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All Journal MEDISAINS Biology, Medicine, & Natural Product Chemistry Mutiara Medika: Jurnal Kedokteran dan Kesehatan JURNAL BIOLOGI INDONESIA Universa Medicina Jurnal Kesehatan Vokasional Jurnal Ilmu Kefarmasian Indonesia YARSI Medical Journal Sumatera Medical Journal Majalah Kesehatan Pharmamedika Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Medicra (Journal of Medical Laboratory Science/Technology) Proceeding ISETH (International Summit on Science, Technology, and Humanity) Junior Medical Journal Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Restu Syamsul Hadi
UNIVERSITAS YARSI
Religion Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Jurnal Kesehatan Vokasional

 1 
In Vivo Study of Telang Cream on Interleukin (IL)-6, Epidermal Growth Factor (EGF), and Wound Reepithelialization Pratiwi, Nike; Irwandi, Nurmayani; Hadi, Restu Syamsul; Thamrin, Nabila Pyrenina; Damayanti, Ndaru Andri; Juniarti, Juniarti; Rahmah, Nunung Ainur
Jurnal Kesehatan Vokasional Vol 10, No 2 (2025): May
Publisher : Sekolah Vokasi Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkesvo.106084

Abstract

Background: Povidone iodine is widely used in wound healing, but it can cause irritation and cellular toxicity. Clitoria ternatea L. has the potential to contain compounds such as rutin, quercetin 3-O-rhamnoside, ternatin, and anthocyanins as natural alternatives in wound healing. In this study, the extract used contains anthocyanins.Objective: The study aimed to evaluate the effects of Clitoria ternatea L. extract cream on the expression of Interleukin-6, Epidermal Growth Factor, and re-epithelialization in Sprague Dawley rat incision wounds.Methods: An in-vivo study with a post-test only control design was conducted on five treatment groups, including a control group without wounds (healthy), povidone iodine, and Clitoria ternatea L. extract cream (5%, 10%, 15%). IL-6 and EGF were analyzed using immunohistochemistry, while re-epithelialization was assessed using hematoxylin-eosin staining.Results: Clitoria ternatea L. extract increased IL-6 and EGF expression, with the highest expression at a 10% concentration. Re-epithelialization was faster in the treatment groups compared to both the positive and negative controls.Conclusion: The 10% Clitoria ternatea L. extract cream demonstrated efficacy comparable to povidone iodine in incision wound healing.
Co-Authors AGUNG ERU WIBOWO Artha Budi Susila Duarsa Azmi, Sabrina CHURIYAH CHURIYAH Damayanti, Ndaru Andri Dewi, Lia Sari Utami Elmi Nuryati Elmi Nuryati FAIZA KARA FABIOLA Fasihah, Mariah Shofwah Fatimah Eliana, Fatimah Firman Arifandi Hakim, Jasir Indra Kusuma Indra Kusuma Irwandi, Nurmayani Juniarti Juniarti Kuslestari, K Kusumah, Indra Marsiati, Himmi Maudina Mahlani Mustofa, Muhammad Samsul Nadira, Nadira Nunung Ainur Rahmah Nur Fadhilah Nur Fadhilah Parwanto, Edy Pendrianto Pendrianto, Pendrianto Pratiwi, Nike Rahmah Aprilia, Yoan Razari, Intan Reza Aditya Digambiro Rizki, Anika Rofilah, Dian Samsul Mustofa Samsul Mustofa Sembiring, Rinawati SISKA A KUSUMASTUTI Sofwan, Achmad TATI NURHAYATI Thamrin, Nabila Pyrenina TITIEK DJANNATUN Titiek Djannatun Tri Panjiasih Susmiarsih Ulviena, Lulu Wening Sari Yulia Suciati Yurika Sandra