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Formulasi Dan Uji Efektivitas Anti Inflamasi Sediaan Krim Ekstrak Etanol Daun Sirsak (Annona muricata L.) Secara In Vitro Chalik, Raimundus; Karim, Djuniasti; Hidayati, Hidayati; Haryuni, Haryuni
Media Farmasi XXX Vol 19, No 1 (2023)
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v19i1.3300

Abstract

Formulation and Anti-Inflammatory Effectiveness of Ethanol Extracts of Soursop Leaves (Annona Muricata L.) Using In Vitro AssayInflammation-reducing medications like steroids and non-steroid anti-inflammatory drugs (NSAIDs) are known to have considerable side effects, so an alternative with minimal side effects is needed. Besides administering anti-inflammatories orally, topical preparations are also increasingly being developed for reasons of practicality and minimal side effects that can occur. Soursop leaves (Annona muricata L.) are commonly utilized by the community as a medicinal plant for treating inflammation. Several studies have shown that soursop leaf extract has anti-inflammatory effects. This research is a laboratory experimental study that aims to test the effectiveness of anti-inflammatory cream preparations of soursop leaf extract in vitro. The cream preparations that had been formulated were tested for stability before and after accelerated storage. Anti-inflammatory effectiveness test in vitro using protein denaturation inhibition method by making each series of Na positive control solution. Diclofenac, cream preparation, and negative control were dissolved using 0.2% BSA solution in TBS solvent pH 6.2 – 6.5. Then the solution was incubated for 30 minutes and heated for 2 minutes at 1000C. After cooling, the solution was homogenized, and absorbance was measured using a UV-visible spectrophotometer at a wavelength of 660 nm. Anti-inflammatory effectiveness is seen from the IC50 value. The results showed that soursop leaf extract cream preparations could inhibit protein denaturation. An IC50 value of 291.11 µg/mL.Keywords: Soursop leaves, anti-inflammation, in vitro, protein denaturatioObat-obat anti-inflamasi seperti golongan steroid dan anti-inflamasi non steroid (AINS) diketahui memiliki efek samping yang patut diperhitungkan sehingga diperlukan suatu alternatif dengan efek samping minimal. Di samping pemberian anti inflamasi per oral, juga semakin banyak dikembangkan sediaan topikal dengan alasan kepraktisan dan efek samping minimal yang dapat ditimbulkan. Salah satu tanaman obat yang sering digunakan oleh masyarakat untuk mengobati inflamasi adalah daun sirsak (Annona muricata L.). Beberapa penelitian menunjukkan bahwa ekstrak daun sirsak memiliki efek anti-inflamasi. Penelitian ini merupakan penelitian eksperimental laboratorium yang bertujuan untuk menguji efektivitas sediaan krim anti-inflamasi ekstrak daun sirsak secara in vitro. Sediaan krim yang telah diformulasi diuji stabilitasnya sebelum dan sesudah penyimpanan dipercepat. Efektivitas anti-inflamasi diuji secara in vitro menggunakan metode inhibisi denaturasi protein dengan membuat masing-masing seri larutan kontrol positif Na. Diklofenak, sediaan krim, dan kontrol negatif yang dilarutkan menggunakan larutan BSA 0,2 % dalam pelarut TBS pH 6.2 – 6.5. Kemudian larutan diinkubasi selama 30 menit dan dipanaskan selama 2 menit pada suhu 1000C. Setelah dingin, larutan dihomogenkan dan dilakukan pengukuran absorbans dengan spektrofotometer UV-Visibel pada panjang gelombang 660 nm. Hasil penelitian menunjukkan sediaan krim ekstrak daun sirsak dapat menghambat denaturasi protein dilihat. Nilai IC50 sebesar 291.11 µg/mLKata kunci : Daun sirsak, anti inflamasi, in vitro, denaturasi protein
EFEKTIVITAS DOSIS PUPUK ORGANIK CAIR TERHADAP HASIL TANAMAN PAKCOY Haryuni, Haryuni; Komala Rosiah, Wildia
Jurnal Agroteknologi dan Pertanian (JURAGAN) Vol 4 No 2 (2023): JURAGAN (JURNAL AGROTEKNOLOGI DAN PERTANIAN) OKTOBER 2023
Publisher : LPPM Universitas Bina Insan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32767/juragan.v4i2.131

