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All Journal VALENSI Bionatura Indonesian Journal of Cancer Chemoprevention ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Journal of Medicine and Health Chimica et Natura Acta Indonesian Journal of Chemistry Jurnal Agrotek Tropika Molekul: Jurnal Ilmiah Kimia Journal of Health Technology Assessment in Midwifery Odonto dental journal Journal of Medicine and Health

Dikdik Kurnia

Departemen Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Padjadjaran

Author-ID : 2680929

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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A New Antiplasmodial Compound from the Papuan Marine Sponge Xestospongia sp. Murtihapsari Murtihapsari; Amir M Suruwaky; Kadarusman Kadarusman; Dikdik Kurnia; Tati Herlina; Unang Supratman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 1, Mei 2018
Publisher : Syarif Hidayatullah State Islamic University

A new antiplasmodial compound, 2-(3H-diazirine-3-yl)benzaldehyde (1), has been isolated from the Papuan marine sponge Xestospongia sp. The structure elucidation of compound 1 was determined by spectroscopic evidences including UV, IR, MS, 1D and 2D-NMR analysis. Compound 1 showed moderate antiplasmodial activity against Plasmodium falciparum with IC50 value of 1.08 x 10-6 mM. DOI:http://dx.doi.org/10.15408/jkv.v4i1.6735

Antibacterial Diterpenoid Against Pathogenic Oral Bacteria of Streptococcus Mutans ATCC 25175 Isolated From Sarang Semut (Myrmecodia Pendans) Mieke H Satari; Boima Situmeang; Indah Permata Yudha; Dikdik Kurnia
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 5, No. 2, November 2019
Publisher : Syarif Hidayatullah State Islamic University

Discovery of new antibacterial agent to treat oral disease caused by pathogenic oral bacteria is an attracted focus to more pay attention of researcher. The tropical natural product is the promising sources of new bioactive as antibacterial compounds. The epiphyte plant of Sarang Semut (M. pendans) empirically has been used as a drug to treat various diseases. Our previous research found that ethyl acetate extract of Sarang Semut inhibited the bacteria growth of Enterococcus faecalis. This study aims to isolate, structure determination and antibacterial activity evaluation of active compound against Streptococcus mutans ATCC 25175. The isolation by combination chromatography on normal and reverse phase resulted an antibacterial compound 1. Based on the analysis of the spectroscopic data including IR, FTIR, 1H-NMR, 13C-NMR, 2D-NMR as well as by mass spectroscopic (MS) and compare to reported data, structure of compound 1 was suggested as terpenoid type diterpene derivative. Antibacterial activity evaluation by Kirby-Bauer method of compound 1 against S. mutans ATCC 25175 showed inhibition zone values were 17.8, 14.5 and 11.1 mm at 10000, 5000 and 1000 ppm, respectively, while the MIC and MBC values were 18.125 ppm with MBC of 2500 ppm, respectively.

Kuersetin dan Kuersetin-3-O-Glukosida dari Kulit Batang Sonneratia Alba (Lythraceae) . Horizon; Betry Pujiastuti; Dikdik Kurnia; Dadan Sumiarsa; Unang Supratman; Yoshihito Shiono
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 1, No. 1, Mei 2015
Publisher : Syarif Hidayatullah State Islamic University

Two flavonoid compounds, quercetin (1) and quercetin-3-O-glucoside (2) have been isolated from the bark of Sonneratia alba (Lythraceae). Chemical structure of both compounds were determined on the basis of spectroscopic data and comparison with those spectra data previously reported. Compound 1 and 2 exhibited antibacterial activity against Gram-positive bacteria, Staphylococcus aureus and Streptococcus mutans with MIC values of 51.2; 48.8; 72.5; dan 100.7 µg/mL respectively.DOI :http://dx.doi.org/10.15408/jkv.v0i0.3151

In Vitro and In Silico Study of Antibacterial Activity of Sirih Merah Leaf Extract (Piper crocatum Ruiz & Pav.) Against Streptococcus mutans Yuliana, Trisna; Yusrin, Yolanda Charmenia Nadine; Fauzi, Puad; Aisyah, Lilis Siti; Kurnia, Dikdik
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 1, May 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.42433

