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All Journal Medula Alami Journal (Alauddin Islamic Medical) Journal Journals of Ners Community J-KESMAS: Jurnal Kesehatan Masyarakat UMI Medical Journal PREPOTIF : Jurnal Kesehatan Masyarakat Borneo Journal of Medical Laboratory Technology Indonesian Journal of Global Health research MAHESA : Malahayati Health Student Journal Wal'afiat Hospital Journal INDONESIAN JOURNAL OF HEALTH SEHATI: Jurnal Kesehatan Molucca Medica jpki Cerdika: Jurnal Ilmiah Indonesia WAL'AFIAT HOSPITAL JOURNAL Fakumi Medical Journal
Rachmat Faisal Syamsu
Bagian IKM-IKK Fakultas Kedokteran, Universitas Muslim Iindonesia, Makassar
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Systematic Review : Efek Resveratrol Terhadap Parameter Hipertensi Raisya Zahra Salmalia; Rachmat Faisal Syamsu; Dwi Pratiwi Ma’ruf
MAHESA : Malahayati Health Student Journal Vol 6, No 5 (2026): Volume 6 Nomor 5 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i5.22767

Abstract

ABSTRACT Hypertension is a major global health issue with rising prevalence and significant morbidity and mortality. Despite available pharmacological therapies, blood pressure control often remains suboptimal, prompting investigation into natural adjunctive interventions. Resveratrol, a polyphenolic compound found predominantly in red grape skin, has demonstrated antioxidant, anti-inflammatory, and endothelial function-enhancing properties, suggesting potential antihypertensive effects. This systematic review aims to evaluate the impact of resveratrol on hypertension-related parameters in experimental animal models. A comprehensive literature search was conducted across PubMed, Scopus, Sinta, and Google Scholar for studies published between 2020 and 2025, focusing on in vivo interventions using pure resveratrol. Ten studies met inclusion criteria, encompassing models such as spontaneously hypertensive rats, DOCA-salt-induced hypertension, cyclosporin A-induced hypertension, and perinatal programming of hypertension. Consistently, resveratrol administration resulted in reduced systolic and diastolic blood pressure, enhanced endothelial nitric oxide (NO) bioavailability, decreased oxidative stress and inflammatory markers, and improved target organ function, particularly in the heart and kidneys. Mechanistically, effects were mediated via eNOS/NO pathway activation, modulation of renin-angiotensin-aldosterone system, antioxidative protection, anti-inflammatory activity, and regulation of cellular stress pathways. These findings support resveratrol as a promising adjunctive agent for hypertension management, offering both blood pressure-lowering and organ-protective benefits. Moreover, its presence in grapes, noted in the Quran for health benefits, highlights the potential for dietary incorporation as part of holistic health approaches. Further clinical studies are warranted to translate these experimental findings into human populations. Keywords: Resveratrol, Hypertension, Blood Pressure, Endothelial Function.  ABSTRAK Hipertensi merupakan masalah kesehatan global dengan prevalensi yang terus meningkat dan kontribusi signifikan terhadap morbiditas serta mortalitas. Meskipun tersedia terapi farmakologis, pengendalian tekanan darah sering kali belum optimal, sehingga penelitian mengenai intervensi tambahan berbasis bahan alami menjadi penting. Resveratrol, senyawa polifenol yang terutama terdapat pada kulit anggur merah, memiliki sifat antioksidan, antiinflamasi, dan meningkatkan fungsi endotel, sehingga berpotensi menurunkan tekanan darah. Sistematic review ini bertujuan mengevaluasi efek resveratrol terhadap parameter hipertensi pada model hewan eksperimental. Pencarian literatur dilakukan di PubMed, Scopus, Sinta, dan Google Scholar untuk studi tahun 2020–2025 dengan intervensi resveratrol murni. Tujuh studi memenuhi kriteria inklusi, meliputi model tikus hipertensi spontan, hipertensi DOCA-salt, hipertensi akibat siklosporin A, dan pemrograman hipertensi perinatal. Secara konsisten, pemberian resveratrol menurunkan tekanan darah sistolik dan diastolik, meningkatkan bioavailabilitas nitric oxide (NO) endotel, menurunkan stres oksidatif dan biomarker inflamasi, serta memperbaiki fungsi organ target, terutama jantung dan ginjal. Mekanisme efek melibatkan aktivasi jalur eNOS/NO, modulasi sistem renin-angiotensin-aldosteron, perlindungan antioksidan, aktivitas antiinflamasi, dan regulasi jalur stres seluler. Temuan ini menunjukkan bahwa resveratrol berpotensi menjadi agen tambahan dalam pengelolaan hipertensi dengan manfaat proteksi organ. Selain itu, kandungan resveratrol dalam anggur, yang disebut dalam Al-Qur’an sebagai buah bermanfaat bagi kesehatan, mendukung potensi penggunaannya dalam pendekatan diet sehat. Studi klinis lebih lanjut diperlukan untuk mentranslasi hasil ini ke populasi manusia. Kata Kunci: Resveratrol, Hipertensi, Tekanan Darah, Fungsi Endotel.
