Abstract

Drug Delivery System in Feline Herdiana, Yedi; Wilar, Gofarana; Sofian, Ferry Ferdiansyah; Pitaloka, Annisa Dyah; Nurhijriah, Yasinta; Safira, Rayhan Zarra; Salsabila, Annisa Siti; Z, Maziyatunisa
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.44274

Abstract

The drug delivery system is an attractive field of study since it has several applications in veterinary and human medicine. In the realm of veterinary medicine, the discovery of new routes of administration or new delivery systems to regulate the release of medications is of great importance. Due to the high number of animals and the special issues related to the administration of drugs and their market potential is very large, it is necessary to modify the dosage form to produce an effective and practicable preparation. Cats are the most popular pet in the world, outnumbering dogs by a ratio of three to one. It is vital to understand the prevalent illness patterns and limits of traditional delivery systems to establish appropriate dosage forms for cats. We believe this publication will be of interest to veterinarians and pharmaceutical scientists working in the field.
Formulation and Characterization of Secretome Hydrogel Based on Sodium Alginate as Anti-Aging Alquraisy, Ayatulloh; Wathoni, Nasrul; Wilar, Gofarana; Suhandi, Cecep
Jurnal Ilmiah Kesehatan (JIKA) Vol. 6 No. 3 (2024): Volume 6 Nomor 3 Desember 2024
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v6i3.1005

Abstract

Hydrogel can be developed as a secretome delivery strategy for controlled release, thereby extending the residence time of the secretome and providing safer and more effective therapeutic effects. Secretome has great potential to prevent skin aging. The enzymes contained in the secretome have antioxidant activity. This study aimed to determine the characterization and anti-aging activity of sodium alginate-based secretome hydrogel preparations. In this research, hydrogel secretome characterization tests were carried out in the form of organoleptics, pH, viscosity, spreadability, HRTEM and also anti-aging activity testing using the DPPH scavenging assay method. The organoleptic test showed that all formulas were pale yellow in color, soft and homogeneous in consistency. pH, viscosity and spreadability tests showed that all formulas entered the standard range for topical preparations. Taking images of the hydrogel surface using HRTEM shows that the secretome has been successfully dispersed into the hydrogel. Anti-aging activity testing carried out has also proven an increase in the percentage of inhibition and IC50 value in the formula along with increasing the secretome dose.
PENDAMPINGAN PENERAPAN PROTOKOL KESEHATAN PENYELENGGARAAN KEGIATAN DI SEKOLAH PADA MASA KENORMALAN BARU PANDEMI COVID-19 Saprudin Darwis, Rudi; Sulastri, Sri; Wilar, Gofarana
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 5, No 4 (2022): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v5i4.1408-1416

Abstract

The Covid-19 pandemic has forced people to change their behavior patterns to suit the situation and conditions during the pandemic, which is called the new normal. One of the things that must change is the pattern of education that must be accompanied by adjustments to the behavior of teachers and students in the learning process. At the time the government implemented Limited Face-to-face Learning (PTMT) there were still many. For this reason, this study aims to support the government's efforts to maintain the sustainability of education by assisting the implementation of health protocols in elementary schools during the new normal period of the Covid-19 pandemic. The study was conducted at SDN Pelangi 1 Sukamukti Village, Majalaya District, Bandung Regency. The method used in mentoring the implementation of health protocols is an extension method accompanied by a simulation of the practice of implementing the 3M health protocol (wearing masks, keeping distance, washing hands) which is attended by half of the students from grades 1 to 6. The results of the mentoring show that the students who initially did not recognize the scope of 3M and how it was implemented correctly, by the end of the activity most of them had applied how to wear masks properly, wash their hands properly, and tend to avoid crowds.
Phytochemical Analysis and Anti-Thrombocytopenic Activity of Dayak Onion (Eleutherine palmifolia (L.) Merr) Extract and Fractions with HR-LCMS Profiling of Active Compounds Apriliana, Anita; Milanda, Tiana; Susilawati, Yasmiwar; Wilar, Gofarana
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.104534

Abstract

Thrombocytopenia, characterized by a low platelet count, poses significant clinical challenges and can arise from various etiologies. This study investigates the anti-thrombocytopenic effects of Dayak onion (Eleutherine palmifolia (L.) Merr) extracts and their fractions in Wistar rats. Ethanolic extracts and fractions were evaluated for their efficacy in enhancing platelet production. Male Wistar rats were administered doses of 100, 200, and 300 mg/kg, and platelet counts were measured at 24, 48, and 72 h post-treatment. Results indicated that all doses of the ethanolic extract significantly increased platelet counts over time, with the ethyl acetate fraction demonstrating the highest efficacy at a dose of 24.087 mg/kg, achieving significant increases as early as 24 h post-administration. Phytochemical analysis revealed substantial levels of phenolics (318.80 mg GAE/g) and flavonoids (45.63 mg QE/g) in the ethyl acetate fraction, with quercetin identified as a prominent compound via HR-LCMS. These findings suggest that Dayak onion possesses promising anti-thrombocytopenic properties, warranting further exploration as a therapeutic agent for accelerating platelet recovery in conditions such as dengue fever.
Immunomodulatory and Acute Toxicity Studies of Peronema canescens Jack Leaves: in vivo Hematological Analysis and in vitro IL-6 Gene Expression Inhibition Muhammad Ryan Radix Rahardhian; Fahriza Ardiansyah; Yasmiwar Susilawati; Gofarana Wilar; Sri Adi Sumiwi; Jutti Levita; Muchtaridi Muchtaridi
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3577

