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All Journal Jurnal Ilmu Dasar Journal of Tropical Soils Jurnal Pendidikan Indonesia Jurnal Keterapian Fisik INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA E-Dimas: Jurnal Pengabdian kepada Masyarakat Jurnal Dinamika Pengabdian (JDP) Science and Technology Indonesia AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat BIOEDUSCIENCE Indonesian Journal of Chemistry Jurnal Perikanan Universitas Gadjah Mada JSFK (Jurnal Sains Farmasi & Klinis) Seminar Nasional Lahan Suboptimal Molekul: Jurnal Ilmiah Kimia JFIOnline SELL (Scope of English Language Teaching, Linguistics, and Literature) Journal CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Jurnal Mesin Nusantara SRIWIJAYA JOURNAL OF ENVIRONMENT Jurnal Ilmiah IT CIDA : Diseminasi Teknologi Informasi Pharmaceutical Sciences and Research (PSR) Gaster Journal of Global Pharma Technology Journal of Pharmacy Science and Technology Journal of Prosthetics Orthotics and Science Technology (JPOST) Jurnal Penelitian Sistem Informasi Jurnal Informatika Polinema (JIP) (MJN) SELL (Scope of English Language Teaching, Linguistics, and Literature) Journal Jurnal Terapi Wicara dan Bahasa Jurnal Kefarmasian Indonesia
Dwi Setyawan
Department Of Pharmaceutics, Faculty Of Pharmacy, Universitas Airlangga, Jl. Dharmawangsa Dalam, Surabaya 60286, Indonesia
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PENINGKATAN LAJU PELARUTAN TRIMETOPRIM MELALUI METODE KO-KRISTALISASI DENGAN NIKOTINAMIDA Zaini, Erizal; Halim, Auzal; Soewandhi, Sundani N.; Setyawan, Dwi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 4 (2011)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Co-crystallization of trimethoprim with nicotinamide had been done using solvent (methanol as a solvent) and melted technique. Kofler’s hot contact methode was used to identify the solid state interaction between these two components. The solid phase was characterized by microscopic, powder X-ray diffraction, thermal DTA and FT-IR spectroscopy analysis. Dissolution rate profile was performed by  paddle methode (Type II USP), distilled water as a medium. Solid state interaction between trimethoprim and nicotinamide show a formation of  conglomerate (simple eutectic) at eutectical point 125 0C. Dissolution rate of co-crystallization product of trimethoprim and nicotinamide increase  significantly compare to physical mixture and intact trimethoprim. ABSTRAK Telah dilakukan ko-kristalisasi trimetoprim dengan bahan tambahan nikotinamida dengan metode pelarutan (menggunakan pelarut metanol) dan peleburan. Metode kontak panas Kofler digunakan untuk identifikasi awal pembentukan interaksi antar kedua komponen. Padatan hasil ko-kristalisasi dikarakterisasi  dengan analisis mikroskopik, difraksi sinar-X, termal DTA dan spektrofotometer FT-IR. Uji laju pelarutan dilakukan dengan metode dayung (tipe II USP) dengan medium air. Hasil interaksi menunjukkan pembentukan konglomerat (eutektikal) antara kedua fase kristalin dalam keadaan padat, dengan titik eutektik pada temperatur 125 0C. Laju pelarutan trimetoprim hasil ko-kristalisasi meningkat secara signifikan dibandingkan dengan campuran fisika dan senyawa tunggal trimetprim.
PENINGKATAN LAJU PELARUTAN TRIMETOPRIM MELALUI METODE KO-KRISTALISASI DENGAN NIKOTINAMIDA Zaini, Erizal; Halim, Auzal; Soewandhi, Sundani N.; Setyawan, Dwi
Jurnal Farmasi Indonesia Vol 5, No 4 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i4.57

Abstract

Co-crystallization of trimethoprim with nicotinamide had been done using solvent (methanol as a solvent) and melted technique. Koflerâ??s hot contact methode was used to identify the solid state interaction between these two components. The solid phase was characterized by microscopic, powder X-ray diffraction, thermal DTA and FT-IR spectroscopy analysis. Dissolution rate profile was performed by  paddle methode (Type II USP), distilled water as a medium. Solid state interaction between trimethoprim and nicotinamide show a formation of  conglomerate (simple eutectic) at eutectical point 125 0C. Dissolution rate of co-crystallization product of trimethoprim and nicotinamide increase  significantly compare to physical mixture and intact trimethoprim. ABSTRAK Telah dilakukan ko-kristalisasi trimetoprim dengan bahan tambahan nikotinamida dengan metode pelarutan (menggunakan pelarut metanol) dan peleburan. Metode kontak panas Kofler digunakan untuk identifikasi awal pembentukan interaksi antar kedua komponen. Padatan hasil ko-kristalisasi dikarakterisasi  dengan analisis mikroskopik, difraksi sinar-X, termal DTA dan spektrofotometer FT-IR. Uji laju pelarutan dilakukan dengan metode dayung (tipe II USP) dengan medium air. Hasil interaksi menunjukkan pembentukan konglomerat (eutektikal) antara kedua fase kristalin dalam keadaan padat, dengan titik eutektik pada temperatur 125 0C. Laju pelarutan trimetoprim hasil ko-kristalisasi meningkat secara signifikan dibandingkan dengan campuran fisika dan senyawa tunggal trimetprim.
