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FORMULASI DAN EVALUASI NANO HIDROGEL EKSTRAK DAUN SERUNAI (Chromolaena odorata L.) DENGAN VARIASI KONSENTRASI POLIMER CARBOPOL 980 Syafira Nabillah; Noval Noval; Nur Hidayah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.995

Hydrogel is an ideal preparation as a wound dressing because it can provide a cold sensation that can reduce swelling in the wound area. Nanoparticles are particles that have a size of 1-1000 nm. Nanoparticles have the advantage of reducing the particle size and delivering the active substance to the target site. In the manufacture of nanohydrogels it is necessary to have a gelling agent in order to obtain a preparation that meets the requirements. In this study, nanohydrogels were made using Chrysanthemum leaf extract (Chromolaena odorata L.) as the active substance and made with various concentrations of carbopol 980 as a gelling agent. The purpose of this study was to determine the effect of variations in the concentration of carbopol 980 on nanohydrogel preparations of chrysanthemum leaf extract. The method used is Quasi Experimental Design. Simplicia was made into extracts and then made into nano preparations and evaluated. Data were analyzed using One Way Anova and Kruskal-Wallis. The particle size of Formula I nanohydrogel preparation was obtained at 412.9 nm. The results of the evaluation of the preparation showed that the nanohydrogel of chrysanthemum leaf extract with variations in the concentration of carbopol 980 had no effect on homogeneity, but it did affect the pH, viscosity, dispersibility, and adhesion test as shown in the One Way Anova statistical test (p<0.05). From the evaluation results, the ideal formula for nano hydrogel preparations was found in formula I with a carbopol 980 concentration of 0.5%.

Inisiasi Protocorm Like Bodies (PLB) Dendrobium sylvanum Siti Malahayati; Noval Noval; Setia Budi
Jurnal Pelayanan Kefarmasian dan Sains Vol 2 No 2 (2022): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v2i2.184

Genus of Dendrobium orchid produces secondary metabolites namely medicinal alkaloid, the main alkaloid in dendrobium is dendrobine. Orchid plant parts that contain secondary metabolites in large quantities are in the form of protocorm like bodies (PLB). This research is about how to do an initiation of PLB from the seed of Dendrobium sylvanum. The aim of this research is to determine the concentration of giberelin (GA3) in Murashige and Skoog (MS) medium for PLB optimal initiation. Seed culture was cultivated in MS medium supplemented with GA3 in 3 concentrations: GA3 1 ppm; GA3 2 ppm; and GA3 4 ppm. The result showed the concentration that can give the optimal growth is GA3 1 ppm based on the appeareance of PLB, colour of PLB, diameter of PLB, growth index, and anatomy of PLB.

Penggunaan Tanaman Sebagai Obat pada Masyarakatan Suku Banjar, Dayak, dan Bugis di Kalimantan Selatan: The Use of Plants as Medicine in the People of Banjar, Dayak, and Bugis Tribes in South Kalimantan Melviani Melviani; Rohama Rohama; Noval Noval
Jurnal Surya Medika (JSM) Vol. 8 No. 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i2.3882

The development of science and technology in the development of pharmaceutical products that are going fast does not make society switch completely to modern medicine; it can be seen from how some of society for generations still utilize the potential of plants for treatment. This research is useful to find out the picture of plants used as medicine in the Banjar Tribe, Dayak Tribe, and Bugis tribe in South Kalimantan. This research method is an observational research design with a cross-sectional approach, using convenience sampling techniques. The results obtained there are 44 types of plants used, with the largest percentage being ginger which serves as body warmth and guava to treat stomach pain (12.0%), betel leaves to reduce body odor (9.0%), turmeric, Dutch jackfruit leaves or soursop leaves and cat whiskers (5.0%), sungkai (4.0%), bay leaves (3.0%) and other plants with a percentage (45%). The type of plant used is herbaceous (40.0%). The largest part of the plant is the leaves (55.0%) processed by boiling (65.0%).

