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All Journal Jurnal Veteriner Jurnal Kedokteran Syiah Kuala Althea Medical Journal Indonesian Journal of Urology Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Jurnal Biosains Pascasarjana Jurnal Farmasi Klinik Indonesia Indonesian Journal of Tropical and Infectious Disease Journal of Agromedicine and Medical Sciences Health Notions Molecular and Cellular Biomedical Sciences (MCBS) Journal Of Vocational Health Studies Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Medik Veteriner J-Dinamika: Jurnal Pengabdian Kepada Masyarakat JURNAL ILKES (Jurnal Ilmu Kesehatan) Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Layanan Masyarakat (Journal of Public Service) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Indonesian Archives of Biomedical Research (InABR) Indonesian Andrology and Biomedical Journal
Arifa Mustika
Faculty Of Medicine, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Indian Journal of Forensic Medicine

 1 
The Effect of Mixed Liquor Administration on The Johnsen’s Score and The Number of Sertoli Cells and Leydig Cells on The Wistar Strain White Rats (Rattus norvegicus) Aqidah Khariri1 , Anny Setijo Rahaju2,4, Arifa Mustika3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13521

Abstract

To analyze the effect of mixed liquor administration on the Johnsen’s score and the number of Sertoli cellsand Leydig cells on the Wistar strain white rats (Rattus norvegicus). A total of 28 rats were divided into 4groups: C, P1, P2, and P3. Rats were given mixed liquor with different dose, namely P1 (1 ml), P2 (2 ml),and P3 (4 ml) each day for 14 days, then compared to C group which was given 4 ml of distilled water usingan oral gavage. Mixed liquor consists of 20% ethanol and 4% methanol. The histopathological features wereevaluated by the Johnsen’s score, the number of Sertoli cells, and Leydig cells in cross-sectional preparationof rat testicular tissue with 400× magnification. Datas were analyzed using the Kruskal-Wallis test and OneWay ANOVA test with a confidence level of p <0.05. The P3 group had the lowest Johnsen’s score and thenumber of Sertoli cells, 6.442±0.293 and 5.942±0.674, respectively. A significant decrease in increased doseoccurred in the Sertoli cell count but not in the Johnsen’s score. Group P2 had the lowest number of Leydigcells, 6.421±0.360. The administration of mixed liquor caused a decrease in Johnsen’s score and the numberof Sertoli cells and Leydig cells on the Wistar strain white rat (Rattus norvegicus).
Effect of Malus sylvestris Extract on Histopathological Features of Hypercholesterolemic Wistar Rat (Rattus norvegicus) Fatty Liver Nadhifa Tanesha Aufazhafarin1 , Alphania Rahniayu2 , Ema Qurnianingsih3 , Arifa Mustika4
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13604

Abstract

Objective: To evaluate the effect of Malus sylvestris extract on improving the degree of steatosis and portalinflammation histopathological features of hypercholesterolemic Rattus norvegicus strain wistar. Method:Forty-two male rats were divided into 6 groups randomly. Hypercholesterolemic fatty liver induced bygiving high-fat diet (HFD) for 46 days on groups 1 to 5, while group 6 given standard diet with the sameamount of time. Simvastatin was administered in group 2 at a dose of 0.36 mg/day. Groups 3, 4, and 5 weregiven Malus sylvestris extract (MSE) as a treatment at doses of 90 mg/day, 180 mg/day, and 360 mg/day insequential order. Simvastatin and MSE were administered for 14 days, from day 33 to 46. On day 47, all ratswere sacrificed and the liver was removed for histopathological slides preparation with hematoxylin-eosin(HE) staining. Histopathological results were analyzed using Kruskal Wallis test followed by Mann Whitneytest. Result: Histopathological analysis showed that Malus sylvestris extract improved steatosis and portalinflammation features compared to HFD-fed rats in group 1 (p<0,05). Conclusion: Malus sylvestris extractimproved the degree of steatosis and portal inflammation histopathological features of hypercholesterolemicrat fatty liver.
Co-Authors Achmad Firdaus Pamudya Wardhana Achmad Ilham Rizwani Adelia Handoko Agesti, Dyah Akbar Kurniawan, Mohammad Alimsardjono, Lindawati Aniek Meidi, Aniek Anny Setijo Rahaju, Anny Setijo Ario Imandiri, Ario Aszar, Farah Dynah Daeq Athoillah, Nabil Bambang Purwanto Cholis Abrori, Cholis Claudi Artha Dau, Daniel Deby Kusumaningrum Desie Dwi Wisudanti Dewinta, Nena Ristra Diah Mira Indramaya Dinda Dwi Purwati D’Arqom, Annette Edith Frederika Puruhito, Edith Frederika Elly Nurus Sakinah, Elly Nurus Faizah Sugiarto Farros Yuftariq Izzad Afla Fatimah, Nurmawati Fedelita Aistania Putri Firsta Wahono Febrianto Firsta Wahono Febrianto Fithriyah, Nathania Elma Gadis M. Sari Gondo Mastutik Halimatus Zahrah Harlina Soetjipto Herisulistyo, Aldilatama I'tishom, Reny Indiastuti, Danti Nur Indri Safitri Mukono, Indri Safitri Irda Bella Isnaini Nur Jannah, Isnaini Nur Jieputra, Alden Kartuti Debora, Kartuti Kenconowungu, Citrawati Dyah Linda Astari, Linda Lukman Hakim Maftuchah Maftuchah Mah Zhook Yueng Miranda Jemyma Mas&#039;ulun MOCHAMMAD THAHA Muhammad Arsy Reza Suyudi Muhammad Faizi, Muhammad Muhammad Hanun Mahyuddin Nabila Anisa Harum Naibaho, Ardy Hamonangan Nanang Haryono Nurina Hasanatuludhhiyah Nurlaili Susanti Pamudya Wardhana, Achmad Firdaus Prabowo, Gwenny Ichsan Priyo Budi Purwono Purwanta, Marijam Puspa Wardhani Putri Aliya Ahadini Qurnianingsih, Ema Rahmadhani, Khafiyah Hikmah Rahmawati, Lita Diah Rejeki, Purwo Sri Renny I’tishom Rizal, M Masrur Roostantia Indrawati Roostantia Indrawati Roostantia Indrawati, Roostantia Safira Raissa Dwi Putri Sandra Dewi Sitaresmi Sari, Gadis M. Siti Khaerunnisa Sjahjenny Mustokoweni, Sjahjenny Sri Purwaningsih Sriwijayanti Sulistyawati Sukarno, Devitya Angielevi Supangat Supangat Suryani Dyah Astuti Susanti, Luthfiana Rofhani Susanto, Ester Chateline Syahruna, Pradipta Reza Teguh Wahjudi Trisniartami Setyaningrum Vania Azalia Gunawan Wibsono, Sony WITA SARASWATI, WITA Wiwin Retnowati Wungu, Citrawati Dyah Kencono Wungu, Citrawati Dyah Kencono Yetti Hernaningsih Yuani Setiawati Zharfan, Rahmat Sayyid Zumara Ma'rifah Azzahra Zumara Ma'rifah Azzahra