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All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) INDONESIAN JOURNAL OF PHARMACY Majalah Farmaseutik PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JFIOnline Medica Hospitalia Jurnal Abdimas Madani dan Lestari (JAMALI) Journal of Holistics and Health Sciences (JHHS) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Farmasi Sains dan Praktis Sciences of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika Indonesian Journal of Pharmacology and Therapy Clinical and Pharmaceutical Sciences Journal
Imaniar Noor Faridah
Fakultas Farmasi Universitas Ahmad Dahlan, Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Kualitas Hidup Dan Pengetahuan Pasien Dengue Di Rumah Sakit Pku Muhammadiyah Yogyakarta Dewi, Masita Sari; Perwitasari, Dyah Aryani; Supadmi, Woro; Faridah, Imaniar Noor
JURNAL FARMASI GALENIKA Vol 10 No 3 (2023): Jurnal Farmasi Galenika Vol 10 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v10i3.309

Abstract

Angka kejadian kasus infeksi dengue tahun 2020 di Kota Yogyakarta sebanyak 296 orang. Berdasarkan manifestasi klinis dengue terbagi menjadi 3 diagnosa yaitu dengue fever (DF), dengue haemorrhagic fever (DHF) dan dengue shock syndrome (DSS). Penularan terjadi akibat gigitan nyamuk Aedes aegypti dan mobilitas yang tinggi. Beberapa faktor yang mempengaruhi angka kejadian yaitu kualitas hidup dan pengetahuan terhadapa penyakit yang berdampak pada tingkat kesehatan. Tujuan penelitian untuk mengetahui kualitas hidup dan pengetahuan. Penelitian ini dilakukan secara observasional dengan pengambilan data prosfektif di Rumah Sakit PKU Muhammadiyah Yogyakarta periode April – Desember 2021. Kualitas hidup pasien dinilai menggunakan kuisioner EQ-5D-Y untuk pasien anak dan EQ-5D-5L untuk pasien dewasa dan pengetahuan dinilai menggunakan kuisioner yang terdiri dari pengetahuan penyakit, pengetahuan pencegahan dan prilaku pencegahan. Hasil penelitian di RS PKU Muhammadiyah Yogyakarta pada pasien dengan diagnosa DHF sebanyak 40% merasa amat sangat bermasalah pada kegiataan yang biasa dilakukan dan sebanyak 40% merasa cukup bermasalah pada dimensi rasa cemas, sedih dan depresi sehingga berpengaruh pada kulitas hidup. Pada pengetahuan penyakit, pengetahuan pencegahan dan perilaku pencegahan pasien DF dan DHF tergolong dalam kategori buruk sehingga perlu adanya promosi kesehatan untuk meningkatkan pengetahuan terhadap kesehatan. Penyakit demam dengue berpengaruh pada kulitas hidup. pengetahuan terhadap penyakit demam dengue dalam kategori buruk.
Potential Drug–Drug Interactions in Antihypertensive Therapy Among Outpatients with Comorbidities: Prevalence, Severity, and Clinical Implications Prita Anggraini Kartika Sari; Rahayu, Ade Rahmawati; Noor Faridah, Imaniar; Supadmi, Woro; Sari, Andriana; Ahmed, Bilal
Clinical and Pharmaceutical Sciences Journal Vol. 2 No. 1 (2026)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v2i1.563

Abstract

Hypertension is a condition that frequently coexists with comorbidities, often necessitating polypharmacy and consequently increasing the risk of drug-drug interactions (DDIs). This study aimed to analyze the pattern and severity of potential DDIs among hypertensive outpatients with comorbidities at North Lombok Regional General Hospital in 2024. This study employed a descriptive observational design with retrospective data collection. A total of 100 outpatient medical records meeting the criteria were selected via probability sampling from the hospital database during January to December 2024. Among the included patients, 50% were aged >60 years, 60% were female, and 91% were covered by the National Health Insurance. Potential DDIs were assessed using the Drugs.com drug interaction checker and categorized based on severity into major, moderate, and minor. A total of 257 potential DDI events were identified, consisting of 19 major interactions (7.4%), 205 moderate interactions (79.8%), and 33 minor interactions (12.8%). The most frequent major interaction was the combination of spironolactone and candesartan, which poses a significant risk of hyperkalemia and hypotension. Moderate interactions were predominantly observed with the combination of furosemide and bisoprolol, which may increase the risk of hyperglycemia and hypertriglyceridemia. Meanwhile, the most frequent minor interaction was aspirin with bisoprolol, which may reduced beta-blocker antihypertensive effect. In conclusion, this study found that moderate severity potential DDIs were the most prevalent and could significantly impact therapeutic outcomes in hypertensive patients with comorbidities. These findings highlight the critical role of clinical pharmacists in identifying and mitigating clinically significant interactions through rigorous prescription monitoring, patient education, and optimization of drug therapy. Strengthened monitoring and evaluation of drug regimens are recommended to minimize the risk of adverse drug reactions and enhance patient safety.
Co-Authors . Inayati A, Faiza Chusnuni A, Faiza Chusnuni Adnan Adnan Ahmed, Bilal Ajeng Diantini Amsriza, Fadli Robbi Ana Hidayati Ana Hidayati Ana Hidayati Andriana Sari Arief Rahman Afief Ariska Wigatiningtyas Arviani, Septania Dini Ayu Lestari B Simanjuntak, Lamhot Bambang Purwoko Barkah Djaka Purwanto Boisi, Cici Feronika Cheung, Rocky Denys Chichi Kusumastuti Desty Kusumaningsih Dewi Wulandari Dewi, Masita Sari Dewintasari, Venty Dyah Aryani Perwitasari Esty Elvinda Faiza Chusnuni A Farida Nur Mufliha Fatimah, Salma Auliya Gina Noor Djalilah Haafizah Dania Herjanti Ratnawiningsih Herjanti Ratnawiningsih Hidayati, Ana Hipmi, Ahmad Fahrian Inayati Inayati Inayati, Inayati Islami, Safira Nur Kaptein, A.A Lalu Muhammad Irham Lamhot B Simanjuntak Lestari, Mardiana Puji Maliza, Rita Maulizah, Rizlah Melinda Widianingrum Melinda Widianingrum Menit Ardhiani Menit Ardhiani Mufliha, Farida Nur Muhammad Fathurrahman Ni Made Ary Sarasmita Nina Mardiana (F01108057) Nur Aida Nur Rahmi Hidayati, Nur Rahmi Pendicho Eko Yuliyanto Pertiwi, Deasy Vanda Pradipta, Indra Prita Anggraini Kartika Sari Purwanto, Barkah Djaka Puspitaningrum, Anisa Nova Raden Mohamad Herdian Bhakti Rahayu, Ade Rahmawati Rezadhini, Melodia Riana Prastiwi Handayani Rizky, Muhammad Arif Saefi Saefi Santoso, Setiyo Budi Saputri, Ginanjar Zukhruf Septiantoro, Bayu Prio Siswandi Siswandi Siswandi, Siswandi Suhendra, Gugun Susilo, Rinto Tri Murti Andayani Wahyu Rahmatulloh Wirawan Adikusuma Woro Supadmi