Karakterisasi dan Formulasi Nanopartikel Ekstrak Tanaman Bundung (Actinoscirpus grossus) dengan Variasi Konsentrasi Basis Kitosan dan Na-TPP Menggunakan Metode Gelasi Ionik: Characterization and Formulation of Nanoparticles Extract of Bundung Plant (Actinoscirpus grossus) with Variations in Concentration of Chitosan and Na-TPP Bases Using the Ionic Gelation Method Yuditha Mutia Windy; Khaliza Natasya Dilla; Jesika Claudia; Noval Noval; Ali Rakhman Hakim
Jurnal Surya Medika (JSM) Vol. 8 No. 3 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i3.4495

Bundung plant extract contains flavonoid secondary metabolite compounds that have the potential to kill Staphylococcus aureus bacteria and inhibit the fungus Candida albicans. Its utilization uses nanoparticle technology because the ability to penetrate cell walls can be penetrated by the size of colloidal particles. Nanoparticles are technologies that have a size of 10-1000 nm. The formation of nanoparticles using chitosan polymer and Na-TPP can produce preparations with good stability. This study aims to determine the characterization and formulation of nanoparticles and the effect of the concentration of chitosan and Na-TPP on the characterization of nanoparticles of plant extracts. This research is an experimental laboratory with a quasi-experimental design method and a one-group posttest-only research design. Bundung plant extracts formulated into nanoparticles with various concentrations of formula 1 (chitosan 0.1% and Na-TPP 0.2%), formula 2 (chitosan 0.15% and Na-TPP 0.15%), and formula 3 (chitosan 0.2% and Na-TPP 0.1%). Then organoleptic and characterization tests were carried out in particle size tests, zeta potential, and data were analyzed by ANOVA. All formulas showed nanoparticle size. The results of the nanoparticle characterization of the extract of the Bundung plant showed that F2 was the formula with the smallest particle size of 328.8 nm, but for the zeta potential value, the stable formula was F3 because it had a zeta potential value close to +/-30mV, i.e., 10.4mV. The statistical results of One Way ANOVA show that the significance value is <0.05, which means that there is an effect of variations in the concentration of chitosan and Na-TPP. Variations in the concentration of chitosan and Na-TPP in each formula can affect the particle size and zeta potential value.

Optimasi Formulasi Sediaan Tablet Effervescent dari Ekstrak Etanol Tanaman Kalangkala (Litsea angulata) sebagai Antioksidan Menggunakan Metode SLD (Simplex Lattice Design): Optimization of Effervescent Tablets Formulation From Ethanol Extract of Kalangkala Plant (Litsea angulata) as Antioxidant Using SLD (Simplex Lattice Design) Method Rohama Rohama; Melviani Melviani; Noval Noval
Jurnal Surya Medika (JSM) Vol. 8 No. 3 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i3.4496

Free radicals trigger various diseases, such as respiratory disorders and cancer. Aware of the bad potential of free radicals, many people consume antioxidants to tackle free radicals. One of them is Kalangkala Plant (Litsea angulata), which contains flavonoids. The potential of Kalangkala plants as antioxidants is formulated in effervescent tablets. The effervescent tablet was evaluated using the Simplex Lattice Design (SLD) method to determine the most optimal formulation. The results showed that the most optimal preparation from the evaluation of powders was F2, while the results of the evaluation of tablets using the SLD method were the most optimal was F3. In addition, the antioxidant activity test using the DPPH method showed that Kalangkala Leaf extract had strong antioxidant activity.

Karakterisasi Nanokapsul Ekstrak Daun Serunai (Chromolaena odorata L.) dengan Variasi Kitosan-Alginat Menggunakan Metode Emulsi-Difusi: Characterization of Nanocapsules of Serunai Leaf Extract (Chromolaena odorata L.) with Chitosan-Alginate Variations Using the Emulsion-Diffusion Method Roosma Hatmayana; Noval Noval; Dede Mahdiyah; Rizki Adhie Ramadhani; Nurul Auliyani
Jurnal Surya Medika (JSM) Vol. 8 No. 3 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i3.4512

