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Gut dysbiosis as a risk factor of neonatal sepsis among preterm infants Marsubrin, Putri Maharani Tristanita; Hikmahrachim, Hardya Gustada; Rohsiswatmo, Rinawati; Yulindhini, Maya; Firmansyah, Agus
Paediatrica Indonesiana Vol. 65 No. 2 (2025): March 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.2.2025.96-102

Abstract

Background Preterm infants are at high risk of developing sepsis. An imbalance between the normal gut and pathogenic microbiomes, known as dysbiosis, has been proposed as a condition that leads to neonatal sepsis. Objective To assess for an association between gut dysbiosis and neonatal sepsis. Methods A prospective cohort study was conducted involving very preterm or very low birth weight infants admitted to the Neonatal Unit, Cipto Mangunkusumo Hospital, Jakarta, from November 2019 to January 2021. The primary outcome was proven and/or clinical neonatal sepsis. The independent variable was gut dysbiosis, defined as a ratio of normal-to-pathogenic gut microbiome <1.0. Gut microbiome analysis was performed using a polymerase chain reaction test from a fecal specimen. Multivariate analysis using multiple logistic regression was conducted with adjustments for potential confounders. Results Forty-three infants were recruited during the study period, with a median gestational age of 30 (range 25-36) weeks and birth weight of 1,170 (range 630-1855) grams. Among them, 28 (65.1%) infants had dysbiosis and 25 (58.2%) developed sepsis. The incidence of sepsis was higher among infants with dysbiosis (20 infants; 71.4%) than those without dysbiosis (5 infants; 33.3%). Dysbiosis and hemodynamically significant patent ductus arteriosus increased the risk of sepsis, with aOR 6.93 (95%CI 1.04 to 46.14; P=0.045) and aOR 22.7 (95%CI 1.45 to 355.29; P=0.026), respectively, after adjusting for sex, birthweight, maternal and infant morbidities, as well as maternal and infant vitamin D status. Conclusion Gut dysbiosis is a risk factor for neonatal sepsis. Maintaining the balance of the gut microbiome is essential from the first day of life.
Carnitine and Infant Formulas Firmansyah, Agus
Paediatrica Indonesiana Vol. 30 No. 5-6 (1990): May-June 1990
Publisher : Indonesian Pediatric Society

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Abstract

Carnitine (gamma-trimethylamino-beta­ hydroxybutyric acid) is a quaternary amine which is capable of forming esters with a variety of acyl groups and was first iden­tified by Gulawitsch and Krimberg in 1905. Carnitine deficiency was first noted by Fraenkel (1984) who observed that if cer­tain insects were fed a diet free of carnitine, they would die in four to five weeks. Since that time, intensive studies had been done and led to suggestion that a primary func­tion of carnitine was as a carrier molecule translocating long-chain fatty acids across the inner mitochondrial membrane to the matrix, where they underwent beta-oxida­tion (Friedman and Fraenkel, 1955). Carnitine is plentiful in human milk and milk-based infant formulas; however, it is lacking in supplemented soy formulas. Since newborn infant may not fully capable of synthesizing carnitine, they must receive an adequate intake of carnitine through the diet. This article describes some aspects of carnitine with special reference to the role of carnitine on fat metabolism.
Pendidikan Kebencanaan perspektif Kisah Yusuf: Telaah Ayat 46-60 Firmansyah, Agus; Kurniawan , Rio; Wisanto , Margono
Amorti: Jurnal Studi Islam Interdisipliner Vol. 2 No. 1 Januari 2023: Amorti: Jurnal Studi Islam Interdisipliner
Publisher : Yayasan Azhar Amanaa Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59944/amorti.v2i1.72

Abstract

This research is a qualitative research method of literature (library research), and data analysis using a thematic interpretation approach. This study aims to determine the interpretation of Q.S. Yusuf verses 46-60 and the values of disaster education implied in Q.S Yusuf 46-60. This study resulted in the story of Yusuf related to the disaster verses 46 to 60. The verses 46-60 are connected with the segment of Yusuf's story contained in the following sections: The interpretation of Yusuf's dream to the king's dream, Yusuf was released from prison, Yusuf was appointed as treasurer of Egypt, and the meeting Joseph with his brother. Disaster education in the story of Yusuf is found in two things related to disaster. These two things are the stages of disaster preparedness and disaster emergency. The preparedness stage fosters a careful, thorough, and anticipatory attitude. The stage of disaster emergency fosters an attitude of concern.
Diagnostic Comparison of Elevated Fecal Leukocytes and sTREM-1 in Children with Acute Diarrhea Caused by Bacterial Infection Yudiyanto, Ade Rachmat; Firmansyah, Agus; Karyanti, Mulya Rahma
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2153

