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Ratih Puspita Febrinasari
Faculty of Medicine, University of Sebelas Maret
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Antioxidant Activity of Methanolic Extract from Date Seeds (Phoenix Dactylifera L.) as A Potential Use of Local Food Waste Imanisa, Octavia Intan; Wijayanti, Lilik; Febrinasari, Ratih Puspita
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.6475

Abstract

Date seeds (Phoenix dactylifera L.) are by-products of the date processing industry that are often discarded, even though they contain potential antioxidant compounds. This study aimed to evaluate the antioxidant activity of methanolic extract from date seeds as a sustainable approach to valorizing food waste. The research was conducted at the Laboratory of the Center for Food and Nutrition Studies, Universitas Gadjah Mada. Date seeds were obtained from small-scale food industries in Klaten, Central Java, then cleaned, dried, macerated, and sieved through mesh 80. A total of 50 grams of powdered seeds were extracted using the Soxhlet method with methanol for 6 hours. The antioxidant activity was measured using the DPPH method by reading the absorbance at 515 nm. The results showed DPPH radical inhibition percentages of 58.87% and 48.75% in two replications, with an average of 53.81%. The data were analyzed descriptively based on the percentage of radical scavenging activity. These findings suggest that date seeds possess considerable antioxidant activity and can be utilized as a natural antioxidant source, while also supporting the upcycling of local food waste into functional food ingredients.
ANALYSIS BIOACTIVE COMPOUNDS AND ANTIOXIDANT ACTIVITY OF EXTRACT BEKUL FRUIT (Ziziphus jujuba Mill.) AS A POTENTIAL NUTRACEUTICAL Windayani, Komang; Dirgahayu, Paramasari; Febrinasari, Ratih Puspita
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 1 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i1.2350

Abstract

Pemanfaatan bahan alami sebagai terapi diet atau nutrisi dalam mengobati atau mencegah suatu penyakit berkembang sangat pesat. Salah satu bahan alami yang memiliki potensi sebagai agen nutraceutical adalah buah bekul Bali (Ziziphus jujuba Mill.). Saat ini belum banyak bukti empiris terkait potensi nutraceutical yang terdapat pada buah bekul (Ziziphus jujuba Mill.) varietas Bali. Penelitian ini bertujuan untuk mengetahui kandungan senyawa bioaktif dan aktivitas antioksidan yang terdapat dalam ekstrak etanol buah bekul (Ziziphus jujuba Mill.) varietas Bali. Metode yang digunakan pada penelitian ini yaitu eksploratorik desain dengan sampel menggunakan buah bekul Bali (Ziziphus jujuba Mill.). Penelitian ini dilaksanakan di Laboratorium Penelitian dan Pengujian Terpadu (LPPT) Universitas Gajah Mada pada bulan April 2024. Proses ekstrasi menggunakan metode maserasi dan uji aktivitas antioksidan dilakukan dengan metode DPPH. Penentuan kadar total flavonoid, fenolik dan saponin menggunakan metode spektrofotometer UV-Vis, sedangkan penentuan kadar quercetin menggunakan metode HPLC. Hasil uji aktivitas antioksidan berdasarkan nilai IC50 tergolong kuat yaitu sebesar 78,57%, kandungan senyawa total flavonoid (114,85 mg QE/g), quercetin (60,00 µg/g), fenolik (109,34 mg GAE/g) dan saponin (9,90 mg/g). Dapat disimpulkan bahwa ekstrak etanol buah bekul (Ziziphus jujuba Mill.) varietas Bali diketahui memiliki kandungan senyawa bioaktif yaitu fenolik, flavonoid dan turunannya seperti quercetin, dan saponin serta memiliki aktivitas antioksidan tergolong kuat yang dapat dimanfaatkan sebagai agen nutraceutical.
PEMBERIAN NUGGET IKAN TENGGIRI YANG DIFORTIFIKASI TEPUNG DAUN KELOR TERHADAP NILAI Z-SCORE TB/U dan BB/U PADA ANAK BALITA STUNTING Haruni, Diah Sekar; Nuhriawangsa, Adi Magna Patriadi; Febrinasari, Ratih Puspita
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 2 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i2.3015

