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All Journal JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Nutrition College Medical Journal of Indonesia Jurnal Keolahragaan Journal of Biomedicine and Translational Research The Indonesian Biomedical Journal Paediatrica Indonesiana AcTion: Aceh Nutrition Journal JOURNAL SPORT AREA Media Medika Muda Journal of Dedicators Community Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Medica Arteriana (Med-Art) Cendana Medical Journal
Nyoman Suci Widyastiti
Departement Of Clinical Pathology, Faculty Of Medicine, Universitas Diponegoro
Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Nutrition intake, insulin-like growth factor-1 hormone levels, somatotype score, and strength performance of adolescent athletes Zetta, Adelia Paradya; Susanto, Hardhono; Noer, Etika Ratna; Muniroh, Muflihatul; Widyastiti, Nyoman Suci
Journal Sport Area Vol 9 No 3 (2024): December
Publisher : UIR Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25299/sportarea.2024.vol9(3).17017

Abstract

Background Problems: Currently, there is still limited identification of nutritional intake, hormonal, and physical performance in adolescent athletes in Indonesia. Research Objectives: This study aims to identify anthropometric, nutritional intake, IGF-1 hormone level, and adolescent athletes’s performance. Methods: The research method used a cross-sectional study. A convenient sample of 58 athletes under Balai Pemusatan Pendidikan dan Latihan Pelajar. The research instrument used Bioelectrical Impedance Analysis (BIA), leg dynamometer, hand grip dynamometer, tape measure, height stature, SQ-FFQ Form, and body fat caliper. Blood samples were collected and tested by a professional laboratory. Data analysis techniques used Pearson’s test for normally distributed data and Spearman’s rank for non-normally distributed data. Findings and Results: The result of this study found a significant (p < 0.05) correlation between energy intake, anthropometric measurement of z score (BMI/Age), and endomorph score with an athlete’s muscle strength. We also found significant differences (p < 0.05) in macronutrient and micronutrient consumption in male and female athletes, and we also found significant differences in somatotype score and muscle strength in male and female athletes. Conclusion: We conclude that many athletes are not consuming the recommended levels of carbohydrates, fat, protein, and some micronutrients. We found a correlation between energy intake and fat intake with leg muscle strength. However, there was no correlation between IGF-1 hormone levels and athlete strength. Intake is thought to indirectly affect grip strength and leg strength.
PERAN DIETARY INFLAMMATORY INDEX DAN KOMPOSISI LEMAK TUBUH DALAM MENINGKATKAN KADAR TNF ALPHA PADA INDIVIDU OBESITAS: TINJAUAN NARATIF Dian Novita; Adriyan Pramono; Ninik Rustanti; Etika Ratna Noer; Nyoman Suci Widyastiti
Journal of Nutrition College Vol 15, No 1 (2026): Januari
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jnc.v15i1.49380