Abstract

Pakcoy (Brassica rapa L.) adalah jenis sayuran yang tergolong ke dalam keluarga Brassicaceae, tanaman sawi pakcoy berasal dari cina (Ernanda, 2017). Pupuk organik cair merupakan pupuk yang ramah lingkungan dan mengandung bahan penting yang di butuhkan untuk membuat tanah subur kembali baik dari fisik, biologi dan kimia. (Puspadewi, et all, 2016). Tujuan dari penelitian ini adalah untuk mengetahui seberapa besar efektivitas dan rekomendasi dari dosis pupuk organik cair terhadap hasil tanaman pakcoy (Brassica rapa L.). Penelitian ini dilaksanakan pada bulan Maret sampai Mei 2021 di Kelurahan Rimbo Recap, Kecamatan Curup, Kabupaten Rejang Lebong. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 6 perlakuan dosis P0 (tanpa perlakuan), P1 (20 ml/1 liter air), P2 (40 ml/1 liter air), P3 (60 ml/1 liter air), P4 (80 ml/1 liter air) dan P5 (100 ml/1 liter air). Pengamatan variabel yaitu tinggi tanaman, jumlah daun, lebar daun, diameter batang, panjang akar dan berat pertanaman pada tanaman pakcoy. Dari hasil penelitian menunjukkan bahwa perlakuan dosis pupuk organik cair berpengaruh sangat nyata pada variabel tinggi tanaman, jumlah daun, lebar daun, diameter batang dan berat pertanaman.
What are the Major Barriers and Challenges Faced by Independent Oil Palm Smallholder Farmers in RSPO Certification? Citra Irawan, Norbertus; Mahananto; Supriyadi, Teguh; Haryuni
Journal of Rural and Urban Community Studies Vol 2 No 2 (2024): August
Publisher : Agribusiness Department, Agriculture Faculty, Tunas Pembangunan University, Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36728/jrucs.v2i2.3917

Abstract

The Roundtable on Sustainable Palm Oil (RSPO) certification is essential for promoting sustainable palm oil production; however, smallholder farmers face significant obstacles in meeting its standards, hindering their growth. This study aims to identify the main barriers and challenges for independent oil palm smallholders in the RSPO certification process and to propose strategies for overcoming these issues. Using a mixed-methods approach, researchers collected data from 60 smallholders through a snowball sampling method and analyzed it using descriptive statistical techniques such as frequency counts and cross-tabulations. Critical barriers identified include high certification costs, lack of knowledge, limited resources, difficulties tracking production yields, and challenges meeting social requirements. Furthermore, smallholders struggle with adapting cultivation practices, accessing markets, maintaining commitment, building capacity, and navigating bureaucratic hurdles. Organizations are urged to adopt market development strategies, enhance their Corporate Social Responsibility (CSR) initiatives, and facilitate better access to sustainable technologies to tackle these challenges. Additionally, enhancing green skills, simplifying record-keeping, reinforcing farmer groups, and offering financial incentives, including soft loans and tailored training, are critical. Streamlining certification procedures will also alleviate administrative burdens, enabling smallholders to adopt sustainable practices more effectively.
Biofortification in Palm Oil Based on Saponin Nanotechnology: Innovation in Nutritional Stability, Antioxidants and for Functional Quality Sapto Priyadi; H. Haryuni; R. Soelistijono; Siti Mardhika Sari
Agricultural Science Vol. 8 No. 1 (2024): September
Publisher : Faculty of Agriculture, Merdeka University Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55173/agriscience.v8i1.152

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Palm oil is the world's main vegetable oil commodity and significantly contributes to the food industry. However, challenges related to the low content of certain nutrients and susceptibility to lipid oxidation are major issues that affect product quality. Fortification technology is an innovative solution to improve palm oil's nutritional value and oxidative stability. This article aims to evaluate the development of modern technology in palm oil fortification, including the addition of vitamin A, vitamin E, bioactive compounds, and the use of natural and synthetic antioxidants. Various methods, such as microencapsulation, nanotechnology, and biofortification techniques, are discussed in the context of their effectiveness in maintaining nutritional stability, preventing lipid oxidation, and extending product shelf life. This review highlights the challenges of implementing fortification technology, including technical and regulatory aspects in the food industry. The results of the review indicate that fortification technology improves nutritional quality and the oxidative stability of palm oil, thus supporting the development of healthier and more value-added food products. The implementation of vitamin A and E fortification with nanotechnology is expected to be able to answer global nutritional challenges and increase the competitiveness of the palm oil industry in the international market. 
Analysis of Crop Rotation and Compost Use on Organic Carrot Production Results in Rejang Lebong Regency Apriantonedi, Reko; Ma'shum, Halim; Haryuni, Haryuni; Utami, Rizky Septika; Fransisko, Eko
West Science Interdisciplinary Studies Vol. 3 No. 01 (2025): West Science Interdisciplinary Studies
Publisher : Westscience Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58812/wsis.v3i01.1632

