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All Journal Jurnal Veteriner Jurnal Riset Kesehatan Quagga Biology, Medicine, & Natural Product Chemistry Journal of Natural Sciences and Mathematics Research Jurnal Ilmiah Universitas Batanghari Jambi Jurnal SOLMA JURNAL KESEHATAN PERINTIS Prosiding Seminar Nasional Multidisiplin Jurnal Inovasi Farmasi Indonesia Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Abdimas Ilmiah Citra Bakti (JAICB) SIMBIOSA Indonesian Journal of Natural Science Education PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) BIO-CONS: Jurnal Biologi dan Konservasi Gema Kesehatan Journal of Engineering Science and Technology Management Journal for Quality in Public Health Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Kesehatan Metro Sai Wawai Jurnal Mahasiswa Kesehatan Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Cendekia Ilmiah Joong-Ki Jurnal Bioteknologi & Biosains Indonesia
savitri, Lisa
Universitas Kadiri
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PREVENTION OF GASTROPROTECTIVE ACTIVITY OF CHINESE BETEL EXTRACT (PEPEROMIA PELLUCIDA L.) ON THE HISTOPATHOLOGICAL FEATURES OF THE STOMACH IN A MOUSE MODEL OF GASTROENTERITIS Savitri, Lisa; Prasetyawan, Fendy; Saristiana, Yuneka; Juwita, Syntia Tanu; Amanda, Cornelia; Mebung, Konradus Klala
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.8156

Abstract

Gastroenteritis is a common gastrointestinal disorder characterized by inflammation of the stomach and small intestine, often leading to symptoms such as diarrhea, vomit-ing, and abdominal pain. This study investigates the gastroprotective effects of Pepe-romia pellucida (Chinese betel) extract on histopathological features of the stomach in a mouse model of gastroenteritis. Male Swiss strain mice, aged 2-3 months, were treated with different doses of P. pellucida extract (100, 300, and 500 mg/kg BW) for 7 days after inducing gastroenteritis with Escherichia coli infection. Histopathological ex-amination showed that the extract significantly reduced cell degeneration, necrosis, and polymorphonuclear leukocyte infiltration in the stomach compared to the negative control group. The highest dose (500 mg/kg BW) exhibited the most prominent gastro-protective effect. These results suggest that P. pellucida possesses promising thera-peutic potential for gastroenteritis, possibly due to its bioactive compounds such as flavonoids, tannins, and saponins. Further studies are needed to explore the underly-ing mechanisms and optimize its therapeutic application.
THE ANTI-APOPTOTIC POTENTIAL OF Paederia foetida L. LEAF EXTRACT THROUGH THE DOWNREGULATION OF CASPASE-3 EXPRESSION IN AN ESCHERICHIA COLI-INDUCED SEPSIS MICE MODEL Savitri, Lisa; Krissanjaya, Rochmad; Juwita, Syntia Tanu; Sukmawati, Datin An Nisa; Probosiwi, Neni; Laili, Nur Fahma; Ilmi, Tsamrotul; Prasetyawan, Fendy
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.8235

Abstract

Sepsis is a life-threatening condition characterized by an abnormal immune response to infection, leading to high mortality rates in intensive care units (ICUs) worldwide. Caspase-3, a crucial enzyme in the apoptosis pathway, plays a significant role in sep-sis-related cellular damage. This study investigates the anti-apoptotic potential of Paederia foetida L. leaf extract by examining its effect on Caspase-3 expression in an Escherichia coli-induced sepsis mice model. Male Balb/c mice were divided into six groups, including positive control, negative control, and treatment groups receiving varying doses of the extract (100 mg/kgBW, 300 mg/kgBW, and 500 mg/kgBW). Caspase-3 expression in the spleen was measured after 24 hours of treatment. The results demonstrated a significant reduction in Caspase-3 expression, particularly in the group treated with 500 mg/kgBW of the extract, indicating its anti-apoptotic effect. These findings suggest that P. foetida leaf extract may serve as a potential therapeutic agent for reducing cell apoptosis in sepsis, warranting further investigation into its mechanisms and clinical pharmacological field.
THE EFFECT OF Paederia foetida L. EXTRACT ON LIVER WEIGHT OF MICE SEPSIS MODEL INFECTED WITH Escherichia coli Savitri, Lisa; Kasimo, Elfred Rinaldo; Krissanjaya, Rochmad
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.8965