Abstract

Stunting is a nutritional problem caused by prolonged malnutrition. Mackerel and Moringa leaves are considered to have many health benefits on children growth. The study aimed to determine the effect of giving mackerel nuggets fortified with moringa flour on the nutritional status of stunted toddlers. The study took place in February and March of 2024, had a pre-post control group. The samples comprised 52 stunted children in West Nias, ranging in age from 24 to 59 months; toddlers with chronic illnesses and those with gluten and seafood allergies were excluded. Four groups were created from the samples: two control groups and two treatment groups. The treatment group received 100 grams of nuggets daily for 60 days, along with the collection of anthropometric data, including height and weight. Height-for-Age (HAZ) data was analyzed using Wilcoxon and Kruskal Wallis test while Weight-for-Age (WAZ) data used Paired T-test and One Way ANOVA test, then followed by a Post Hoc test. There was no significant difference in the increase in HAZ between treatments (p=0.741), but there was an effect of giving nuggets with the addition of moringa leaves at 3% (p=0.046) and 7% (p=0.007) on HAZ at 0,010 and 0,016 respectively. Weight-for-Age (WAZ) value increased differently for each treatment (p=0.001), with the most significant difference in the giving of nuggets fortified with 7% moringa leaves, namely 0,206. The conclusion of this study was that giving mackerel nuggets fortified with moringa flour increased HAZ and WAZ of stunted toddlers.
Increasing Knowledge and Parenting Patterns of Stunting Toddlers in Stunting Toddler Mothers in Jatikuwung Jatipuro Village, Karanganyar Darnoto, Sri; Ernawati, Dwi Arini; Mustara, Mustara; Oktaviani, Oktaviani; Kristiani, Shinta; Yanuarini, Triatmi Andri; Pamungkasari, Eti Poncorini; Febrinasari, Ratih Puspita
Jurnal SOLMA Vol. 12 No. 3 (2023)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v12i3.12866

Abstract

Background: Berdasarkan hasil SSGI tahun 2022 prevalensi stunting balita di Indonesia masih cukup besar yaitu 21,6%. Bupati Karanganyar melalui SK Tahun 2023 menyatakan bahwa Lokus stunting di Kecamatan Jatipuro Karanganyar yang tertinggi adalah Desa Jatikuwung. Kegiatan ini bertujuan untuk melakukan peningkatan pengetahuan stunting sebagai upaya penurunan stunting di Desa Jatikuwung Jatipuro. Metode: Kegiatan diawali dengan analisis data sekunder dan dilanjutkan Focus Discussion Group (FGD) secara luring dan daring dengan peserta 44 orang yang terdiri dari Tim TPPS Kabupaten, Kecamatan dan Desa. Kegiatan ini dilaksanakan selama bulan Juni 2023 di Balai Desa Jatikuwung Kec. Jatipuro. Hasil: Dari Hasil intervensi yang dilaksanakan dapat diketahui bahwa telah terjadi peningkatan pengetahuan pada ibu balita stunting dengan kategori sangat baik 41,6% menjadi 75%.  Kesimpulan: Pengetahuan ibu balita, ibu hamil dan kader meningkat setelah mendapatkan penyuluhan tentang stunting dan pola asuh.
Improving hospital formulary drug decision making with multi-criteria decision analysis (MCDA): case study from a national government hospital in Indonesia Kristin, Erna; Bustami, Mursyid; Pinzon, Rizaldy Taslim; Alfi Yasmina; Susanto, Agnes; Febrinasari, Ratih Puspita
Indonesian Journal of Pharmacology and Therapy Vol 4 No 3 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.7932