Serunai (Chromolaena odorata L.) is a plant that has been widely used in medicine, one of which is as an antidiabetic. But treatment using plant extracts has drawbacks to the solubility of the active substance and its bioavailability in the body. Nanocapsules are one of the systems in particle technology that can solve this problem by utilizing a polymer that will encapsulate the active substance and release it slowly at the intended target. To achieve this, the manufacture of nanocapsules must meet several characteristic requirements such as particle size, potential zeta, absorption efficiency, and emulsion stability. This study was conducted to identify the nanocapsules characteristics of Serunai leaf extract (Chromolaena odorata L.) with chitosan-alginate variations and identify the influence of chitosan-alginate variations on the characteristics of nanocapsules. This study is a laboratory experimental study with a one-group posttest-only design. The manufacture of Serunai leaf extract nanocapsules using the emulsion-diffusion method, which is then characterized including particle size determination, potential zeta determination, absorption efficiency test (%EE), and emulsion stability test. The results obtained from the determination of the particle size of Formula I 196.4 nm, Formula II 264.2 nm, and Formula III 207.4 nm, potential zeta Formula I -36.1 mV, Formula II -40.1 mV, and Formula III -36.5 mV, the formula I %EE values 99.7%, Formula II 99.8%, and Formula III 99.7%, as well as all formulas indicating the emulsion type m/a. Three formulas have met the requirements of nanocapsules characteristics. The formula is best obtained in Formula II with a chitosan concentration of 0.3% and alginate of 0.6%, so chitosan-alginate variations influence the characteristic results.

FORMULASI DAN EVALUASI NANO HIDROGEL EKSTRAK DAUN SERUNAI (Chromolaena odorata L.) DENGAN VARIASI KONSENTRASI POLIMER CARBOPOL 980 Syafira Nabillah; Noval Noval; Nur Hidayah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.995

Hydrogel is an ideal preparation as a wound dressing because it can provide a cold sensation that can reduce swelling in the wound area. Nanoparticles are particles that have a size of 1-1000 nm. Nanoparticles have the advantage of reducing the particle size and delivering the active substance to the target site. In the manufacture of nanohydrogels it is necessary to have a gelling agent in order to obtain a preparation that meets the requirements. In this study, nanohydrogels were made using Chrysanthemum leaf extract (Chromolaena odorata L.) as the active substance and made with various concentrations of carbopol 980 as a gelling agent. The purpose of this study was to determine the effect of variations in the concentration of carbopol 980 on nanohydrogel preparations of chrysanthemum leaf extract. The method used is Quasi Experimental Design. Simplicia was made into extracts and then made into nano preparations and evaluated. Data were analyzed using One Way Anova and Kruskal-Wallis. The particle size of Formula I nanohydrogel preparation was obtained at 412.9 nm. The results of the evaluation of the preparation showed that the nanohydrogel of chrysanthemum leaf extract with variations in the concentration of carbopol 980 had no effect on homogeneity, but it did affect the pH, viscosity, dispersibility, and adhesion test as shown in the One Way Anova statistical test (p<0.05). From the evaluation results, the ideal formula for nano hydrogel preparations was found in formula I with a carbopol 980 concentration of 0.5%.

Pelatihan Pembuatan Spray Tanaman Serai untuk Mencegah DBD dalam Meningkatkan Kesehatan dan Ekonomi Keluarga Melviani Melviani; Dyan Fitri Nugraha; Nadya Novianty; Noval Noval
Indonesia Berdaya Vol 4, No 3 (2023)
Publisher : UKInstitute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/ib.2023486

Dengue Hemorrhagic Fever (DHF) is a major health problem in Indonesia caused by dengue virus infection carried by the Aedes aegypty mosquito. It is not new that people's main choice to avoid mosquito bites is to use mosquito repellent products containing synthetic insecticides that are widely sold in the market and used by burning, spraying, applying and even electronics that require electricity. Synthetic insecticides are associated with events that can harm the environment and health. Therefore, switching to natural ingredients that are relatively much safer is considered important. One plant with mosquito-repellent power is lemongrass (Cymbopogon citratus). The purpose of this service is to provide skills to the community in processing lemongrass into mosquito repellent spray to prevent dengue fever which is also valuable in improving the family economy. The methods used in this service are education about dengue fever, the benefits of lemongrass, and tips on managing a business and training on making lemongrass plant spray. The service participants seemed very enthusiastic in participating in the entire series of activities. Abstrak: Demam Berdarah Dengue (DBD) merupakan masalah kesehatan utama di Indonesia yang disebabkan oleh infeksi virus dangeu yang dibawa oleh nyamuk Aedes aegypty. Bukan hal baru bahwa pilihan utama masyarakat untuk menghindari gigitan nyamuk adalah dengan menggunakan produk anti nyamuk yang mengandung insektisida sintetik yang banyak dijual di pasaran yang digunakan dengan cara dibakar, disemprot, dioleskan bahkan eletrik yang membutuhkan aliran listrik. Penggunaan insektisida sintetik dikaitkan dengan kejadian yang dapat membahayakan lingkungan dan kesehatan. Oleh karena itu, dianggap penting untuk beralih pada bahan alami yang relatif jauh lebih aman. Salah satu tanaman yang mempunyai daya penolak nyamuk adalah serai (Cymbopogon citratus). Tujuan pengabdian ini adalah untuk memberikan keterampilan pada masyarakat dalam mengolah serai menjadi spray anti nyamuk untuk mencegah DBD yang juga bernilai dalam menignkatkan ekonomi keluarga. Metode yang digunakan dalam pengabdian ini adalah edukasi mengenai DBD, manfaat serai, dan tips mengelola usaha serta pelatihan pembuatan spray tanaman serai. Peserta pengabdian nampak sangat antusias dalam mengikuti seluruh rangkaian kegiatan.