Abstract

Sepsis is a critical medical condition characterized by a systemic immune response to in-fection, which can lead to severe organ dysfunction and mortality. Bacterial sepsis, par-ticularly caused by Escherichia coli, poses a significant risk due to its potential to harm tissues and organs, including the liver. The liver plays a central role in metabolic process-es and host defense during sepsis, making it a key organ of interest. This study aimed to investigate the effect of Paederia foetida leaf extract on liver weight in a mice sepsis mod-el. Mice were divided into six groups: normal control (N), negative control (K-) receiving distilled water, positive control (K+) receiving ciprofloxacin, treatment 1 (P1) receiving P. foetida extract at 100 mg/kg BW, treatment 2 (P2) receiving 300 mg/kg BW, and treat-ment 3 (P3) receiving 500 mg/kg BW. After 14 days of treatment, significant differences in liver weight were observed among the groups, with the highest mean and standard de-viation recorded in the P1 group (1.3750 ± 0.3932). Liver abnormalities, including swell-ing, lobular thickening, and weight increase, were identified, indicating the liver’s adap-tive response to toxic substances during sepsis. Interestingly, the normal control group exhibited higher liver weights compared to the treatment groups, possibly due to fatty substance accumulation within the liver tissues. These findings suggest that P. foetida ex-tract may influence liver weight changes in sepsis, potentially modulating metabolic and detoxification processes. Further studies focusing on histopathological and biochemical mechanisms are needed to clarify the therapeutic potential of P. foetida in managing liver dysfunction associated with sepsis.
BLOOD SMEAR EXAMINATION AND DIFFERENTIAL COUNT IN RATS WITH ESCHERICHIA COLI ESBL AND KLEBSIELLA PNEUMONIAE CARBAPENEMASE INFECTIONS Savitri, Lisa; Kasimo, Elfred Rinaldo; Ihsan, Kharisul; Faizal, Imam Agus
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.10708

Abstract

Sepsis is an irregular body response to severe infection, triggering uncontrolled inflammation that can lead to extensive tissue damage. It can progress to septic shock with multiple organ failure, resulting in death if left untreated. Laboratory examinations, such as leukocyte differential count in hematology, help understand the distribution pattern of white blood cells associated with health conditions. Laboratory research was conducted on mice injected with E. coli ESBL or K. pneumoniae carbapenemase. After 24 hours, observations were made on apoptosis in the spleen and liver of mice. Mouse blood was processed to count white blood cell types with a differential count. The results were analyzed to compare the control group with the bacterial infection groups of E. coli ESBL and K. pneumoniae carbapenemase. The research results indicate that the neutrophil count in the E. coli ESBL group is still within the normal range and lower (44.5±1.915%) compared to the K. pneumoniae carbapenemase group (55.75±8.342%). Similarly, the lymphocyte count in the E. coli ESBL group is within the normal range and lower (77.5±3.109%) compared to the K. pneumoniae carbapenemase group (91.25±7.588%). This highlights the crucial role of neutrophils and lymphocytes in responding to severe bacterial infections such as K. pneumoniae carbapenemase. Previous studies indicate neutrophilia and lymphocytopenia as markers of severe bacterial infections. Neutrophils are the primary defense against bacterial infections and can be rapidly recruited to the infection site, while specific infections can trigger prolonged neutrophil recruitment from hematopoietic tissues.
Evaluation of Paederia foetida L. Extract on Liver Weight Alterations in an Escherichia coli Sepsis Mouse Model Savitri, Lisa; Elfred Rinaldo Kasimo; Rochmad Krissanjaya
Journal of Natural Sciences and Mathematics Research Vol. 11 No. 1 (2025): June
Publisher : Faculty of Science and Technology, Universitas Islam Negeri Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/jnsmr.v11i1.23323

