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All Journal E-Jurnal Ekonomi dan Bisnis Universitas Udayana Sosiohumaniora Journal of Educational, Health and Community Psychology Jurnal Pendidikan Matematika Universitas Lampung Jurnal Pembelajaran Fisika Wardah Taqdir Berkala Kedokteran PROFIT : Kajian Pendidikan Ekonomi dan Ilmu Ekonomi HIGIENE: Jurnal Kesehatan Lingkungan Jurnal Sisfokom (Sistem Informasi dan Komputer) International Journal of Supply Chain Management Jurnal Ilmu Perilaku Jurnal Riset dan Aplikasi: Akuntansi dan Manajemen JCPS (Journal of Current Pharmaceutical Sciences) Bitnet: Jurnal Pendidikan Teknologi Informasi Jurnal Ilmu Kesehatan Bhakti Husada: Health Sciences Journal JPK: Jurnal Proteksi Kesehatan Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Idarotuna: Jurnal Kajian Manajemen Dakwah Journal SAGO Gizi dan Kesehatan Al-Ulum: Jurnal Pendidikan Islam Jurnal Ilmiah Wahana Pendidikan Pillar of Physics: Jurnal Berkala Ilmiah Fisika Al-Ulum: Jurnal Pendidikan Islam Jurnal Pengabdian Mandiri Gemilang: Jurnal Manajemen dan Akuntansi Bulletin of Indonesian Islamic Studies Jurnal Pengabdian Kreativitas Pendidikan Mahakam (JPKPM) Jurnal Fisioterapi dan Kesehatan Indonesia Tabayyun Jurnal Abdimastek (Pengabdian Masyarakat Berbasis Teknologi) Faedah: Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia Perspektif: Jurnal Pendidikan dan Ilmu Bahasa Prosiding Seminar Nasional Unimus Jurnal Cakrawala Pendidikan dan Biologi (jucapenbi)
Hamidah Hamidah
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Journal : Berkala Kedokteran

 1 
Perbedaan Kadar LDH Serum Total Sebelum dan Sesudah Kemoterapi pada Berbagai Kelompok Stadium Kanker LNH Hamidah Hamidah; Muh.Darwin Prenggono; Farida Heriyani
Berkala Kedokteran Vol 12, No 1 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.026 KB) | DOI: 10.20527/jbk.v12i1.356