Co-Authors AA Sudharmawan, AA Abdulkadir Rahardjanto, Abdulkadir Achmad Radjaram Agnes Nuniek Winanta Ahmad Zainul AM Mufarrih Amanda Della Yudatama Astuti, Ely Setyo Atok Miftachul Hudha Auzal Halim Bambang Widjaja Bambang Widjaja Bambang Widjaja Bambang Widjaja Betari, Sita Desti Bhisma Murti Bidarinjani, Mouria D Budianta, D Dafa C, Muhammad Dewanthy, Kyrana Sekar Dewi Isadiartuti Dewi Melani Hariyadi Dicky Pratama Dina Ayu Fatmawati Diyah, Nuzul Wahyuning Ekojono Ekojono Erizal Zaini Fadjar Mulya Fajar R, Allak Farid, Saif Aiman Fatati, Muhibbah Fatkur Rhohman, Fatkur Fauzi Ahmad Muda Fauzia, Alfi Nur Fendy Hardian Permana Ferdinand Hukama Taqwa Fery Eko Pujiono, Fery Eko Fikria, Laila Hidayatul Finas Rahmayanti Gatot Sugiarto Gilkes, Robert Hafidz, Moh Handayani, Ning Rahayu Hartanto, Agus Dwi Havidhatul Maulia Herlina Hanum, Herlina HERMANU JOEBAGIO Ichsan Luqmana Indra Putra, Ichsan Luqmana Indra Idha Kusumawati Iin Hindun Ina Sholihah Widiati, Ina Sholihah Indah Sayekti Indah Sayekti, Indah Juni Ekowati Kanzaffa, Firly Afnauriza Tedja Kuamit, Thanawit Kuni Zu’aimah Barikah Kurdi Wijaya, Moh Kurniawan, Muhammad Fariez Lina Winarti Maghzarini, Nessa Regitha Marcellino Rudyanto Maren, A Maria Lucia Ardhani Dwi Lestari Martinus, Ali Melanny Ika Sulistyowaty Misbahul Munir Moh. Mirza Nuryady Muhammad Adi Nugroho Muhammad Setiyawan Muhibbah Fatat Muhibbah Fatati Ningsih, Cica Trimandasari Noorma Rosita Novira Widajanti, Novira Nugroho, Surya Adi Nurhayati Damiri Nuri Nuruddin, Mahrus Naufal Nurwidodo, Nurwidodo Oktavia Eka Puspita, Oktavia Eka Paramita, Diajeng Putri Paserena, Karinda Dwi Prameswari, Putu Pradnya Mimba Pratiwi, Ambar Priatna, S J Pujiono, Ferry Eko Raden Joko Kuncoroningrat Susilo Rani, Karina Citra Refraugati, Irwandi Retno Sari Rohana, Melissa Rosalin Ismayoeng Gusdian Rudy Salam, Rudy Samsun hadi Sari, Ketut Intan Yunika Septiani, Annisa Eka Shofiatul Izzah Al Amaliyah Siammita, Dhea Anansya Siswandono, S. Siswandono, Siswandono Soraya, Yasmin Sukma Adhi Permata Sundani N. Soewandhi, Sundani N. Syafi'ie, Hisyam Tahta Amrillah Tongway, David Tri Agus Siswoyo Utami, Inggita Viddy Agustian Rosidi Wahyu Prihanta Warsito Warsito Widji Soeratri Winantari, Agnes Nuniek Yuanita Windusari Yudi Wicaksono Yudi Wicaksono Yudi Wicaksono Yuli Ainun Najih Zidan, Sabry A. H. Zimy Fianti Ningtyas Zimy Fianti Ningtyas, Zimy Fianti