Abstract

Sepsis is a critical medical condition caused by a systemic immune response to infection and is often associated with severe organ dysfunction and high mortality. Bacterial sepsis, including cases triggered by Escherichia coli, can damage host tissues as the immune response becomes dysregulated. Infections involving E. coli in the digestive tract have become increasingly common. Among the affected organs, the liver plays a key role in metabolic regulation and host defense during sepsis. This study investigated the effect of Paederia foetida L. leaf extract on liver weight in a murine sepsis model. Introducing E. coli induces systemic infection and establishes the sepsis model, a commonly used approach in experimental studies to mimic the clinical features of sepsis. After acclimation, mice received treatments for 14 days across several groups: a normal control (N), a negative control (K–) given distilled water, a positive control (K+) given ciprofloxacin, and three treatment groups receiving P. foetida extract at 100 mg/kg BW (P1), 300 mg/kg BW (P2), and 500 mg/kg BW (P3). The analysis revealed significant differences among groups, with the highest mean liver weight recorded in P1 (1.3750 ± 0.3932). Liver abnormalities included enlargement, increased organ mass, swelling, and thickening of one liver lobe, which may reflect heightened hepatic workload during infection and toxin clearance. Interestingly, the normal group showed greater liver weight than several treatment groups, possibly due to fatty accumulation within hepatic tissue, which can influence overall organ mass.
Safety Evaluation of Burdock (Arctium Lappa L.) Root Extract: Effects on Spleen Histopathology and Peripheral Lymphocytes in Wistar Rats Faizal, Imam Agus; Afrilla, Rananda; Farabi, Meka Faizal; Savitri, Lisa
Jurnal Riset Kesehatan Vol 14 No 2 (2025): NOVEMBER 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v14i2.13839

Abstract

Arctium lappa L. (burdock) root contains phytochemicals—including flavonoids, saponins, and phenolic compounds—reported to exhibit immunomodulatory activity. This study evaluated the safety of Arctium lappa L. root extract through a 28-day post-test experimental design involving male and female Wistar rats. Eight animals were randomized into four groups receiving oral doses of 0, 150, 300, or 450 mg/kg BW/day. Lymphocyte counts were measured using an automated analyzer, and splenic histopathology was assessed on Hematoxylin–Eosin–stained sections using semiquantitative scoring. Lymphocyte values (mean ± SD) showed no significant differences among groups (p > 0.05; small effect size) and remained within physiological limits, with males ranging from 4.14 ± 0.21 to 7.96 ± 0.34 ×10³/µL and females from 2.04 ± 0.18 to 15.43 ± 0.52 ×10³/µL. No necrotic lesions were identified in any dose group. Splenic congestion and extramedullary hematopoiesis were mild to moderate, remaining below 30–50% involvement without architectural disruption. These findings indicated that repeated oral exposure to A. lappa extract up to 450 mg/kg BW/day did not induce structural injury or suppress immune-cell profiles, supporting its preliminary safety for further toxicological and immunopharmacological investigation.
Karakterisasi Ecoenzyme dari Limbah Buah Nenas Jenis Smooth Cayenne Kultivar Pasir Kelud (PK-1) sebagai Disinfektan dalam Pembersih Lantai Krissanjaya, Rochmad; Hermanto, Dhony; Ismillayli, Nurul; Savitri, Lisa; Muttaqin, Saiful; Kasimo, Elfred Rinaldo; Probojati, Rasyadan Taufiq; Anjarwati, Aprilia; Apriana, Dita
BIO-CONS : Jurnal Biologi dan Konservasi Vol. 7 No. 2 (2025): BIO-CONS: Jurnal Biologi dan Konservasi
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31537/biocons.v7i2.2880

Abstract

Limbah nanas Smooth Cayenne PK-1 berpotensi sebagai bahan baku ecoenzyme disinfektan alami. Penelitian ini mengkarakterisasi ecoenzyme dari tiga bagian buah (daging, kulit, batang) hasil fermentasi 90 hari, lalu memformulasikannya menjadi pembersih lantai. Hasil karakterisasi menunjukkan ecoenzyme dari kulit memiliki aktivitas antibakteri tertinggi, didukung kandungan fenolik dan pH asam (3,2–3,5). Formula pembersih lantai optimum diperoleh dengan konsentrasi 20% ecoenzyme kulit nanas. Formula ini memenuhi standar SNI 06-4085-1996: pH 7,2, viskositas 1150 cP, stabilitas emulsi baik, dan stabil selama 30 hari penyimpanan. Produk menunjukkan aktivitas antibakteri signifikan terhadap E. coli (zona hambat 12,5 mm) serta efektif menghilangkan noda minyak (90,2%). Analisis regresi mengonfirmasi 20% sebagai titik optimum. Hal ini menunjukkan bahwa ecoenzyme dari kulit nanas PK-1 merupakan disinfektan alami yang efektif dan stabil untuk pembersih lantai ramah lingkungan, sekaligus mendukung pemanfaatan limbah pertanian bernilai tambah.
Analisis Kekerabatan Populasi Drosophila di Besuki, Bangil, dan Lumajang Berdasarkan Karakter Morfologi Savitri, Lisa; Ihsan, Kharisul; Krissanjaya, Rochmad
SIMBIOSA Vol 14, No 2 (2025): SIMBIOSA
Publisher : Program Studi Pendidikan Biologi, Universitas Riau Kepulauan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33373/simbiosa.v14i2.8415