POTENSI ANTISEPTIK POLIHERBAL DAUN SIRIH (Piper betle), KULIT JERUK NIPIS (Citrus aurantifolia) DAN TANAMAN BUNDUNG (Actinuscirpus grossus) PADA TINDAKAN KEPERAWATAN DAN KEBIDANAN Darini Kurniawati; Noval Noval; Kunti Nastiti
DINAMIKA KESEHATAN: JURNAL KEBIDANAN DAN KEPERAWATAN Vol 11, No 1 (2020): Dinamika Kesehatan Jurnal Kebidanan dan Keperawatan
Publisher : Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/dksm.v11i1.552

Latar Belakang: Antiseptik adalah senyawa kimia yang digunakan untuk membunuh atau menghambat pertumbuhan mikroorganisme pada jaringan yang hidup seperti permukaan kulit dan membran mukosa. Daun sirih, jeruk nipis, bundung sudah banyak digunakan masyarakat untuk obat. Antiseptik dari poliherbal diyakini lebih aman dari pada zat kimia sintetis.Tujuan: Tujuan penelitian ini untuk mengetahui kemampuan antiseptik terhadap bakteri Staphylococcus aureus dari campuran ekstrak daun sirih, jeruk nipis dan bundung sebagai pengganti antiseptic dari bahan zat kimia sintetis pada tindakan keperawatan dan kebidanan.Metode: Metode penelitian adalah eksperimental dengan membuat formulasi uji konsentrasi F1 20%, F2 30%, F3 F4 40% dan F5 50% dan diujikan terhadap bakteri Staphylococcus aureus dengan metode difusi disk.Hasil: Hasil penelitian menunjukkan bahwa daya antiseptik Daun Sirih, Jeruk Nipis dan Â Bundung efektif sebagai antiseptic pada konsentrasi 40%Â dengan efektifitas yang sama dari bahan antiseptic zat kimia sintetis. Konsentrasi Â F1 20% tidak ada daya hambat dengan nilai yang sama pada kontrol negatif, pada F2 30% terdapat daya hambat lemah sebesar 7 mm, pada F3 40% terdapat daya hambat kuat sebesar 23 mm sama dengan kontrol positif, dan pada F4 50% terdapat daya hambat sangat kuat lebih besar dari kontrol positif yaitu 40 mm.Simpulan: Antiseptik dari bahan alam kombinasi Daun Sirih, Jeruk Nipis dan Bundung pada konsentrasi 40% mempunyai efektifitas antiseptic yang sama dari antiseptic dengan bahan zat kimia sintetis. Antiseptik poliherbal ini bisa digunakan untuk keperluan tindakan keperawatan dan kebidanan.Â Kata Kunci: Daun sirih-kulit jeruk nipis-tanaman bundung, antiseptik, tindakan keperawatan dan kebidananAbstractBackground: Antiseptic is a chemical compound used to kill or inhibit the growth of microorganisms in living tissues such as the surface of the skin and mucous membranes. Betel leaf, lime, bundung have been widely used by the community for medicine. Antiseptics from polyherbal are believed to be safer than synthetic chemicals.Purpose: The purpose of this study was to determine the antiseptic ability of Staphylococcus aureus bacteria from a mixture of betel, lime, and bundung extracts as an antiseptic substitute for synthetic chemicals in nursing and obstetrics.Methods: The research method was experimental by making test formulations with concentrations of F1 20%, F2 30%, F3 F4 40%, and F5 50% and tested against Staphylococcus aureus bacteria using the disk diffusion method.Results: The results showed that the antiseptic power of Betel, Lime and Bundung leaves was effective as an antiseptic at a concentration of 40% with the same effectiveness of synthetic chemical antiseptic substances. The concentration of F1 20% has no inhibitory power with the same value in the negative control, at F2 30% there is a weak inhibitory power of 7 mm, at F3 40% there is a strong inhibitory power of 23 mm, the same as the positive control, and at F4 50% there is Very strong inhibition power is greater than the positive control, which is 40 mm.Conclusion: Antiseptic made from natural ingredients a combination of Betel, Lime, and Bundung Leave at a concentration of 40% has the same antiseptic effectiveness as antiseptic with synthetic chemical substances. This polyherbal antiseptic can be used for the purposes of nursing and midwifery action.Keywords: Betel leaf-lime peel-bundung plant, antiseptic, nursing and obstetrics measures