Co-Authors Abbas Zavey Nurdin Achmad Harun Muchsin Ade Rahmy Sujuthi Ahmad Fahd Alifian Alamanda Irwan Amirah Mardhiyah Anak Agung Istri Sri Wiadnyani Andi Alamanda Irwan Andi Fahira Arsal Andi Fahirah Arsal Andi Husni Esa Darussalam Andi Tenri Sanna Andini Marccela Andini Sangkal Anna Sri Dewi Annisa Ancha Annisa Duratul Hikmah Arina Fathiyyah Arifin Armanto Makmun Arni Isnaini Arfah Aryanti Bamahry Aryanti R. Bamahry Asrini Safitri Ayu Ulfiah Azis Dahliah Dinda Permatasari Dwi Pratiwi Ma’ruf Erlin Syahril Fahmi Satrio Hidayat Fendy Dwimartyono Hanna Aulia Namirah Hermiaty Hermiaty Hermiaty Nasruddin Hermiaty Nasaruddin Hermiaty Nasruddin Hermiaty Nasruddin Hermiaty Nasruddin Ida Royani Iffa Nabila Zulfitria Inayah Al Fatiha Indhi Aulia Tasya Indy Inna Mutmainnah Musa Irmayanti Haidir Bima Irna Diyana Kartika Irsanti Sasmita Tauhid Kesya Azzahra Putri Lu’lu Luqyana Amirah Salsabila Miftahul Jannah Moch. Erwin Rachman Mochammad Erwin Rachman Mochammad Erwin Rachman Mohammad Reza Zainal Abidin Mona Nulanda Mona Nulanda Muh. Farid Jamal Muhammad Alief Akbar Muhammad Alim Jaya muhammad yastrib semme Muhammad Zuhal Darwis Mukhbita Alifia Danial Nabila Maulidiana Putri Nasrudin Andi Mappaware Nesyana Nurmadilla Nirwana Laddo Nur Ahmad Tabri Nur Akhsan Diana Nur Ashianty Hadijah Nur Fadhillah Khalid Nurfachanti Fattah Nurfachanti Fattah Nurfadillah Khalid Nurmadilla, Nesyana Nurqalbi Faizal Nurul qalbi nuqa Paulus Rahmawati Mamile Raisya Zahra Salmalia Rasfayanah Rasfayanah, Rasfayanah Ratih Natasha Maharani Reghita Avrilya Reski Amaliah Rezky Pratiwi LB Ririn Ramadhani Ridwan Rismayanti Rizqie Hayyudiah Sandra Kariati Satharia Lausiri Satya Wicaksana Sutantri Shulhana Mokhtar Shulhana Mokhtar Shulhana Mokhtar Sidrah Darma Sigit Dwi Pramono Siska Nuryanti Siska Nuryanti Siska Nuryanti Sommeng, Faisal Sri Sulfianti Sri Wahyu Sri Wahyuni Gayatri Sulfiani Sulfiani Sultan Buraena Syamsu Rijal Tendri Azzahra Trisha Mel Anggun Koedoeboen Widya Lestari Ningsih Husain Wiriansya, Edward Pandu Yusriani Mangarengi Zulfah Midah Zulfitriani Murfat Zulfiyah Surdam