Abstract

Penelitian ini bertujuan untuk mengkaji hubungan kekerabatan populasi Drosophila dari tiga lokasi di Jawa Timur, yaitu Besuki, Bangil, dan Lumajang, berdasarkan karakter morfologi. Sampel diperoleh melalui penangkapan langsung dan diamati menggunakan parameter panjang tubuh, lebar sayap, dan intensitas pigmen. Analisis deskriptif, Principal Component Analysis (PCA), dan analisis klaster digunakan untuk menentukan pola variasi dan kedekatan morfologi antar populasi. Hasil penelitian menunjukkan adanya variasi signifikan pada ketiga parameter, di mana populasi Besuki dan Bangil menunjukkan ukuran tubuh lebih besar dibandingkan Lumajang. Pigmentasi tubuh populasi Bangil lebih gelap dibandingkan dua lokasi lainnya. Analisis PCA dan klaster menunjukkan kedekatan kekerabatan Besuki–Bangil, sedangkan Lumajang membentuk kelompok tersendiri. Variasi ini diduga dipengaruhi oleh kondisi lingkungan lokal, faktor genetik, dan aspek biotik. Hasil penelitian ini menegaskan potensi penggunaan morfologi Drosophila sebagai indikator awal hubungan kekerabatan dan adaptasi lokal.
Analisis Histopatologi Efek Antiinflamasi Ekstrak Etanol Daun Akar Sebiak (Gynura procumbens (Lour.) Merr.): Histopathological Analysis of the Anti-inflammatory Effect of Ethanol Extract of Akar Sebiak Leaves (Gynura procumbens (Lour.) Merr. Saristiana, Yuneka; Prasetyawan, Fendy; Savitri, Lisa
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 7 No. 1 (2025): Volume 7 No 1 2025
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v7i1.6670

Abstract

Penelitian ini bertujuan mengevaluasi efek antiinflamasi ekstrak etanol daun Akar Sebiak (Gynura procumbens (Lour.) Merr.) melalui analisis histopatologi pada tikus putih jantan yang diinduksi Complete Freund’s Adjuvant (CFA). Hewan uji dibagi menjadi lima kelompok: kontrol normal, kontrol positif (Triamsinolon Asetonid), kontrol negatif (CMC-Na 1%), dan ekstrak dosis 100 mg/kg BB serta 200 mg/kg BB. Parameter yang diamati meliputi penurunan volume udem, jumlah leukosit total, dan lebar joint space. Hasil menunjukkan ekstrak dosis 100 mg/kg BB dan 200 mg/kg BB menurunkan volume udem masing-masing sebesar 43,33% dan 49,15%, menurunkan jumlah leukosit, serta memperbaiki joint space dibandingkan kontrol negatif. Efek antiinflamasi ini diduga terkait kandungan flavonoid, alkaloid, dan triterpenoid/steroid yang menghambat jalur inflamasi. Meskipun potensi ekstrak signifikan, efeknya masih di bawah triamsinolon asetoniid.
Pengenalan Metode Imunodiagnostik Dasar untuk Pencegahan Penyakit Menular di Peternakan Savitri, Lisa; Kasimo, Elfred Rinaldo; Krissanjaya, Rochmad; Prasetyawan, Fendy; Saristiana, Yuneka; Amanda, Cornelia; Mebung, Konradus Klala
Abdimas Galuh Vol 8, No 1 (2026): Maret 2026
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v8i1.23354