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This study investigates the impact of crop rotation and compost use on organic carrot production yield in Rejang Lebong District. Using a quantitative approach, data were collected from 60 organic carrot farmers through a structured questionnaire with a Likert scale (1–5). The data were analyzed using SPSS version 25 to examine the effects of these practices on yield. The findings reveal that both crop rotation and compost use have significant positive effects on organic carrot yields, with compost use showing the strongest influence. A synergistic effect was observed when both practices were combined, leading to improved soil health, nutrient availability, and pest management. The study highlights the importance of integrating sustainable agricultural practices to optimize organic carrot production. These insights are valuable for farmers, policymakers, and agricultural stakeholders aiming to enhance productivity while maintaining sustainability.
Optimalisasi Pengetahuan Ibu Tentang Stunting Melalui Edukasi Kesehatan Berbasis Booklet Erviana; Muhammad Taufik Page; Haryuni; Masniati; Irna Megawati
Citra Delima Scientific journal of Citra Internasional Institute Vol. 8 No. 2 (2025): Citra Delima Scientific journal of Citra Internasional Institute
Publisher : Institut Citra Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33862/citradelima.v8i2.489

Abstract

Lack of maternal knowledge can be one of the factors that can influence the incidence of stunting in children. One thing that can increase knowledge is by providing health education with booklet media. Booklet media is a small book size designed to provide education for readers in the form of strategies and tips for solving problems. The purpose of this study was to analyze the effectiveness of booklet media in increasing maternal knowledge about stunting in Tallu Banua village. The research method used in this study was a quasi-experimental design with a one group pretest-posttest design. The study population was mothers who had stunted children with a sample size of 32 people. The sampling technique used consecutive sampling. The analysis was carried out using the Marginal Homogeneity test. The results of the study showed that booklet media had an influence on increasing maternal knowledge where there was an increase in knowledge before and after being given education with booklet media with a p-Value of 0.000 (p <0.05). The conclusion in this study is that health education with booklet media is effective in increasing maternal knowledge about stunting.
Sustainable Agriculture Education through Processing Tobacco Stem into Liquid Organic Fertilizer Karunia Irfan , Ramadahan; Ardhanesdian Rizqi , Setyadi; Haryuni, Haryuni; Priyadi, Sapto; Achmad Fatchul, Aziez; Mutiarra Ridyo Arum
Journal of Community Capacity Empowerment Vol 3 No 1 (2025): February 2025
Publisher : Universitas Tunas Pembangunan Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36728/jcce.v3i1.4569

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Processing agricultural waste into value-added products is an important step in supporting sustainable agriculture. One of the wastes that has great potential to be processed is tobacco stem waste, which is often considered as waste without value. This educational activity aims to provide knowledge and skills to farmers in processing tobacco stem waste into liquid organic fertilizer. This education is carried out through a participatory approach, involving counseling, technical demonstrations, and direct practice. The results of the activity showed that participants were able to understand the importance of waste management in supporting agricultural sustainability. Participants also succeeded in practicing the process of processing tobacco stem waste into liquid organic fertilizer, which includes shredding, fermentation using local microorganisms, and packaging the final product. The positive impacts of this activity include increasing farmer awareness of waste management, reducing dependence on chemical fertilizers, and cost efficiency in their farming systems. In addition, the application of liquid organic fertilizer from tobacco stems can also increase soil fertility naturally and support environmental conservation efforts. However, there are several challenges in implementing this activity, such as the lack of supporting facilities and the need for further assistance to ensure the sustainability of technology adoption by farmers. Overall, this educational activity has a positive impact on improving farmer skills and innovative waste management, while supporting more environmentally friendly and sustainable agriculture.
Effect of Dolomite Dosage and Chicken Manure on the Growth and Yield of Red Onions (Allium ascanolicum L.) Prabawati, Dimar; Supriyadi, Teguh; Dewi, Tyas Soemarah Koernia; Budiyono, Agus; Haryuni
Journal of Rural and Urban Community Studies Vol 3 No 1 (2025): February
Publisher : Agribusiness Department, Agriculture Faculty, Tunas Pembangunan University, Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36728/jrucs.v3i1.4657

