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All Journal JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Medical Journal of Indonesia Jurnal Keolahragaan Journal of Biomedicine and Translational Research The Indonesian Biomedical Journal Paediatrica Indonesiana JOURNAL SPORT AREA Journal of Biology Education Media Medika Muda Journal of Dedicators Community Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Cendana Medical Journal
Nyoman Suci Widyastiti
Department Of Clinical Pathology, Faculty Of Medicine, Diponegoro University, Semarang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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PERBEDAAN ANTARA RASIO NEUTROFIL/ LIMFOSIT DAN RASIO PLATELET/ LIMFOSIT PADA KEHAMILAN NORMAL, PREEKLAMSIA RINGAN DAN BERAT Setianingrum, Elisabeth Levina Sari; Widyastiti, Nyoman Suci
Cendana Medical Journal Vol 7 No 2 (2019): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (170.962 KB) | DOI: 10.35508/cmj.v7i2.1807

Abstract

Preeklamsi disebabkan hipoperfusi plasenta, pelepasan sitokin dan disfungsi endotel sebagai respons inflamasi. Neutrofil/Limfosit Ratio (NLR) dan Platelet/ Limfosit Ratio (PLR) merupakan petanda inflamasi sistemik pada berbagai penyakit inflamasi. Membandingkan NLR dan PLR sebagai petanda inflamasi pada kehamilan normal, Preeklamsia Ringan (PER) dan Preeklamsia Berat (PEB). Penelitian observasional analitik dengan pendekatan belah lintang terhadap 102 pasien kehamilan di RSUP dr. Kariadi yang terbagi menjadi 3 kelompok (normal, PER, PEB). Neutrofil dan limfosit dihitung dengan hitung jenis nilai absolut trombosit berdasarkan hematology analizer. Analisis data menggunakan uji Kruskal Wallis dilanjutkan uji post hoc Mann-Whitney. Median NLR pada kehamilan normal ialah 4,15(1,34;5,86) pada PER 5,56 (1,78;8,5) dan PEB 10,98 (5,57;18,8) terdapat perbedaan NLR kehamilan normal dengan PEB dan PER dengan PEB. Median PLR pada kehamilan normal 151,44 (92,34;381,54) PER 134,72 (30,84;491,38) dan PEB 153,35 (26,34;441,14) tidak terdapat perbedaan PLR pada kehamilan normal dan PER (p=0,359) kehamilan normal dan PEB (p=0,965) PER dan PEB(p=0,535). Terdapat perbedaan NLR antara kehamilan normal dengan PEB dan PER dengan PEB, tidak terdapat perbedaan PLR antara ketiganya
Effect of arum manis mango peel extract on cholesterol and triglyceride levels in dyslipidemic Sprague-Dawley rats Saputra, Taufik; Naufal, Haidar Satya; Utomo, Astika Widy; Widyastiti, Nyoman Suci; Kurniawan, Muhammad Farhan; Azizah, Arfianty Nur
Medical Journal of Indonesia Vol. 32 No. 3 (2023): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.236960

Abstract

BACKGROUND Dyslipidemia is characterized by an increase in low-density lipoprotein (LDL) and triglyceride (TG) levels and a decrease in high-density lipoprotein (HDL). Cholestyramine as an antidyslipidemia has several side effects, so an alternative is needed. Pectin is a natural substance with a mechanism of action similar to that of cholestyramine. Mango peel is one of the sources of pectin, containing 10–15% of this substance. This study aimed to prove the effect of arum manis mango (Mangifera indica L.) peel extract on LDL, HDL, and TG levels in dyslipidemic Sprague-Dawley rats. METHODS 25 Sprague-Dawley rats were divided into 5 groups. All groups were given high-fat diet for the first 18 days, followed by standard feed (negative control group), cholestyramine (Sequest®) 80 mg/200 g body weight (standard treatment group), and mango peel extract (M-90 [90 mg/day], M-180 [180 mg/day], and M-360 [360 mg/day] groups) for the next 15 days. LDL and HDL levels were analyzed using the cholesterol oxidase-phenyl aminopyrazolone method and TG level using the glycerol-3-phosphate-oxidase-phenol-aminophenazone method. RESULTS The M-360 group reduced the LDL level (p = 0.015), while the standard treatment group increased the HDL level (p = 0.042). Although significant TG level changes were found in the negative control, standard treatment, and M-360 groups (p = 0.042), the mean differences of LDL, HDL, and TG levels between groups were not significantly different (p = 0.245, 0.328, and 0.454, respectively). CONCLUSIONS M. indica peel extract reduced LDL and TG levels at 360 mg/day.
Co-Authors Abd. Rasyid Syamsuri Adieba Warda Hayya Afriana, Rizky Dyas Agus Fitrianto Ainun Najib Amelia, Sesa Anies Anies Ardhea Jaludamascena Ariosta Ariosta Arulita Ika Fibriana Astika Widy Utomo, Astika Widy Azizah, Arfianty Nur Banundari Rachmawati Budhi Setianto Dea Amanda Caressa Devi Ermawati Diana Nur Afifah, Diana Nur Djuara P Lubis Dwi Retnoningrum Edi Dharmana Edi Dharmana Edward Kurnia Setiawan Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Ekowati, Liana Elida Soviana Elsa Naviati Erna Mirani Etika Ratna Noer Fathur Nur Kholis Galang Bela Nusa Hadian Hadian Hardhono Susanto Hardhono Susanto Henna Rya Abdurachmin Hertanto Wahyu Subagio I Made Miarta Yasa Ima Arum Lestarini Imam Budiwiyono Indranila Kustarini Samsuria K. Heri Nugroho HS, K. Heri Kurniawan, Muhammad Farhan Kusmiyati DK Kusmiyati Tjahjono Mabruratussania Maherdika Mahalul Azam Maria Mexitalia Martha Irene Kartasurya Meira Erawati Meita Hendrianingtyas Moedrik Tamam Moedrik Tamam Muji Rahayu Mulya Agustina Mulyono Mulyono Muniroh, Muflihatul Nahwa Arkhaesi Najma Khairani Harahap Naufal, Haidar Satya Novianti, Anugrah Nugroho, Trilaksana Partiwi, Rina Purwanto Adipireno Purwanto AP R. Lindeman Ratih Budinastiti Retnoningrum, Dwi Rina Pratiwi Roziana Roziana, Roziana Rr. Sri Ratna Rahayu Ruth Hanna Kristina Safitri, Titis Yoga Saputra, Taufik Setianingrum, Elisabeth Levina Sari Setiawan L, I Edward Kurnia Silitonga, Marisi Elizabeth R. Suhartono Suhartono, Suhartono Susanti Lestari Thijs Eijsvogels Tri Indah Winarni Udin Bahrudin Umi S Intansari Widodo, Sabar Widyastuti, Trioni Yanuarita Tursinawati Yanuarius Alvin Pratama Budianto Yetty Movieta Nancy Yetty Movieta Nency Yetty Movieta Nency Yetty Movieta Nency, Yetty Movieta Yuliana Yuliana Zetta, Adelia Paradya