Abstract

Penyakit menular pada ternak masih menjadi salah satu kendala utama dalam usaha peternakan rakyat karena dapat menurunkan produktivitas dan menyebabkan kerugian ekonomi. Salah satu upaya pencegahan yang dapat dilakukan adalah deteksi dini penyakit melalui metode imunodiagnostik dasar. Namun, tingkat pemahaman peternak mengenai prinsip kerja dan pemanfaatan metode imunodiagnostik masih relatif rendah. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan pemahaman peternak mengenai pengenalan penyakit menular serta prinsip dasar metode imunodiagnostik sebagai langkah awal pencegahan penyakit di peternakan. Kegiatan dilaksanakan melalui penyuluhan interaktif, diskusi dua arah, serta demonstrasi penggunaan alat imunodiagnostik dasar berupa kit uji cepat. Sasaran kegiatan adalah peternak ternak rakyat di wilayah sasaran pengabdian. Evaluasi dilakukan melalui pengukuran tingkat pengetahuan peserta sebelum dan sesudah kegiatan serta observasi partisipasi aktif selama kegiatan berlangsung. Hasil kegiatan menunjukkan adanya peningkatan pemahaman peternak terkait jenis penyakit menular, prinsip reaksi antigen–antibodi, dan manfaat penggunaan metode imunodiagnostik dalam deteksi dini penyakit. Selain itu, peternak menunjukkan antusiasme dan partisipasi aktif selama proses penyuluhan dan demonstrasi. Kegiatan ini memberikan kontribusi positif dalam meningkatkan kesadaran peternak terhadap pentingnya pencegahan penyakit menular melalui pendekatan diagnostik sederhana yang aplikatif di tingkat peternakan rakyat.
Co-Authors Afrilla, Rananda Agung Dwi Wahyu Widodo Agustanti, Khalimatus Nur Eka Alimansur, Moh Alves, Silvina Sandra X. Amanda, Cornelia Aminah Alfiani Ana Retnowati Anjarwati, Aprilia Antoro, Ester Lianawati Apriana, Dita Arif Budi Setiawan Besan, Emma Jayanti Datin An Nisa Sukmawati Dhony Hermanto Edda, Ilda Rambu Eka Wahyuningtiyas Elfred Rinaldo Kasimo Elfred Rinaldo Kasimo Elfred Rinaldo Kasimo Elfred Rinaldo Kasimo Elfred Rinaldo Kasimo, Elfred Rinaldo Elly Megasari Ester Lianawati Antoro Ester Lianawati Antoro Ester Lianawati Antoro Ester Lianawati Antoro Evi Laela Sari Farabi, Meka Faizal Fendy Prasetyawan Fitri, Devi Nor Freitas, João Gregório Freitas, Maria Do Carmo Da Costa Herman Hilmi, Mochammad Hanif Ida Septika Wulansari Ida Septika Wulansari Ida Septika Wulansari Ida Septika Wulansari Ihsan, Kharisul Indrayanti, Dian Iza Dwi Muslikha Juan Vega Mahardhika Juwita, Syntia Tanu Kadir, Mujtahid Bin Abd Kadir, Mujtahid Bin And Kasimo, Elfred Khalimatus Nur Eka Agustanti Kharisma Rahmasari Kharisul Ihsan Kharisul Ihsan Kholis, Akbar Nur Kholis, Muhammad Akbar Nur Laili, Nur Fahma La’ally Maula Lian Pandu Farendra Loviana, Novi Maria Do Carmo Da Costa Freitas Masyhuri, Aga Adi Mebung, Konradus Klala Megasari, Elly Meri, Meri Mika Tri Kumala Swandari, Mika Tri Kumala Mila Putri Daniati Mochamad Hanif Hilmi Mosse1, Yosep Muhammad Nurul Fadel Muslikha, Iza Dwi Muttaqin, Saiful Neni Probosiwi Novirma Yanti Novyananda Salmasfattah Novyananda Salmasfattah Nur Fahma Laili Nur Fahma Laili Nurul Ismillayli Ornai, Andre Mario Sequeira Alves Rasyadan Taufiq Probojati Renaldi Umbu Ndamung Kale Restyana, Anggi Restyana, Anggy Retnowati, Ana Rochmad Krissanjaya Salmasfattah, Novyananda Sanjaya, Rochmad Kris Shinta Mayasari Shinta Mayasari Sueb Sugeng Santoso Syntia Tanu Juwita Syntia Tanu Juwita Syntia Tanu Juwita Syntia Tanu Juwita Syntia Tanu Juwita Tiyas, Eka Wahyuning Tridoso Sapto A Tsamrotul Ilmi Willy Sandhika Wulansari, Ida Septika Yanti, Novirma Yosep Mosse yunadi, frisca dewi Yuneka Saristiana