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All Journal Prosiding Seminar Biologi AL KAUNIYAH Biosfer: Jurnal Tadris Biologi Prosiding Pendidikan Sains Jurnal Inovasi Teknologi Pendidikan Jurnal Farmasi Klinik Indonesia Bioeksperimen: Jurnal Penelitian Biologi Jurnal Pendidikan Biologi Journal of Biology Education AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Jurnal Penelitian Pendidikan IPA (JPPIPA) BIOEDUKASI PEDAGOGIA Biosfer: Jurnal Pendidikan Biologi JBN (Jurnal Bedah Nasional) Bioedukasi: Jurnal Pendidikan Biologi Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Bioedusiana: Jurnal Pendidikan Biologi JURNAL MEDIA KESEHATAN Journal of Pharmaceutical Care Anwar Medika Jurnal Kesehatan Tambusai Bioscientist : Jurnal Ilmiah Biologi MAHESA : Malahayati Health Student Journal DUNIA KEPERAWATAN: JURNAL KEPERAWATAN DAN KESEHATAN Molekul: Jurnal Ilmiah Kimia Biosaintifika: Journal of Biology & Biology Education Proceeding of International Conference on Biology Education, Natural Science, and Technology Folia Medica Indonesiana
UMI FATMAWATI
Program Studi Pendidikan Biologi/FKIP-Universitas Sebelas Maret, Surakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Molecular Docking of Gamma Amino Butyric Acid GABA on Rattus Norvegicus B-receptor as Antidiabetic Indrowati, Meti; Harlita; Fatmawati, Umi; Ariyanto, Joko; Retnaningtyas, Estu
Jurnal Penelitian Pendidikan IPA Vol 10 No 7 (2024): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i7.8044

Abstract

Earlier research reported that GABA had a correlation with diabetes in processes of glucose homeostasis. This study aims to identify the validity of B-receptor Rattus norvegicus as GABA protein target, modeling the structure and knowing the binding affinity between GABA and B-receptor Rattus norvegicus through molecular docking.   The research was carried out using in-silico method.  The interaction of GABA with the target protein was determined using SuperPred, followed by modeling the protein target using SwissadMe. Ramachandran Plot and Errat Procheck are used to determine the validity of the protein target. Molecular docking was determined using Pyrx and PyMol. The results showed that GABA binding to the B- receptor Rattus norvegicus has biological activity as glucose oxidase inhibitor and antidiabetic.  The conclusion are: B-receptor Rattus norvegicus is a valid protein target for binding to GABA; there are four 3-dimensional models of B-receptor Rattus norvegicus and the best model has 98.43% sequence identity; the binding affinity of GABA (ligand) on B-receptor Rattus norvegicus from the best model is -3.4 kcal/mol energy, 1.773 RMSD lower bound, and 1.81 RMSD upper bound. It is suggested that this research might be used as an empirical basis to further investigate GABA as antidiabetic.
Implementation of Bacteria Isolate as a Fertilizer and Bioinsecticide Agent for the Mealybug Santosa, Slamet; Fatmawati, Umi
Bioeksperimen: Jurnal Penelitian Biologi Vol 9, No 2: September 2023
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v9i2.20516

Abstract

This research about the implementation of bacteria in papaya plantation soil in Kebumen that has been isolated and characterized and purified. This study aims to determine the potential of local isolate bacteria from papaya agricultural soil: 1). as PGPR bacteria or fertilizing bacteria for chili, eggplant and tomato plants and 2) as a natural bioinsecticide. mealybugs on papaya plants. The samples used were bacteria from the preliminary isolation that had been carried out, namely from the genera Bacillus, Pseudomonas, Erwinia, Exyguobacterium, Serratia, Stenotropomonas, and Acinetobacter. The study was conducted using 50 stems of each plant. Bioinsecticides are applied to papaya trees that are attacked by mealybugs. Measurement of plant growth was measured at 7 days and 30 days after planting. As for bioinsecticides, spraying was carried out 3 times. The results of the study can be concluded in the form of the implementation of bacteria as PGPR which can increase the growth of cayenne pepper (Capsicum frutescens), purple eggplant (Solanum melongena L) and tomato (Solanum lycopersicum Mill) and can be used as a bioinsecticide to reduce mealybugs (Paracoccus marginatus) on papaya plants (Carica papaya L.)
ANALISA FAKTOR – FAKTOR YANG MEMPENGARUHI TINGKAT PEMAHAMAN PASIEN TENTANG SWAMEDIKASI DI APOTEK Hidayatullah, Rio Renaldi; Narsih, Umi; Fatmawati, Umi
Jurnal Kesehatan Tambusai Vol. 6 No. 4 (2025): DESEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i4.50918

