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All Journal HAYATI Journal of Biosciences EKSAKTA: Journal of Sciences and Data Analysis Indonesian Journal of Cancer INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal Paediatrica Indonesiana Journal of Medicine and Health Molecular and Cellular Biomedical Sciences (MCBS) Syntax Literate: Jurnal Ilmiah Indonesia Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JFL : Jurnal Farmasi Lampung Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Ilmu Kefarmasian Indonesia Majalah Kedokteran Andalas Jurnal Jamu Indonesia Majalah Patologi Indonesia Jurnal Ekonomi Muhammadiyah Journal of Geriatric Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Indonesian Journal of Medical Chemistry and Bioinformatics Jurnal Kefarmasian Indonesia Indonesian Journal of Jamu Journal of Medicine and Health
Wawaimuli Arozal
Universitas Indonesia
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Journal : Muhammadiyah Journal of Geriatric

 1 
Potensi Moringa Oleifera sebagai Agen Neuroprotektif pada Kondisi Penuaan di Otak Safutra, Muhamad Sadam; Barinda, Agian Jeffilano; Arozal, Wawaimuli
Muhammadiyah Journal of Geriatric Vol. 4 No. 2 (2023): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mujg.4.2.138-151

Abstract

Penyakit neurodegeneratif merupakan penyakit yang banyak menimbulkan kejadian morbiditas dan mortalitas pada lansia. Selama proses penuaan, secara progresif kemampuan fungsional otak akan menurun. Penuaan otak dapat dimanifestasikan sebagai penurunan memori dan kognitif, yang biasanya terjadi oleh karena perubahan plastisitas struktural dendritik yang dapat berkembang menjadi penyakit neurodegeneratif. Sampai saat ini, belum ada pengobatan yang efektif untuk penyakit neurodegeneratif. Beberapa obat digunakan untuk menghilangkan gejala meskipun biasanya menimbulkan banyak efek samping. Oleh karena itu penelitian dan pengembangan obat dari berbagai tumbuhan yang memiliki efek neuroprotektif sebagai suplemen untuk memperbaiki fungsi otak banyak dilakukan. Kelor (Moringa oleifera (MO)) diketahui mempunyai aktivitas anti inflamasi, antiapoptosis, disamping juga memiliki nilai gizi yang baik. Komponen bioaktif yang terdapat dalam ekstrak MO diantaranya polifenol, saponin, tannin, isothiocyanate dan flavonoid diduga berperan sebagai neuroprotektif. Mekanisme molekuler yang terlibat pada MO sebagai neuroprotektif adalah jalur Nuclear factor kappa-beta (NF‐kB) dan Nuclear erythroid 2-related factor 2 (Nrf2), glukosinolat yang terdapat dalam MO akan terhidrolisis menjadi isothiocyanate yang akan  secara langsung berinteraksi dengan Kelch-like ECH-associated protein 1 (Keap1) di sitoplasma dan menyebabkan translokasi Nrf2 ke nukleus, selanjutnya Nrf2 akan berikatan dengan Antioxidant response element (ARE) yang akan menghasilkan enzim-enzim detoksifikasi. Selain itu Nrf2 juga menghambat translokasi NFkB ke nukleus sehingga menekan ekspresi sitokin Interleukin (IL) dan Tumor nuclear factor-α (TNF-α) yang berperan dalam inflamasi. Mekanisme lain yang mungkin adalah jalur pensinyalan Tropomyosin receptor kinase B (TrkB). Dengan demikian MO berpotensi kuat sebagai agen neuroprotektif pada penuaan otak.
Moringa oleifera as the potential herb medicine for neurodegenerative diseases: a narrative review Dewi, Yulia Ratna; Barinda, Agian Jeffilano; Arozal, Wawaimuli
Muhammadiyah Journal of Geriatric Vol. 5 No. 1 (2024): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mujg.5.1.1-13

