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Journal : Nutrisia

Efek Kombinasi Doxorubicin dan Ekstrak Daun Pepaya (Carica papaya L.) terhadap Sel Payudara Pada Tikus Sprague Dawley yang Diinduksi DMBA (7,12-Dimethilbenzene(a)ntrazena) Fatma Zuhrotun Nisa; Mary Astuti; Sofia Mubarika Haryana; Agnes Murdiat
JURNAL NUTRISIA Vol 18 No 2 (2016): September 2016
Publisher : Poltekkes Kemenkes Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1224.887 KB) | DOI: 10.29238/jnutri.v18i2.52

Abstract

Background: treatment of cancer is currently done by biopsy and chemotherapy. Chemotherapy is a cancer treatment that is costly and toxic effect conferring on normal cells. Objective: to know the effect of combination chemotherapy with Doxorubicin as agents of papaya leaf extract as an agent against chemo preventive breast cells on rat Sprague Dawley DMBA induced. Method: this research is experimental research with design post test only with control group. This research uses 60 rats which are divided into 6 groups of placebo groups, groups, groups of DMBA, Doxorubicin, papaya leaf extract groups, group 1 combination (Doxorubicin 50 50 Papaya leaf extract) and group 2 combination (Doxorubicin 25 75 papaya leaf extract). Research time during the 120 days that consists of the first 3 weeks of treatment were given continued grant of DMBA during 5 weeks (twice a week) and continued treatment back to 6 weeks. The analysis was conducted for three times at the end of week 8, the end of the week to 12 and the end of the week to 16. Any analysis will be carried out the killing mice by as much as 3 tails per group. Parameters measured is histopathology breast tissue and breast cancer cell proliferation. Results: the breast tissue histopathology observations indicate that treatment combination I have the ability to prevent the occurrence of breast cancer and also improve the breast cells underwent karsinogenesis. Conclusion: the results of staining method with IHC (Immunohistochemistry) Ki-67 shows that treat the combination I have the lowest level of proliferation than the treatment and the combination of papaya leaf extract II. Keyword: papaya leaves, cancer, breast, Doxorubicin
Co-Authors . Irianianiwati . Suharno Abdurahman Laqif Abdurahman Laqif Addin Trirahmanto Agnes Murdiat Agnes Murdiati Agus Surono Ahmad Ghozali Ahmad Ghozali Ahmad Hamim Sadewa Akbar Satria Fitriawan Akira Hosoyama Akira Hosoyama Alfasunu, Serafim Aminuyati Angga Dwi Prasetyo Anwar, Sumadi Lukman Aprilia Indra Kartika Aprilia Indra Kartika Aris Haryanto Aris Haryanto Arsi Palupi Atsushi Yamazoe Atsushi Yamazoe AWM. Boersma Bambang Hariwiyanto Bambang Hariwiyanto Bambang Hariwiyanto Bernadia Branitamahisi Bernadia Branitamahisi Bolhuis RLH Camelia Herdini Christiana Tri Nuryana Christina Hari Nawangsih Priharsanti Christina Prihharsanti Cita Herawati Daan Khambri Damiana Sapta Candrasari Danarto Danarto Danarto Danarto Danarto Danarto Demas Bayu Handika Dessy Arisanty Dewi Agustina Dewi Sahfitri Tanjung Dewi Sahfitri Tanjung Diah Rumekti Hadiati Dibyo Pramono Didik Setyo Heiyanto Didik Setyo Heriyanto Dinna Rakhmina Dwi Aris Agung Nugrahaningsih Dwi Nur Indah Sari Edy Meiyanto Eka Savitri Endang Astuti Endang Astuti Fatma Zuhrotun Nisa Fatma Zuhrotun Nisa Firly Putri Fardhila Hanafi, Arif Riswahyudi Hartopo, Anggoro B. Heru Pradjatmo Hideaki Nojiri Hideaki Nojiri Ibnu G Gandjar, Ibnu G Ibnu G. Gandjar Ibnu G. Gandjar Ibnu G. Gandjar Ibnu G. Ganjar, Ibnu G. Ibnu Purwanto Ida Ayu Preharsini Ida Ayu Preharsini Kusuma Ifrinda Giantari Imelda, Priscillia Indwiani Astuti Indwiani Astuti Indwiani Astuti Indwiani Astuti Indwiani Astuti Iqmal Tahir Irianiwati Widodo Isnatin Miladiyah Iwan Dwiprahasto Iwan Dwiprahasto Jaap Middeldorp Jajah Fachiro JAKA WIDADA Jayusman, Achmad Mulawarman Jumina Jumina Juwita Raditya K. Nooter K. Nooter Ketut Sofjan Firdausi, Ketut Sofjan KV Rao, KV M. Munir Mae S.H. Wahyuningnsih Mae Sri Hartati Wahyuningsih Mark T Hamann, Mark T Mark T. Hamann Mary Astuti Mary Astuti Maya Esther Wullur Moningka Meutia Srikandi Fitria Mohammad Hakimi Nanda Qoriansas Nastiti Wijayanti Nastiti Wijayanti Nastiti Wijayanti Neneng Ratnasari Nilasari, Fita Nooter K Nor Sri Inayati Nor Sri Inayati Novi Febrianti Nur Arfian Nur Arfian Nur Signa Gumilas Oktriani R Oostrum RG Pamungkas Bagus Satriyo Perkasa, DP Pinandi Sri Pudyani Puji Lestari R. Danarto, R. R.L.M. Bolhuis Rachma Greta Perdana Putri Rachma Greta Putri Raden Danarto Renovaldi, Dede Retno Arianingrum Retno Sunarminingsih Sudibyo Rina Triasih Risky Oktriani Ronny Martien S. Sismindari Sagung Rai Indrasari Salugu Masesadji Sari Eka Pratiwi Sa’adah N Shanti Listyawati SHANTI LISTYAWATI Shanti Listyawati Shinta Hartanto Siregar, Fajri M. Sismindari . Sismindari Sismindari Sismindari Sismindari Siti Boedina Kresno Siti Nur Chasanah Siti Nur Chasanah Soenarto Sastrowiyoto Sri Nuryani Wahyuningrum Sri Nuryani Wahyuningrum Sri Nuryani Wahyuningrum Sri Nuryani Wahyuningrum Sri Suparwitri Stefani Candra Firmanti Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sukarti Moeljopawiro Sumadi, Firasti A.N Sumawan, Herman Susanna Hutajulu Tatsuo Takeya, Tatsuo Teguh Aryandono Tiara Puspita Agustin Tirta wardana Torizal GF Tri Wibawa Triana Hertiani Umar Anggara Jenie Umar Anggara Jenie Wardana T wardana, Tirta Widhiastuti, Stefani Santi Wirsma Arif Harahap Yanwirasti - Yohanes Widodo Wirohadidjojo Yosi B. Murti Yosi Bayu Murti Ysrafil, Ysrafil