Abstract

Swamedikasi adalah praktik umum masyarakat dalam menangani keluhan kesehatan ringan tanpa resep dokter. Meskipun memberikan kemudahan dan efisiensi, praktik ini memiliki risiko tinggi jika dilakukan tanpa pemahaman yang memadai. Penelitian ini dilatarbelakangi oleh tingginya prevalensi swamedikasi di Indonesia, terutama di wilayah pedesaan seperti Apotek Trisna Farma yang minim edukasi kesehatan. Tujuan utama dari penelitian ini adalah untuk menganalisis faktor-faktor internal dan eksternal yang mempengaruhi tingkat pemahaman pasien dalam melakukan swamedikasi. Pertanyaan penelitian difokuskan pada hubungan antara usia, jenis kelamin, pendidikan, pekerjaan, penghasilan, domisili, iklan, referensi orang lain, pengalaman pribadi, dan persepsi biaya terhadap tingkat pemahaman pasien. Penelitian ini menggunakan desain kuantitatif dengan pendekatan cross-sectional. Sampel sebanyak 100 responden diperoleh melalui teknik purposive sampling. Instrumen yang digunakan berupa kuesioner tertutup, dan data dianalisis menggunakan uji Chi-Square. Hasil penelitian menunjukkan bahwa 40% responden memiliki pemahaman yang kurang tentang swamedikasi. Ditemukan bahwa faktor usia (p=0,004), jenis kelamin (p=0,001), pendidikan (p=0,003), pekerjaan (p=0,003), penghasilan (p=0,002), domisili (p=0,002), iklan (p=0,001), referensi orang lain (p=0,001), pengalaman pribadi (p=0,000), dan biaya (0,000) berhubungan signifikan terhadap tingkat pemahaman. Penelitian ini menegaskan pentingnya peran apoteker dalam memberikan edukasi swamedikasi yang tepat dan aman. Hasil studi ini dapat menjadi dasar pengembangan program intervensi edukatif di apotek, khususnya bagi masyarakat pedesaan. Penelitian lanjutan disarankan untuk menggunakan pendekatan kualitatif guna mengeksplorasi lebih dalam aspek perilaku, motivasi, dan persepsi pasien dalam swamedikasi.
Analysis of IFN-gamma and IL-10 Levels as Markers of Inflammation and Response Therapy of Anti-Tuberculosis in MDR Lung TB Patients Setyawati, Herni; Soedarsono, Soedarsono; Yulistiani, Yulistiani; Fatmawati, Umi
Folia Medica Indonesiana Vol. 55, No. 4
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Multidrug-Resistant Tuberculosis (MDR TB) is caused by an organism that is resistant to at least isoniazid and rifampisin, the two most potent TB drug. Immune response to against Mycobacterum tuberculosis infection is related to the function of immunity. The function of interferon-γ (pro-inflammatory) is to activate macrophages, to stimulate antimicrobial molecules (to reactive oxygen species and nitric oxide), and to inhibits interleukin-10. Interleukin-10 function is to triggers humoral immunity, to inhibit IFN- γ. This study aimed to analyze level changes and the correlation with clinical data, also months of MDR TB patients who received standard OAT therapy. This was an observational study using cross sectional design. There were 29 patients who received standard MDR TB OAT therapy from 1-24 months, who met the inclusion criteria. Then, the patients were divided based on duration of the therapy, which are the initial/intensive and advanced phase. The initial phase divided into 2: first one is for 1-4 months therapy's time (5 patients) and the second one is for more than 4-8 months (6 patients). Then, the advanced group divided into two groups again, which are third group with more than 8-16 months (13 patients) and fouth group with more than 16-24 months (5 patients). Then, measured serum concentration IFN-γ, IL-10 at the start of the study and 4 weeks later with the ELISA method. This research during the period July-December (6 months). IFN-γ post concentrations were decreased by 39.14 ± 139.12 pg/mL (p > 0.05). The concentration of IL-10 was decreased by 33.93 ± 109.20pg/mL (p>0.05). Based on the TB score bandim method during pre and posts results were 1 patient experienced severity change from severity class 1 to 2, 1 patient from severity class 2 to 1, 1 patient remained in severity 2 and 26 patient remained in severity 1. The results showed that serum IFN-γ and IL-10 levels in initial/intensive and advanced phase patients who received MDR TB regiment after four weeks did not changed,
Efektivitas Kombinasi Dosis Tetap pada Tuberkulosis Nasal-HIV Anak: Laporan Kasus Suharyati, Titin; Herawati, Fauna; Fatmawati, Umi
Indonesian Journal of Clinical Pharmacy Vol 14, No 3 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2025.v14i3.58065