Abstract

This study aimed to look at the applicability of the multi-criteria decision analysis (MCDA) framework to improve hospital formulary drug decision-making. The case study method was used to investigate MCDA implementation in the National Brain Center Hospital Jakarta, Indonesia. A two stage-workshop was held on October 29th, 2019 and 5 February 5th, 2020, where participants conducted a hands-on experience in applying MCDA for selecting off-patent pharmaceuticals (OPPs) for the hospital formulary. The results of the workshop created awareness of MCDA that can be beneficial in transparently selecting OPP, which is not based only on price while involving multiple stakeholders. As a follow-up, MCDA was used during the drug selection process for the National Brain Center Hospital formulary in 2021 with criteria in accordance with the workshops, namely: 1) equivalence with the reference (originator) product; 2) real-world clinical or economic outcomes; 3) quality assurance; 4) reliability of drug supply; 5) stability and drug formulation; 6) pharmacovigilance, and 7) price advantages. In conclusion, the MCDA method can be implemented with customized criteria and weighting based on hospital needs to help with drug selection for the hospital formularies.
Phytochemical Characterization and In Vitro Antioxidant Activity of Murraya Koenigii Leaf Extract Nafi'ah, Radifatun; Febrinasari, Ratih Puspita; Sari, Yulia
Journal of Health and Nutrition Research Vol. 4 No. 3 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i3.459

Abstract

Murraya koenigii (curry leaf) is a tropical plant known for its diverse phytochemical content and potent antioxidant activity. However, limited studies have provided comprehensive quantitative data on its bioactive compounds, especially from Indonesian varieties. This study aimed to quantitatively analyze flavonoid, saponin, and tannin content in young and mature curry leaves and evaluate their in vitro antioxidant activity using the DPPH assay. An experimental design was conducted from January to March 2025. Ethanolic extracts of young and mature M. koenigii leaves from Aceh were prepared via maceration. Phytochemical quantification was performed using spectrophotometric methods, and antioxidant capacity was assessed using the DPPH radical scavenging assay with IC₅₀ determination. Young leaves showed higher levels of total flavonoids (0.19%), saponins (3.34%), and tannins (5.77%) compared to mature leaves (0.13%, 2.53%, and 4.58%, respectively). However, mature leaf extract exhibited stronger antioxidant activity with an IC₅₀ value of 46.77 μg/mL (very strong category), while young leaves showed 53.14 μg/mL (strong category). This suggests that antioxidant efficacy is influenced more by compound maturity and synergistic effects than total concentration. Mature M. koenigii leaves have superior antioxidant potential despite lower phytochemical concentrations, highlighting the importance of compound quality and interactions between compounds.
Proximate and Phytochemical Composition of Bajakah (Spatholobus littoralis Hassk) Extract and its Effect on Fasting Blood Glucose in STZ-HFD-Induced Diabetic Rats Dara, Rizki Wulan; Lisyawati, Shanti; Febrinasari, Ratih Puspita
Journal of Health and Nutrition Research Vol. 4 No. 3 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i3.558

Abstract

The rising global prevalence of type 2 diabetes mellitus (T2DM) highlights the urgent need for plant-based therapeutic alternatives. Spatholobus littoralis Hassk, locally known as Bajakah, is a traditional medicinal plant from West Kalimantan, Indonesia, that is widely used by indigenous communities for regulating blood sugar levels. This study aimed to characterize the proximate and phytochemical composition of Bajakah wood extract and evaluate its antidiabetic potential in rats induced with a high-fat diet (HFD) and Streptozotocin (STZ). The extraction was performed using a 70% ethanol maceration method. Proximate analysis revealed low moisture (4.57%), ash (0.54%), total fat (0.81%), and protein (0.41%), with carbohydrates being the most abundant component (6.67%). Phytochemical screening using UV-Vis spectrophotometry identified total phenols (12.98%), flavonoids (1.16%), tannins (1.65%), and saponins (0.13%). The in vivo test on diabetic rats showed that the administration of Bajakah extract at a dose of 150 mg/kg body weight (BW) for 14 days significantly reduced fasting blood glucose levels from 279.46 ± 2.39 mg/dL to 115.62 ± 13.73 mg/dL (P= 0,028), corresponding to a 58,6% reduction. This reduction was greater than that of the positive control group, which was treated with Acarbose. The high content of phenolics and other bioactive compounds is strongly suggested to contribute to the antihyperglycemic effect through antioxidant mechanisms, inhibition of digestive enzymes, and enhancement of insulin sensitivity. This study these findings support the therapeutic potential of Bajakah wood extract from West Kalimantan as a complementary agent for management of T2DM.
Efforts to Improve Public Understanding of COVID-19 Prevention through Kader Empowerment Setyani, Rizka Ayu; Mudayana, Ahmad Ahid; Sistiarani, Colti; Astikasari, Nita Dwi; Mulyani, Sri; Febrinasari, Ratih Puspita; Sumardiyono
Jurnal SOLMA Vol. 11 No. 1 (2022)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v11i1.8416

