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All Journal International Journal of Public Health Science (IJPHS) Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Ilmu Dasar Jurnal Kedokteran Syiah Kuala Majalah Kedokteran Bandung e-Journal Pustaka Kesehatan Jurnal Kesehatan Masyarakat Indonesian Journal of Tropical and Infectious Disease JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) Journal of Agromedicine and Medical Sciences JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Elkawnie MIX : Jurnal Ilmiah Manajemen The Indonesian Journal of Occupational Safety and Health Majalah Kedokteran Sriwijaya Universa Medicina Paediatrica Indonesiana Jurnal Bioteknologi & Biosains Indonesia (JBBI) Medical Laboratory Technology Journal Journal Of Vocational Health Studies Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan NurseLine Journal Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Prima JPSCR : Journal of Pharmaceutical Science and Clinical Research Indonesian Journal for Health Sciences (IJHS) SRIWIJAYA JOURNAL OF MEDICINE Journal of Health Sciences Action Research Literate (ARL) Jurnal Lingkar Mutu Pendidikan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Public Health and Preventive Medicine Archive Berita Kedokteran Masyarakat Jurnal Indonesia Sosial Sains Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) ASPIRATOR - Journal of Vector-Borne Diseases Studies Jurnal Lingkar Mutu Pendidikan
Dini Agustina
Departemen Mikrobiologi Fakultas Kedokteran Universitas Jember, Jember
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : e-Journal Pustaka Kesehatan

 1 
Pengaruh Pemberian Ekstrak Etanol Daun Mirabilis jalapa terhadap Pertumbuhan Vibrio cholerae (The Effect of Mirabilis jalapa's Leaves Ethanolic Extract against the Growth of Vibrio cholerae) Habibbur Rochman Salim; Dini Agustina; Jauhar Firdaus
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Vibrio cholerae is one of the most common bacteria causing acute diarrhea. First-line treatment of diarrhea is tetracycline. However, the drug has some side effects. Therefore it is necessary to have an alternative therapy for V. cholerae especially from herbs. The purpose of this study was to determine the ability and the minimal inhibitory concentration (MIC) of Mirabilis jalapa leaves extract in inhibiting the growth of V. cholerae in in vitro method. This research used a Quasi Experimental Design with Post Test Only Control Group Design. The method of this study used diffusion method on Mueller Hinton Agar. The sample used was V. cholerae culture from the Laboratory of Microbiology Medical Faculty Brawijaya University. The inhibition growth of V. cholerae was observed start at a concentration of 1 mg/ml and increased by increasing concentrations of the extract. Spearman correlation test showed value p=0.000 and r=0.993, indicating significant correlation between the leaves extract of M. jalapa and V. cholerae diameter inhibition zone. These results indicated that M. jalapa leaves extract could inhibit the growth of V. cholerae and had qualitatively MIC 1 mg/ml, while quantitatively 0.2 mg/ml. Keywords: microbiology, Mirabilis jalapa, Vibrio cholerae, in vitro
Efek Penambahan Vitamin C terhadap Aktivitas Klindamisin dalam Menghambat Pertumbuhan Streptococcus pneumoniae secara In Vitro Bagus Dwi Kurniawan; Dini Agustina; Erfan Efendi
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.9744

Abstract

Pneumonia is one of the lower respiratory tract infection involving respiratory bronchioles and alveoli that mostly caused by Streptococcus pneumoniae.Clindamycin is one of the drug of choice for pneumoniae. This drugs inhibits the growth of S. pneumoniae by producing ROS (Reactive Oxygen Species). Recent study has shown that vitamin C could generate ROS leading to DNA-damage on bacteria. The aims of this study was to know the possible benefit effect of adding vitamin C towards clindamycin inhibition activity against the growth of S. pneumoniae in vitro. This research was conducted by using 7 groups which consist of negative control (aquades), positive control (clindamycin), and test group 1 until 5 that given the combination of clindamycin and vitamin C as follows 2,5 mg/ml; 5 mg/ml; 10 mg/ml; 20 mg/ml; and 40 mg/ml. The inhibition effect of growing S. pneumoniae shown by the inhibition zone diameter. The average of inhibition zone on negative control, positive control, and test group were 5; 24,12; 24,62; 26,08; 27,58; 28,74; and 29,76 mm. These result show a significant correlation based on Pearson test (the coefficient correlation’s result is +0,910). The logarithmic regression revealed the minimal concentration of vitamin C was 1,767 mg/ml. It can be concluded that vitamin C increased the activity of clindamycin by inhibiting the growth of S.pneumoniae in vitro. Keywords: Streptococcus pneumoniae, ROS, Clindamycin, Vitamin C
Respon Imunogenitas Protein Permukaan 19 kDa Streptococcus pneumoniae (Immunogenicity Response of Streptococcus pneumoniae 19 kDa Surface Protein) Muhammad Dimas Arya Candra Permana; Dini Agustina; Bagus Hermansyah
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Pneumonia is the main common cause of children death in the world. Microbiological studies found the major causes of pneumonia is Streptococcus pneumoniae. Infection of S.pneumoniae influenced by several virulence factors, one of which is surface protein. The purpose of this study was to determine the immunogenicity of 19 kDa S.pneumoniae surface protein through hemagglutination inhibition and adhesion inhibition test. Adhesion inhibition test used antibodies that is formed from surface protein, to inhibit bacterial adhesion to the enterocytes. Hemagglutination inhibition test also used antibodies that formed from surface protein, to inhibit the agglutination of erythrocytes caused by S.pneumoniae. The results showed that antibodies, which was formed from 19 kDa S.pneumoniae surface protein, were able to inhibit hemagglutination process up to 1X dilution. Adhesion inhibition test showed that the higher antibody dilution, the greater the adhesion index. Pearson correlation analysis of the adhesion test showed that there was a significant correlation between antibody dilution with bacterial adhesion index (R= -0,787; p=0,036). It can be concluded that the 19 kDa surface protein of S.pneumoniae was immunogenic.   Keywords: Streptococcus pneumoniae, surface protein, antibody
Efektivitas Kombinasi Vankomisin dan Vitamin C terhadap Pertumbuhan MRSA (Methicillin Resistant Staphylococcus aureus) (Effectiveness of Vancomycin and Vitamin C Combination on MRSA (Methicillin Resistant Staphylococcus aureus) Growth) Ulin Nuha Jazmin; Dini Agustina; Rony Prasetyo
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6796

