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All Journal Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Majalah Kesehatan Pharmamedika Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research IJOEP : International Journal of Ecophysiology International Journal Of Science, Technology & Management (IJSTM) Unri Conference Series: Community Engagement JOURNAL LA MEDIHEALTICO Cakradonya Dental Journal Journal of Pharmaceutical and Sciences.
Aminah Dalimunthe
Departement Of Pharmacology, Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary

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Journal : Jurnal Ners

 1 
Cardio Protective Effect of Ethanolic Extract Vernonia Amygdalina Delile on Rats Induced L-NAME Harahap, Rizki Doli Hartama; Harahap, Urip; Dalimunthe, Aminah
Jurnal Ners Vol. 9 No. 1 (2025): JANUARI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i1.30981

Abstract

This study aimed to analyse the effects of ethanol extract of African leaves (Vernonia Amygdalina Del.) on the levels plasma renin, IL-6 and cardiac histopathology in L-NAME-induced rats. This research stage includes the preparation of ethanol extract of African leaves, standardization of extracts and testing the effectiveness of African leaves on rat heart damage. Data were analysed using one-way ANOVA with p<0.05. testing the cardioprotective effectiveness of ethanol extract of African leaves in hypertension model rats and then examining heart histopathology using HE staining and analysing parameters, namely plasma renin and IL-6 levels. This study used 6 groups, each group consisted of 5 male rats, namely the normal group, negative control by administering L-NAME 40 mg/kgBB, positive control by administering L-NAME plus lisinopril 2.5 mg/kgBB, EEDA 100 mg/kgBB, EEDA 300 mg/kgBB and EEDA 500 mg/kgBB. L-NAME responds to heart damage such as degeneration and necrosis of heart cells. In the negative group, plasma renin levels were 40.60 ± 9.98 ng/mL while the EEDA group with a dose of 500 mg/kgBB experienced the highest decrease in plasma renin compared to other EEDA groups and positive controls, namely 13.80 ± 1.30 ng/mL. The positive control group obtained plasma renin levels of 14.20 ±1.79 ng/mL. In the negative group, IL-6 levels were 4.80 ± 1.30 pg/mL while the group given EEDA, the group with a dose of 500 mg/kgBB experienced a decrease in IL-6, namely 1.52 ±0.96 ng/mL. The positive control group experienced a decrease in IL-6 levels of 0.77 ± 0.20 ng/mL. The result can be concluded that EEDA reduces plasma renin, IL-6 levels, improves the condition of cardiac cell degeneration and necrosis.
Pengaruh Konseling Apoteker Terhadap Pengetahuan Pasien Diabetes di Apotek Kf 27 Medan Butar, Ririn Anastasia Butar; M.S, Wiryanto; Dalimunthe, Aminah
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.47397

Abstract

Abstract This study aimed to analyze the effect of pharmacist counseling on the knowledge of patients with Type 2 Diabetes Mellitus (T2DM) at Kimia Farma 27 Pharmacy, Medan. The study employed a quasi-experimental design with a one-group pretest-posttest approach. A total of 112 T2DM patients participated, selected through total sampling. Data were collected using a validated questionnaire administered before and after pharmacist counseling. The results showed a significant increase in the average knowledge score from 3.07 ± 1.69 to 7.36 ± 1.70, with a p-value of 0.000. The direct counseling sessions, supported by written educational materials, effectively improved patients’ understanding. These findings highlight the strategic role of pharmacists in enhancing medication literacy in primary healthcare settings. This intervention serves as a strong foundation for developing standardized pharmacy counseling modules in community pharmacies. Keywords: pharmacist counseling, medication literacy, type 2 diabetes mellitus, patient education, community pharmacy.
Co-Authors . S, Aminah Ade Sri Rohani Anayanti Arianto Angga Nugraha Sanjaya Anjelisa Z. Hsb, Poppy Arfita Sipahutar Arianto, Anayanti Butar, Ririn Anastasia Butar Candrika, Candrika Darmirani, Yosi Denny Satria, Denny Effendy De Lux Putra, Effendy De Lux Embun Suci Nasution Emil Salim Hafid Syahputra Hakim Bangun* Harahap, Rizki Doli Hartama Herawaty Ginting Iksen, Iksen Julia Reveny Khairunnisa Khairunnisa Khairunnisa Lisda Rimayani Lubis, Arga Lubis, Meiva Amelia Lumbanraja, Linnon Bastian M.S, Wiryanto Masfria Masfria Muhammad Wahyu, Muhammad Nasri Nasri, Nasri Nasution, Azizah Nazliniwaty Nazliniwaty* Nurul Suci Pintauli, Sondang Prayoga, Andre Putri Fiari, Hera Zalia Rexi, Daniel Reza Destri Anggi Simbolon, Rohana Oktofariday Siti Morin Sinaga Sitorus, Panal Sondang Pintauli Sumaiyah Tarigan, Betharina Br Tarigan, Eunike Victorita Tri Susanti Sirait Urip Harahap Vadhila, Mumtaz Wardono, Sri Waruwu, Syukur Berkat Wira Septama, Abdi Wiryanto Wiryanto Wiryanto Wiryanto Yuandani Zumaira