Abstract

Background: Kasus COVID-19 di Indonesia masih terus ada dan mengalami pasang surut, salah satunya di Kabupaten Klaten. Keterbatasan petugas kesehatan dan rendahnya kesadaran masyarakat dalam menerapkan protokol kesehatan menjadi salah satu penyebab masih adanya kasus COVID-19 di Kabupaten Klaten. Kegiatan ini bertujuan untuk meningkatkan peran kader kesehatan dalam membantu meningkatkan kesadaran masyarakat menerapkan protokol kesehatan. Kegiatan ini dilakukan bekerjasama dengan Puskesmas Trucuk 1 dan Puskesmas Trucuk 2. Peserta kegiatan berjumlah 60 orang perwakilan seluruh Desa di Kecamatan Trucuk. Metode: Metode yang digunakan Focus Group Discussion, workshop serta pelatihan yang dilakukan pada bulan November-Desember 2021. Hasil kegiatan yaitu ada peningkatan pemahaman peserta setelah dilakukan kegiatan workshop dan pelatihan. Hasil: Pelatihan dengan praktik simulasi menambah wawasan peserta dalam melakukan edukasi kepada masyarakat. Kesimpulan: Peran kader kesehatan dapat menjadi solusi dalam menyadarkan masyarakat.
Co-Authors . Suyatmi . Widardo A.A. Ketut Agung Cahyawan W Adi Magna Patriadi Nuhriawangsa Ahmad Ahid Mudayana Akhmad Azmiardi Alfi Yasmina Ali, Agni Shalha Anshari, Shafira Yasmine Asaduddin, Aiman Hilmi Asih Anggraini Bachnas, Muhammad Adrianes Binti Maulina Brian Wasita Bustami, Mursyid Colti Sistiarani Dara, Rizki Wulan Dedi Febriandaru DIAN LESTARI Didik Gunawan Tamtomo Dilma’aarij, Dilma’aarij Dyonisa Nasirochmi Pakha Erna Kristin Ernawati, Dwi Arini Eti Poncorini Pamungkasari Hamka, Dwi Wulandari Aaas Hanif Mustikasari Harioputro, Dhani Redhono Haruni, Diah Sekar Imanisa, Octavia Intan Indarta, Ardhia Fefrine Kristiani, Shinta Laksmi Wardhani, Tri Martya Ningrum Lilik Wijayanti Lisyawati, Shanti MIFTAKHUL JANNAH Mustara, Mustara Mustiqa Febriniata Nafi'ah, Radifatun Nita Dwi Astikasari Nur Hafidha Hikmayani Oktaviani oktaviani Paramasari Dirgahayu Rahardjo, Setyo Sri Rio Nanda Pratama Riris Arizka Wahyu Kumala, Riris Arizka Wahyu Rizaldy Pinzon RR. Ella Evrita Hestiandari Satwika, Ariq Ratya Setyani, Rizka Ayu Shinta Shinta Solikah, Tri Agusti Sri Darnoto Sri Mulyani Sumardiyono Susanto, Agnes Syamsiar, Syamsiar Vitri Widyaningsih Widardo . Windayani, Komang Yanuarini, Triatmi Andri Yulia Lanti Retno Dewi