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All Journal HAYATI Journal of Biosciences Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Buletin Agrohorti Jurnal Ilmu Pertanian Indonesia Jurnal Hortikultura Indonesia (JHI) Jurnal Lanskap Indonesia Agrovigor: Jurnal Agroekoteknologi Jurnal Pengkajian dan Pengembangan Teknologi Pertanian Jurnal Penelitian Tanaman Industri Buletin Penelitian Tanaman Rempah dan Obat AGRIVITA, Journal of Agricultural Science Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Planta Tropika Caraka Tani: Journal of Sustainable Agriculture EnviroScienteae Jurnal Penelitian Pertanian Tanaman Pangan Jurnal Agroqua: Media Informasi Agronomi dan Budidaya Perairan Jurnal Teknik Pertanian Lampung (Journal of Agricultural Engineering) Journal of Tropical Crop Science Journal of Environmental Science and Sustainable Development Jurnal Penelitian Tanaman Industri (Littri) Buletin Penelitian Tanaman Rempah dan Obat Jurnal Kedokteran Hewan Jurnal Tumbuhan Obat Indonesia
Sandra Arifin Aziz
Department Of Agronomy And Horticulture, Faculty Of Agriculture, IPB University (Bogor Agricultural University), Jl. Meranti, Kampus IPB Darmaga, Bogor 16680, INDONESIA
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Veterinary

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Journal : Jurnal Kedokteran Hewan

 1 
INSTANT GRANULES OF Zingiber officinale AND Cajanus cajan LEAVES IMPROVED LIVER HISTOLOGICAL PROFILE IN DIABETIC MODEL RATS Manalu, Johanes Marojahan; Sadiah, Siti; Aziz, Sandra Arifin; Astawan, Made; Ridwan, Taopik; Wresdiyati, Tutik
Jurnal Kedokteran Hewan Vol 19, No 3 (2025): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v19i3.47330

Abstract

Diabetes mellitus can cause significant microstructural damage in liver tissue. This study evaluated the effectiveness of instant granules of Zingiber officinale and Cajanus cajan leaves on the liver histological profile in diabetic model rats. A total of 25 male Sprague Dawley rats were assigned into five groups. The group consist of negative control (NC), positive control (PC), metformin control group at a dose of 150 mg/kg BW (MET), and two treatment groups of instant granules of Z. officinale and C. cajan leaves at a dose of 300 mg/kg BW (T1) and 150 mg/kg BW (T2) for 28 days treatment. The diabetic condition was obtained by single induction of streptozotocin (35 mg/kg BW). The liver tissue was stained using hematoxylin-eosin staining to observe the cytoplasm intensity, central vein diameter, and nucleus intensity of liver cells in diabetic model rats. The results showed that administration of the instant granules significantly decrease liver microstructural damage (P0.01). The 150 mg/kg BW (T2) dose showed the most optimal effectiveness by successfully decreasing cytoplasmic intensity, reducing central vein dilation, and decreasing nuclear cell intensity. The research result indicate that instant granules have strong hepatoprotective properties that can repair liver microstructural damage caused by diabetes.
Co-Authors , Adiwirman , Nazi , Nirwan ,, Herlina . Herlina . TRIVADILA A.A. Ketut Agung Cahyawan W Abdul Munif Agus Yudhi Pardiyanto Andika Akbarul Iman Andria Afrida Anggia Murni Ani Kurniawati Anisya Elsa Shafira Ari, Ahmad Nur Hidayat Gena Arista, Nor Isnaeni Dwi Atang Sutandi Auliya Ilmiawati Ayunina, Krisetya Azmi, Tubagus Kiki Kawakibi Bayuanggara Cahya Ramadhan betty betty Betty Tjhia BUDI MARTONO DADANG DADANG Danar Hadisugelar Dewi Sukma Dhedy Kristanto Didy Sopandie Diny Dinarti DINY DINARTY, DINY Dyah Iswantini Edi Santosa Ekawati, Rina Eman Ayu Sasmita Jati, Gusti Fajar Pangestu Fauziah, Ni'mah Fhonna, Tasya Nurizki Giyanto, dan GUSMAINI GUSMAINI Gusmaini Gusmaini GUSMAINI GUSMAINI, GUSMAINI Haridjaja, Oteng Herlina, NFN Hesti Pujiwati Hesti Pujiwati Hilda Susanti Hilda Susanti I Ketut Suada Ina Kusheryani INDRIANI, YULIA Ira Fauziah Noer Irmanida Batubara Ismail Saleh Ismail Saleh Ismiyanti, Ismiyanti Isna Tustiyani Isna Tustiyani Jamil, Anna Moslihat Kailola, Joan Joulanda Grace Karimuna, Siti Rahmah Ketty Suketi Krisetya Ayunina Kurniawati, Ari Kurniawati, Ari LATIFAH K. DARUSMAN Leo Mualim M. Rafi MADE ASTAWAN Manalu, Johanes Marojahan MARIA BINTANG Maya Melati Ma’rufah, Siti Hilda Meity Suradji Sinaga Miftahudin . Mohamad Rafi Mufa'adi, Ardianto Muhamad Syukur Muhammad Farid Muhammad Farid Muhammad Syukur Munawaroh, Nafi'atul Munif Ghulamahdi Mustika Tripatmasari Tripatmasari Nafi'atul Munawaroh Neni Musyarofah NFN Herlina Ni'mah Fauziah Noer, Ira Fauziah Nur Faridah, dan Didah Nuri Andarwulan NURLIANI BERMAWIE NURLIANI BERMAWIE Nurliani Bermawie Nurliani Bermawie Nurwita Dewi Oteng Haridjaja Parwito Pebra Heriansyah Purwono Purwono, Purwono Purwono, dan Putri, Astrid Aditya Putri, Fiadini Rahmi Taufika Ramadhan, Bayuanggara Cahya Ramadhani, Elrisa Rasmani, Rasmani Ray March Syahadat Ray March Syahadat Refa Firgiyanto Respita, Intan Annisa rina ekawati Rizva, Dian Novira Sari, Galuh Yunita Shafira, Anisya Elsa Siti Hilda Ma’rufah Siti Maryam Harahap Siti Maryam Harahap Siti Sadiah Slamet Susanto Sri Astuti Rais Stefani Daryanto Sudirman Yahya Sudirman Yahya Tamsin, Aqlia Hanna Nurfatiha Taopik Ridwan Taopik Ridwan Tatik Raisawati Toyip Toyip Tutik Wresdiyati Wahyu Arif Sudarsono Wahyu Arif Sudarsono Waras Nurcholis Wardani, Eska Ayu Winarso D. Widodo Yudiansyah Yudiansyah