Abstract

Bawang merah (Allium ascalonicum L.) merupakan komoditas hortikultura yang vital di Indonesia, dengan permintaan yang terus meningkat seiring dengan pertumbuhan penduduk. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian dolomit terhadap pertumbuhan dan hasil bawang merah (Allium ascalonicum L.), untuk mengetahui pengaruh pemberian pupuk kandang ayam terhadap pertumbuhan dan hasil bawang merah (Allium ascalonicum L.), untuk mengetahui pengaruh interaksi antara dosis dolomit dan pupuk kandang ayam yang memberikan pengaruh terbaik terhadap pertumbuhan dan hasil bawang merah (Allium ascalonicum L.). Penelitian ini dilaksanakan pada tanggal 17 Agustus sampai dengan 20 Oktober 2023, di Desa Bangsalan, Kecamatan Teras, Kabupaten Boyolali, Jawa Tengah, pada ketinggian tempat 227 meter di atas permukaan laut, menggunakan Rancangan Acak Kelompok Lengkap (RAKL) faktorial dengan tiga kali ulangan. Dua faktor diperiksa: yang pertama adalah aplikasi dolomit (D) pada tiga level—D0 (tanpa dolomit), D1 (5 ton/ha), dan D2 (10 ton/ha); yang kedua adalah aplikasi pupuk kandang ayam (F) pada empat level—F0 (tanpa pupuk kandang ayam), F1 (5 ton/ha), F2 (10 ton/ha), dan F3 (15 ton/ha). Hasil penelitian menunjukkan bahwa dolomit secara signifikan memengaruhi pertumbuhan dan hasil bawang merah, khususnya memengaruhi diameter umbi, jumlah umbi per tanaman, berat umbi segar per tanaman, dan berat umbi kering per tanaman dan plot. Itu juga berdampak signifikan pada jumlah umbi per plot. Kotoran ayam terutama memengaruhi berat umbi kering per plot dan secara signifikan memengaruhi tinggi tanaman, berat tangkai kering per tanaman, diameter umbi, berat umbi segar per tanaman, dan berat umbi kering per tanaman. Interaksi antara dolomit dan kotoran ayam secara signifikan memengaruhi berat tangkai segar per tanaman, berat umbi kering per tanaman dan plot, diameter umbi, dan jumlah umbi. Hasil tertinggi diperoleh pada kombinasi D2F3 dengan berat umbi kering per petak sebesar 1441,10 gram (25,60 ton/ha), sedangkan hasil terendah diperoleh pada kombinasi D0F0 yaitu sebesar 1151,10 gram (20,46 ton/ha). Penggunaan dolomit dan pupuk kandang ayam secara tunggal maupun kombinasi memberikan pengaruh positif terhadap pertumbuhan dan hasil umbi, sehingga dapat disimpulkan bahwa pemberian kedua jenis amelioran tersebut secara bersamaan lebih efektif dalam meningkatkan produktivitas tanaman dibandingkan dengan perlakuan tunggal.
Inventory of Diseases in Red Shallot Plants (Allium ascalonicum) Haryuni, Haryuni; Setyadi, Ardhanesdian Rizqi; Suprapti, Endang; Dewi, Tyas Soemarah Kurnia; Irawan, Norbertus Citra; Rahman, Azhar Aditya
Biosaintifika: Journal of Biology & Biology Education Vol. 16 No. 3 (2024): December 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v16i3.16546

Abstract

Shallots (Allium ascalonicum) are a popular spice vegetable cultivated in Indonesia, ranging from lowlands to highlands. Their demand continues to grow as they are an essential kitchen commodity, although their prices often fluctuate. This research aimed to examine the disease symptoms in shallot plants caused by pathogenic fungi and to identify the types of pathogenic fungi present on agricultural land in Bangsalan Village, Boyolali Regency. The study consisted of three blocks, each containing 12 plots, and each plot comprising 15 plants. From each plot, five plants were randomly selected as samples. This qualitative research utilized observational and descriptive methods, where symptoms observed in the field were described and identified based on macroscopic and microscopic characteristics. Macroscopic identification revealed symptoms such as wilting, rot, and spots on both leaves and tubers. Microscopic identification confirmed infections by the fungi Colletotrichum sp. (causing anthracnose), Fusarium spp., and Aspergillus sp. on shallots. The findings from this study provide valuable recommendations for managing shallot diseases in subsequent planting seasons if similar symptoms are observed.
The Effect of Planting Media and Liquid Organic Fertilizer Interval on the Growth and Yield of Chili Peppers Haryuni; Rani Latifah; Achmad Fatchul Aziez; Endang Suprapti; Tyas. S. K. Dewi; Siti Mardhika Sari
Agricultural Science Vol. 8 No. 2 (2025): March
Publisher : Faculty of Agriculture, Merdeka University Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55173/agriscience.v8i2.160

