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Dwi Setyawan
Department Of Pharmaceutics, Faculty Of Pharmacy, Universitas Airlangga, Jl. Dharmawangsa Dalam, Surabaya 60286, Indonesia
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Journal : Journal of Global Pharma Technology

 1 
Effect of Pregelatinization on Suweg Tuber Starch (Amorphophallus Paeonifolius) as Tablet Crusher Dwi Setyawan
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Disintegrant tablet from starch is more often used to crush the tablet that has been swallowed. However, the material of this starch is tablet crusher which very weak. In contrast to the suweg starch (Amorphophallus paeonifolius) which has undergone pregelatinization where the content of amylose and amylopectin and the water absorption capacity that is high enough so that it can crush the tablet quickly. The aim of this study was to determine the influence of pregelatinization towards elephant foot yam (Amorpophallus paeonifolius) starch as disintegrant against tablet physical quality profile of the Paracetamol tablet. Method: The research was carried out by making suweg natural starch which then it made a suspension in the water with a concentration of 20% and heated to the temperature of 60 ± 5 0C and 70 ± 5 0C within 15 minutes. After the suweg pregelatin starch has been made, then a paracetamol tablet and a qualitative examination also made which includes the determination of the paracetamol infrared spectrum, the examination of moisture content, the testing with iodine, the testing with optical microscopy, X-ray diffraction analysis, the starch thermal analysis with DTA, and the examination of swelling power which then compared to each tablet formula made by the wet granulation method. after that, it was continued with the examination of the granule quality, including the examination of moisture content, the examination of granule particle size and number of fines, the examination of flow velocity and rest angle of the granule. Moreover, it was carried out an evaluation of the paracetamol tablet physical quality in the form of hardness test, friability test, and disintegration time test. The data obtained was further analyzed by One Way ANOVA. Result: Tablet formula with pregelatinization of suweg natural starch can reduce the hardness, increased the tablet disintegration time, and made no difference in friability compared to the formulas containing natural suweg tuber starch and SSG. The result of increased disintegration time was then compared with the result of the swelling power test, but did not indicate a correlation both of them. The different of disintegration was not showed a correlation with values of swelling power. Keywords: Suweg Tuber Starch, Starch Pregelatinization, Pregelatinized Starch Tablet.
Co-Authors AA Sudharmawan, AA Abdulkadir Rahardjanto, Abdulkadir Achmad Radjaram Agnes Nuniek Winanta Ahmad Zainul AM Mufarrih Amanda Della Yudatama Astuti, Ely Setyo Atok Miftachul Hudha Auzal Halim Bambang Widjaja Bambang Widjaja Bambang Widjaja Bambang Widjaja Betari, Sita Desti Bhisma Murti Bidarinjani, Mouria D Budianta, D Dafa C, Muhammad Dewanthy, Kyrana Sekar Dewi Isadiartuti Dewi Melani Hariyadi Dicky Pratama Dina Ayu Fatmawati Diyah, Nuzul Wahyuning Ekojono Ekojono Erizal Zaini Fadjar Mulya Fajar R, Allak Farid, Saif Aiman Fatati, Muhibbah Fatkur Rhohman, Fatkur Fauzi Ahmad Muda Fauzia, Alfi Nur Fendy Hardian Permana Ferdinand Hukama Taqwa Fery Eko Pujiono, Fery Eko Fikria, Laila Hidayatul Finas Rahmayanti Gatot Sugiarto Gilkes, Robert Hafidz, Moh Handayani, Ning Rahayu Hartanto, Agus Dwi Havidhatul Maulia Herlina Hanum, Herlina HERMANU JOEBAGIO Ichsan Luqmana Indra Putra, Ichsan Luqmana Indra Idha Kusumawati Iin Hindun Ina Sholihah Widiati, Ina Sholihah Indah Sayekti Indah Sayekti, Indah Juni Ekowati Kanzaffa, Firly Afnauriza Tedja Kuamit, Thanawit Kuni Zu’aimah Barikah Kurdi Wijaya, Moh Kurniawan, Muhammad Fariez Lina Winarti Maghzarini, Nessa Regitha Marcellino Rudyanto Maren, A Maria Lucia Ardhani Dwi Lestari Martinus, Ali Melanny Ika Sulistyowaty Misbahul Munir Moh. Mirza Nuryady Muhammad Adi Nugroho Muhammad Setiyawan Muhibbah Fatat Muhibbah Fatati Ningsih, Cica Trimandasari Noorma Rosita Novira Widajanti, Novira Nugroho, Surya Adi Nurhayati Damiri Nuri Nuruddin, Mahrus Naufal Nurwidodo, Nurwidodo Oktavia Eka Puspita, Oktavia Eka Paramita, Diajeng Putri Paserena, Karinda Dwi Prameswari, Putu Pradnya Mimba Pratiwi, Ambar Priatna, S J Pujiono, Ferry Eko Raden Joko Kuncoroningrat Susilo Rani, Karina Citra Refraugati, Irwandi Retno Sari Rohana, Melissa Rosalin Ismayoeng Gusdian Rudy Salam, Rudy Samsun hadi Sari, Ketut Intan Yunika Septiani, Annisa Eka Shofiatul Izzah Al Amaliyah Siammita, Dhea Anansya Siswandono, S. Siswandono, Siswandono Soraya, Yasmin Sukma Adhi Permata Sundani N. Soewandhi, Sundani N. Syafi'ie, Hisyam Tahta Amrillah Tongway, David Tri Agus Siswoyo Utami, Inggita Viddy Agustian Rosidi Wahyu Prihanta Warsito Warsito Widji Soeratri Winantari, Agnes Nuniek Yuanita Windusari Yudi Wicaksono Yudi Wicaksono Yudi Wicaksono Yuli Ainun Najih Zidan, Sabry A. H. Zimy Fianti Ningtyas Zimy Fianti Ningtyas, Zimy Fianti