Abstract

Tuberkulosis (TB) adalah penyakit yang disebabkan oleh Mycobacterium tuberculosis (MTB) yang selain mengenai parenkim paru, juga mampu menginfeksi organ lain. Tuberkulosis nasal dapat bersifat primer atau sekunder akibat tuberkulosis paru atau lupus fasialis. Tuberkulosis nasal harus dipertimbangkan dalam diagnosis banding granuloma nasal kronis. TB pada saluran pernapasan atas jarang terjadi dan hampir tidak dilaporkan dalam penelitian. Kami melaporkan kasus TB primer nasal, TB paru disertai HIV. Pasien di rawat inap di ruang isolasi khusus TB karena mengalami benjolan di hidung yang membesar dengan ukuran 3x3 cm disertai mimisan, demam yang naik turun, serta berat badan menurun dan berkurang nafsu makan. Tes bakteri tahan asam dan pemeriksaan histopatologi memastikan diagnosis tuberkulosis nasal. Gejala pasien setelah dua setengah bulan pengobatan anti-TB dan antiretroviral belum membaik. Setelah di rawat inap selama 78 hari, akhirnya pasien meninggal. Kasus ini menunjukkan bahwa memulai pengobatan segera, pengelolaan malnutrisi, serta pemantauan kejadian efek samping dan interaksi antar obat dapat memengaruhi keberhasilan terapi pada pasien dengan TB nasal.
Co-Authors Agustini, Lukisiari Anggraini, Meisi Anjani, Fullaikhah Arafa, Maretania Aryanti, Yuni Azis, Fahmi Dimas Abdul Bowo Sugiharto Budi Suprapti Dewi Puspita Sari Diharjo, Dewi DWI OETOMO ESTU RETNANINGTYAS N Fiqhunnisa, Anindita Handayani, Sri Harlita Harlita Harlita Havyarimana, Célestin Herawati, Fauna Herni Setyawati Hidayati, Movita Hidayatullah, Rio Renaldi I Wayan Gede Saraswasta Joko Ariyanto Mahanani, Lina Mansur, Mifta Maulida, Meirina Nur Meti Indrowati Narsih, Umi Nuraini Annisa, Nuraini Nuridha Fauziyah Nurmiyati Nurmiyati Nurmiyati Permatasari, Vera Prameselly, Qorisha Lutfia Prastya, Muhamad Eka Primahana, Gian PUGUH KARYANTO Puti, Tunjung Nala Reza, Salsabiela Praha Karima Riezky Maya Probosari Rosita, Lisa Rr Tutik Sri Hariyati Rumulus, Rasyidin Sajidan Sajidan Setiani, Indra Slamet Santosa Soedarsono Soedarsono Sri Dwiastuti Suharyati, Titin Suranto Suranto Ummi Nur Afinni Dwi Jayanti, Ummi Nur Afinni Utomo, Tegar Budi yati, indri Yudi Rinanto Yulistiani Yulistiani, Yulistiani Yuniar, Rizka Zienitha, Anggie Meilinda