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All Journal Pharmaciana: Jurnal Kefarmasian The Journal of Pure and Applied Chemistry Research Jurnal Riset Kimia IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Science and Technology Indonesia Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Surya Abdimas Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu Kefarmasian Indonesia Jurnal Pengabdian Al-Ikhlas Bioscientist : Jurnal Ilmiah Biologi Jurnal Kimia dan Kemasan Jurnal Riset Fisika Indonesia Molekul: Jurnal Ilmiah Kimia Bulletin of Chemical Reaction Engineering & Catalysis Bencoolen Journal of Pharmacy Rafflesia Journal of Natural and Applied Sciences (RJNAS)
SALPRIMA YUDHA S
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Universitas Bengkulu, Bengkulu, 38122, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Assessment of the subchronic toxicity of ethanol extract of Merdeka-leaves (Chromolaena odorata L.) on SGOT, SGPT, and histological alterations in the kidneys and liver of male rats Pertiwi, Reza; Azhar, Afra Wafiqah; Dominica, Dwi; Yudha, Salprima; Rahmawati, Reza; Putri, Yona Harianti
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.30278

Abstract

The Merdeka plant (Chromolaena odorata L.) is known for its various pharmacological benefits, including gastroprotection, antibacterial, antihyperglycemic effects, and wound healing promotion. To ensure safe use in the community, it is important to evaluate its potential toxicity. This study examined the effects of ethanol extract of Merdeka leaf (C. odorata) on liver function by measuring the levels of serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic-pyruvate transaminase (SGPT) in male rats (Rattus norvegicus). Twenty-five male Wistar rats were split into five groups: three treatment groups that received ethanol extract at doses of 150 mg/kg BW, 300 mg/kg BW, and 600 mg/kg BW, a negative control group that received 0.5% Na CMC, and a normal control group that received no treatment. For 28 days, the extract was taken orally every day. Following surgery, liver and kidney tissues were removed for histology on day 29, and blood samples were obtained via the aorta. The findings demonstrated that rats administered 600 mg/kg BW of ethanol extract had significantly greater SGOT and SGPT levels than controls (p < 0.05), suggesting that high dose of Merdeka leaf extract may have an impact on kidney and liver functions.
Membran Alginat Padina sp. - Polietilen Glikol (AP-PEG): Preparasi, Karakterisasi dan Aplikasinya sebagai Enkapsulan Herlina Herlina; Aswin Falahudin; Irfan Gustian; Agus Martono H. Putranto; Morina Adfa; Salprima Yudha S
ALCHEMY Jurnal Penelitian Kimia Vol 17, No 1 (2021): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.17.1.41713.63-73

