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Journal : Sainstek : Jurnal Sains dan Teknologi

STUDI INTERAKSI LIGAN PEPTIDOID DAN PEPTIDA DENGAN ENZIM PROTEASE NS3/NS2B VIRUS DENGUE Amelia, Fitri
Sainstek : Jurnal Sains dan Teknologi Vol 6, No 1 (2014)
Publisher : IAIN Batusangkar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.346 KB) | DOI: 10.31958/js.v6i1.100

Abstract

Peptide has a high bioactivity and specificity, possess low interaction to other drugs and has a low toxicity values . However, peptide -based drugs have drawbacks, which are rapidly degraded in the digestive system due to the activity of the protease enzyme that peptide drugs are not suitable to be developed as an oral medication. The purpose of this study to determine whether the value of  peptidoid is higher than the peptide and to analize the influences between interaction and  DG of Peptidoid KGPE is the higher  than its peptide, -16.13874 kkal/mol. The high number of  hydrogen donor for Hydogen bonding derived ligand can lower the value of KiKey words: peptidoid,peptide-base drug, protease NS3/NS2B
KARAKTERISASI PLASTIK BIODEGRADABLE NATA DE SOYA MENGGUNAKAN PLASTICIZER ASAM OLEAT Maryati, Meri; Iryani, Iryani; Amelia, Fitri
Sainstek : Jurnal Sains dan Teknologi Vol 6, No 1 (2014)
Publisher : IAIN Batusangkar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.797 KB) | DOI: 10.31958/js.v6i1.105

Abstract

The purpose of this study were to analyze the morphology, tensile strength, power degradation and the degree of crystallinity of plastic nata de soya. This plastic using oleic acid plasticizer  with various volume 30 , 40 and 50 mL and 30 mL glycerol 3 %. Plastic morphology test using Scanning Electron Microscope ( SEM ). Tensile strength test using a test tensometer and crystallinity using X - ray diffraction instrument ( XRD ). Power degradation is determined by hoards of plastic in the soil for 10 days. The longer plastic soaked for 6 days then getting flat plastic surface morphology, the lower of  value of tensile strength is 7.87 MPa, the lower of power degradation is 23. 72 % and the higher the degree of crystallinity is 39.96 %. Key words: oleic acid, plasticizer , biodegradable  plastic, nata de soya
COMPARATIVE MODELLING PROTEIN VAKSIN NA BTB H5N1 MENGGUNAKAN SWISS MODEL Amelia, Fitri; Iryani, Iryani
Sainstek : Jurnal Sains dan Teknologi Vol 4, No 2 (2012)
Publisher : IAIN Batusangkar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (419.795 KB) | DOI: 10.31958/js.v4i2.72

Abstract

Vaccine sequence of Neuraminidase BTB from previous research was studied by using swiss model server. Protein template was gotten from RSCB database by comparing the vaccine sequence with PDB database. HTY protein was used as a template for this vaccine. Template had 0.00e-1 E value, and 97% identity. The protein vaccine that has been modelled by swiss model had  good quality as immune inducer. Base on ramachandran plot analysis, protein model 1, 2, and 3 have amino acid residues in favoured region higher than 70%. They are 82,0% and 78,2%. Model 1 has the lowest non glysine amino acid residues in disallowed region area, that is 0%.   3D Structure of vaccine had 2086  hits of similarity with database on NCBI Key words: comparing modelling, H5N1 vaccine, swiss model