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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Penelitian Fisika dan Aplikasinya (JPFA) Jurnal Penelitian dan Pembelajaran IPA Jurnal Penelitian Pendidikan IPA (JPPIPA) PENDIPA Journal of Science Education JURNAL PENDIDIKAN TAMBUSAI Jurnal Basicedu TESLA: Jurnal Teknik Elektro EDUKATIF : JURNAL ILMU PENDIDIKAN JURNAL PENDIDIKAN MIPA Science Education and Application Journal Jurnal ABDINUS : Jurnal Pengabdian Nusantara JPPIPA (Jurnal Penelitian Pendidikan IPA) Jurnal Abdi: Media Pengabdian Kepada Masyarakat Jurnal Penelitian Pendidikan Matematika dan Sains Studies in Learning and Teaching Eduproxima : Jurnal Ilmiah Pendidikan IPA CENDEKIA : Jurnal Ilmu Pengetahuan IJORER : International Journal of Recent Educational Research EDUTECH : Jurnal Inovasi Pendidikan Berbantuan Teknologi SCIENCE : Jurnal Inovasi Pendidikan Matematika dan IPA BIOCHEPHY: Journal of Science Education Jurnal Pijar MIPA PENSA E-JURNAL: PENDIDIKAN SAINS Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram Journal of Comprehensive Science Jurnal Basicedu International Journal of Current Educational Research JIPI (Jurnal IPA dan Pembelajaran IPA) Jurnal Pendidikan MIPA
MOHAMMAD BUDIYANTO
Program Studi Pendidikan IPA FMIPA Universitas Negeri Surabaya
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Physics Social Sciences Other

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Phytochemical Screening and In Silico Prediction of Gynura divaricata Ethanolic Extract as A Potential PIM-1 Inhibitor: Phytochemical and In Silico Prediction of Gynura divaricata Puspitarini , Sapti; Hermanto, Feri Eko; Rohim, Abd; Dliyauddin, Moh; Hendratmoko, Ahmad Fauzi; Budiyanto, Mohammad; Ilhami, Fasih Bintang
Journal of Tropical Life Science Vol. 16 No. 01 (2026)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.16.01.06