Abstract

This study aims to determine the effect of planting media and the interval of application of liquid organic fertilizer of banana stems on the growth and yield of chili pepper plants (Capsicum frutescens L.). The study was conducted in the greenhouse of the Faculty of Agriculture, UTP Surakarta from December 2024 to February 2025 using a factorial complete randomized block design (RAKL) with two factors: planting media (soil, soil + manure, soil + manure + rice husks) and the interval of application of liquid organic fertilizer (without liquid organic fertilizer, once every 5 days, once every 10 days, once every 15 days). The results showed that the planting media of soil + manure + rice husks (M2) had a very significant effect on plant height, fresh weight, dry weight, number of fruits, and harvested fruit weight, with the highest results in plant height (74.729 cm), fresh weight (76.688 g), and harvested fruit weight (576.75 g). The 15-day liquid organic fertilizer application interval (P3) also showed a significant effect on plant growth and yield, with the highest plant height (67.336 cm) and the highest harvest fruit weight (524.56 g). The conclusion of this study is that the use of a mixture of soil, manure, and rice husks as a planting medium and a 15-day POC application interval is the best combination to increase the growth and yield of chili pepper. This study also shows that banana stem liquid organic fertilizer can be an alternative environmentally friendly and sustainable organic fertilizer.
Co-Authors Achmad Fatchcul Aziez Achmad Fatchul Aziez Achmad Fatchul, Aziez Achmad Fatkhul Aziez Achmadi Priyatmojo Adi Prasetyo Adnan AF Aziez AF Aziez Agung Prasetyo Agus Budiyono Alfiansyah Al Afghani Erping Sitompul Anggi Ardianto Anggraini, Selviana Apriantonedi, Reko Apriyansyah, Jaka Ardhanesdian Rizqi , Setyadi ARDIANOR ARDIANOR, ARDIANOR Arif Hidayanto Azhar Aditya Rahman D. DARYANTI Daryanti Daryanti DARYANTI DARYANTI Dewi, Tyas Soemarah Koernia Dian Rakhmawati Didik Dwi Ardiyanto Dwi Susilo U Dwi Susilo Utami Dwi Susilo Utami Dwi Susilo Utami Dwi Susilo Utami Dwi Susilo Utami Dwi Susilo Utami Eko Fransiko Eko Fransisko Eko Hartoyo Endang Suprapti Erma Cahyani Erna Siaga, Erna Erviana Fatkur Fatkur Fransisko, Eko Hafiza, Sularmi Hakiki, Iqmal Harjanto FP UTP Ska HARJANTO HARJANTO HARTOYO, EKO Hidayati Hidayati Irna Megawati Irvansyah Cahya Perwita ISKANDAR ismah Khoirunnisa Januar Pandapotan JOKO KUSNANTO Karim, Djuniasti Karunia Irfan , Ramadahan Kembarawati Kembarawati Komala Rosiah, Wildia Kris Julianto Kusriani Prasetyowati Kusriani Prasetyowati kusuma, galih sekar permata Lisarut Sahayana Hutapea Loso, Sugito Lutfi Ali Setiawan Ma'shum, Halim Mahananto Mardian Apriansi Masniati Ma’shum, Halim Muchlis Zainuri Muhamad Amin Muhammad Taufik Page Mutiarra Ridyo Arum Norbertus Citra Irawan Nugroho, Benny Parwito Parwito, Parwito Prabawati, Dimar Prasetio, Suji Tegar R Soelistijono Raimundus Chalik Ramadhan, Karunia Irfan Rani Latifah Ratih Dwi Kartikasari Ratih. D Kartikasari Risky Rita Afrina Rizky Septika Utami Rochmadi Rochmadi Sagita, Yelin Sapto Priyadi Setie Harieni Setyadi, Ardhanesdian Rizqi Siti Mardhika Sari SRI HANDOYO Suswadi Teguh Supriyadi Teguh Teguh Tiara, Dewi Titik Nuryati, Titik Tyas Soemarah K. Tyas Soemarah K.D Tyas Soemarah K.D Tyas Soemarah Koernia Dewi Tyas SOEMARAH KURNIA DEWI Tyas. S. K. Dewi Utami, Rizky Septika Veri Dwi Arum Putri Serang Wiyono Wiyono Wiyono