Abstract

Diarrhea is a health problem that most often occurs in children. Various etiologies of diarrhea can cause prolonged diarrhea and become malnourished (malnutrition). The etiology of diarrhea can be caused by a bacterial infection and requires antibiotics, so that detection is needed as early as possible. Examination of soluble triggering expressed receptors on myeloid cells-1 (sTREM-1) can predict bacterial infection in children with acute diarrhea. The study aims to know how much the diagnostic value of fecal leukocytes test compared to sTREM-1. A cross-sectional study of children aged 6-60 months with acute diarrhea without complications and other diseases. In the subjects, clinical manifestation was performed (fever, vomiting, abdominal pain), fecal leukocyte test and sTREM-1 test as a standard reference. Children, aged 6-60 months with acute diarrhea due to bacterial infections with sTREM-1 > 470 pg/mL as many as 2 of 64 subjects and fecal leukocytes > 10/HPF as many as 14 of 64 subjects, most male, normal nutritional status and had clinical manifestation of fever, vomiting and without abdominal pain. Increased fecal leukocytes > 10 / HPF has a sensitivity of 50%, specificity 79.1%, positive predictive value 7.1%, negative predictive value 98%, accuracy 78%, positive likelihood ratio 2.18 and negative likelihood ratio 0.63. Fecal leukocyte test > 10/HPF as a diagnostic confirmation is not good in diagnosing acute diarrhea due to bacterial infection.
Sosialisasi Pembuatan Mikroorganisme Lokal (MOL) dari Sampah Rumah Tangga pada Pekon Way Kerkai Achmad, Feerzet; Setianingrum, Nur; Jarwinda, Jarwinda; Satria, Arysca Wisnu; Firmansyah, Agus; Susanto, Herri
Babakti: Journal of Community Engangement Vol. 1 No. 1 (2024): April
Publisher : Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/babakti.v1i1.5

Abstract

Pekon/Desa Way Kerkai, Kecamatan Lemong, Kabupaten Pesisir Barat, Lampung yang memiliki potensi komoditi kopi dan cabai. Adanya lahan pertanian yang cukup luas tetapi limbah pertanian yang dibuang begitu saja tanpa dimanfaatkan secara maksimal, dapat mencemari lingkungan dan mempengaruhi hasil pertanian di Pekon Way Kerkai. Demikian halnya dengan pengelolaan sampah organik rumah tangga masyarakat yang dibuang begitu saja tanpa ada proses lebih lanjut dan berpotensi mencemari lingkungan. Tujuan Kegiatan KKN PPM ini adalah memberikan pengetahuan kepada masyarakat dan petani tentang bagaimana cara mengelola limbah dan sampah organik menjadi pupuk cair atau Mikroorganisme Lokal (MOL). Metode yang diterapkan dalam kegiatan ini yaitu penyuluhan dan pelatihan pembuatan MOL. Hasil dari kegiatan ini yaitu masyarakat dan petani memahami tentang proses pembuatan dan manfaat pupuk organik cair berbahan MOL untuk tanaman. Pemahaman petani meningkat dari rata-rata 30% sebelum pelatihan dan mencapai 90% setelah pelatihan ini berdasarkan kuisioner yang dibagikan sebelum dan sesudah pelatihan. Selain itu pelatihan ini dapat menjadi usaha atau bisnis serta sebagai bentuk memanfaatkan limbah yang tidak termanfaatkan dengan baik.
Pengaruh Pemberian POC Jamur Keberuntungan Abadi (JAKABA) Terhadap Pertumbuhan dan Hasil Tanaman Okra (Abelmoschus esculentus L) Muhammad Alfatih; Firmansyah, Agus; Edward Bahar
PUCUK : Jurnal Ilmu Tanaman Vol 5 No 1 (2025): Juni
Publisher : Fakultas Pertanian Universitas Ratu Samban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58222/pucuk.v5i1.463

Abstract

Penelitian ini bertujuan untuk menganalisis pengaruh pemberian Pupuk Organik Cair (POC) berbasis Jamur Keberuntungan Abadi (Jakaba) terhadap pertumbuhan dan hasil tanaman okra (Abelmoschus esculentus L). Penelitian ini dilakukan menggunakan Rancangan Acak Lengkap (RAL) dengan lima perlakuan dan tiga ulangan, yang mencakup dosis POC jakaba 40 ml/liter, 50 ml/liter, 60 ml/liter, 70 ml/liter, dan kontrol tanpa POC jakaba. Beberapa parameter yang diamati dalam penelitian ini meliputi tinggi tanaman (cm), jumlah daun (helai), diameter batang (cm), jumlah buah (buah), dan bobot buah segar (gram). Hasil penelitian menunjukkan bahwa Berdasarkan hasil analisis sidik ragam, pemberian POC jakaba tidak berpengaruh nyata terhadap tinggi tanaman, meskipun terdapat peningkatan rata-rata tinggi pada setiap perlakuan. Artinya, secara statistik peningkatan tersebut belum cukup signifikan. Sebaliknya, pada parameter jumlah daun, diameter batang, jumlah buah, dan bobot buah segar, pemberian POC jakaba menunjukkan pengaruh yang nyata, dengan dosis 70 ml/liter memberikan hasil terbaik. Tanaman pada dosis ini menghasilkan rata-rata jumlah daun 5,96 helai, diameter batang 0,37 cm, jumlah buah 6,55 buah, dan bobot buah segar 230,88 gram. Maka dapat disimpulkan bahwa POC jakaba berpengaruh nyata pada sebagian besar parameter pertumbuhan dan hasil tanaman okra, kecuali tinggi tanaman. Hal ini menunjukkan bahwa efektivitas pupuk dapat berbeda pada tiap aspek pertumbuhan, tergantung dosis dan respon fisiologis tanaman.
PENERAPAN INTERVENSI SEMI FOWLER PADA PASIEN DENGAN MASALAH POLA NAFAS TIDAK EFEKTIF DI RUANG PICU RUMAH SAKIT IMMANUEL BANDUNG Firmansyah, Agus
Jurnal Ilmu Kesehatan Immanuel Vol. 19 No. 1 (2025): Jurnal Ilmu Kesehatan Immanuel
Publisher : Institut Kesehatan Immanuel