Abstract

Pengembangan penelitian tentang material berbasiskan sumber daya alam lokal dan dapat diperbaharui terus dikembangkan akhir-akhir ini. Hal tersebut didasari adanya kebutuhan material baru dengan karakteristik yang lebih menguntungkan dan dapat digunakan pada aplikasi yang spesifik. Penelitian ini bertujuan untuk mempelajari preparasi membran alginat-polietilen glikol (AP-PEG) dan aplikasinya sebagai enkapsulan. Alginat yang digunakan adalah hasil ekstraksi dari rumput laut cokelat Padina sp. Dengan metode maserasi jalur asam alginat. Preparasi membrane alginat Padina sp.-polietilen glikol (AP-PEG) dilakukan dengan perbandingan PEG-AP = 1:5; 1:10; 1:15; 0:1 (b/b). Analisis gugus fungsi terhadap seluruh membran yang dihasilkan, menunjukkan bahwa membran AP-PEG yang dihasilkan diprediksi sebagai hasil blending secara fisika karena tidak ada gugus fungsi baru yang terbentuk. Membran dengan perbandingan berat PEG-AP=1:15 memiliki karakteristik terbaik dengan persentase swelling sebesar 1465,5%, stress sebesar 14,588 MPa, strain 0,07 dan Modulus Young sebesar 193,13 MPa. Hasil analisis morfologi menunjukkan bahwa banyak rongga ditemukan pada membrane tersebut. Hasil uji disolusi terhadap membrane tersebut menunjukkan bahwa, pada pH 1,2 membran tersebut dapat melepaskan vitamin C sebesar 78,12% selama 60 menit dan tidak mengalami cracking. Di sisi lain, pada pH 7,2 membran tersebut dapat melepaskan vitamin C sebesar 83,54% dan cracking terjadi dalam waktu 12 menit. Hasil penelitian ini menunjukkan bahwa komposit AP-PEG dapat dibuat dari rumput laut coklat dan memiliki kemampuan sebagai enkapsulan.   Alginate Padina sp.-Polyethylene Glycol (AP-PEG) Membranes: Preparation, Characterization and Their Application as Encapsulant. The development of research on materials based on local and renewable natural resources has been continuously being developed recently. This is based on the need for new materials with more favorable characteristics and can be used in specific applications. This research aims to study the synthesis of alginate-polyethylene glycol (AP-PEG) membranes and their application as an encapsulant. The alginate was extracted from the brown seaweed Padina sp. by maceration method using alginic acid pathway. Alginate Padina sp.-polyethylene glycol (AP-PEG) alginate membrane was prepared with a ratio of PEG:AP = 1: 5, 1:10, 1:15 and 0:1 (w/w). The functional group analysis showed that the resulting AP-PEG membranes were predicted as a result of physical blending due to no new functional groups are formed. The membrane with a weight ratio of PEG:AP = 1:15 had the best characteristics, with a percentage of swelling of 1465.5%, stress of 14.588 MPa, 0.07 strain, and Young Modulus of 193.13 MPa. Morphological analysis showed that the membrane obtained had many cavities. The dissolution test showed that the AP-PEG membrane was able to release vitamin C of 78.12% for 60 minutes at pH 1.2 and no cracking was observed, while at pH 7.2 the membrane was able to distribute vitamin C by 83.54% and cracking occurs within 12 minutes. The results of this study indicate that AP-PEG composites can be made from brown seaweed and have good encapsulant capabilities.
Co-Authors Afra Wafiqah Azhar Agus Martono H. Putranto Alvin Reagen, Muhamad Anisa Ulya Darajat Annisa Ramadhani Aritonang, Anthoni Batahan Asdim Asdim Askhan, Jimmy Aswin Falahudin Aswin Falahudin Aswin Falahudin Aswin Falahudin Aswin Falahudin Aswin Falahudin Aswin Falahudin Avidlyandi, Avidlyandi Azhar, Afra Wafiqah Bambang Trihadi Buistu Arba’a Nuyuh Putri Charles Banon Demi Dama Yanti Dennie Oktrin Wicaksono Dominica, Dwi Doni Notriawan Dwita Oktiarni Efendi, Pahran Eka Angasa Eka Angasa Etriyanto Arman Falahudin, Aswin Fatan Umbara Febriansyah, Rahmaga Herlina Herlina Herlina Herlina I Putu Mahendra Ika Diana Evita Insin, Numpon Irfan Gustian Irfan Gustian Irfan Gustian Irfan Gustian John Hendri Kazi, Mohsin Khafit Wiradimafan Liana Wahyuni Liesaiani Daefisal, Octakireina M. Rafi Mardlia, Zulfikri Achid Mifta Violina Aniza Morina Adfa Morina Adfa Muhamad Alvin Reagen Munifilia Ekasari Nasution, Riski Padilah Nazarudin Nazarudin Nazarudin Nesbah Nesbah Nesbah, Nesbah Noor Haida Mohd Kaus Notriawan, Doni Nurhasana, Devi Octakireina Liesaini Daefisal Oman Zuas Oman Zuas Perdani, Meka Saima Putri, Yona Putri, Yona Harianti Rahmawati, Reza Rais Akbar Syahputra Reagen, Muhamad Alvin Reza Pertiwi Reza Pertiwi Reza Pertiwi Riski Padilah Nasution Risky Hadi Wibowo Risky Hadi Wibowo Saiqa Ikram Saiqa Ikram Setyo Eko Nugroho Nugroho Sirikanjana Thongmee Sri Ningsih Suli Anggria Murni Supriati, Rochmah Suripto D Yuwono Swadexi Istiqphara Swadexi Istiqphara Swadexi Istiqphara Swadexi Istiqphara, Swadexi Syalfinaf Manaf Teja Dwi Sutanto Triawan, Deni Agus Umi K Yaumidin Wibowo, Risky Hadi Wuri Prameswari Yaumidin, Umi K Yuwono, Suripto D