Pelatihan Pembuatan Salep Tanaman Kalangkala (Litsea angulata) untuk Mengatasi Penyakit Kutu Air pada Masyarakat Terdampak Banjir Rohama Rohama; Noval Noval; Faisal Rahman
Indonesia Berdaya Vol 4, No 3 (2023)
Publisher : UKInstitute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/ib.2023501

Indonesia in one of the tropical countries that has high temperatures and humidity, which is a good atmosphere for the growth of fungi. Banjar Regency became one of the districts affected by the worst floods in 2020 and 2021. It is known that the incidence of diseases caused by fungi in Indonesia ranged from 2,93 – 27,6% for 2009 – 2011 and the prevalence of skin diseases in flood-affected communities was 47,57%. Empirically, the people of South Kalimantan use the Kalangkala plant for treatments such as diarrhea, skin diseases, anticancer and antimicrobials. Kalangkala is also known to contain flavonoid compounds that function as antimicrobials and kalangkala leaf extract has inhibitory power against Staphylococcus aureus bacterium that causes skin diseases. From a preliminary study, 83% of respondents said they knew about kalangkala plants but as many as 79% did not know that kalangkala plants have properties. And 93% of respondents said they wanted to know how to make an ointment for water fleas. To find out the level of knowledge of the community before and after the delivery of education and training, pre-tests and post-tests were carried out, followed by the community of RT 02 Gudang Hirang Village. Based on the percentage obtained, it shows that there is an increase in public understanding regarding when to stop using ointment by 6% and signs of damaged ointment by 26%. As many as 87% of the people who took part in the ointment making training stated that they could show how to make the ointment that had been delivered. Abstrak: Indonesia merupakan salah satu negara beriklim tropis yang memiliki suhu dan kelembaban tinggi, dimana merupakan suasana yang baik bagi pertumbuhan jamur. Kabupaten Banjar menjadi salah satu Kabupaten terdampak Banjir paling parah pada tahun 2020 dan 2021. Diketahui insidensi penyakit yang disebabkan oleh jamur di Indonesia berkisar 2,93-27,6% untuk tahun 2009-2011 dan prevalensi penyakit kulit pada masyarakat yang terdampak banjir sebesar 47,57%. Secara empiris masyarakat Kalimantan Selatan menggunakan tanaman Kalangkala untuk pengobatan seperti diare, penyakit kulit, antikanker dan antimikroba. Kalangkala juga diketahui mengandung senyawa flavonoid yang berfungsi sebagai antimikroba dan ekstrak daun kalangkala memiliki daya hambat terhadap bakteri Staphylococcus aureus bakteri penyebab penyakit kulit. Dari studi pendahuluan sebanyak 83% responden mengatakan mengetahui tentang tanaman kalangkala namun sebanyak 79% tidak mengetahui bahwa tanaman kalangkala memiliki khasiat. Dan 93% responden mengatakan ingin mengetahui bagaimana cara pembuatan salep untuk kutu air. Untuk mengetahui tingkat pengetahuan masyarakat sebelum dan sesudah penyampaian edukasi dan pelatihan dilakukan pre-test dan post-test yang diikuti masyarakat RT 02 Desa Gudang Hirang.Berdasarkan presentase yang didapatkan menunjukkan terjadi peningkatan pemahaman masyarakat terkait kapan menghentikan penggunaan salep sebanyak 6% dan tanda-tanda salep rusak sebanyak 26%. Sebanyak 87% masyarakat yang mengikuti pelatihan pembuatan salep menyatakan bisa menunjukkan bagaimana cara pembuatan salep yang telah disampaikan.

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