Abstract

Neurodegenerative diseases, such as Alzheimer's and Parkinson's, significantly burden the global older adult population. These diseases are characterized by the degeneration of nerve cells and subsequent damage, leading to the gradual loss of neurological function and subsequently affecting the quality of life of older adult people. This study explores the potential role of Moringa oleifera (MO) on neurological diseases. MO, a plant rich in bioactive compounds such as flavonoids, polyphenols, saponins, and tannins, has been proven to possess potent antioxidant effects. Oxidative stress is a primary contributor to the pathogenesis of neurodegenerative diseases, and MO can protect nerve cell damage by enhancing antioxidant activity. In the context of Parkinson's disease, MO has demonstrated the ability to reduce cataleptic symptoms and protect dopaminergic neurons, which are crucial in preventing a decline in dopamine production in the brain. In Alzheimer's disease, MO can improve memory function, reduce oxidative stress, and inhibit the activity of Acetylcholinesterase (AChE) enzymes involved in neurotransmitter dysfunction. While further research is needed to gain a deeper understanding of MO's mechanisms and more specific therapeutic potential, the existing evidence suggests that its constituents and effects hold significant promise as a natural solution for combating the effects of neurodegenerative diseases. As the number of individuals affected by these diseases continues to rise worldwide, further investigation into MO as a neuroprotective agent could pave the way for developing more effective therapies for these conditions.
Co-Authors Agatha Grace Agian Jeffilano Barinda Andrea Laurentius Arleni Bustami Aryo Tedjo Barinda, Again Jeffilano Bernie Endyarni Medise Cong, Tzeto Han Deni Rahmat Dewi Sukmawati Dewi, Yulia Ratna Djumhana Atmakusuma Djumhana Atmakusuma, Djumhana Dwita, Nounik Cheri Edhiatmi, Marsetyo Erlina, Linda Erni H Purwaningsih Erni H Purwaningsih, Erni H Erni Hernawati Purwaningsih, Erni Hernawati Ernie Purwaningsih Eviarini, Prawitasari Eziefule, Oluebube Magnificient Fadhillah, Muhamad Rizqy Fadilah Fadilah Fadilah, Fadilah Fajarido, Ariski Femmi Dwinda Agustini Franciscus D. Suyatna Gregorius Bhaskara Wikanendra Gusti Khatimah, Nurul Hanifah Oswari Hedi R. Dewoto Heri Wibowo Hesty Utami Husna, Fauzul Indah D Dewijanti Indah D Dewijanti, Indah D Irawan Mangunatmadja Jusman, Sri Widia Azraki Kapuangan, Christopher Kartika, Kartika Handayani Kenichi Watanabe Khatimah, Nurul Gusti Kuncoro, Daviet Dwi Kurniasari Kurniasari Kusmardi Kusmardi Kusmardi Kusmardi Laurentius, Andrea Lee, Hee Jae Marliana Sri Rejeki Marliana Sri Rejeki Marliana Sri Rejeki Marselina Marselina Marsetyo Edhiatmi Meilei Ma Melva Louisa Muhamad Sadam Safutra Musridharta, Eka Nabillah, Deya Adiby Nafrialdi Nafrialdi Nastiti Kaswandani Ni Made Dwi Sandhiutami Novi Silvia Hardiany Nur Azizah Nurwulan Adi Ismaya Pebriani, Mala Primadhani, Suci Widya Punniyakoti T. Veeraveedu Puspita Eka Wuyung Puspita Eka Wuyung Putri, Rizky Clarinta Radiana Dhewayani Antarianto Radoti Merlin Rani Hendiyani Rani Sauriasari Rani Sauriasari, Rani Rejeki, Marliana Sri Ria Anggraeni Rianto Setiabudy Rianto Setiabudy Riski Amanda, Clara Roro Rukmi Windi Perdani, Roro Rukmi ROS SUMARNY Ros Sumarny Safutra, Muhamad Sadam Safutra, Sadam Sagala, Radoti Merlin SEPTELIA INAWATI WANANDI Sesilia Keban Sesilia Keban, Sesilia Setyo Handryastuti Shimizu, Ippei Silmi Hanifah Soni Siswanto Sumiati, Yati Supraja Dwiyono Suyatna, Franciscus D Syarifah Dewi Thandavarayan, Rajarajan Amirthalingam Tri Yuliani Tri Yuliani, Tri Triana, Novi Tzeto Han Cong Ulfa T Wahyuni Ulya, Nurul Vetnizah Juniantito Vivian Soetikno Vivian Soetikno Wardani, Amanda Saphira Wikanendra, Gregorius Bhaskara Yati Sumiyati