Abstract

ABSTRACTBackground: Obesity is a global health issue associated with low-grade chronic inflammation due to increased production of pro-inflammatory cytokines, particularly Tumor Necrosis Factor Alpha (TNF-α). TNF-α plays a role in the development of insulin resistance and metabolic disorders in obese individuals. Additionally, diet contributes to inflammation, which can be measured using the Dietary Inflammatory Index (DII). A higher DII score indicates a pro-inflammatory diet, which is linked to elevated TNF-α levels. Body fat distribution, especially visceral fat accumulation, also contributes to the increased production of pro-inflammatory cytokines;Objective: This study aimed to explore the relationship between a pro-inflammatory diet, body fat composition, and TNF-α levels in obese individuals;Methode: This study employs a narrative review approach by gathering data from various national and international articles. The search was conducted through multiple databases, including Google Scholar, PubMed, ScienceDirect, and ResearchGate. Data were retrieved using selected keywords such as Dietary Inflammatory Index, body fat composition, TNF-α, and obesity in adults;Results: The review results indicate that a high DII diet, characterized by high consumption of sugar, saturated fats, and low fiber intake, contributes to increased inflammation. Meanwhile, body fat distribution, particularly visceral fat, also triggers TNF-α production, exacerbating chronic inflammatory conditions;Conclusion: The interaction between diet and body fat composition indicates that obese individuals with a pro-inflammatory diet have a higher risk of persistent systemic inflammation. Therefore, intervention strategies that prioritize an anti-inflammatory diet and proper body fat management are crucial in reducing TNF-α levels and preventing obesity-related health complications;Keywords: Body fat composition; dietary inflammatory index; inflammation; obesity in adults; TNF-α ABSTRAKLatar Belakang: Obesitas merupakan salah satu masalah kesehatan masyarakat yang ditandai dengan akumulasi lemak tubuh berlebih dan berisiko menimbulkan komplikasi metabolik. Salah satu mekanisme penting yang mendasari komplikasi tersebut adalah inflamasi kronis tingkat rendah, yang ditandai dengan peningkatan kadar sitokin pro-inflamasi seperti TNF-α. Pola makan yang bersifat pro-inflamasi diketahui dapat meningkatkan respon inflamasi tubuh, termasuk kadar TNF-α. Selain itu, komposisi lemak tubuh terutama tingginya massa lemak juga berperan dalam meningkatkan produksi sitokin tersebut. Meski masing-masing faktor ini sudah pernah diteliti, masih sedikit penelitian yang melihat hubungan antara pola makan, lemak tubuh, dan kadar TNF-α secara bersamaan pada orang yang obesitas;Tujuan: Penelitian ini bertujuan untuk mengeksplorasi hubungan antara pola makan pro-inflamasi, komposisi lemak tubuh dan kadar TNF-α pada individu obesitas;Metode:  Studi ini menggunakan pendekatan tinjauan naratif dengan mengumpulkan data dari berbagai artikel nasional dan internasional. Pencarian dilakukan melalui beberapa databese seperti Google Scolar, PubMed, dan Science Direct dan Researchgate. Data dicari dengan menggunakan beberapa kata kunci terpilih seperti Dietary Inflammatory Index, body fat compotition, TNF-α, dan obesity in adults;Hasil: Hasil kajian menunjukkan bahwa pola makan dengan nilai DII tinggi yang ditandai dengan konsumsi tinggi gula, lemak jenuh, dan tendah serat, berkontribusi terhadap peningkatan peradangan. Sementara itu, distribusi lemak tubuh terutama lemak viseral juga memicu produksi TNF-α yang memperparah kondisi inflamasi kronis;Simpulan: Interaksi antara pola makan dan komposisi lemak tubuh ini menunjukkan bahwa individu obesitas dengan pola makan pro-inflamasi memiliki risiko lebih tinggi terhadap inflamasi sistemik yang berkelanjutan. Oleh karena itu, strategi intervensi yang mengedepankan pola makan anti-inflamasi dan pengelolaan komposisi lemak tubuh sangat penting dalam mengurangi kadar TNF-α dan mencegah komplikasi kesehatan terkait obesitas;Kata Kunci: Dietary inflammatory index; inflamasi; komposisi lemak tubuh; obesitas dewasa; TNF-α
Analisis Faktor Risiko Mortalitas pada Pasien COVID-19 dengan Keganasan Non-Hematologi Nyoman Suci Widyastiti; Dyah Mustika Nugraheni; Dwi Retnoningrum; Ariosta Ariosta; Fathur Nur Kholis; Nur Farhanah; Selamat Budijitno; Endy Cahyono Kristiawan
Medica Arteriana (Med-Art) Vol 7, No 2 (2025): Desember 2025
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/medart.7.2.2025.74-81