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36051/jiki.v19i1.298

Abstract

Diabetic Ketoacidosis (DKA) is an emergency condition due to hyperglycemia that can be life-threatening for clients with diabetes mellitus. As a result of various factors and characterized by narrowing of the airways, resulting in shortness of breath in patients. One thing that can be done is providing a Semi-Fowler position, which is an important way to restore respiration to normal and reduce shortness of breath significantly. The purpose of this study was to analyze the application of semi-fowler interventions with a medical diagnosis of diabetic ketoacidosis with nursing problems of ineffective breathing patterns at Immanuel Hospital, Bandung. The method used was a case study and data collection using interviews, observations and documentation. The results of the nursing care analysis obtained the main nursing problem in the patient, namely ineffective breathing patterns. Nursing interventions carried out to overcome the main nursing problem were to provide airway management with a semi-fowler position after the intervention, the problem of ineffective breathing patterns could be resolved, marked by respiration returning to normal and a decrease in the frequency of shortness of breath in patients. Therefore, it is hoped that this intervention can be collaborated with other interventions as one of the actions in carrying out comprehensive nursing care.
ANALISIS KEPUASAN PENGGUNA TERHADAP APLIKASI TOKOPEDIA DI WILAYAH KECAMATAN PASAR KEMIS MENGGUNAKAN PENDEKATAN TECHNOLOGY ACCEPTANCE MODEL Firmansyah, Agus; Andreyatsha, Andreyatsha; Bibit Sudarsono
Journal of Data Analytics, Information, and Computer Science Vol. 2 No. 4 (2025): Oktober
Publisher : Yayasan Nuraini Ibrahim Mandiri

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Abstract

Penelitian ini bertujuan untuk menganalisis kepuasan pengguna terhadap aplikasi Tokopedia di wilayah Kecamatan Pasar Kemis dengan menggunakan pendekatan Technology Acceptance Model (TAM). Model ini menitikberatkan pada dua variabel utama, yaitu Perceived Usefulness (PU) dan Perceived Ease of Use (PEOU), yang diyakini memengaruhi Attitude Toward Using, Behavioral Intention to Use, dan akhirnya kepuasan pengguna. Metode penelitian yang digunakan adalah kuantitatif dengan teknik pengumpulan data melalui penyebaran kuesioner kepada 100 responden pengguna Tokopedia. Analisis data dilakukan menggunakan Structural Equation Modeling (SEM) berbasis Partial Least Squares (PLS). Hasil Perceived Usefulness berpengaruh signifikan terhadap Attitude Toward Using dengan koefisien 0.670 (t-statistik 3.244, p-value 0.001), dan juga terhadap PEOU dengan koefisien sebesar 0.962 (t-statistik 67.061, p-value 0.000). Hal ini mengindikasikan bahwa persepsi kegunaan aplikasi Tokopedia sangat berkontribusi dalam membentuk sikap positif pengguna dan persepsi terhadap kemudahan penggunaan aplikasi. PEOU tidak memiliki pengaruh signifikan secara langsung terhadap ATU, dengan koefisien 0.318 (t-statistik 1.528, p-value 0.127), yang berarti kemudahan penggunaan saja belum cukup untuk membentuk sikap positif terhadap aplikasi. Sebaliknya, ATU memiliki pengaruh sangat signifikan terhadap Behavioral Intention to Use dengan koefisien 0.960 (t-statistik 74.220, p-value 0.000), dan BITU juga berpengaruh sangat signifikan terhadap Actual Usage dengan koefisien 0.934 (t-statistik 36.121, p-value 0.000). Temuan ini menyimpulkan bahwa sikap positif memiliki peran kunci dalam membentuk niat dan perilaku penggunaan aktual secara berkelanjutan.