Sirih merah leaf (Piper crocatum Ruiz & Pav) is a natural material that has the potential to be used as a natural antibacterial agent in treating dental caries caused by Streptococcus mutans because it is known to contain secondary metabolite compounds that have antibacterial properties that can inhibit the activity of glucosyltransferase and glucan-binding protein (Gbp) enzymes produced by S. mutans. This study was conducted to determine the antibacterial activity of Sirih merah leaf extract against S. mutans using the Kirby-Bauer method and to predict the potential molecular activity of antibacterial compounds contained in Sirih merah leaves in inhibiting the growth of S. mutans bacteria in silico using the molecular docking method. Antibacterial activity testing of Sirih merah leaf extract fractions obtained from methanol extract showed that fractions 7 and 10 are active fractions because they can inhibit the growth of S. mutans at the highest concentration of 10% with a strong inhibition zone category. The active fractions were then analyzed by the LC-HRMS method to obtain active compounds. The results of the in silico molecular docking test showed that the active compounds of Sirih merah leaves have the potential to interact with the GtfB and GbpC enzymes of S. mutans, where the best binding energy in the interaction of cafedrine compounds is -8.75 kcal/mol and -9.27 kcal/mol. The docking results were validated through a molecular docking process using native ligands with RMSD values of 1,861 Å and 3,170 Å.

Co-Authors . Horizon Ambrosius Purba Amir M. Suruwaky ANNE NURAINI Anni Yuniarti Ariwibowo, ⁠Taufiq Azmi, Mohamad Nurul Bashari, Muhammad Hasan Betry Pujiastuti Binartha, Ciptadhi Oka Boima Ramses Situmeang Budi Setiabudiawan Cut Soraya Dadan Sumiarsa Danny Hilmanto Darma, Joshua Denny Nurdin Dharsono, Hendra Dian Adhita Diana Rakhmawaty Djulia Onggo Djulia Onggo Dudi Aripin Elizabeth Fitriana Sari Elline, Elline Erni Suminar Euis Julaeha Fajar Fatriadi Fauzi, Puad Fernando, Theodorus Aldo Gondowidjojo, Yolanda Dwiutami Hafiz, Ersanda Harizon Harizon Hendra Dian Adhita Hendra Dian Adhyta Dharsono Huda, Fathul Indah Permata Yudha Irma Mulyani Irma Mulyani Iwan Hastiawan Iwan Hastiawan Jamaludin Al-Anshori Jeffrey Jeffrey Kadarusman Kiki Maesaroh Komariah Komariah Kusumadewi, Vira Lilis Siti Aisyah, Lilis Siti Meilinah Hidayat - Meiny Faudah Amin Mia Miranti Rustama Mieke H Satari Mieke H Satari Mieke H Satari Mieke H. Satari Mieke Hemiawati Satari Mohamad Nurzaman Muchtan Sujatno - Murtihapsari . Nugraha Sutadipura - Putri, Salsabila Aqila Putri, Tenny Qomarilla, Nurul Rahmat Budiarto Rahmi Alma Farah Adang, Rahmi Alma Farah Ratna Annisa Utami RIKA MELIANSYAH Rismawati Rismawati Sahara, Elvi Sahiratmadja, Edhyana Kusumastuti Santhy Wyantuti Satari, Mieke Hermiawati Setiawan - Shiono, Yoshihito Sinaga, Siska Elisahbet Siswina, Tessa Siti Julaeha, Siti SYARIFUL MUBAROK Tati Herlina Tati Herlina Taufiq Ariwibowo Tri Mayanti Unang Supratman Yoshihito Shiono Yuli Ainun Rosidah Yuliana, Trisna Yulianto, Fiky Yuniarti, Eveline Yusi Deawati Yusi Deawati Yusrin, Yolanda Charmenia Nadine Zein, Muhammad Ihda H. L. Zulfan M. Alibasyah

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