Abstract

Latar Belakang: Corona Virus Disease-19 (COVID-19) merupakan masalah kesehatan dunia yang sangat serius. Gejala yang berat dapat berujung kematian terutama pada individu yang memiliki komorbid seperti penyakit jantung koroner, diabetes melitus, hipertensi dan pada kondisi imunosupresi seperti pada pasien dengan keganasan. Studi terdahulu menunjukkan peningkatan risiko mortalitas pada pasien keganasan yang terinfeksi COVID-19. Penelitian ini bertujuan untuk menganalisis hubungan antara jenis kelamin, jenis keganasan, hipertensi, diabetes melitus, derajat keparahan penyakit, nilai lymphocyte-to-CRP ratio (LCR), dan kadar kreatinin serum dengan tingkat mortalitas pada pasien COVID-19 dengan keganasan non-hematologi.Metode: Penelitian ini merupakan penelitian cross-sectional retrospektif yang dilaksanakan pada bulan Mei 2023 hingga Juni 2023 dengan mengambil data pasien COVID-19 dengan keganasan non-hematologi di RSUP Dr. Kariadi Semarang pada periode bulan Maret 2020 hingga Desember 2022. Semua data diambil melalui rekam medis elektronik (RME) RSUP Dr. Kariadi Sema-rang. Nilai cut-off untuk LCR dan kadar kreatinin serum masing-masing adalah 100 dan 1,3 mg/dL. Data kategorik dianalisis menggunakan uji Chi-square untuk mendapatkan nilai p dan Prevalence Ratio (PR). Uji regresi logistik digu-nakan untuk mengetahui hubungan independen antara derajat keparahan penya-kit dan kadar kreatinin serum terhadap tingkat mortalitas.Hasil: Seratus satu pasien diikutkan dalam penelitian dengan 48 kasus mortalitas. Hubungan antara jenis kelamin, jenis keganasan, hipertensi, diabetes melitus, dan nilai LCR dengan tingkat mortalitas didapatkan masing-masing nilai p = 0,924; p = 0,847; p = 0,101; p = 0,916; p = 0,143. Hubungan antara derajat keparahan penyakit dan kadar kreatinin serum dengan tingkat mortalitas didapatkan masing-masing nilai p < 0,001 (PR = 22,148) dan p = 0,009 (PR = 3,604). Hasil analisis mutivariat menunjukkan bahwa nilai PR dari hubungan antara derajat keparahan penyakit dan kadar kreatinin serum dengan tingkat mortalitas pasien masing-masing adalah 27,547 dan 7,090.Kesimpulan: Jenis kelamin, jenis keganasan, hipertensi, diabetes melitus, dan nilai LCR tidak berhubungan dengan tingkat mortalitas. Derajat keparahan penyakit dan peningkatan kadar kreatinin serum berhubungan dengan tingkat mortalitas.
Elevated Serum Netrin-1, Platelet-to-Lymphocyte Ratio, and Monocyte-to-Lymphocyte Ratio are Associated with Impaired Fasting Glucose in Adults with Central Obesity Brian Eka Putera; Meita Hendrianingtyas; Nyoman Suci Widyastiti; Dwi Retnoningrum; Purwanto Adipireno
The Indonesian Biomedical Journal Vol 18, No 4 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i4.4282