Abstract

Nephrotoxicity due to prolonged use of vancomycin becomes a big issue in patients with MRSA infections and the use of vitamin C has been proved to decrease this side effect. Vitamin C with its combination with antibiotic will halt MRSA growth by forming Reactive Oxygen Species (ROS). This study aimed to determine the effect of vancomycin and vitamin C combination in order to halt the MRSA growth and the minimum concentration of vitamin C which can decrease the Minimum Inhibitory Concentration (MIC) of vancomycin. This study used a quasi experimental design with 7 groups, 1 as negative control which only given vancomycin and 6 other groups which given vancomycin and vitamin C with following concentration 0,4; 0,8; 1,6; 3,2; 6,4; and 12,8 mg/mL. We used microdilution method with 4 repetitions to measure the MIC value. This study revealed that there were no difference between control and other groups, the MIC of vancomycin is 1 µg/mL. Combination effect was measured by Fractional Inhibitory Concentration Index (FICI) calculation which showed indifferent effect to all groups. This study concluded that combination of vancomycin and vitamin C effect has no difference with control group and by adding vitamin C until 12,8 mg/mL did not decrease MRSA growth. Keywords: MRSA, vancomycin, vitamin C, Minimum Inhibitory Concentration (MIC)
Efek Ekstrak Air Kulit Buah Delima (Punica granatum L) terhadap Salmonella typhimurium secara In Vivo (The Effect of Pomegranate (Punica granatum L) Peel Aqueous Extract on Salmonella typhimurium In Vivo) Anastasia Citra Purwani; Dini Agustina; Yuli Hermansyah
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Salmonella typhi infection is commonly treated by an antimicrobial agent such as levofloxacin. At the moment, herbal usage has risen as an alternative therapy. Pomegranate (Punica granatum L) is a commonly used herb which contains flavonoid as its major active compound. Aqueous extract of pomegranate peel had been known for its antimicrobial effect to S. typhi on in vitro study. The aim of this research was to investigate the activity of aqueous extract of pomegranate peel to S. typhimurium in vivo and find the antimicrobial effect of different concentrations. The study was conducted by using typhoid fever model in mice infected by S. typhimurium. Each mice was treated with aqueous pomegranate peel extract in three consentrations: 0,65 mg/ml, 1,3 mg/ml and 2,6 mg/ml for treatment groups and levofloxacin 1,3 mg/ml for positive control group. Ileum of each mice was isolated and cultured. The result of post hoc LSD test showed that negative control group significantly different with treatment group and the result of Pearson test showed p=0,000 and r = -0,865. In conclusion, aqueous extract of pomegranate peel had an antimicrobial activity on S. typhimurium in vivo where the higher extract concentration the lesser number of S. typhimurium colony.   Keywords: Antimicrobial, Pomegranate, Salmonella typhimurium
Daya Antibakteri Kombinasi Kitosan Cangkang Udang Putih (Litopenaeus vannamei) dan Siprofloksasin terhadap Salmonella typhi (Antibacterial Activity of Combination of White Shrimp (Litopenaeus vannamei) Shells Chitosan and Ciprofloxacin against Salmonella Sarah Marsa Tamimi; Dini Agustina; Cicih Komariah
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