Abstract

BACKGROUND: Peronema canescens Jack is traditionally employed in the treatment of inflammation, malaria, and immune-related disorders. Despite its traditional use, scientific evidence on its immunomodulatory effects, interleukin (IL)-6 modulation, hematological impact, as well as its related acute toxicity data remains limited. Therefore, this study was conducted to investigate the immunostimulatory potential of P. canescens leaf extract through in vitro and in vivo assessments and evaluate its acute toxicity profile.METHODS: The in vitro immunomodulatory activity of P. canescens ethanolic extract, n-hexane fraction (NHF), ethyl acetate fraction (EAF), and water fraction (WF) were assessed by measuring IL-6 inhibition in lipopolysaccharide-stimulated RAW 264.7 macrophages. For in vivo analysis, Balb/C mice were divided into six groups: a normal control (Na-CMC), a positive control (50 mg/kg BW/day Stimuno Phyllanthus niruri extract), a negative control (80 mg/kg BW/day cyclophosphamide as immunosuppressant), and 3 treatment groups receiving P. canescens extract at doses of 100, 200, and 400 mg/kg BW/day. Hematological parameters, including white blood cell (WBC) counts, lymphocyte percentages, and neutrophil percentages, were analyzed. Acute toxicity studies were performed by administering P. canescens extract at doses of 300, 2000, and 5000 mg/kg BW over observation period.RESULTS: EAF exhibited the most pronounced IL-6 inhibition in vitro. In vivo, the administration of P. canescens extract at 200 and 400 mg/kg BW significantly elevated WBC and lymphocyte levels while concurrently reducing neutrophil counts. No mortality or neurotoxic manifestations were observed, confirming the P. canescens extract’s safety profile up to 5000 mg/kg BW.CONCLUSION: P. canescens leaf extract, particularly EAF, demonstrates robust immunomodulatory activity with a favorable safety margin. These findings underscore its potential therapeutic application in immune modulation.KEYWORDS: Peronema canescens Jack, immunomodulatory, IL-6 inhibition, acute toxicity, hematology, cytokines
Proximate and Phytochemical Analysis of the Ethanol Extract of Abelmoschus manihot Leaves Collected from Tinoor Dua Village, North Tomohon, North Sulawesi Wilar, Gofarana; Levita, Jutti; Giano Tikoalu, Lie Christian; Wahyuni, Indah Suasani
Jurnal Ilmiah Farmako Bahari Vol 17 No 1 (2026): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v17i1.42999

Abstract

The flowers of Abelmoschus manihot have been broadly studied in China for their phytochemical content and biological activities; however, the leaves have been explored only to a limited extent. In Manado, Sulawesi, Indonesia, the leaves of this plant are the most important ingredient in tinutuan porridge. The total phenols (TPC) and total flavonoids (TFC) in the leaves collected in Bogor, Manado, Tomohon, and Kotamobagu have been previously reported. This study aimed to provide data on the proximate and phytochemical composition (TPC, TFC, and quercetin levels) of the ethanol extract of A. manihot leaves collected from Tinoor Dua Village, North Tomohon, North Sulawesi, Indonesia. Extraction was carried out at room temperature using 70% ethanol. The phytochemical screening test was conducted according to a standard procedure for plant extracts. The proximate composition of the extract was analyzed in accordance with SNI 01-2891-1992. The TPC and TFC were determined by following the procedures outlined in SNI 01-2891-1992. Additionally, the TPC and TFC were also determined in accordance with SNI 01-2891-1992, and the procedures outlined in the Indonesian Herbal Pharmacopoeia were followed. Quercetin levels were analyzed using HPLC. Proximate analysis revealed 35.60% of total ash, 28.56% of carbohydrate, 18.31% of water, 11.01% of protein, and 6.53% of fat, whereas the TPC was 1350 mg GAE/100 g extract, the TFC was 2670 mg QE/100 g extract, and quercetin in the extract was 373.7 ± 0.18 mg/L. These findings will support further exploration for the development of A. manihot leaves as a nutritional food or nutraceutical supplement.
Co-Authors Abdurahman Ridho Almira Agustini Hadirana Alquraisy, Ayatulloh Anggi Setiadi Anita Apriliana Aurizal Risandy Irawan Cristin, Elsa Daw Eka Rosalianti Ellin Febrina ELSA DAW CRISTIN Fahriza Ardiansyah Fathurrahmi Fathurrahmi Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Giano Tikoalu, Lie Christian Hasna Shafira Zahra Hidayat, Taufik Septiyan Holis Abdul Holik, Holis Abdul Ichsan Nurul Bari Ida Musfiroh -, Ida Musfiroh Indah Suasani Wahyuni Irma Erika Herawati Irma Melyani Puspitasari Jutti Levita MEGANTARA, SANDRA Mia Arifka Muchtaridi Muchtaridi Muhammad Ryan Radix Rahardhian Mutakin Mutakin Nasrul Wathoni Nisa Masyitah Nurhijriah, Yasinta Pitaloka, Annisa Dyah Renny Amelia Rudi Saprudin Darwis Rudi Saprudin Darwis Safira, Rayhan Zarra Salsabila, Alisha Zahra Salsabila, Annisa Siti Setiadi, Anggi Sri Adi Sumiwi Sri Sulastri Sri Sulastri Sriwidodo Sriwidodo Suhandi, Cecep Syifa Nabilah Subakti Putri TIANA MILANDA Winarni, Rina Yasmiwar Susilawati Yedi Herdiana, Yedi Z, Maziyatunisa Zahra Siti Hanifah Zahra, Hasna Shafira