Abstract

BACKGROUND: Adults with central obesity may develop impaired fasting glucose (IFG) due to chronic low-grade inflammation. Although C-reactive protein (CRP) is a common marker of systemic inflammation, it is nonspecific and cannot fully capture obesity-related inflammatory pathways. Netrin-1 promotes macrophage retention in visceral adipose tissue, thereby sustaining inflammation and insulin resistance, while platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) reflect complementary inflammatory pathways; however, their discriminatory performance and associations with IFG remain uncertain. Therefore, this study was conducted to evaluate these markers in adults with central obesity.METHODS: Blood samples from 88 adults with central obesity were obtained, and fasting glucose concentration was measured using hexokinase method to determine IFG status. Serum Netrin-1 was measured using an enzyme-linked immunosorbent assay (ELISA), serum CRP was measured using fluorescence immunoassay (FIA); PLR and MLR were calculated from complete blood counts. Receiver operating characteristic (ROC) analysis assessed discriminatory performance, while exploratory logistic regression adjusted for age, sex, and BMI to examine biomarker associations with IFG.RESULTS: Among 88 participants, 54.5% had IFG. The AUCs were 0.694, 0.627, 0.689, and 0.532 for Netrin-1, PLR, MLR, and CRP, respectively. In crude prevalence-ratio (PR) analysis, Netrin-1 ≥315.35 pg/mL (PR=1.742; p=0.006), PLR ≥132.43 (PR=1.593; p=0.019), and MLR ≥0.20 (PR=2.119; p<0.001) were associated with IFG, whereas CRP was not. In separate ROC analysis, MLR had an AUC of 0.689 (p=0.002). After adjustment for age, sex, and BMI; MLR ≥0.20 remained associated with IFG (adjusted OR=7.516; p<0.001).CONCLUSION: Elevated serum Netrin-1, PLR, and MLR were associated with IFG in adults with central obesity. MLR showed the strongest crude association and was the only evaluated inflammatory biomarker retained in the exploratory adjusted logistic regression model. As an inexpensive index derived from a routine complete blood count, MLR may complement fasting-glucose assessment by helping characterize the inflammatory phenotype of adults with central obesity.KEYWORDS: central obesity, C-reactive protein, impaired fasting glucose, netrin-1, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio
Co-Authors Abd. Rasyid Syamsuri Adhika Bastian Bagas Prananta Adieba Warda Hayya Adriyan Pramono Afriana, Rizky Dyas Agus Fitrianto Ahmad Ni’Matullah Al-Baarri Ahmad Syauqy Ahmad Syauqy Ainun Najib Amelia, Sesa Anies Anies Ardhea Jaludamascena Ariosta Ariosta Ariosta Ariosta Ariosta Ariosta Ariosta Ariosta Ariosta Ariosta Arulita Ika Fibriana Astika Widy Utomo, Astika Widy Azizah, Arfianty Nur Banundari Rachmawati Brian Eka Putera Budhi Setianto Charles Limantoro Dea Amanda Caressa Devi Ermawati Dian Novita Diana Nur Afifah, Diana Nur Djuara P Lubis Dwi Retnoningrum Dwi Retnoningrum Dwi Retnoningrum Dyah Mustika Nugraheni Edi Dharmana Edi Dharmana Edward Kurnia Setiawan Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi Ekowati, Liana Elida Soviana Elsa Naviati Endang Mahati Endang Mahati Endy Cahyono Kristiawan Erna Mirani Etika Ratna Noer Etika Ratna Noer Etika Ratna Noer Fathur Nur Kholis Fathur Nur Kholis Fathur Nur Kholis Galang Bela Nusa Hadian Hadian Hardhono Susanto Hardhono Susanto Henna Rya Abdurachmin Hertanto Wahyu Subagio I Edward Kurnia Setiawan L I Made Miarta Yasa Ima Arum Lestarini Imam Budiwiyono Indranila Kustarini Samsuria K. Heri Nugroho HS, K. Heri Kurniawan, Muhammad Farhan Kusmiyati DK Kusmiyati Tjahjono Mabruratussania Maherdika Mahalul Azam Maria Mexitalia Martha Irene Kartasurya Masdayani Junita Napitupulu Meira Erawati Meita Hendrianingtyas Meita Hendrianingtyas Meita Hendrianingtyas Michael Kevin Mochamad Ali Sobirin Moedrik Tamam Moedrik Tamam Monikasari Monikasari Muji Rahayu Mulya Agustina Mulyono Mulyono Muniroh, Muflihatul Nahwa Arkhaesi Najma Khairani Harahap Nani Maharani Naufal, Haidar Satya Neni Susilaningsih Neni Susilaningsih Neni Susilaningsih Ninik Rustanti Novianti, Anugrah Nugroho, Trilaksana Nur Farhanah Nur Farhanah Partiwi, Rina Purwanto Adipireno Purwanto Adipireno Purwanto AP Qorry Amanda R. Lindeman Rafika Eviana Ratih Budinastiti Retnoningrum, Dwi Rezya Salsabela Rezya Salsabela Rina Pratiwi Roziana Roziana, Roziana Rr. Sri Ratna Rahayu Ruth Hanna Kristina Sabar Widodo Salma Tyas Salsabila Saputra, Taufik Selamat Budijitno Selamat Budijitno Setianingrum, Elisabeth Levina Sari Silitonga, Marisi Elizabeth R. Suhartono Suhartono, Suhartono Susanti Lestari Thijs Eijsvogels Titis Yoga Safitri Tri Indah Winarni Udin Bahrudin Udin Bahrudin Umi S Intansari Vega Karlowee Widyastuti, Trioni Yan Wisnu Prajoko Yan Wisnu Prajoko Yanuarita Tursinawati Yanuarius Alvin Pratama Budianto Yetty Movieta Nancy Yetty Movieta Nency Yetty Movieta Nency Yetty Movieta Nency Yetty Movieta Nency, Yetty Movieta Yuliana Yuliana Zetta, Adelia Paradya