yphoid fever is an acute infectious disease in the intestinal tract caused by Salmonella typhi. The prevalence of typhoid fever in Indonesia in 2013 was 81% per 100,000 population. Ciprofloxacin is a large-spectrum antibiotics, but in some countries ciprofloxacin has been known to be resistant to S. typhi. Therefore, other methods are needed to improve the effectiveness of ciprofloxacin by combining with chitosan. Chitosan is a polysaccharide which known to be effective in some positive and negative Gram bacteria and able to overcome the resistance of some antibiotics. The research objective was to determine the effect of antibacterial and Minimum Inhibitory Concentration (MIC) of the combination of Litopenaeus vannamei chitosan and ciprofloxacin against S. typhi. The method used to obtain the value of the MIC was microdilution method with quasy-experimental research design and posttest only control group design. MIC which already been obtained then used to find the Fractional Inhibitory Concentration Index (FICI) using a checkerboard test to interpret the effect of the combination. The MIC combination showed different results in each repetition that chitosan: 15.63 to 62.5 µg/mL and ciprofloxacin from 0.03 to 0.5 µg/mL and known to have a smaller value than the MIC single. While the value of FICI from 5 repetitions was 0.476. So, it could be concluded that the combination of chitosan and ciprofloxacin has an antibacterial effect on S. typhi and have a synergistic combination effect. Keywords: Salmonella typhi, chitosan, ciprofloxacin, microdilution method, checkerboard test.
Co-Authors Ali Santosa Anaditya Wahyu Kumudhaningsih Anastasia Citra Purwani Angga Mardro Raharjo Angga Mardro Raharjo, Angga Mardro Aprilya Pratiwi, Nadilla Arief Subhan Aryasatya, Dimas Widyadhana Bhanu Astuti Setyawardani Bagus Dwi Kurniawan Bagus Dwi Kurniawan Bagus Hermansyah Bagus Hermansyah Budi Suharjo Cahyaningrum, Endiningtyas Cholis Abrori, Cholis Cicih Komariah De Rorna, Masrahma Reinataya Denaneer Rahmadatu Desie Dwi Wisudanti Diana C. Mufida Diana Chusna Mufida Diana Chusna Mufida Dina Helianti Dion Krismashogi Dharmawan Dua , Mikhael Dwita Aryadina Rachmawati El Milla, Kardiana Izza Ellen Ocktavironita Elvia Rahmi Marga Putri Enny Suswanti Enny Suswati ENNY SUSWATI Erfan Efendi Erma Sulistyaningsih Fitri, Nadya Eka Gama Wisnu Sanjaya Habib Mustofa Habibbur Rochman Salim Habibi, Ali Hamzah, Salsabilla Maula Zalfa El Hanifa Rizki A.S. Hibatulloh, Muhammad Farhan Hidayat Hidayat Himma, Alyatul I Nyoman Semita Iftinan, Karenzha Ika Rahmawati Sutejo Intan Palupi Irawan Fajar Kusuma Jamalullail, Jamalullail Jauhani, Muhammad Afiful Jauhar Firdaus Kirana Nadyatara Kristianningrum Dian Sofiana Kusiyanto Taslim, Fitranda Laila Rizqi Kurniawati Lailatis Shofia Laksmi Indreswari M. Ali Shodikin Mei Liana Wati Miftakhul Huda Muhammad A. Shodikin Muhammad Ali Shodikin Muhammad Dimas Arya Candra Permana Mukhamad Najib Napitupulu , Frengki Nastiti Bekti Utami Nihayah Lukman Nisrina Salsabila Firmansyah Nita Alfianti Noorhamdani AS Noorhamdani AS Nugraha, Bima Setia Sandya Nurul Indah Saffanah Nurul Indah Saffanah Nurus Saffana Yulianto Pralampita, Pulong Wijang Primadana, Aditya Putra Uta, Diego Rafi Putra, Muhamad Dwi Eka Putra, Yudha Ananta Khaerul Ramadhani, Alfiyah Regina Finka Rinda Yanuarisa Rony Prasetyo Rosita Dewi Rustono - Ryan Ravi Is Syahputra S.Pd. M Kes I Ketut Sudiana . Sa'adah, Ajeng Samrotu Sakinah, Elly N Salsabila, Yuna Annisa Salsabilla Maula Zalfa El Hamzah Saputra, Antonius Dwi Sarah Marsa Tamimi Semita, I Nyoman septa surya wahyudi, septa surya Setyawardani, Astuti Sheilla Rachmania, Sheilla Shodikin, M. Ali Shofia, Lailatis Siti Marissa Aisyah Siti Zulaikha Sumarno Retoprawiro Supangat Supangat Syahputri, Siti Ananda Hardita Tristianti, Farmitalia Nisa Udi Rusadi Ulfa Elfiah Ulin Nuha Jazmin Widaningsih, Titi Widhiasari Normaningtyas Wiwien Sugih Utami Yudha Nurdian Yuli Hermansyah Yuli Rahmantia, Vania Yuna Annisa Salsabila Yunita Armiyanti