Abstract

Abstract: Lactate dehydrogenase (LDH) is tumor prognostic for Non Hodgkin Lymphoma (NHL) and it levels would be elevated. The several papers has reported there are an association of total serum LDH levels and staging group of NHL. The study aimed to determine the differences of total serum LDH levels before and after the combination chemotherapy CHOP (Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) for NHL’s patients at RSUD Ulin Banjarmasin during 3 years. It was an observational analyticstudy design and cross-sectional approach, data collected with design method of totally sampling. Of the 51 patient medical records who included, 54,9% were staging group I-II and 45,1% were staging group III-IV. The first statistic analytic used dependent T test with p=0,303 (p>0,05)showed no differencesof total serum LDH levels before and after the combination chemotherapy CHOP in NHL’s patients with staging group I-II. The second statistic analytic used alternative wilcoxon test with p=0,013 (p<0,05) showed differencesof total serum LDH levels before and after the combination chemotherapy CHOP in NHL’s patients with staging groupIII-IV. The third statistic analytic used alternative mann whitney test with p=0,161 (p>0,05) showed no differencesof total serum LDH levels after the combination chemotherapy CHOP in NHL’s patients between staging group I-II and III-IV.Keywords: total serum LDH levels, NHL, combination chemotherapy CHOP Abstrak: Laktat dehidrogenase (LDH) adalah tumor prognostic pada kanker Limfoma Non Hodgkin (LNH) dan kadarnya selalu menunjukan peningkatan. Penelitian sebelumnya melaporkan bahwa terdapat hubungan antara kadar LDH serum total dengan kelompok stadium kanker LNH. Penelitian ini bertujuan untuk mengetahui perbedaan kadar LDH serum total sebelum dan sesudah kemoterapi kombinasi CHOP (Siklofosfamid, Doksorubisin, Vinkristin, dan Prednison) pada penderita kanker LNH di RSUD Ulin Banjarmasin selama 3 tahun.Penelitian ini menggunakan rancangan studi observasional analitik dan metode pendekatan cross sectional, pengambilan sampel dengan teknik rancangan totally sampling. Dari 51 data rekam medik yang termasuk kriteria inklusi, 54,9% kelompok stadium I-II dan 45,1% kelompok stadium III-IV. Analisis statistik pertama menggunakan uji T berpasangandengan p=0,303 (p>0,05) sehingga tidak terdapat perbedaan kadar LDH serum total sebelum dan sesudah kemoterapi kombinasi CHOP pada penderita kanker LNH kelompok stadium I-II. Analisis statistik kedua menggunakan uji alternatif yaitu uji wilcoxondengan p=0,013 (p<0,05) sehingga terdapat perbedaan kadar LDH serum total sebelum dan sesudah kemoterapi kombinasi CHOP pada penderita kanker LNH kelompok stadium III-IV. Analisis statistik ketiga menggunakan uji alternatif yaitu uji mann whitney dengan p=0,161 (p>0,05) sehingga tidak terdapat perbedaan kadar LDH serum total sesudah kemoterapi kombinasi CHOP pada penderita kanker LNH antara kelompok stadium I-II dan III-IV. Kata-kata kunci: kadar LDH serum total, LNH, kemoterapi kombinasi CHOP
Co-Authors Abdurahman Abdurrahman Alfiansyah Alfiansyah Alifia Khana Fitrah Amelia Risnauli br. Lumbangaol Anang Walian Anisa Musyarrof Asep Darmansyah Astuti Dola Bastina Budiman Budiman Caswita Caswita Dewi Susita Farida Heriyani Faudah Ashri Nurfurqoni Faudah Astri Nurfakrohni Fitria Fitria Gemelthree Ardiatus Subekti Halimatussakdiah Halimatussakdiah Hapzi Ali Harrizkie Arie Pradana Hengki Hengki Herda Ariyani Husen Hutagalung Ijah Bahijah Indira Karima Umaroe Indrawati Indrawati Irma Nur Amalia Irsan Herlandi Putra Jasmani Jasmani Jomima Batlajery Jufrizal Jufrizal Junaedi Abdillah, Junaedi Khalimah Tussakdiyah Kurniati Puji Lestari Laurentinus Laurentinus M. Fachjri Kurniawan MARIA BINTANG Maryanah Maryanah Mega Sari Mita Kurniati Muchlis R. Luddin Muhammad Abrar Muhammad Akbar Muhammad Faqih Muhammad Nazemi Muhammad Redha Anshari Muhtarudin Muhtarudin Mukffan Mukffan Mu’alimin Mu’alimin Nadira Nadira Fajri Nina Primasari Nuriyah Nuriyah Nursida Dewi Okkita Rizan Okkita Rizan Prenggono, Muhamad Darwin Purwana E.S., Dedi Putri Dewi Anggia Rafi&#039;i Rafi&#039;i Rahayu, Diah Rully Hevrialni Rustiana, Erna Saddan Yasir Saikou Gassama Sarwindah Sarwindah Siska Helina Siti Afiqah Bt Mohamed Tahir SITI FATIMAH Sosialita, Tiara Diah Sri Harini Sri Hastuti Noer Sri Hertimi Sri Indriani Sujono Sujono Sumaina Duku Syahril Romli Thoibatun Nafisah Tjiptohadi Sawarjuwono Ulfa Sari Febriani Undang Rosidin Usep Suhud Wawan Gunawan Wawan Gunawan Wibowo Wibowo Widarto Rachbini Widarto Rachbini Wildan Wildan Windayanti Windayanti Wiwin Hendriani Yan Sartika Yulia Djahir