Abstract

The pharmacological properties and traditional uses of medicinal plants often correlate with their bioactive constituents, which contribute to diverse therapeutic effects, including anticancer activity. Cancer remains one of the leading causes of mortality worldwide, and the discovery of novel anticancer agents from natural sources continues to be an important research focus. Gynura divaricata is a medicinal herb widely used in traditional Asian medicine for treating diseases. Recent studies have reported that G. divaricata contains several bioactive compounds. such as flavonoids, phenolic acids, terpenoids, and alkaloids, which are known for their antioxidant and anticancer properties. However, despite its traditional use and pharmacological potential, the molecular mechanisms underlying the anticancer activity of G. divaricata remain poorly understood. This study aimed to screen the phytochemical content of the ethanolic leaf extract of G. divaricata and to predict its potential anticancer activity through computational analysis targeting the PIM-1 protein. The DPPH inhibition, total flavonoid content, and total phenolic content of the extract were evaluated. Phytochemical profiling was performed using LC-HRMS. Molecular docking and molecular dynamics simulations were conducted to predict the interactions between the active compounds of G. divaricata and the PIM-1 protein. The extract exhibited 50% DPPH inhibition at a concentration of 2071.01 ppm, with total flavonoid and total phenolic contents of 107.44 ± 4.41 mg QE/g and 10.96 ± 0.49 mg GAE/g, respectively. Identified bioactive compounds, including curcumin, (+)-ar-turmerone, and 4-coumaric acid, were further analyzed through molecular docking to assess their interactions with the PIM-1 kinase. The docking results revealed that these compounds showed favorable binding affinities to the active site of PIM-1, suggesting their potential as anticancer agents. This study is the first to report the potential of G. divaricata active compounds as PIM-1 inhibitors, warranting further validation through both in vitro and in vivo studies.  
Co-Authors A.A. Ketut Agung Cahyawan W Adinda Arlin Husniyyah Afni, Khairul Agustin, Zulfani Nurdiana Ahmad Fauzi Hendratmoko AHMAD QOSYIM Alifia Suryatin Ramadani Alima, Siti Aisyah Amalia Hanifah Amelia Nur Safitri Amirah, Amelia Balqis Mukti Anastasya Herlina Anggraeni Angelia Kartika Cahyasari Arini Dwi Mayasari Aris Rudi Purnomo Aris Rudi Purnomo Aris Rudi Purnomo Awidhia Wandi Puri Swasti Ayatillah, Arini Maila Beni Setiawan BENI SETIAWAN Cheng, Tsung-Hui Chintya Dea Fadilah Cholifatul Hasanah Dea Damar Wahyu Pradana Deva Kurniawati Diah Permatasari Dian Nurfahzuni Dimas Galih Kirana Diny Narista Azizah Dita Aurellia Akmal Dliyauddin, Moh Durotun Ayu Fauziah Dwi Sri Handayani DYAH ASTRIANI Dyah Binti Astuti Dyah Puspita Ningrum Eggy Wahyu Ristanti EKASARI, DIANA Elok Sudibyo Elok Sudibyo ELOK SUDIBYO Elok Sudibyo Elsa Monica, Elsa Endang Susantini Enny Susiawati Enny Susiyawati Erman Erman Erman Erman ERMAN ERMAN Faola Firnanda Farihatul Maslahah Farit Nisaussa’adah Fasih Bintang Ilhami Fasih Bintang Ilhami, Fasih Bintang Fatikhin, Achmad Choirul Fatimatuz Zahro Febrianda Wilasari Febriliani, Avelin Fida Rachmadiarti Fira Amalia Qonita Firdaus Galang Sasmito Aji Hariyono, Eko Harun, Sulaiman Wadi Hening Mahardika Jati Hermanto, Feri Eko Isnawati Isnawati Itsnawati, Savinah Khofifah Indar Parawangsa KIKI SEPTARIA Kuntjoro, Sunu Laila Fahira LAILY ROSDIANA Larasati, Respati Ayu Nikmah Leni Dwi Septiany Li'anatul Mufidah Lyta Adela Rossely M Munasir Madlazim Madlazim Mas Al Fath Imru'ul Qais As-Syauqi Maulidatul Kurnia Pratiwi Mirza Roma Apsari Mirza Roma Apsari Mochammad Izzur Rizky Aulia Moh Yasin Monica*, Elsa Muhamad Arif Mahdiannur Muhammad Andika Putra Mursyidah, Roihana Waliyyul Nabilah, Hasna Nadi Suprapto NAHDLIA, AYU Nimas Arumningtyas Noer Hanifah, Khinanti NUR INDASARI, PRILY Nurdiah, Renita Fuji Nurin Handini, Iftitah Nurlita, Nurlita Oktaviana, Dian Prabowo Prabowo Prabowo Prabowo Pradana, Dea Damar Wahyu Pratiwi, Maulidatul Kurnia Purnomo, Aris Rudi Purnomo, Aris Rudi Puspita Dwi Ratnasari Puspitarini , Sapti Puspitasari, Ayu Diah Qosyim , Ahmad Raharjo, Raharjo Rahman, Nanang Raka Prasetyo Nurhaddi Refida Khoirun Hidayati Respati Ayu Nikmah Larasati Rini, Sapti Puspita Rinie Pratiwi Puspitawati Rinie Pratiwi Puspitawati RISKA GLACISSIA, ZANA Rizqi Afnan Rohim, Abd Roudhoutul Aulia Rochim ROVIATIN, IIN SADIYAH, HALIMATUS Sapti Puspitarini Sari, Dhita Ayu Permata Satriawan, Muhammad Septianingrum, Jijah Shavira Mitha Febriza Santoso Siti Marpuah, Siti Sukarmin Sulaiman Wadi Harun Sulis Idillah Ulfa Sunarti, Titin Sunu Kuntjoro Susiyawati, Enny Swasti, Awidhia Wandi Puri Syafri Milanto Syamsul Arifin TARZAN PURNOMO Titin Sunarti Tri Maryono TUTUT NURITA Ulfa, Sulis Idillah Valencya Risma Agatha Venna Yulia Rachmawati Wahyu Budi Sabtiawan Zainul Arifin Imam Supardi Zayzda, Nurul Azizah